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Information on EC 2.3.3.5 - 2-methylcitrate synthase and Organism(s) Pseudomonas aeruginosa

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.5 2-methylcitrate synthase
IUBMB Comments
The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1, citrate (Si)-synthase. Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate.
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This record set is specific for:
Pseudomonas aeruginosa
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The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
methylcitrate synthase, 2-methylcitrate synthase, prpc2, 2-mcs, citrate synthase ii, 2-mc synthase, 2-mcs1, rv1131, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-methylcitrate oxaloacetate-lyase
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-
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MCA condensing enzyme
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MCS
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-
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Methylcitrate synthase
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methylcitrate synthetase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
condensation
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-
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PATHWAY SOURCE
PATHWAYS
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-, -
SYSTEMATIC NAME
IUBMB Comments
propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)
The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1, citrate (Si)-synthase. Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate.
CAS REGISTRY NUMBER
COMMENTARY hide
57827-78-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
show the reaction diagram
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
show the reaction diagram
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene sequenced
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Miyakoshi, S.; Uchiyama, H.; Someya, T.; Satoh, T.; Tabuchi, T.
Distribution of the methylcitric acid cycle and beta-oxidation pathway for propionate catabolism in fungi
Agric. Biol. Chem.
51
2381-2387
1987
Aspergillus niger, Citeromyces matritensis, Cryptococcus neoformans, Cutaneotrichosporon curvatum, Cyberlindnera saturnus, Cyberlindnera saturnus IAM 4094, Debaryomyces hansenii, Diutina catenulata, Kluyveromyces marxianus, Lipomyces starkeyi, Metschnikowia pulcherrima, Mucor rouxianus, Neurospora crassa, no activity in Candida rugosa, Ogataea angusta, Priceomyces haplophilus, Pseudomonas aeruginosa, Rhizopus microsporus var. chinensis, Rhizopus microsporus var. chinensis IAM 6003, Saccharomyces cerevisiae, Saccharomyces cerevisiae SANK 50182, Saccharomycopsis fibuligera, Schwanniomyces polymorphus, Starmerella gropengiesseri, Starmerella magnoliae, Torulaspora delbrueckii, Ustilago crus-galli, Ustilago crus-galli F-B-6, Ustilago utriculosa, Ustilago utriculosa F-B-5, Vanrija humicola, Wickerhamiella pararugosa, Wickerhamomyces anomalus, Yarrowia lipolytica
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Manually annotated by BRENDA team
Karlsson, E.N.; Abou-Hachem, M.; Holst, O.; Danson, M.J.; Hough, D.W.
Rhodothermus marinus: a thermophilic bacterium producing dimeric and hexameric citrate synthase isoenzymes
Extremophiles
6
51-56
2002
Escherichia coli, Pseudomonas aeruginosa, Rhodothermus marinus
Manually annotated by BRENDA team
Watson, D.; Lindel, D.L.; Fall, R.
Pseudomonas aeruginosa contains an inducible methylcitrate synthase
Curr. Microbiol.
8
17-21
1983
Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO, Pseudomonas citronellolis, Pseudomonas putida, Yarrowia lipolytica
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Manually annotated by BRENDA team
Braemer, C.O.; Steinbuechel, A.
The methylcitric acid pathway in Ralstonia eutropha: new genes identified involved in propionate metabolism
Microbiology
147
2203-2214
2001
Aspergillus nidulans, Cupriavidus metallidurans, Escherichia coli, Neisseria meningitidis, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas putida KT 2240, Salmonella enterica, Vibrio cholerae serotype O1
Manually annotated by BRENDA team
Braemer, C.O.; Silva, L.F.; Gomez, J.G.C.; Priefert, H.; Steinbuechel, A.
Identification of the 2-methylcitrate pathway involved in the catabolism of propionate in the polyhydroxyalkanoate-producing strain Burkholderia sacchari IPT101T and analysis of a mutant accumulating a copolyester with higher 3-hydroxyvalerate content
Appl. Environ. Microbiol.
68
271-279
2002
Aspergillus nidulans, Burkholderia cepacia, Burkholderia cepacia contig261, Cupriavidus metallidurans, Cupriavidus metallidurans (Q937N9), Escherichia coli, Escherichia coli (Q8X694), Escherichia coli O157:H17, Escherichia coli O157:H17 (Q8X694), Legionella pneumophila (Q9XBT3), Neisseria meningitidis, Paraburkholderia sacchari, Paraburkholderia sacchari IPT101, Pseudomonas aeruginosa, Pseudomonas aeruginosa (Q9I5E3), Pseudomonas fluorescens, Pseudomonas fluorescens contig267, Pseudomonas putida, Pseudomonas putida contig10768, Pseudomonas putida KT 2240, Pseudomonas syringae, Pseudomonas syringae contig5376, Pyrococcus furiosus, Salmonella enterica, Salmonella enterica (Q56063), Shewanella putrefaciens, Shewanella putrefaciens contig93, Vibrio cholerae (Q9KSC1), Vibrio cholerae serotype O1
Manually annotated by BRENDA team
Claes, W.A.; Puehler, A.; Kalinowski, J.
Identification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle
J. Bacteriol.
184
2728-2739
2002
Aspergillus nidulans, Corynebacterium glutamicum, Corynebacterium glutamicum (Q8NSH7), Corynebacterium glutamicum (Q8NSL1), Cupriavidus metallidurans, Cupriavidus metallidurans (Q937N9), Escherichia coli, Escherichia coli (P31660), Paraburkholderia sacchari, Pseudomonas aeruginosa, Salmonella enterica (Q56063), Salmonella enterica, Yarrowia lipolytica
Manually annotated by BRENDA team