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Information on EC 2.3.3.13 - 2-isopropylmalate synthase and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC2.3.3.13
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IUBMB Comments
Requires K+.
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This record set is specific for:
Pseudomonas aeruginosa
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Word Map
The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms
Synonyms
alpha-isopropylmalate synthase, isopropylmalate synthase, 2-isopropylmalate synthase, mtipms, alpha-ipms, osipms1, rol17, alpha-isopropylmalate synthetase, alpha-ipm synthase, alpha-ipms-14cr, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-hydroxy-4-methyl-3-carboxy-pentanoate 2-oxo-3-methyl-butanoate lyase (CoA-acetylating)
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3-hydroxy-4-methyl-3-carboxyvalerate 2-oxo-3-methyl-butyrate lyase (CoA-acetylating)
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alpha-IPM synthase
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Alpha-IPM synthetase
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Alpha-isopropylmalate synthase
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alpha-isopropylmalate synthase I
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alpha-isopropylmalate synthase II
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alpha-isopropylmalate synthetase
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alpha-isopropylmalic synthetase
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IPM synthase
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IPM-synthase
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IPMS
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isopropylmalate synthase
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isopropylmalate synthetase
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synthase, 2-isopropylmalate
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synthase, alpha-isopropylmalate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aldol condensation
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Requires K+.
CAS REGISTRY NUMBER
COMMENTARY hide
9030-98-2
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
show the reaction diagram
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?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
show the reaction diagram
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first enzyme in biosynthesis of L-Leu
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
show the reaction diagram
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first enzyme in biosynthesis of L-Leu
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-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A3M5D6D0_PSEAI
594
0
66000
TrEMBL
-
A0A8G4KK85_PSEAI
592
0
65808
TrEMBL
-
A0A8G7FH99_PSEAI
592
0
65862
TrEMBL
-
A0A0A8RE98_PSEAI
289
0
32238
TrEMBL
-
A0A8G2JST5_PSEAI
592
0
65832
TrEMBL
-
A0A8G5GK95_PSEAI
592
0
65775
TrEMBL
-
A0A2R3J0F4_PSEAI
556
0
61859
TrEMBL
-
A0A069Q6E5_PSEAI
556
0
61723
TrEMBL
-
A0A8G4J2V0_PSEAI
592
0
65834
TrEMBL
-
A0A8G2S837_PSEAI
592
0
65808
TrEMBL
-
A0A8G2Z7F1_PSEAI
592
0
65806
TrEMBL
-
A0A0A8REN7_PSEAI
265
0
29349
TrEMBL
-
A0A431XCS9_PSEAI
565
0
62858
TrEMBL
-
A0A367MHI7_PSEAI
365
0
40043
TrEMBL
-
A0A8G7TKP6_PSEAI
592
0
65834
TrEMBL
-
A0A8G3PM36_PSEAI
592
0
65775
TrEMBL
-
A0A8B5A7A2_PSEAI
592
0
65818
TrEMBL
-
A0A8G3FIC8_PSEAI
592
0
65832
TrEMBL
-
A0A8G6ZHP5_PSEAI
592
0
65862
TrEMBL
-
A0A8G2Z622_PSEAI
592
0
65902
TrEMBL
-
A0A8G7SMB9_PSEAI
592
0
65779
TrEMBL
-
A0A8F9JAY9_PSEAI
556
0
61751
TrEMBL
-
A0A7M2ZXP4_PSEAI
592
0
65808
TrEMBL
-
A0A8G3BE11_PSEAI
592
0
65818
TrEMBL
-
A0A8G3YUS7_PSEAI
592
0
65818
TrEMBL
-
A0A8G6HDH9_PSEAI
592
0
65803
TrEMBL
-
A0A5E5QW84_PSEAI
455
0
50699
TrEMBL
-
A0A643EN89_PSEAI
592
0
65813
TrEMBL
-
A0A431XCF6_PSEAI
556
0
61806
TrEMBL
-
A0A5R1BAI3_PSEAI
592
0
65818
TrEMBL
-
A0A7M3AVU5_PSEAI
592
0
65832
TrEMBL
-
A0A8G6GKX6_PSEAI
558
0
61298
TrEMBL
-
A0A8F9PDV6_PSEAI
556
0
61695
TrEMBL
-
A0A8G4LUF6_PSEAI
592
0
65770
TrEMBL
-
A0A8G3Q470_PSEAI
592
0
65813
TrEMBL
-
A0A1Y0GQG2_PSEAI
592
0
65804
TrEMBL
-
A0A8G4MNT8_PSEAI
592
0
65763
TrEMBL
-
A0A8G6SDN0_PSEAI
592
0
65780
TrEMBL
-
A0A8F9P4Q3_PSEAI
556
0
61663
TrEMBL
-
A0A2R3IQB9_PSEAI
564
0
62727
TrEMBL
-
A0A1Y0GFQ0_PSEAI
455
0
50642
TrEMBL
-
A0A367LT09_PSEAI
70
0
7795
TrEMBL
-
A0A367M211_PSEAI
153
0
17403
TrEMBL
-
A0A8G4HBW9_PSEAI
592
0
65832
TrEMBL
-
A0A8G6X513_PSEAI
592
0
65786
TrEMBL
-
A0A6A9K505_PSEAI
592
0
65694
TrEMBL
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stieglitz, B.I.; Calvo, J.M.
Distribution of the isopropylmalate pathway to leucine among diverse bacteria
J. Bacteriol.
118
935-941
1974
Alcaligenes viscolactis, Bacillus subtilis, Bradyrhizobium japonicum, Cereibacter sphaeroides, Chromatium sp., Chromatium sp. D, Escherichia coli, Escherichia coli B / ATCC 11303, Hydrogenomonas sp., Klebsiella aerogenes, Methylorubrum extorquens, Micrococcus luteus, Micrococcus sp., Paenibacillus polymyxa, Proteus vulgaris, Pseudomonas aeruginosa, Pseudomonas fluorescens, Rhodococcus opacus, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team