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Information on EC 2.3.2.27 - RING-type E3 ubiquitin transferase and Organism(s) Mus musculus

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.27 RING-type E3 ubiquitin transferase
IUBMB Comments
RING E3 ubiquitin transferases serve as mediators bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) and an acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. Unlike EC 2.3.2.26, HECT-type E3 ubiquitin transferase, the RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin. Many members of the RING-type E3 ubiquitin transferase family are not able to bind a substrate directly, and form a complex with a cullin scaffold protein and a substrate recognition module (the complexes are named CRL for Cullin-RING-Ligase). In these complexes, the RING-type E3 ubiquitin transferase provides an additional function, mediating the transfer of a NEDD8 protein from a dedicated E2 carrier to the cullin protein (see EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase). cf. EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
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This record set is specific for:
Mus musculus
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-lysine
=
[E2 ubiquitin-conjugating enzyme]-L-cysteine
+
[acceptor protein]-N6-ubiquitinyl-L-lysine
Synonyms
brca1, parkin, e3 ubiquitin ligase, e3 ligase, c-cbl, ciap2, trim5alpha, rnf43, trim25, trim5, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TRIM3
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
RING E3 ubiquitin transferases serve as mediators bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) and an acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. Unlike EC 2.3.2.26, HECT-type E3 ubiquitin transferase, the RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin. Many members of the RING-type E3 ubiquitin transferase family are not able to bind a substrate directly, and form a complex with a cullin scaffold protein and a substrate recognition module (the complexes are named CRL for Cullin-RING-Ligase). In these complexes, the RING-type E3 ubiquitin transferase provides an additional function, mediating the transfer of a NEDD8 protein from a dedicated E2 carrier to the cullin protein (see EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase). cf. EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-ubiquitinyl-[UbcH5a]-L-cysteine + [p21]-L-lysine
[UbcH5a]-L-cysteine + N6-ubiquitinyl-[p21]-L-lysine
show the reaction diagram
-
substrate p21 is a protein necessary for the proliferation of a subset of platelet-derived growth factor-transformed proneural glioma cells
UbcH5a is a preferred E2 enzyme for TRIM3-dependent p21 ubiquitination. Ubiquitination is practically eliminated in a p21 K15R/K74R/K91R/K136R quadruple mutant
-
?
[RNF180-ubiquitin-carrier protein UbcH6]-S-ubiquitinyl-L-cysteine + [Zic2]-L-lysine
[RNF180-ubiquitin-carrier protein UbcH6]-L-cysteine + [Zic2]-N6-ubiquitinyl-L-lysine
show the reaction diagram
Zic2, belongs to the Zic family nuclear zinc finger proteins
-
-
?
[RNF220-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [RF220]-L-lysine
[RNF220-ubiquitin-carrier protein]-L-cysteine + [RNF220]-N6-ubiquitinyl-L-lysine
show the reaction diagram
-
isoform RNF220 can bind ubiquitin-conjugating enzyme and mediate auto-ubiquitination of itself
-
?
[RNF220-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [Sin3B]-L-lysine
[RNF220-ubiquitin-carrier protein]-L-cysteine + [Sin3B]-N6-ubiquitinyl-L-lysine
show the reaction diagram
Sin3B, a global regulator of gene transcription, which serves as an essential scaffold protein of the Sin3/HDAC corepressor complex
isoform RNF220 specifically interacts with Sin3B both in vitro and in vivo. Sin3B can be regulated by the ubiquitin-proteasome system. Co-expression of RNF220 and Sin3B promotes the ubiquitination and proteasomal degradation of Sin3B
