We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).
The taxonomic range for the selected organisms is: Bos taurus The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
glycogen synthase, gbssi, granule-bound starch synthase, starch synthase i, granule bound starch synthase, gsy2p, glycogen synthase 2, gys-2, glycogen synthase-2, cg-gys,
more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
glucosyltransferase, uridine diphosphoglucose-glycogen
-
-
-
-
glycogen synthetase (starch)
-
-
-
-
UDP-glucose-glycogen glucosyltransferase
-
-
-
-
UDP-glycogen synthase
-
-
-
-
UDPG-glycogen synthetase
-
-
-
-
UDPG-glycogen transglucosylase
-
-
-
-
uridine diphosphoglucose-glycogen glucosyltransferase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP-alpha-D-glucose + [(1->4)-alpha-D-glucosyl]n = UDP + [(1->4)-alpha-D-glucosyl]n+1
reaction mechanism
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
hexosyl group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP-glucose:glycogen 4-alpha-D-glucosyltransferase
The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP-glucose + glycogen
glycogen + UDP
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP-glucose + glycogen
glycogen + UDP
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UTP
-
affects glucose-6-phosphate binding
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SO42-
-
stimulatory effect increases as the enzyme becomes more phosphorylated
glucose 6-phosphate
-
-
glucose 6-phosphate
-
synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
additional information
-
0.26 - 0.34
UDP-glucose
-
without glucose-6-phosphate
0.33 - 0.34
UDP-glucose
-
with glucose-6-phosphate
additional information
additional information
-
regulation by phosphorylation
-
additional information
additional information
-
dependent on enzyme form and pH
-
additional information
additional information
-
values for phosphorylated enzyme forms
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
6.7
-
synthase I, enzyme form 1, absence of Na2SO4
7.1
-
synthase I, enzyme form 2, absence of Na2SO4
7.7
-
synthase I, enzyme form 1, presence of Na2SO4
8
-
synthase I, enzyme form 2, presence of Na2SO4
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
GYS1_BOVIN
736
0
83814
Swiss-Prot
other Location (Reliability: 2 )
A0A3Q1MNY2_BOVIN
672
0
77202
TrEMBL
other Location (Reliability: 5 )
E1B9X7_BOVIN
710
0
81536
TrEMBL
other Location (Reliability: 5 )
Q58CX0_BOVIN
604
0
69108
TrEMBL
other Location (Reliability: 2 )
A0A3Q1LJJ0_BOVIN
678
0
78176
TrEMBL
other Location (Reliability: 5 )
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
phosphoprotein
-
phosphorylation of glucose-6-phosphate independent enzyme, i.e. I enzyme, results in glucose-6-phosphate dependent enzyme, i.e. D enzyme
phosphoprotein
-
phosphorylation at 3 different sites
phosphoprotein
-
phosphorylation leads to loss of activity
phosphoprotein
-
incorporation of 1-3 phosphates per subunit
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-70°C, at least 6 months
-
-70°C, stable for at least 3 months
-
-70°C, stable up to 6 months
-
liquid N2, 50 mM Tris/HCl buffer, pH 7.0, 1 mM DTT, 50% glycerol
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Dickey-Dunkirk, S.; Killilea, S.D.
Purification of bovine heart glycogen synthase
Anal. Biochem.
146
199-205
1985
Bos taurus
brenda
Mitchell, J.W.; Thomas, J.A.
Phosphorylation of bovine heart glycogen synthase by two protein kinases. Kinetic properties of phosphorylated forms of the enzyme
J. Biol. Chem.
256
6160-6169
1981
Bos taurus
brenda
Rasmussen, L.H.; Pedersen, K.M.; Juhl, H.
Purification and properties of glycogen synthase I from bovine polymorphonuclear leucocytes
Biochimie
67
615-623
1985
Bos taurus
brenda
Nakai, C.; Thomas, J.A.
Effects of magnesium on the kinetic properties of bovine heart glycogen synthase D
J. Biol. Chem.
250
4081-4086
1975
Bos taurus
brenda
Thomas, J.A.; Larner, J.
Purification and properties of glycogen synthase I from bovine heart: two kinetic forms
Biochim. Biophys. Acta
293
62-72
1973
Bos taurus
brenda