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Information on EC 2.3.3.8 - ATP citrate synthase and Organism(s) Gallus gallus

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.8 ATP citrate synthase
IUBMB Comments
The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate---CoA ligase).
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This record set is specific for:
Gallus gallus
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Word Map
The taxonomic range for the selected organisms is: Gallus gallus
The enzyme appears in selected viruses and cellular organisms
Synonyms
atp-citrate lyase, atp citrate lyase, citrate cleavage enzyme, atp:citrate lyase, adenosine triphosphate citrate lyase, atp citrate synthase, atp citrate (pro-s)-lyase, atp-citrate synthase alpha chain protein 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ACL
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adenosine triphosphate citrate lyase
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ATP citrate (pro-S)-lyase
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ATP-citric lyase
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ATP:citrate lyase
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ATP:citrate oxaloacetate lyase ((pro-3S)-CH2COO--> acetyl-CoA) (ATP-dephosphorylating)
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ATP:citrate oxaloacetate-lyase (pro-3S-CH2COO->acetyl-CoA, ATP dephosphorylating)
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ATP:citrate oxaloacetate-lyase CoA-acetylating and ATP-dephosphorylating
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Citrate cleavage enzyme
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citrate-ATP lyase
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citric cleavage enzyme
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA
show the reaction diagram
cleaves citrate with inversion of configuration
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]
The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate---CoA ligase).
CAS REGISTRY NUMBER
COMMENTARY hide
9027-95-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + citrate + CoA
ADP + phosphate + acetyl-CoA + oxaloacetate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + citrate + CoA
ADP + phosphate + acetyl-CoA + oxaloacetate
show the reaction diagram
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one of the key enzymes of lipogenesis
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?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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low activity
Manually annotated by BRENDA team
additional information
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influence of different feeding regimens on the specific activities of the enzyme in different tissues
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A1D5PSE5_CHICK
1101
0
121150
TrEMBL
other Location (Reliability: 2)
Q5F3V2_CHICK
1101
0
121132
TrEMBL
other Location (Reliability: 2)
F1P269_CHICK
1091
0
120143
TrEMBL
other Location (Reliability: 2)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Spector, L.B.
Citrate cleavage and related enzymes
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
7
357-389
1972
Bos taurus, Gallus gallus, Columba livia, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
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Manually annotated by BRENDA team
Hoffmann, G.E.; Andres, H.; Weiss, L.; Kreisel, C.; Sander, R.
Properties and organ distribution of ATP citrate (pro-3S)-lyase
Biochim. Biophys. Acta
620
151-158
1980
Gallus gallus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Hoffmann, G.E.; Kraupe, P.; Weiss, L.; Wittmann, J.
Avian ATP citrate (pro-3S)-lyase
Hoppe-Seyler's Z. Physiol. Chem.
361
1117-1119
1980
Gallus gallus, Columba livia, Rattus norvegicus
Manually annotated by BRENDA team
Lenz, H.; Buckel, W.; Wunderwald, P.; Biedermann, G.; Buschmeier, V.; Eggerer, H.; Cornforth, J.W.; Redmond, J.W.; Mallaby, R.
Stereochemistry of si-citrate synthase and ATP-citrate-lyase reactions
Eur. J. Biochem.
24
207-215
1971
Gallus gallus
Manually annotated by BRENDA team