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
MLN4924
-
Nedd8 activating enzyme (NAE1) inhibitor, interferes with the activation of all cullin E3-ligases
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
of adult and developing animals, particularly in the ventricular layer of the cerebral cortex at embryonic stages
Manually annotated by BRENDA team
developing lens
Manually annotated by BRENDA team
-
primary myoblast cell
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
the RING domain is required for proper cellular localization
Manually annotated by BRENDA team
integral membrane protein
Manually annotated by BRENDA team
nuclear envelope
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CIKS_MOUSE
555
0
62440
Swiss-Prot
other Location (Reliability: 2)
MAEA_MOUSE
396
0
45336
Swiss-Prot
other Location (Reliability: 2)
PELI2_MOUSE
419
0
46272
Swiss-Prot
other Location (Reliability: 2)
PELI3_MOUSE
445
0
48168
Swiss-Prot
other Location (Reliability: 1)
PP1RB_MOUSE
131
0
14544
Swiss-Prot
other Location (Reliability: 1)
RN152_MOUSE
203
1
22353
Swiss-Prot
other Location (Reliability: 2)
RN157_MOUSE
685
0
74534
Swiss-Prot
other Location (Reliability: 2)
RN165_MOUSE
347
0
39736
Swiss-Prot
Mitochondrion (Reliability: 5)
TRI56_MOUSE
734
0
79513
Swiss-Prot
other Location (Reliability: 4)
TRI58_MOUSE
485
0
55371
Swiss-Prot
other Location (Reliability: 2)
UBE4B_MOUSE
1173
0
133318
Swiss-Prot
other Location (Reliability: 4)
UBR7_MOUSE
425
0
48065
Swiss-Prot
other Location (Reliability: 2)
BRE1A_MOUSE
973
0
113520
Swiss-Prot
other Location (Reliability: 2)
BRE1B_MOUSE
1001
0
113967
Swiss-Prot
other Location (Reliability: 2)
CBL_MOUSE
913
0
100564
Swiss-Prot
other Location (Reliability: 2)
DTX3L_MOUSE
748
0
83044
Swiss-Prot
other Location (Reliability: 5)
DTX3_MOUSE
347
0
37982
Swiss-Prot
Mitochondrion (Reliability: 4)
GOLI_MOUSE
419
2
46376
Swiss-Prot
Secretory Pathway (Reliability: 4)
LIN41_MOUSE
855
0
92054
Swiss-Prot
other Location (Reliability: 2)
MARH9_MOUSE
348
2
37888
Swiss-Prot
Secretory Pathway (Reliability: 5)
MARHB_MOUSE
400
2
44223
Swiss-Prot
other Location (Reliability: 2)
MIB1_MOUSE
1006
0
110088
Swiss-Prot
other Location (Reliability: 5)
NHLC1_MOUSE
401
0
42690
Swiss-Prot
other Location (Reliability: 2)
RN123_MOUSE
1314
0
148652
Swiss-Prot
Mitochondrion (Reliability: 5)
RN125_MOUSE
233
0
26362
Swiss-Prot
other Location (Reliability: 3)
RN126_MOUSE
313
0
34081
Swiss-Prot
other Location (Reliability: 2)
RN128_MOUSE
428
1
46276
Swiss-Prot
Secretory Pathway (Reliability: 2)
RN133_MOUSE
382
1
43102
Swiss-Prot
Secretory Pathway (Reliability: 3)
RNF5_MOUSE
180
2
19837
Swiss-Prot
other Location (Reliability: 1)
RNF6_MOUSE
667
0
74091
Swiss-Prot
other Location (Reliability: 3)
RNF8_MOUSE
488
0
55517
Swiss-Prot
other Location (Reliability: 3)
RNFT1_MOUSE
395
5
45277
Swiss-Prot
other Location (Reliability: 1)
SH3R1_MOUSE
892
0
93447
Swiss-Prot
other Location (Reliability: 2)
SH3R2_MOUSE
735
0
80066
Swiss-Prot
other Location (Reliability: 5)
SH3R3_MOUSE
878
0
93130
Swiss-Prot
Secretory Pathway (Reliability: 5)
SIA1A_MOUSE
282
0
31137
Swiss-Prot
Mitochondrion (Reliability: 4)
SIA1B_MOUSE
282
0
31122
Swiss-Prot
Mitochondrion (Reliability: 4)
TIF1A_MOUSE
1051
0
116657
Swiss-Prot
other Location (Reliability: 2)
TIF1B_MOUSE
834
0
88847
Swiss-Prot
Mitochondrion (Reliability: 5)
TRAIP_MOUSE
470
0
53149
Swiss-Prot
other Location (Reliability: 4)
TRIML_MOUSE
470
0
53787
Swiss-Prot
other Location (Reliability: 2)
UHRF1_MOUSE
782
0
88304
Swiss-Prot
other Location (Reliability: 3)
UHRF2_MOUSE
803
0
90106
Swiss-Prot
other Location (Reliability: 3)
BRAP_MOUSE
591
0
66991
Swiss-Prot
other Location (Reliability: 4)
DTX4_MOUSE
616
0
66821
Swiss-Prot
Secretory Pathway (Reliability: 3)
HAKAI_MOUSE
491
0
54444
Swiss-Prot
other Location (Reliability: 1)
LTN1_MOUSE
1767
0
198921
Swiss-Prot
