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Information on EC 2.3.2.27 - RING-type E3 ubiquitin transferase and Organism(s) Dictyostelium discoideum

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.27 RING-type E3 ubiquitin transferase
IUBMB Comments
RING E3 ubiquitin transferases serve as mediators bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) and an acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. Unlike EC 2.3.2.26, HECT-type E3 ubiquitin transferase, the RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin. Many members of the RING-type E3 ubiquitin transferase family are not able to bind a substrate directly, and form a complex with a cullin scaffold protein and a substrate recognition module (the complexes are named CRL for Cullin-RING-Ligase). In these complexes, the RING-type E3 ubiquitin transferase provides an additional function, mediating the transfer of a NEDD8 protein from a dedicated E2 carrier to the cullin protein (see EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase). cf. EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
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Dictyostelium discoideum
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Word Map
The taxonomic range for the selected organisms is: Dictyostelium discoideum
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-lysine
=
[E2 ubiquitin-conjugating enzyme]-L-cysteine
+
[acceptor protein]-N6-ubiquitinyl-L-lysine
Synonyms
brca1, parkin, e3 ubiquitin ligase, e3 ligase, c-cbl, ciap2, trim5alpha, rnf43, trim25, trim5, more
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
RING E3 ubiquitin transferases serve as mediators bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) and an acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. Unlike EC 2.3.2.26, HECT-type E3 ubiquitin transferase, the RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin. Many members of the RING-type E3 ubiquitin transferase family are not able to bind a substrate directly, and form a complex with a cullin scaffold protein and a substrate recognition module (the complexes are named CRL for Cullin-RING-Ligase). In these complexes, the RING-type E3 ubiquitin transferase provides an additional function, mediating the transfer of a NEDD8 protein from a dedicated E2 carrier to the cullin protein (see EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase). cf. EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
LTN1_DICDI
1864
0
213101
Swiss-Prot
other Location (Reliability: 3)
PRP19_DICDI
514
0
56811
Swiss-Prot
other Location (Reliability: 1)
UBR7_DICDI
465
0
53363
Swiss-Prot
other Location (Reliability: 1)
CBLA_DICDI
665
0
74962
Swiss-Prot
other Location (Reliability: 5)
BRE1_DICDI
1080
0
126556
Swiss-Prot
other Location (Reliability: 2)
Q54VX1_DICDI
457
0
51186
TrEMBL
other Location (Reliability: 1)
Q86H89_DICDI
911
0
102290
TrEMBL
other Location (Reliability: 1)
Q75JM9_DICDI
2230
0
260319
TrEMBL
other Location (Reliability: 1)
Q54X37_DICDI
267
0
30552
TrEMBL
Mitochondrion (Reliability: 4)
Q54JV0_DICDI
1580
0
182496
TrEMBL
other Location (Reliability: 2)
Q54JT8_DICDI
1814
0
211442
TrEMBL
other Location (Reliability: 3)
Q54DM5_DICDI
388
1
44849
TrEMBL
Secretory Pathway (Reliability: 1)
Q54X17_DICDI
742
0
84006
TrEMBL
other Location (Reliability: 1)
Q54JE9_DICDI
1755
0
204893
TrEMBL
other Location (Reliability: 1)
Q54TF7_DICDI
407
0
46214
TrEMBL
other Location (Reliability: 3)
Q55FX6_DICDI
365
0
41917
TrEMBL
other Location (Reliability: 2)
Q54QZ3_DICDI
2375
0
268691
TrEMBL
other Location (Reliability: 2)
Q55DC5_DICDI
423
0
46336
TrEMBL
other Location (Reliability: 3)
Q54ND8_DICDI
281
2
30579
TrEMBL
other Location (Reliability: 1)
Q54IW6_DICDI
2023
0
231875
TrEMBL
other Location (Reliability: 2)
B0G146_DICDI
614
0
70356
TrEMBL
other Location (Reliability: 3)
Q54TM9_DICDI
974
0
108480
TrEMBL
other Location (Reliability: 1)
Q54DM4_DICDI
1569
0
178617
TrEMBL
other Location (Reliability: 1)