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Information on EC 2.3.2.27 - RING-type E3 ubiquitin transferase and Organism(s) Sus scrofa

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2 Transferases

2.3 Acyltransferases

2.3.2 Aminoacyltransferases

2.3.2.27 RING-type E3 ubiquitin transferase

IUBMB Comments

RING E3 ubiquitin transferases serve as mediators bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) and an acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. Unlike EC 2.3.2.26, HECT-type E3 ubiquitin transferase, the RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin. Many members of the RING-type E3 ubiquitin transferase family are not able to bind a substrate directly, and form a complex with a cullin scaffold protein and a substrate recognition module (the complexes are named CRL for Cullin-RING-Ligase). In these complexes, the RING-type E3 ubiquitin transferase provides an additional function, mediating the transfer of a NEDD8 protein from a dedicated E2 carrier to the cullin protein (see EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase). cf. EC 2.3.2.31, RBR-type E3 ubiquitin transferase.

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Sus scrofa

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Word Map

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2.3.2.27
brca2
ovarian
women
proteasome
germline
hereditary
ligases
pink1
tumour
mitophagy
tumorigenesis
checkpoint
adaptor
polyubiquitination
neurodegenerative
parp
estrogen
counsel
chromatin
high-risk
histone
predisposition
pten
early-onset
rad51
founder
ubiquitin-proteasome
serous
dopaminergic
prophylactic
sumo
triple-negative
ubiquitin-mediated
mastectomy
proteasome-dependent
ubiquitin-dependent
basal-like
ubiquitin-like
xiap
sumoylation
fanconi
ubiquitin-conjugating
deubiquitinating
alpha-synuclein
medicine
mammography
first-degree
analysis
polycomb
fork
centrosome
chk1

The taxonomic range for the selected organisms is: Sus scrofa
The enzyme appears in selected viruses and cellular organisms

Reaction Schemes

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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine

[acceptor protein]-L-lysine

[E2 ubiquitin-conjugating enzyme]-L-cysteine

[acceptor protein]-N6-ubiquitinyl-L-lysine

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine

[acceptor protein]-L-lysine

[E2 ubiquitin-conjugating enzyme]-L-cysteine

[acceptor protein]-N6-ubiquitinyl-L-lysine

Synonyms

brca1, parkin, e3 ubiquitin ligase, e3 ligase, c-cbl, ciap2, trim5alpha, rnf43, trim25, trim5, show all synonyms

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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)

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Q865W2 pBLAST

TRI50_PIG

All organisms
Arabidopsis thaliana
Caenorhabditis elegans
Capsicum annuum
Danio rerio
Glycine max
Homo sapiens
Human gammaherpesvirus 8
Human gammaherpesvirus 8 GK18
Malus domestica
Mus musculus
Nicotiana tabacum
Oryza sativa
Oryza sativa Japonica Group
Prunus persica
Rattus norvegicus
Saccharomyces cerevisiae
Solanum lycopersicum
Solanum pimpinellifolium
Solanum pimpinellifolium PI365967
Vitis pseudoreticulata