other Location (Reliability: 5)
MARH1_MOUSE
289
2
32347
Swiss-Prot
other Location (Reliability: 4)
MARH2_MOUSE
246
2
27186
Swiss-Prot
other Location (Reliability: 2)
MARH3_MOUSE
218
2
24491
Swiss-Prot
other Location (Reliability: 2)
MARH4_MOUSE
409
2
45201
Swiss-Prot
Secretory Pathway (Reliability: 1)
PJA1_MOUSE
578
0
63906
Swiss-Prot
Mitochondrion (Reliability: 3)
PJA2_MOUSE
707
0
77958
Swiss-Prot
other Location (Reliability: 1)
RC3H2_MOUSE
1187
0
131295
Swiss-Prot
other Location (Reliability: 3)
RN166_MOUSE
237
0
26064
Swiss-Prot
Mitochondrion (Reliability: 4)
RN167_MOUSE
347
1
38014
Swiss-Prot
Secretory Pathway (Reliability: 1)
RN168_MOUSE
565
0
64779
Swiss-Prot
other Location (Reliability: 5)
RN169_MOUSE
694
0
75796
Swiss-Prot
Mitochondrion (Reliability: 2)
SYVN1_MOUSE
612
6
67296
Swiss-Prot
Secretory Pathway (Reliability: 2)
TM129_MOUSE
362
2
40628
Swiss-Prot
Secretory Pathway (Reliability: 1)
TRI62_MOUSE
475
0
54298
Swiss-Prot
other Location (Reliability: 4)
TRI63_MOUSE
350
0
39491
Swiss-Prot
other Location (Reliability: 2)
TRIM1_MOUSE
705
0
79774
Swiss-Prot
other Location (Reliability: 3)
TRIM2_MOUSE
744
0
81445
Swiss-Prot
other Location (Reliability: 2)
ZN363_MOUSE
261
0
30014
Swiss-Prot
other Location (Reliability: 2)
ZN598_MOUSE
908
0
99192
Swiss-Prot
other Location (Reliability: 3)
BIRC2_MOUSE
612
0
69676
Swiss-Prot
other Location (Reliability: 4)
BIRC3_MOUSE
600
0
67228
Swiss-Prot
other Location (Reliability: 1)
BIRC6_MOUSE
4882
0
532170
Swiss-Prot
other Location (Reliability: 5)
DCST1_MOUSE
732
4
84332
Swiss-Prot
other Location (Reliability: 4)
MDM2_MOUSE
489
0
54558
Swiss-Prot
other Location (Reliability: 2)
PZRN3_MOUSE
1063
0
119401
Swiss-Prot
other Location (Reliability: 2)
RAD18_MOUSE
509
0
57412
Swiss-Prot
other Location (Reliability: 2)
RFFL_MOUSE
377
0
42249
Swiss-Prot
other Location (Reliability: 5)
RN135_MOUSE
417
0
46462
Swiss-Prot
other Location (Reliability: 3)
RN138_MOUSE
245
0
28299
Swiss-Prot
other Location (Reliability: 1)
RN139_MOUSE
668
11
76185
Swiss-Prot
Secretory Pathway (Reliability: 3)
RNF12_MOUSE
600
0
66377
Swiss-Prot
other Location (Reliability: 2)
RNF13_MOUSE
381
1
42732
Swiss-Prot
Secretory Pathway (Reliability: 1)
RO52_MOUSE
470
0
54175
Swiss-Prot
other Location (Reliability: 2)
TRI16_MOUSE
556
0
62943
Swiss-Prot
other Location (Reliability: 2)
TRI17_MOUSE
477
0
54863
Swiss-Prot
other Location (Reliability: 2)
TRI18_MOUSE
680
0
76136
Swiss-Prot
other Location (Reliability: 3)
ZNRF1_MOUSE
227
0
23843
Swiss-Prot
Mitochondrion (Reliability: 5)
ZNRF2_MOUSE
238
0
23705
Swiss-Prot
other Location (Reliability: 3)
ZNRF3_MOUSE
913
1
98967
Swiss-Prot
other Location (Reliability: 4)
COP1_MOUSE
733
0
80441
Swiss-Prot
Mitochondrion (Reliability: 2)
DZIP3_MOUSE
1204
0
138021
Swiss-Prot
other Location (Reliability: 1)
E4F1_MOUSE
783
0
84296
Swiss-Prot
other Location (Reliability: 3)
FANCL_MOUSE
375
0
42527
Swiss-Prot
other Location (Reliability: 2)
I2BP1_MOUSE
584
0
61751
Swiss-Prot
other Location (Reliability: 5)
I2BPL_MOUSE
775
0
80565
Swiss-Prot
Mitochondrion (Reliability: 5)
MGRN1_MOUSE
532
0
58477
Swiss-Prot
other Location (Reliability: 2)
RN103_MOUSE
683
4
79189
Swiss-Prot
Secretory Pathway (Reliability: 1)
RN111_MOUSE
989
0
107896
Swiss-Prot
other Location (Reliability: 2)
SHPRH_MOUSE
1674
0
191490
Swiss-Prot
other Location (Reliability: 4)
TRAF2_MOUSE
501
0
56026
Swiss-Prot
other Location (Reliability: 2)
TRAF3_MOUSE
567
0
64294
Swiss-Prot
other Location (Reliability: 1)
TRAF4_MOUSE
470
0
53504
Swiss-Prot
other Location (Reliability: 2)
TRAF6_MOUSE
530
0
60070
Swiss-Prot
other Location (Reliability: 1)
TRI40_MOUSE
246
0
27903
Swiss-Prot
other Location (Reliability: 1)
TRI41_MOUSE
630
0
71818
Swiss-Prot
other Location (Reliability: 2)
ZFP91_MOUSE
572
0
63389
Swiss-Prot
other Location (Reliability: 2)
ZSWM2_MOUSE
631
0
71793
Swiss-Prot
Mitochondrion (Reliability: 4)
DTX2_MOUSE
619
0
67195
