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EC Tree
IUBMB Comments This entry has been included to accommodate those citrate synthases for which the stereospecificity with respect to C-2 of oxaloacetate has not been established [cf. EC 2.3.3.1, citrate (Si)-synthase and EC 2.3.3.3, citrate (Re)-synthase].
The taxonomic range for the selected organisms is: Drosophila melanogaster The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
citrate synthetase, mitochondrial citrate synthase, peroxisomal citrate synthase, si-citrate synthase, type ii citrate synthase, citrate condensing enzyme, citrate synthase cit1, bifunctional citrate synthase/2-methylcitrate synthase,
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citrate condensing enzyme
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citrate oxaloacetate-lyase (CoA-acetylating)
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citrate oxaloacetate-lyase, CoA-acetylating
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citrate synthetase
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citric-condensing enzyme
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oxalacetic transacetase
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oxaloacetate transacetase
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synthase, citrate
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acetyl-CoA + H2O + oxaloacetate = citrate + CoA
mechanism
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-, -, -, -, -, -, -, -, -, -, -, -, -
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acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
This entry has been included to accommodate those citrate synthases for which the stereospecificity with respect to C-2 of oxaloacetate has not been established [cf. EC 2.3.3.1, citrate (Si)-synthase and EC 2.3.3.3, citrate (Re)-synthase].
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acetyl-CoA + oxaloacetate + H2O
citrate + CoA
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?
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2-oxoglutarate
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competitive against oxaloacetate
ATP
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competitive against acetyl-CoA
propionyl-CoA
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competitive against acetyl-CoA
succinyl-CoA
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mixed-type inhibition
additional information
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tricarboxylic acid cycle intermediates
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0.38
2-oxoglutarate
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versus oxaloacetate, competitive
0.125
ATP
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versus acetyl-CoA
0.0024 - 0.0225
propionyl-CoA
0.0024
propionyl-CoA
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versus acetyl-CoA, competitive
0.0225
propionyl-CoA
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versus oxaloacetate, noncompetitive
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brenda
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CISY_DROME
464
0
51574
Swiss-Prot
Mitochondrion (Reliability: 5 )
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48700
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2 * 48700, SDS-PAGE
additional information
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amino acid composition
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dimer
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2 * 48700, SDS-PAGE
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Lee, S.; Park, C.; Yim, J.
Characterization of citrate synthase purified from Drosophila melanogaster
Mol. Cells
7
599-604
1997
Drosophila melanogaster
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