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Information on EC 2.4.1.17 - glucuronosyltransferase and Organism(s) Arabidopsis thaliana
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2.4.1.17 glucuronosyltransferaseIUBMB Comments
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
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Word Map
- 2.4.1.17
-
glucuronidation
- hyperbilirubinemia
- hepatocytes
- irinotecan
- gilbert
- s-transferase
- cyp3a4
- phenobarbital
-
unconjugated
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drug-metabolizing
-
disposition
-
pharmacogenetic
-
udp-glucuronic
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interindividual
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drug-drug
-
concentration-time
-
extrahepatic
- acetaminophen
-
sulfotransferase
-
mycophenolic
- neutropenia
-
pregnane
- 3-methylcholanthrene
-
benzoapyrene
-
o-deethylase
- jaundice
- androsterone
- cyp2c9
- drug development
-
endobiotics
-
slco1b1
-
vitro-in
- lamotrigine
-
clint
- sult1a1
-
herb-drug
- propofol
- atazanavir
- diagnostics
-
cdna-expressed
- cyp1b1
- analysis
-
androstane
-
pharmacogenomics
- raltegravir
- 7-ethoxyresorufin
- aminopyrine
- pharmacology
- medicine
- ethylmorphine
- zidovudine
-
ethoxycoumarin
-
sults
- beta-naphthoflavone
-
oatp1b1
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
ugt1a1, udp-glucuronosyltransferase, ugt2b7, ugt1a9, ugt1a6, ugt1a, ugt2b17, ugt1a4, udp-glucuronyltransferase, udpgt, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1-naphthol glucuronyltransferase
-
-
-
-
1-naphthol-UDP-glucuronosyltransferase
-
-
-
-
17-OH steroid UDPGT
-
-
-
-
17beta-hydroxysteroid UDP-glucuronosyltransferase
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-
-
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3-OH androgenic UDPGT
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-
-
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3alpha-hydroxysteroid UDP-glucuronosyltransferase
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-
-
-
4-hydroxybiphenyl UDP-glucuronosyltransferase
-
-
-
-
4-methylumbelliferone UDP-glucuronosyltransferase
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-
-
-
4-nitrophenol UDP-glucuronosyltransferase
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-
-
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4-nitrophenol UDP-glucuronyltransferase
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-
-
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4-nitrophenol UDPGT
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-
-
-
bile acid uridine 5'-diphosphoglucuronyltransferase
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-
-
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bilirubin glucuronyltransferase
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-
-
-
bilirubin monoglucuronide glucuronyltransferase
-
-
-
-
bilirubin UDP-glucuronosyltransferase
-
-
-
-
bilirubin UDPglucuronosyltransferase
-
-
-
-
bilirubin UDPGT
-
-
-
-
bilirubin uridine diphosphoglucuronyltransferase
-
-
-
-
ciramadol UDP-glucuronyltransferase
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-
-
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estriol UDP-glucuronosyltransferase
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-
-
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estrone UDP-glucuronosyltransferase
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-
-
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glucuronosyltransferase, uridine diphospho-
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-
-
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glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol
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-
-
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glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl
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-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin
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-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-estradiol
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-estriol
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-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-
-
-
-
-
glucuronyltransferase, uridine diphospho-GT
-
-
-
-
morphine glucuronyltransferase
-
-
-
-
p-hydroxybiphenyl UDP glucuronyltransferase
-
-
-
-
p-nitrophenol UDP-glucuronosyltransferase
-
-
-
-
p-nitrophenol UDP-glucuronyltransferase
-
-
-
-
p-nitrophenylglucuronosyltransferase
-
-
-
-
p-phenylphenol glucuronyltransferase
-
-
-
-
phenyl-UDP-glucuronosyltransferase
-
-
-
-
PNP-UDPGT
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-
-
-
UDP glucuronate-estradiol-glucuronosyltransferase
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-
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UDP glucuronate-estriol glucuronosyltransferase
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-