Swiss-Prot
other Location (Reliability: 4)
HLTF_MOUSE
1003
0
113317
Swiss-Prot
other Location (Reliability: 5)
JADE2_MOUSE
829
0
92174
Swiss-Prot
other Location (Reliability: 2)
MYLIP_MOUSE
445
0
49849
Swiss-Prot
other Location (Reliability: 2)
OBI1_MOUSE
722
0
79958
Swiss-Prot
Secretory Pathway (Reliability: 4)
PELI1_MOUSE
418
0
46259
Swiss-Prot
other Location (Reliability: 2)
RBX1_MOUSE
108
0
12274
Swiss-Prot
other Location (Reliability: 3)
RMD5A_MOUSE
391
0
43993
Swiss-Prot
other Location (Reliability: 1)
RN213_MOUSE
5148
0
584258
Swiss-Prot
other Location (Reliability: 1)
RNF41_MOUSE
317
0
35891
Swiss-Prot
other Location (Reliability: 2)
RNF43_MOUSE
784
2
86304
Swiss-Prot
Secretory Pathway (Reliability: 1)
RNF4_MOUSE
194
0
21911
Swiss-Prot
other Location (Reliability: 4)
TRI33_MOUSE
1142
0
123843
Swiss-Prot
other Location (Reliability: 1)
TRI35_MOUSE
501
0
57345
Swiss-Prot
other Location (Reliability: 2)
TRI36_MOUSE
729
0
82791
Swiss-Prot
other Location (Reliability: 1)
TRI37_MOUSE
961
0
107660
Swiss-Prot
other Location (Reliability: 1)
TRI38_MOUSE
471
0
54430
Swiss-Prot
other Location (Reliability: 3)
TRI39_MOUSE
488
0
56369
Swiss-Prot
other Location (Reliability: 2)
UBR1_MOUSE
1757
0
200240
Swiss-Prot
other Location (Reliability: 2)
UBR2_MOUSE
1755
0
199155
Swiss-Prot
other Location (Reliability: 1)
UBR3_MOUSE
1889
0
212757
Swiss-Prot
other Location (Reliability: 3)
UBR4_MOUSE
5180
0
572290
Swiss-Prot
other Location (Reliability: 1)
ZNRF4_MOUSE
327
0
35628
Swiss-Prot
Secretory Pathway (Reliability: 1)
BARD1_MOUSE
765
0
84254
Swiss-Prot
Mitochondrion (Reliability: 4)
CBLB_MOUSE
982
0
109092
Swiss-Prot
other Location (Reliability: 2)
CBLC_MOUSE
496
0
55715
Swiss-Prot
Mitochondrion (Reliability: 3)
CNOT4_MOUSE
575
0
63474
Swiss-Prot
other Location (Reliability: 1)
DTX1_MOUSE
627
0
68119
Swiss-Prot
other Location (Reliability: 5)
MUL1_MOUSE
352
2
39835
Swiss-Prot
Secretory Pathway (Reliability: 4)
NOSIP_MOUSE
301
0
33209
Swiss-Prot
other Location (Reliability: 2)
PRP19_MOUSE
504
0
55239
Swiss-Prot
other Location (Reliability: 2)
RBBP6_MOUSE
1790
0
199587
Swiss-Prot
other Location (Reliability: 2)
RING1_MOUSE
406
0
42631
Swiss-Prot
other Location (Reliability: 2)
RN145_MOUSE
663
12
74648
Swiss-Prot
other Location (Reliability: 5)
RN146_MOUSE
359
0
38934
Swiss-Prot
other Location (Reliability: 2)
RN149_MOUSE
394
1
42553
Swiss-Prot
Secretory Pathway (Reliability: 4)
SIAH2_MOUSE
325
0
34758
Swiss-Prot
Mitochondrion (Reliability: 4)
TRI13_MOUSE
407
1
46958
Swiss-Prot
other Location (Reliability: 2)
BIRC7_MOUSE
285
0
31992
Swiss-Prot
other Location (Reliability: 5)
CHFR_MOUSE
664
0
73871
Swiss-Prot
other Location (Reliability: 2)
LRSM1_MOUSE
727
0
83976
Swiss-Prot
other Location (Reliability: 4)
MKRN1_MOUSE
481
0
53008
Swiss-Prot
other Location (Reliability: 3)
MKRN2_MOUSE
416
0
46597
Swiss-Prot
other Location (Reliability: 5)
MKRN3_MOUSE
544
0
59434
Swiss-Prot
other Location (Reliability: 1)
NEUL1_MOUSE
574
0
61778
Swiss-Prot
Mitochondrion (Reliability: 4)
NEUL3_MOUSE
254
0
28040
Swiss-Prot
other Location (Reliability: 2)
PIAS1_MOUSE
651
0
71618
Swiss-Prot
other Location (Reliability: 2)
PIAS2_MOUSE
621
0
68426
Swiss-Prot
other Location (Reliability: 1)
PIAS4_MOUSE
507
0
55570
Swiss-Prot
other Location (Reliability: 3)
RC3H1_MOUSE
1130
0
125378
Swiss-Prot
other Location (Reliability: 3)
RING2_MOUSE
336
0
37623
Swiss-Prot
other Location (Reliability: 2)
RN183_MOUSE
190
1
21625
Swiss-Prot
other Location (Reliability: 2)
RN185_MOUSE
192
2
20520
Swiss-Prot
other Location (Reliability: 2)
RN186_MOUSE
226
2
24704
Swiss-Prot
other Location (Reliability: 3)
RN187_MOUSE
236
0
26313
Swiss-Prot
other Location (Reliability: 3)
RNF25_MOUSE
456
0
51227
Swiss-Prot
other Location (Reliability: 2)
RNF26_MOUSE
424
5
46914
Swiss-Prot
Secretory Pathway (Reliability: 1)
RNF34_MOUSE
376
0
42030
Swiss-Prot
other Location (Reliability: 5)
RNF37_MOUSE
