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Information on EC 2.3.2.27 - RING-type E3 ubiquitin transferase and Organism(s) Drosophila melanogaster

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.27 RING-type E3 ubiquitin transferase
IUBMB Comments
RING E3 ubiquitin transferases serve as mediators bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) and an acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. Unlike EC 2.3.2.26, HECT-type E3 ubiquitin transferase, the RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin. Many members of the RING-type E3 ubiquitin transferase family are not able to bind a substrate directly, and form a complex with a cullin scaffold protein and a substrate recognition module (the complexes are named CRL for Cullin-RING-Ligase). In these complexes, the RING-type E3 ubiquitin transferase provides an additional function, mediating the transfer of a NEDD8 protein from a dedicated E2 carrier to the cullin protein (see EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase). cf. EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
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This record set is specific for:
Drosophila melanogaster
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Word Map
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The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-lysine
=
[E2 ubiquitin-conjugating enzyme]-L-cysteine
+
[acceptor protein]-N6-ubiquitinyl-L-lysine
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-lysine
=
[E2 ubiquitin-conjugating enzyme]-L-cysteine
+
[acceptor protein]-N6-ubiquitinyl-L-lysine
Synonyms
brca1, parkin, e3 ubiquitin ligase, e3 ligase, c-cbl, ciap2, trim5alpha, rnf43, trim25, trim5, more
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
RING E3 ubiquitin transferases serve as mediators bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) and an acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. Unlike EC 2.3.2.26, HECT-type E3 ubiquitin transferase, the RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin. Many members of the RING-type E3 ubiquitin transferase family are not able to bind a substrate directly, and form a complex with a cullin scaffold protein and a substrate recognition module (the complexes are named CRL for Cullin-RING-Ligase). In these complexes, the RING-type E3 ubiquitin transferase provides an additional function, mediating the transfer of a NEDD8 protein from a dedicated E2 carrier to the cullin protein (see EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase). cf. EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SINAL_DROME
351
0
39645
Swiss-Prot
Mitochondrion (Reliability: 4)
SINA_DROME
314
0
33707
Swiss-Prot
other Location (Reliability: 4)
GOLI_DROME
461
2
52623
Swiss-Prot
Secretory Pathway (Reliability: 1)
HRD1_DROME
626
6
69272
Swiss-Prot
Secretory Pathway (Reliability: 1)
DIAP1_DROME
438
0
48038
Swiss-Prot
other Location (Reliability: 1)
HAKAI_DROME
473
0
49261
Swiss-Prot
other Location (Reliability: 2)
LTN1_DROME
1747
0
198640
Swiss-Prot
other Location (Reliability: 5)
DTX_DROME
738
0
82186
Swiss-Prot
Mitochondrion (Reliability: 5)
GZL_DROME
536
2
58824
Swiss-Prot
Secretory Pathway (Reliability: 1)
UBR1_DROME
1824
0
208361
Swiss-Prot
other Location (Reliability: 1)
UBR3_DROME
2219
0
247095
Swiss-Prot
other Location (Reliability: 1)
MUL1_DROME
338
1
37844
Swiss-Prot
Secretory Pathway (Reliability: 4)
RING1_DROME
435
0
47256
Swiss-Prot
other Location (Reliability: 1)
BRE1_DROME
1044
0
119060
Swiss-Prot
other Location (Reliability: 3)
TRIM9_DROME
740
0
80192
Swiss-Prot
other Location (Reliability: 4)
IRU_DROME
380
0
40319
Swiss-Prot
other Location (Reliability: 1)
NSE1_DROME
235
0
26774
Swiss-Prot
other Location (Reliability: 4)
KCMF1_DROME
599
0
62398
Swiss-Prot
other Location (Reliability: 2)
MIB_DROME
1226
0
129872
Swiss-Prot
other Location (Reliability: 2)
RN181_DROME
147
0
17037
Swiss-Prot
other Location (Reliability: 1)
TOPRS_DROME
1038
0
113313
Swiss-Prot
other Location (Reliability: 2)
Q9VUV7_DROME
315
0
36093
TrEMBL
other Location (Reliability: 2)
Q9W149_DROME
867
0
95939
TrEMBL
other Location (Reliability: 5)
M9PCC6_DROME
235
0
26774
TrEMBL
other Location (Reliability: 4)
B7Z083_DROME
365
0
38851
TrEMBL
other Location (Reliability: 2)