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UDP glucuronic acid transferase
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-
-
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UDP glucuronosyltransferase
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-
-
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UDP glucuronyltransferase
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-
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UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase
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-
-
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UDP-glucuronate-bilirubin glucuronyltransferase
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-
-
-
UDP-glucuronosyltransferase
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-
-
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UDP-glucuronyltransferase
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-
-
-
UDPGA transferase
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-
-
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UDPGA-glucuronyltransferase
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-
-
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UDPglucuronate beta-D-glucuronosyltransferase
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-
-
-
UDPglucuronosyltransferase
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-
-
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UDPGT
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-
-
-
uridine 5'-diphosphoglucuronyltransferase
-
-
-
-
uridine diphosphate glucuronyltransferase
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-
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uridine diphosphoglucuronate-bilirubin glucuronosyltransferase
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-
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uridine diphosphoglucuronosyltransferase
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-
-
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uridine diphosphoglucuronyltransferase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
Ascorbate and aldarate metabolism, Biosynthesis of secondary metabolites, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolism of xenobiotics by cytochrome P450, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Retinol metabolism, Steroid hormone biosynthesis
-
-, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
CAS REGISTRY NUMBER
COMMENTARY
37205-52-0
-
37277-52-4
-
37277-66-0
-
61969-98-0
-
62213-43-8
-
62213-47-2
-
9030-08-4
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
transfer of glucuronic acid (GlcA) from UDP-GlcA to glycosyl inositol phosphorylceramides (GIPCs)
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
transfer of glucuronic acid (GlcA) from UDP-GlcA to glycosyl inositol phosphorylceramides (GIPCs)
-
-
?
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
IPUT1 belongs to a glycosyltransferase family that transfers sugars with a retaining mechanism resulting in alpha-linked sugars, consistent with the alpha conformation of the GlcA in glycosyl inositol phosphorylceramides (GIPCs)
metabolism
the enzyme is involved in the plant-type sphingolipid pathway
physiological function
inositol phosphorylceramide glucuronosyltransferase1 (IPUT1) transfers GlcA from UDP-GlcA to glycosyl inositol phosphorylceramides (GIPCs)
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). GUX6_ARATH
537
5
60011
Swiss-Prot
Secretory Pathway (Reliability: 2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
introduction of Arabdiopsis thaliana IPUT1 gene together with genes for a UDP-glucose dehydrogenase from Arabidopsis thaliana and a human UDP-GlcA transporter into a yeast mutant deficient in the endogenous inositol phosphorylceramide (IPC) mannosyltransferase. In this engineered yeast strain, IPUT1 transfers GlcA to IPC
additional information
-
introduction of Arabdiopsis thaliana IPUT1 gene together with genes for a UDP-glucose dehydrogenase from Arabidopsis thaliana and a human UDP-GlcA transporter into a yeast mutant deficient in the endogenous inositol phosphorylceramide (IPC) mannosyltransferase. In this engineered yeast strain, IPUT1 transfers GlcA to IPC
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene IPUT1, functional enzyme overexpression in Saccharomyces cerevisiae, coexpression with a human UDP-GlcA transporter, GIPCs from Saccharomyces cerevisiae do not contain GlcA. Production of GlcA-IPC in yeast
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rennie, E.A.; Ebert, B.; Miles, G.P.; Cahoon, R.E.; Christiansen, K.M.; Stonebloom, S.; Khatab, H.; Twell, D.; Petzold, C.J.; Adams, P.D.; Dupree, P.; Heazlewood, J.L.; Cahoon, E.B.; Scheller, H.V.
Identification of a sphingolipid alpha-glucuronosyltransferase that is essential for pollen function in Arabidopsis
Plant Cell
26
3314-3325
2014
Nicotiana benthamiana, Arabidopsis thaliana (Q8GWB7), Arabidopsis thaliana
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