539
0
58732
Swiss-Prot
other Location (Reliability: 4)
RNF38_MOUSE
464
0
52168
Swiss-Prot
other Location (Reliability: 4)
TRI47_MOUSE
641
0
69912
Swiss-Prot
other Location (Reliability: 2)
TRI50_MOUSE
483
0
54607
Swiss-Prot
other Location (Reliability: 2)
TRIM6_MOUSE
488
0
56152
Swiss-Prot
other Location (Reliability: 2)
TRIM7_MOUSE
510
0
57021
Swiss-Prot
other Location (Reliability: 2)
TRIM8_MOUSE
551
0
61602
Swiss-Prot
other Location (Reliability: 2)
TRIM9_MOUSE
817
0
90870
Swiss-Prot
other Location (Reliability: 1)
TTC3_MOUSE
1979
0
223931
Swiss-Prot
other Location (Reliability: 1)
BRCA1_MOUSE
1812
0
198795
Swiss-Prot
other Location (Reliability: 2)
CHIP_MOUSE
304
0
34909
Swiss-Prot
other Location (Reliability: 1)
LNX1_MOUSE
728
0
80157
Swiss-Prot
other Location (Reliability: 1)
MARH5_MOUSE
278
4
31232
Swiss-Prot
other Location (Reliability: 2)
MARH6_MOUSE
909
14
102273
Swiss-Prot
other Location (Reliability: 1)
MARH7_MOUSE
693
0
76599
Swiss-Prot
Mitochondrion (Reliability: 3)
MARH8_MOUSE
286
2
32243
Swiss-Prot
other Location (Reliability: 3)
NSE1_MOUSE
266
0
30708
Swiss-Prot
Mitochondrion (Reliability: 3)
RFWD3_MOUSE
774
0
84312
Swiss-Prot
other Location (Reliability: 1)
RMD5B_MOUSE
393
0
44421
Swiss-Prot
other Location (Reliability: 2)
RN112_MOUSE
654
2
71275
Swiss-Prot
Mitochondrion (Reliability: 2)
RN114_MOUSE
229
0
25745
Swiss-Prot
other Location (Reliability: 3)
RN115_MOUSE
305
0
33859
Swiss-Prot
other Location (Reliability: 2)
RN216_MOUSE
853
0
97682
Swiss-Prot
other Location (Reliability: 1)
RN220_MOUSE
566
0
62693
Swiss-Prot
other Location (Reliability: 2)
TRI23_MOUSE
574
0
63931
Swiss-Prot
other Location (Reliability: 5)
TRI25_MOUSE
634
0
71726
Swiss-Prot
other Location (Reliability: 2)
TRI26_MOUSE
545
0
62809
Swiss-Prot
other Location (Reliability: 1)
TRI27_MOUSE
513
0
58513
Swiss-Prot
other Location (Reliability: 3)
TRI31_MOUSE
507
0
57127
Swiss-Prot
other Location (Reliability: 2)
TRI32_MOUSE
655
0
72057
Swiss-Prot
other Location (Reliability: 3)
XIAP_MOUSE
496
0
56079
Swiss-Prot
other Location (Reliability: 1)
CIP1_MOUSE
276
0
31386
Swiss-Prot
other Location (Reliability: 2)
KCMF1_MOUSE
381
0
41791
Swiss-Prot
other Location (Reliability: 2)
MEX3C_MOUSE
652
0
68574
Swiss-Prot
Secretory Pathway (Reliability: 2)
MIB2_MOUSE
973
0
105961
Swiss-Prot
other Location (Reliability: 1)
NEU1B_MOUSE
546
0
58527
Swiss-Prot
Mitochondrion (Reliability: 4)
PPIL2_MOUSE
521
0
59065
Swiss-Prot
other Location (Reliability: 3)
RAG1_MOUSE
1040
0
119185
Swiss-Prot
other Location (Reliability: 2)
RN170_MOUSE
286
3
33414
Swiss-Prot
other Location (Reliability: 5)
RN180_MOUSE
592
1
67371
Swiss-Prot
other Location (Reliability: 1)
RN181_MOUSE
165
0
19101
Swiss-Prot
other Location (Reliability: 2)
RN182_MOUSE
247
2
27444
Swiss-Prot
other Location (Reliability: 2)
TOPRS_MOUSE
1033
0
117082
Swiss-Prot
other Location (Reliability: 2)
TRAF7_MOUSE
594
0
66487
Swiss-Prot
Mitochondrion (Reliability: 3)
TRI11_MOUSE
467
0
52580
Swiss-Prot
other Location (Reliability: 2)
TRI68_MOUSE
485
0
56098
Swiss-Prot
other Location (Reliability: 2)
TRI69_MOUSE
500
0
57312
Swiss-Prot
other Location (Reliability: 2)
Q9D9M9_MOUSE
248
0
28389
TrEMBL
other Location (Reliability: 1)
Q3U8L1_MOUSE
501
0
56026
TrEMBL
other Location (Reliability: 2)
A0A0R4IZY1_MOUSE
618
0
67066
TrEMBL
other Location (Reliability: 4)
F6S742_MOUSE
344
0
38041
TrEMBL
other Location (Reliability: 3)
Q9CSX9_MOUSE
159
0
16609
TrEMBL
other Location (Reliability: 3)
A0A0R4J1R1_MOUSE
612
6
67329
TrEMBL
Secretory Pathway (Reliability: 2)
B9EKI5_MOUSE
938
0
104592
TrEMBL
other Location (Reliability: 2)
A2AHZ2_MOUSE
282
0
31154
TrEMBL
Mitochondrion (Reliability: 4)
A0A087WRE9_MOUSE
264
0
29226
TrEMBL
other Location (Reliability: 2)
F7D553_MOUSE
239
0
25894
TrEMBL
other Location (Reliability: 4)
Q9DB86_MOUSE
265
0
29329
TrEMBL
other Location (Reliability: 1)
D3Z4X6_MOUSE
116
0
12372
TrEMBL
