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IUBMB CommentsThe enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate---CoA ligase).
The taxonomic range for the selected organisms is: Gallus gallus
The enzyme appears in selected viruses and cellular organisms
Synonyms
atp-citrate lyase, atp citrate lyase, citrate cleavage enzyme, atp:citrate lyase, adenosine triphosphate citrate lyase, atp citrate synthase, atp citrate (pro-s)-lyase, atp-citrate synthase alpha chain protein 2,
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adenosine triphosphate citrate lyase
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ATP citrate (pro-S)-lyase
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ATP:citrate lyase
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ATP:citrate oxaloacetate lyase ((pro-3S)-CH2COO--> acetyl-CoA) (ATP-dephosphorylating)
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ATP:citrate oxaloacetate-lyase (pro-3S-CH2COO->acetyl-CoA, ATP dephosphorylating)
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ATP:citrate oxaloacetate-lyase CoA-acetylating and ATP-dephosphorylating
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Citrate cleavage enzyme
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citrate-ATP lyase
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citric cleavage enzyme
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ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA
cleaves citrate with inversion of configuration
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acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]
The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate---CoA ligase).
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ATP + citrate + CoA
ADP + phosphate + acetyl-CoA + oxaloacetate
ATP + citrate + CoA
ADP + phosphate + acetyl-CoA + oxaloacetate
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ATP + citrate + CoA
ADP + phosphate + acetyl-CoA + oxaloacetate
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ATP + citrate + CoA
ADP + phosphate + acetyl-CoA + oxaloacetate
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cleaves citrate with inversion of configuration
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ATP + citrate + CoA
ADP + phosphate + acetyl-CoA + oxaloacetate
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specific for citrate
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ATP + citrate + CoA
ADP + phosphate + acetyl-CoA + oxaloacetate
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one of the key enzymes of lipogenesis
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ATP + citrate + CoA
ADP + phosphate + acetyl-CoA + oxaloacetate
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one of the key enzymes of lipogenesis
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additional information
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brenda
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low activity
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additional information
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influence of different feeding regimens on the specific activities of the enzyme in different tissues
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A0A1D5PSE5_CHICK
1101
0
121150
TrEMBL
other Location (Reliability: 2)
Q5F3V2_CHICK
1101
0
121132
TrEMBL
other Location (Reliability: 2)
F1P269_CHICK
1091
0
120143
TrEMBL
other Location (Reliability: 2)
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Spector, L.B.
Citrate cleavage and related enzymes
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
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357-389
1972
Bos taurus, Gallus gallus, Columba livia, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
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brenda
Hoffmann, G.E.; Andres, H.; Weiss, L.; Kreisel, C.; Sander, R.
Properties and organ distribution of ATP citrate (pro-3S)-lyase
Biochim. Biophys. Acta
620
151-158
1980
Gallus gallus, Homo sapiens, Rattus norvegicus
brenda
Hoffmann, G.E.; Kraupe, P.; Weiss, L.; Wittmann, J.
Avian ATP citrate (pro-3S)-lyase
Hoppe-Seyler's Z. Physiol. Chem.
361
1117-1119
1980
Gallus gallus, Columba livia, Rattus norvegicus
brenda
Lenz, H.; Buckel, W.; Wunderwald, P.; Biedermann, G.; Buschmeier, V.; Eggerer, H.; Cornforth, J.W.; Redmond, J.W.; Mallaby, R.
Stereochemistry of si-citrate synthase and ATP-citrate-lyase reactions
Eur. J. Biochem.
24
207-215
1971
Gallus gallus
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