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The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms
Synonyms
alpha-isopropylmalate synthase, isopropylmalate synthase, 2-isopropylmalate synthase, mtipms, alpha-ipms, osipms1, rol17, alpha-isopropylmalate synthetase, alpha-ipm synthase, alpha-ipms-14cr,
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3-hydroxy-4-methyl-3-carboxy-pentanoate 2-oxo-3-methyl-butanoate lyase (CoA-acetylating)
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3-hydroxy-4-methyl-3-carboxyvalerate 2-oxo-3-methyl-butyrate lyase (CoA-acetylating)
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alpha-IPM synthase
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Alpha-IPM synthetase
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Alpha-isopropylmalate synthase
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alpha-isopropylmalate synthase I
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alpha-isopropylmalate synthase II
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alpha-isopropylmalate synthetase
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alpha-isopropylmalic synthetase
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isopropylmalate synthase
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isopropylmalate synthetase
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synthase, 2-isopropylmalate
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synthase, alpha-isopropylmalate
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aldol condensation
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acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Requires K+.
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2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
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2-oxo-3-methylbutanoate + acetyl-CoA + H2O
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first enzyme in biosynthesis of L-Leu
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2-oxo-3-methylbutanoate + acetyl-CoA + H2O
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first enzyme in biosynthesis of L-Leu
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brenda
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A0A3M5D6D0_PSEAI
594
0
66000
TrEMBL
-
A0A8G4KK85_PSEAI
592
0
65808
TrEMBL
-
A0A8G7FH99_PSEAI
592
0
65862
TrEMBL
-
A0A0A8RE98_PSEAI
289
0
32238
TrEMBL
-
A0A8G2JST5_PSEAI
592
0
65832
TrEMBL
-
A0A8G5GK95_PSEAI
592
0
65775
TrEMBL
-
A0A2R3J0F4_PSEAI
556
0
61859
TrEMBL
-
A0A069Q6E5_PSEAI
556
0
61723
TrEMBL
-
A0A8G4J2V0_PSEAI
592
0
65834
TrEMBL
-
A0A8G2S837_PSEAI
592
0
65808
TrEMBL
-
A0A8G2Z7F1_PSEAI
592
0
65806
TrEMBL
-
A0A0A8REN7_PSEAI
265
0
29349
TrEMBL
-
A0A431XCS9_PSEAI
565
0
62858
TrEMBL
-
A0A367MHI7_PSEAI
365
0
40043
TrEMBL
-
A0A8G7TKP6_PSEAI
592
0
65834
TrEMBL
-
A0A8G3PM36_PSEAI
592
0
65775
TrEMBL
-
A0A8B5A7A2_PSEAI
592
0
65818
TrEMBL
-
A0A8G3FIC8_PSEAI
592
0
65832
TrEMBL
-
A0A8G6ZHP5_PSEAI
592
0
65862
TrEMBL
-
A0A8G2Z622_PSEAI
592
0
65902
TrEMBL
-
A0A8G7SMB9_PSEAI
592
0
65779
TrEMBL
-
A0A8F9JAY9_PSEAI
556
0
61751
TrEMBL
-
A0A7M2ZXP4_PSEAI
592
0
65808
TrEMBL
-
A0A8G3BE11_PSEAI
592
0
65818
TrEMBL
-
A0A8G3YUS7_PSEAI
592
0
65818
TrEMBL
-
A0A8G6HDH9_PSEAI
592
0
65803
TrEMBL
-
A0A5E5QW84_PSEAI
455
0
50699
TrEMBL
-
A0A643EN89_PSEAI
592
0
65813
TrEMBL
-
A0A431XCF6_PSEAI
556
0
61806
TrEMBL
-
A0A5R1BAI3_PSEAI
592
0
65818
TrEMBL
-
A0A7M3AVU5_PSEAI
592
0
65832
TrEMBL
-
A0A8G6GKX6_PSEAI
558
0
61298
TrEMBL
-
A0A8F9PDV6_PSEAI
556
0
61695
TrEMBL
-
A0A8G4LUF6_PSEAI
592
0
65770
TrEMBL
-
A0A8G3Q470_PSEAI
592
0
65813
TrEMBL
-
A0A1Y0GQG2_PSEAI
592
0
65804
TrEMBL
-
A0A8G4MNT8_PSEAI
592
0
65763
TrEMBL
-
A0A8G6SDN0_PSEAI
592
0
65780
TrEMBL
-
A0A8F9P4Q3_PSEAI
556
0
61663
TrEMBL
-
A0A2R3IQB9_PSEAI
564
0
62727
TrEMBL
-
A0A1Y0GFQ0_PSEAI
455
0
50642
TrEMBL
-
A0A367LT09_PSEAI
70
0
7795
TrEMBL
-
A0A367M211_PSEAI
153
0
17403
TrEMBL
-
A0A8G4HBW9_PSEAI
592
0
65832
TrEMBL
-
A0A8G6X513_PSEAI
592
0
65786
TrEMBL
-
A0A6A9K505_PSEAI
592
0
65694
TrEMBL
-
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Stieglitz, B.I.; Calvo, J.M.
Distribution of the isopropylmalate pathway to leucine among diverse bacteria
J. Bacteriol.
118
935-941
1974
Alcaligenes viscolactis, Bacillus subtilis, Bradyrhizobium japonicum, Cereibacter sphaeroides, Chromatium sp., Chromatium sp. D, Escherichia coli, Escherichia coli B / ATCC 11303, Hydrogenomonas sp., Klebsiella aerogenes, Methylorubrum extorquens, Micrococcus luteus, Micrococcus sp., Paenibacillus polymyxa, Proteus vulgaris, Pseudomonas aeruginosa, Pseudomonas fluorescens, Rhodococcus opacus, Salmonella enterica subsp. enterica serovar Typhimurium
brenda