other Location (Reliability: 4)
E9Q524_MOUSE
547
0
60850
TrEMBL
other Location (Reliability: 1)
B1AUZ9_MOUSE
474
0
52995
TrEMBL
other Location (Reliability: 1)
D3Z733_MOUSE
449
0
50772
TrEMBL
other Location (Reliability: 2)
Q3TVL4_MOUSE
489
0
54588
TrEMBL
other Location (Reliability: 2)
B2RWG3_MOUSE
268
0
30603
TrEMBL
Mitochondrion (Reliability: 5)
Q3U7K7_MOUSE
462
0
53328
TrEMBL
other Location (Reliability: 3)
F6XYB0_MOUSE
209
0
24221
TrEMBL
other Location (Reliability: 1)
A0A0U1RP95_MOUSE
79
0
8609
TrEMBL
other Location (Reliability: 1)
A0A6I8MWZ7_MOUSE
550
0
61327
TrEMBL
other Location (Reliability: 1)
A0A087WQQ3_MOUSE
73
0
8269
TrEMBL
other Location (Reliability: 2)
B2RUG2_MOUSE
946
0
102634
TrEMBL
other Location (Reliability: 1)
Q8CAW0_MOUSE
378
0
42437
TrEMBL
other Location (Reliability: 2)
B1AVF4_MOUSE
685
0
77842
TrEMBL
other Location (Reliability: 4)
A2A9P8_MOUSE
375
0
41162
TrEMBL
other Location (Reliability: 1)
A0A087WP87_MOUSE
211
0
23186
TrEMBL
other Location (Reliability: 3)
Q921R6_MOUSE
309
0
34787
TrEMBL
other Location (Reliability: 2)
E9Q3A0_MOUSE
717
0
81338
TrEMBL
other Location (Reliability: 1)
Q148V5_MOUSE
1187
0
131247
TrEMBL
other Location (Reliability: 3)
D6RHT6_MOUSE
1135
0
130728
TrEMBL
other Location (Reliability: 1)
Q8C6X9_MOUSE
501
0
56086
TrEMBL
other Location (Reliability: 2)
Q8C2U3_MOUSE
115
0
13418
TrEMBL
other Location (Reliability: 2)
Q3TKQ2_MOUSE
849
0
98202
TrEMBL
other Location (Reliability: 2)
Q3TWR1_MOUSE
501
0
55959
TrEMBL
other Location (Reliability: 2)
A0A1L1SSN4_MOUSE
168
0
19188
TrEMBL
other Location (Reliability: 2)
Q3TVH5_MOUSE
461
0
51820
TrEMBL
other Location (Reliability: 1)
D6RD03_MOUSE
1179
0
135983
TrEMBL
other Location (Reliability: 1)
A2AV05_MOUSE
242
0
27346
TrEMBL
other Location (Reliability: 4)
A0A0R4J1T2_MOUSE
776
1
88825
TrEMBL
other Location (Reliability: 1)
Q2TA94_MOUSE
452
0
50745
TrEMBL
Mitochondrion (Reliability: 3)
Q8CAR4_MOUSE
506
0
54785
TrEMBL
other Location (Reliability: 3)
A0A494BBF6_MOUSE
268
0
31161
TrEMBL
other Location (Reliability: 4)
Q99LD7_MOUSE
329
0
34967
TrEMBL
other Location (Reliability: 3)
Q148V4_MOUSE
1187
0
131265
TrEMBL
other Location (Reliability: 3)
Q3UMS9_MOUSE
558
0
64145
TrEMBL
other Location (Reliability: 2)
Q5NCB7_MOUSE
510
0
56993
TrEMBL
other Location (Reliability: 2)
Q9Z1D2_MOUSE
1812
0
198804
TrEMBL
other Location (Reliability: 2)
Q3TJA0_MOUSE
418
0
46188
TrEMBL
other Location (Reliability: 2)
Q497M7_MOUSE
859
0
99542
TrEMBL
other Location (Reliability: 2)
Q78NA6_MOUSE
1040
0
119161
TrEMBL
other Location (Reliability: 2)
Q6NV63_MOUSE
1811
0
198615
TrEMBL
other Location (Reliability: 2)
A2RRJ6_MOUSE
1006
0
110088
TrEMBL
other Location (Reliability: 5)
E9QPQ6_MOUSE
419
0
46173
TrEMBL
other Location (Reliability: 2)
W4VSP9_MOUSE
309
0
34801
TrEMBL
other Location (Reliability: 2)
F6RDS0_MOUSE
517
0
56293
TrEMBL
other Location (Reliability: 2)
Q3TJV7_MOUSE
381
1
42698
TrEMBL
Secretory Pathway (Reliability: 1)
D6RFU5_MOUSE
1197
0
137811
TrEMBL
other Location (Reliability: 4)
Q3UTG4_MOUSE
268
1
30249
TrEMBL
Secretory Pathway (Reliability: 1)
E9PYW4_MOUSE
567
0
65039
TrEMBL
other Location (Reliability: 4)
D3Z485_MOUSE
622
1
71373
TrEMBL
other Location (Reliability: 1)
A0A0G2JFV4_MOUSE
77
0
8124
TrEMBL
other Location (Reliability: 3)
E0CXC2_MOUSE
719
0
81371
TrEMBL
other Location (Reliability: 3)
F6ZBL2_MOUSE
641
0
69749
TrEMBL
other Location (Reliability: 2)
B1NE43_MOUSE
83
0
9358
TrEMBL
other Location (Reliability: 1)
Q8C4F9_MOUSE
244
1
27465
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0U1RP17_MOUSE
51
0
6218
TrEMBL
other Location (Reliability: 1)
Q569X0_MOUSE
487
0
54398
TrEMBL
other Location (Reliability: 2)
A2AVP4_MOUSE
1125
0
124708
TrEMBL
other Location (Reliability: 3)
B1NE42_MOUSE
78
0
8497
TrEMBL
other Location (Reliability: 1)
A2RS02_MOUSE
237
0
26064
TrEMBL
Mitochondrion (Reliability: 4)
Q3U3G2_MOUSE
313
0
