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Information on EC 2.4.1.117 - dolichyl-phosphate beta-glucosyltransferase and Organism(s) Homo sapiens

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.117 dolichyl-phosphate beta-glucosyltransferase
IUBMB Comments
Solanesyl phosphate and ficaprenyl phosphate can act as acceptors, but more slowly.
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This record set is specific for:
Homo sapiens
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
udp-glucose:dolichyl-phosphate glucosyltransferase, udp-glucose:dolichylphosphate glucosyltransferase, dolichyl-phosphate beta-glucosyltransferase, udp-glucose dolichyl-phosphate glucosyltransferase, udp-glucose:dolichol phosphate glucosyltransferase, udp-glucose:dolichyl phosphate glucosyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glucosyltransferase, uridine diphosphoglucose-dolichol
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polyprenyl phosphate:UDP-D-glucose glucosyltransferase
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UDP-glucose dolichyl-phosphate glucosyltransferase
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UDP-glucose:dolichol phosphate glucosyltransferase
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UDP-glucose:dolicholphosphoryl glucosyltransferase
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UDP-glucose:dolichyl monophosphate glucosyltransferase
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UDP-glucose:dolichyl phosphate glucosyltransferase
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UDP-glucose:dolichylphosphate glucosyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate
show the reaction diagram
sequential mechanism
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase
Solanesyl phosphate and ficaprenyl phosphate can act as acceptors, but more slowly.
CAS REGISTRY NUMBER
COMMENTARY hide
71061-42-2
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-glucose + dolichyl phosphate
UDP + dolichyl beta-D-glucosyl phosphate
show the reaction diagram
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?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
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divalent cation required, maximum stimulation in presence of Ca2+. Co2+, Mg2+ or Mn2+ can replace Ca2+
Co2+
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divalent cation required, maximum stimulation in presence of Ca2+. Co2+, Mg2+ or Mn2+ can replace Ca2+
Mg2+
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divalent cation required, maximum stimulation in presence of Ca2+. Co2+, Mg2+ or Mn2+ can replace Ca2+
Mn2+
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divalent cation required, maximum stimulation in presence of Ca2+. Co2+, Mg2+ or Mn2+ can replace Ca2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Phospholipid
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required, phosphatidylethanolamine most effective
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00015 - 0.00033
UDP-glucose
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1 - 0.17
UDP
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.3
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second optimum at pH 7.2
7.2
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second optimum at pH 5.3
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ALG5_HUMAN
324
1
36946
Swiss-Prot
Secretory Pathway (Reliability: 1)
A0A7P0T8X9_HUMAN
251
0
28529
TrEMBL
Secretory Pathway (Reliability: 1)
Q9HC03_HUMAN
324
1
36964
TrEMBL
Secretory Pathway (Reliability: 1)
A0A7P0TAL2_HUMAN
259
1
29205
TrEMBL
Secretory Pathway (Reliability: 1)
A0A7P0T9C7_HUMAN
286
1
32789
TrEMBL
Secretory Pathway (Reliability: 1)
A0A7P0T9B8_HUMAN
310
1
35139
TrEMBL
Secretory Pathway (Reliability: 1)
A0A7P0T901_HUMAN
291
0
33727
TrEMBL
other Location (Reliability: 2)
A0A7P0TB27_HUMAN
304
1
34807
TrEMBL
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
36000
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x * 36000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 36000, SDS-PAGE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
uridine or UDPglucuronic acid, 5 mM, protects solubilized enzyme against rapid inactivation
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
5 mM uridine or UDPglucuronic acid reconstitutes inactivated enzyme
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Matern, H.; Bolz, R.; Matern, S.
Isolation and characterization of UDP-glucose dolichyl-phosphate glucosyltransferase from human liver
Eur. J. Biochem.
190
99-105
1990
Homo sapiens
Manually annotated by BRENDA team
Matern, H.; Matern, S.
Control of dolichyl phosphoglucose formation in human liver microsomes. Kinetic and inhibition studies of nucleosides, nucleotides and analogues of UDPglucose
Biochim. Biophys. Acta
1004
67-72
1989
Homo sapiens
Manually annotated by BRENDA team
Gartung, C.; Matern, S.; Matern, H.
The submicrosomal localization of uridine 5'-diphosphate-glucose dolichyl-phosphate glucosyltransferase and bile acid glucosyltransferase in the human liver
J. Hepatol.
20
32-40
1994
Homo sapiens
Manually annotated by BRENDA team