Q9VSK2_DROME
878
0
94788
TrEMBL
Mitochondrion (Reliability: 3)
Q9VXP1_DROME
277
2
30368
TrEMBL
other Location (Reliability: 2)
B5RJD9_DROME
351
0
39645
TrEMBL
Mitochondrion (Reliability: 4)
Q4V6Q2_DROME
144
2
16504
TrEMBL
Secretory Pathway (Reliability: 3)
Q9VV48_DROME
819
0
90377
TrEMBL
other Location (Reliability: 2)
Q9VVS2_DROME
265
0
28954
TrEMBL
other Location (Reliability: 2)
Q7K231_DROME
517
0
58959
TrEMBL
other Location (Reliability: 1)
F6JA49_DROME
258
0
28858
TrEMBL
other Location (Reliability: 2)
Q8MM55_DROME
243
0
28296
TrEMBL
other Location (Reliability: 5)
A0A0B4KHH2_DROME
626
6
69272
TrEMBL
Secretory Pathway (Reliability: 1)
Q9VY21_DROME
210
0
24381
TrEMBL
Mitochondrion (Reliability: 5)
Q9VY98_DROME
789
0
83861
TrEMBL
other Location (Reliability: 2)
B4F597_DROME
158
0
18504
TrEMBL
Mitochondrion (Reliability: 5)
B4F599_DROME
158
0
18518
TrEMBL
Mitochondrion (Reliability: 5)
K7ZEG1_DROME
144
0
15855
TrEMBL
other Location (Reliability: 3)
Q7K4D1_DROME
838
0
92058
TrEMBL
other Location (Reliability: 1)
P91683_DROME
448
0
51488
TrEMBL
Mitochondrion (Reliability: 3)
A1A749_DROME
108
0
12584
TrEMBL
other Location (Reliability: 1)
Q7KLW9_DROME
505
0
55199
TrEMBL
other Location (Reliability: 2)
Q9W4W4_DROME
626
0
69456
TrEMBL
other Location (Reliability: 1)
N0A8E6_DROME
127
0
14906
TrEMBL
Mitochondrion (Reliability: 5)
Q8MM56_DROME
243
0
28297
TrEMBL
other Location (Reliability: 5)
O46034_DROME
448
0
51473
TrEMBL
Mitochondrion (Reliability: 3)
A9YHB9_DROME
248
0
27659
TrEMBL
other Location (Reliability: 2)
Q8IR26_DROME
283
2
31154
TrEMBL
other Location (Reliability: 2)
Q8IQM1_DROME
164
2
18714
TrEMBL
other Location (Reliability: 2)
Q9VJ14_DROME
1049
0
114868
TrEMBL
other Location (Reliability: 4)
Q86DT7_DROME
221
0
26011
TrEMBL
other Location (Reliability: 2)
Q9VFY3_DROME
239
1
27185
TrEMBL
other Location (Reliability: 1)
A1A736_DROME
108
0
12600
TrEMBL
other Location (Reliability: 1)
Q9VIK5_DROME
274
3
31102
TrEMBL
Secretory Pathway (Reliability: 3)
Q8IGT4_DROME
867
0
95970
TrEMBL
other Location (Reliability: 5)
Q86DT6_DROME
221
0
25983
TrEMBL
other Location (Reliability: 2)
M9PI73_DROME
1115
0
120298
TrEMBL
other Location (Reliability: 2)
Q9VW25_DROME
376
0
39510
TrEMBL
other Location (Reliability: 2)
Q8IRV4_DROME
221
0
24112
TrEMBL
Mitochondrion (Reliability: 5)
Q8MTX7_DROME
243
0
28327
TrEMBL
other Location (Reliability: 5)
X2JGB3_DROME
1044
0
119060
TrEMBL
other Location (Reliability: 3)
A0A1Z1CK50_DROME
194
1
22688
TrEMBL
other Location (Reliability: 1)
Q9TVX6_DROME
386
0
43809
TrEMBL
other Location (Reliability: 3)
Q86DT5_DROME
221
0
26011
TrEMBL
other Location (Reliability: 2)
A0A0B4KFY0_DROME
696
0
75598
TrEMBL
other Location (Reliability: 2)
B4F591_DROME
158
0
18490
TrEMBL
Mitochondrion (Reliability: 5)
M9NFA7_DROME
1824
0
208361
TrEMBL
other Location (Reliability: 1)
Q8MTX8_DROME
243
0
28269
TrEMBL
other Location (Reliability: 3)
F6JA46_DROME
255
0
28556
TrEMBL
other Location (Reliability: 1)
Q8SWW8_DROME
676
0
73183
TrEMBL
other Location (Reliability: 2)
X2JB60_DROME
314
0
33707
TrEMBL
other Location (Reliability: 4)
Q8SZQ1_DROME
376
0
39496
TrEMBL
other Location (Reliability: 2)
M9PDZ8_DROME
2236
0
249046
TrEMBL
other Location (Reliability: 1)
N0BRZ8_DROME
127
0
14888
TrEMBL
Mitochondrion (Reliability: 5)
C0ML75_DROME
158
0
18460
TrEMBL
Mitochondrion (Reliability: 5)
Q9VY20_DROME
285
0
32861
TrEMBL
Mitochondrion (Reliability: 3)
Q9VJW5_DROME
328
0
37447
TrEMBL
other Location (Reliability: 2)
Q9XYW6_DROME
289
0
33864
TrEMBL
other Location (Reliability: 1)
B7Z078_DROME
448
0
47763
TrEMBL
other Location (Reliability: 2)
Q9VP20_DROME
386
0
43759
TrEMBL
other Location (Reliability: 3)
B4F594_DROME
158
0
18520
TrEMBL
Mitochondrion (Reliability: 5)
C0ML78_DROME
158
0
18536
TrEMBL
Mitochondrion (Reliability: 5)
Q9NHP2_DROME
838
0
92010
TrEMBL
other Location (Reliability: 1)
O76862_DROME
397
0
44819
TrEMBL
Mitochondrion (Reliability: 3)
Q24055_DROME
87
0
9425
TrEMBL
other Location (Reliability: 2)
Q9NEG2_DROME
295
0
32179
TrEMBL
Mitochondrion (Reliability: 5)
Q9W4V2_DROME
229
0
25139
TrEMBL
Mitochondrion (Reliability: 5)
Q86DT8_DROME
221
0
26011
TrEMBL
other Location (Reliability: 2)
Q86NN7_DROME
771
0
82179
TrEMBL
other Location (Reliability: 2)
F6JA40_DROME
258
0
28842
TrEMBL
other Location (Reliability: 2)