34081
TrEMBL
other Location (Reliability: 2)
F6X2H0_MOUSE
157
0
17997
TrEMBL
other Location (Reliability: 2)
E9Q3J1_MOUSE
395
0
42949
TrEMBL
Mitochondrion (Reliability: 4)
A3KMI3_MOUSE
657
1
72655
TrEMBL
other Location (Reliability: 2)
A0A1Y7VP88_MOUSE
710
0
79206
TrEMBL
other Location (Reliability: 1)
G3X9U0_MOUSE
452
0
50687
TrEMBL
Mitochondrion (Reliability: 3)
D3YXE6_MOUSE
255
0
27377
TrEMBL
other Location (Reliability: 2)
A0A0G2JGT7_MOUSE
166
0
18429
TrEMBL
Secretory Pathway (Reliability: 1)
E9QAG7_MOUSE
417
0
47307
TrEMBL
other Location (Reliability: 1)
B1AV01_MOUSE
642
0
71747
TrEMBL
other Location (Reliability: 3)
B2RR25_MOUSE
243
0
27228
TrEMBL
other Location (Reliability: 2)
Q6PD02_MOUSE
400
0
44623
TrEMBL
Secretory Pathway (Reliability: 2)
Q8C5V4_MOUSE
481
0
52945
TrEMBL
other Location (Reliability: 3)
G5E8T2_MOUSE
1979
0
223909
TrEMBL
other Location (Reliability: 1)
D3Z6V8_MOUSE
411
0
44263
TrEMBL
other Location (Reliability: 2)
E9QLH4_MOUSE
788
0
87548
TrEMBL
other Location (Reliability: 1)
E9QM14_MOUSE
416
0
46428
TrEMBL
other Location (Reliability: 1)
H7BX02_MOUSE
1121
0
124397
TrEMBL
other Location (Reliability: 3)
Q921V6_MOUSE
470
0
54147
TrEMBL
other Location (Reliability: 2)
D3Z2K0_MOUSE
382
1
43557
TrEMBL
other Location (Reliability: 1)
E9QNZ2_MOUSE
1204
0
138021
TrEMBL
other Location (Reliability: 1)
Q3V1R9_MOUSE
850
0
98316
TrEMBL
other Location (Reliability: 2)
Q5NCC2_MOUSE
161
0
18368
TrEMBL
other Location (Reliability: 5)
D3YV13_MOUSE
350
0
38149
TrEMBL
other Location (Reliability: 4)
A0A0U1RNG8_MOUSE
110
0
12450
TrEMBL
other Location (Reliability: 2)
A0A338P6W3_MOUSE
1624
0
182541
TrEMBL
other Location (Reliability: 1)
Q3TYJ0_MOUSE
304
0
34911
TrEMBL
other Location (Reliability: 1)
Q8BUY4_MOUSE
531
0
59582
TrEMBL
other Location (Reliability: 3)
F6QC57_MOUSE
1892
0
213072
TrEMBL
other Location (Reliability: 3)
I6L9G8_MOUSE
691
0
76577
TrEMBL
other Location (Reliability: 5)
H9KV17_MOUSE
223
0
24753
TrEMBL
other Location (Reliability: 2)
B3DFI9_MOUSE
950
0
107638
TrEMBL
Secretory Pathway (Reliability: 3)
Q9CSA3_MOUSE
178
0
20744
TrEMBL
other Location (Reliability: 2)
Q14B86_MOUSE
724
0
81092
TrEMBL
other Location (Reliability: 5)
D3Z1Y1_MOUSE
608
6
66944
TrEMBL
Secretory Pathway (Reliability: 2)
E9QQ99_MOUSE
561
5
61447
TrEMBL
Secretory Pathway (Reliability: 2)
Q2M4H7_MOUSE
913
0
100550
TrEMBL
other Location (Reliability: 2)
A0A0X1KG60_MOUSE
961
0
109338
TrEMBL
other Location (Reliability: 2)
A0A0G2JDR7_MOUSE
151
0
16909
TrEMBL
other Location (Reliability: 4)
A0A1X7SB71_MOUSE
488
0
54143
TrEMBL
other Location (Reliability: 1)
B1AVF5_MOUSE
715
0
81202
TrEMBL
other Location (Reliability: 4)
Q8C2F3_MOUSE
140
0
15890
TrEMBL
other Location (Reliability: 2)
A0A1B4Z9R9_MOUSE
356
0
40808
TrEMBL
other Location (Reliability: 1)
A0A0R4J057_MOUSE
445
0
48139
TrEMBL
other Location (Reliability: 1)
F6VZ99_MOUSE
200
0
22383
TrEMBL
other Location (Reliability: 2)
Q3UT88_MOUSE
1130
0
125454
TrEMBL
other Location (Reliability: 3)
A0A0U1RQ85_MOUSE
896
0
98509
TrEMBL
other Location (Reliability: 2)
A2AIR0_MOUSE
174
0
19537
TrEMBL
other Location (Reliability: 2)
Q99MS2_MOUSE
317
0
35905
TrEMBL
other Location (Reliability: 2)
Q3TR87_MOUSE
140
0
15891
TrEMBL
other Location (Reliability: 2)
B7ZNW2_MOUSE
379
0
42508
TrEMBL
other Location (Reliability: 2)
Q5SRW7_MOUSE
418
0
46259
TrEMBL
other Location (Reliability: 2)
Q8CB78_MOUSE
352
1
39430
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0N4SVF7_MOUSE
478
0
53817
TrEMBL
other Location (Reliability: 3)
Q3UHM2_MOUSE
542
0
61592
TrEMBL
other Location (Reliability: 1)
A0A1Y7VKW0_MOUSE
314
0
36248
TrEMBL
other Location (Reliability: 3)
A2AIR2_MOUSE
606
0
70389
TrEMBL
other Location (Reliability: 2)
Q3UC35_MOUSE
146
0
16962
TrEMBL
other Location (Reliability: 2)
Q3UHJ1_MOUSE
542
0
61564
TrEMBL
other Location (Reliability: 1)
D3Z734_MOUSE
428
0
48430
TrEMBL
other Location (Reliability: 2)
