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Information on EC 2.3.3.1 - citrate (Si)-synthase and Organism(s) Mus musculus

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.1 citrate (Si)-synthase
IUBMB Comments
The stereospecificity of this enzyme is opposite to that of EC 2.3.3.3, citrate (Re)-synthase, which is found in some anaerobes. Citrate synthase for which the stereospecificity with respect to C-2 of oxaloacetate has not been established are included in EC 2.3.3.16, citrate synthase (unknown stereospecificity).
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Mus musculus
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
citrate synthase, citrate (si)-synthase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
(R)-citric synthase
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citrate oxaloacetate-lyase ((pro-3S)-CH2COO---> acetyl-CoA)
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citrate synthase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
addition
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]
The stereospecificity of this enzyme is opposite to that of EC 2.3.3.3, citrate (Re)-synthase, which is found in some anaerobes. Citrate synthase for which the stereospecificity with respect to C-2 of oxaloacetate has not been established are included in EC 2.3.3.16, citrate synthase (unknown stereospecificity).
CAS REGISTRY NUMBER
COMMENTARY hide
9027-96-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
show the reaction diagram
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?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
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citrate synthase is a key enzyme of the citric acid cycle that provides energy for cellular function. Additionally, the enzyme plays a critical role in providing citrate derived acetyl-CoA for lipogenesis and cholesterologenesis
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CISY_MOUSE
464
0
51737
Swiss-Prot
Mitochondrion (Reliability: 3)
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the mRNA expression of citrate synthase in liver is reduced by 42% in the staggerer mice (which possess a nonfunctional retinoic acid receptor-related orphan receptor alpha protein) relative to the wild type mice
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Crumbley, C.; Wang, Y.; Banerjee, S.; Burris, T.P.
Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor alpha (RORalpha)
PLoS ONE
7
e33804
2012
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Alhindi, Y.; Vaanholt, L.M.; Al-Tarrah, M.; Gray, S.R.; Speakman, J.R.; Hambly, C.; Alanazi, B.S.; Gabriel, B.M.; Lionikas, A.; Ratkevicius, A.
Low citrate synthase activity is associated with glucose intolerance and lipotoxicity
J. Nutr. Metab.
2019
8594825
2019
Mus musculus (Q9CZU6), Mus musculus
Manually annotated by BRENDA team