A0A0X1KG61_MOUSE
869
0
96000
TrEMBL
other Location (Reliability: 2)
A0A0U1RPJ4_MOUSE
901
0
102377
TrEMBL
other Location (Reliability: 2)
Q69ZH4_MOUSE
276
0
30167
TrEMBL
Secretory Pathway (Reliability: 4)
Q5DTK6_MOUSE
676
0
72975
TrEMBL
other Location (Reliability: 3)
Q2M4I1_MOUSE
1757
0
200205
TrEMBL
other Location (Reliability: 2)
Q8C521_MOUSE
217
0
23840
TrEMBL
other Location (Reliability: 3)
A0A286YCB2_MOUSE
178
0
20017
TrEMBL
other Location (Reliability: 1)
A2AAP0_MOUSE
659
0
72262
TrEMBL
other Location (Reliability: 2)
Q9D776_MOUSE
363
0
40455
TrEMBL
other Location (Reliability: 5)
A0A494BBI6_MOUSE
277
0
31892
TrEMBL
Mitochondrion (Reliability: 3)
E9QQ33_MOUSE
891
0
93344
TrEMBL
other Location (Reliability: 2)
Q99NN8_MOUSE
258
0
29226
TrEMBL
other Location (Reliability: 1)
A0A068BFS4_MOUSE
406
0
42613
TrEMBL
other Location (Reliability: 2)
Q3TR28_MOUSE
787
0
87477
TrEMBL
other Location (Reliability: 1)
A0A0G2JEM4_MOUSE
131
0
14209
TrEMBL
Secretory Pathway (Reliability: 1)
Q5KU40_MOUSE
486
0
53522
TrEMBL
other Location (Reliability: 3)
Q3UEV2_MOUSE
325
0
34758
TrEMBL
Mitochondrion (Reliability: 4)
A0A0U1RP47_MOUSE
895
0
98318
TrEMBL
other Location (Reliability: 2)
Q0P617_MOUSE
131
0
15100
TrEMBL
other Location (Reliability: 3)
E9Q392_MOUSE
556
0
62498
TrEMBL
other Location (Reliability: 2)
D3Z7U8_MOUSE
148
0
16698
TrEMBL
other Location (Reliability: 2)
D6RDD2_MOUSE
1162
0
134021
TrEMBL
other Location (Reliability: 1)
F7D0T8_MOUSE
506
0
54841
TrEMBL
other Location (Reliability: 4)
E9PWJ5_MOUSE
743
2
81811
TrEMBL
Secretory Pathway (Reliability: 1)
Q3UT93_MOUSE
376
0
40190
TrEMBL
Mitochondrion (Reliability: 2)
Q3UCL2_MOUSE
462
0
53326
TrEMBL
other Location (Reliability: 3)
Q8CED3_MOUSE
496
0
55676
TrEMBL
other Location (Reliability: 5)
A2AIR1_MOUSE
117
0
13032
TrEMBL
other Location (Reliability: 2)
Q3UHE0_MOUSE
1755
0
199173
TrEMBL
other Location (Reliability: 1)
A0A3Q4EHU1_MOUSE
179
0
20847
TrEMBL
other Location (Reliability: 1)
Q3UPU3_MOUSE
1755
0
199198
TrEMBL
other Location (Reliability: 1)
Q3TAE7_MOUSE
445
0
49833
TrEMBL
other Location (Reliability: 2)
Q3UFK3_MOUSE
395
0
42965
TrEMBL
Mitochondrion (Reliability: 4)
D3YZH4_MOUSE
160
4
18534
TrEMBL
Secretory Pathway (Reliability: 2)
Q8CAQ7_MOUSE
501
0
56026
TrEMBL
other Location (Reliability: 2)
Q6NSS3_MOUSE
604
0
67737
TrEMBL
Mitochondrion (Reliability: 3)
Q6XC89_MOUSE
444
0
51034
TrEMBL
other Location (Reliability: 2)
A0A0R4J0C0_MOUSE
280
0
32039
TrEMBL
Mitochondrion (Reliability: 4)
Q8CDH2_MOUSE
556
0
62526
TrEMBL
other Location (Reliability: 2)
A2AAN9_MOUSE
681
0
74476
TrEMBL
other Location (Reliability: 2)
D3YZ03_MOUSE
469
0
53702
TrEMBL
other Location (Reliability: 1)
A4PBT3_MOUSE
233
0
26358
TrEMBL
other Location (Reliability: 3)
HOIL1_MOUSE
508
0
57534
Swiss-Prot
-
RNF31_MOUSE
1066
0
119314
Swiss-Prot
-
PDB
SCOP
CATH
UNIPROT
ORGANISM
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ubiquitination
isoform RNF180 itself is heavily ubiquitinated and degraded by the proteasome
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ogawa, M.; Mizugishi, K.; Ishiguro, A.; Koyabu, Y.; Imai, Y.; Takahashi, R.; Mikoshiba, K.; Aruga, J.
Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase
Genes Cells
13
397-409
2008
Mus musculus (Q3U827)
Manually annotated by BRENDA team
Kong, Q.; Zeng, W.; Wu, J.; Hu, W.; Li, C.; Mao, B.
RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination
Biochem. Biophys. Res. Commun.
393
708-713
2010
Mus musculus (Q6PDX6)
Manually annotated by BRENDA team
Raheja, R.; Liu, Y.; Hukkelhoven, E.; Yeh, N.; Koff, A.
The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity
Biochem. J.
458
537-545
2014
Mus musculus
Manually annotated by BRENDA team
Suisse, A.; Bekes, M.; Huang, T.T.; Treisman, J.E.
The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity
Fly
12
118-126
2018
Mus musculus
Manually annotated by BRENDA team