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Information on EC 2.3.2.27 - RING-type E3 ubiquitin transferase and Organism(s) Danio rerio

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.27 RING-type E3 ubiquitin transferase
IUBMB Comments
RING E3 ubiquitin transferases serve as mediators bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) and an acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. Unlike EC 2.3.2.26, HECT-type E3 ubiquitin transferase, the RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin. Many members of the RING-type E3 ubiquitin transferase family are not able to bind a substrate directly, and form a complex with a cullin scaffold protein and a substrate recognition module (the complexes are named CRL for Cullin-RING-Ligase). In these complexes, the RING-type E3 ubiquitin transferase provides an additional function, mediating the transfer of a NEDD8 protein from a dedicated E2 carrier to the cullin protein (see EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase). cf. EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
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This record set is specific for:
Danio rerio
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Word Map
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The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-lysine
=
[E2 ubiquitin-conjugating enzyme]-L-cysteine
+
[acceptor protein]-N6-ubiquitinyl-L-lysine
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-lysine
=
[E2 ubiquitin-conjugating enzyme]-L-cysteine
+
[acceptor protein]-N6-ubiquitinyl-L-lysine
Synonyms
brca1, parkin, e3 ubiquitin ligase, e3 ligase, c-cbl, ciap2, trim5alpha, rnf43, trim25, trim5, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
STIP1 homology and U-Box containing protein 1
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
RING E3 ubiquitin transferases serve as mediators bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) and an acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. Unlike EC 2.3.2.26, HECT-type E3 ubiquitin transferase, the RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin. Many members of the RING-type E3 ubiquitin transferase family are not able to bind a substrate directly, and form a complex with a cullin scaffold protein and a substrate recognition module (the complexes are named CRL for Cullin-RING-Ligase). In these complexes, the RING-type E3 ubiquitin transferase provides an additional function, mediating the transfer of a NEDD8 protein from a dedicated E2 carrier to the cullin protein (see EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase). cf. EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
isoform CHIP
UniProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MAEA_DANRE
396
0
45342
Swiss-Prot
other Location (Reliability: 2)
PIS4A_DANRE
505
0
55810
Swiss-Prot
other Location (Reliability: 3)
PP1RB_DANRE
122
0
13106
Swiss-Prot
other Location (Reliability: 1)
R213A_DANRE
5209
0
596751
Swiss-Prot
other Location (Reliability: 1)
R213B_DANRE
5061
0
577550
Swiss-Prot
other Location (Reliability: 2)
RN152_DANRE
198
1
21736
Swiss-Prot
other Location (Reliability: 4)
LIN41_DANRE
824
0
90678
Swiss-Prot
other Location (Reliability: 4)
MIB1_DANRE
1030
0
112688
Swiss-Prot
other Location (Reliability: 4)
RNF8_DANRE
485
0
55325
Swiss-Prot
other Location (Reliability: 1)
RNFT1_DANRE
419
5
47191
Swiss-Prot
other Location (Reliability: 4)
MARH2_DANRE
249
2
27937
Swiss-Prot
other Location (Reliability: 1)
MARH4_DANRE
421
2
46352
Swiss-Prot
Secretory Pathway (Reliability: 5)
RN168_DANRE
474
0
53248
Swiss-Prot
other Location (Reliability: 3)
RN169_DANRE
630
0
71358
Swiss-Prot
Mitochondrion (Reliability: 5)
RN170_DANRE
266
3
29628
Swiss-Prot
other Location (Reliability: 4)
SYVN1_DANRE
625
5
68757
Swiss-Prot
Secretory Pathway (Reliability: 2)
TM129_DANRE
361
2
41146
Swiss-Prot
Secretory Pathway (Reliability: 1)
ZN598_DANRE
953
0
106912
Swiss-Prot
other Location (Reliability: 3)
MDM2_DANRE
445
0
49950
Swiss-Prot
other Location (Reliability: 1)
PZR3B_DANRE
1053
0
118456
Swiss-Prot
other Location (Reliability: 2)
ZNRF1_DANRE
215
0
22875
Swiss-Prot
other Location (Reliability: 5)
ZNRF2_DANRE
217
0
22638
Swiss-Prot
Mitochondrion (Reliability: 3)
ZNRF3_DANRE
868
1
94667
Swiss-Prot
Secretory Pathway (Reliability: 1)
E4F1_DANRE
719
0
80136
Swiss-Prot
other Location (Reliability: 1)
MGRN1_DANRE
529
0
58146
Swiss-Prot
other Location (Reliability: 2)
TRAF6_DANRE
542
0
61806
Swiss-Prot
other Location (Reliability: 1)
RNF41_DANRE
318
0
36128
Swiss-Prot
other Location (Reliability: 2)
UBR3_DANRE
1863
0
210579
Swiss-Prot
Mitochondrion (Reliability: 4)
MUL1A_DANRE
341
2
38585
Swiss-Prot
Secretory Pathway (Reliability: 5)
NOSIP_DANRE
304
0
33332
Swiss-Prot
other Location (Reliability: 3)
RN146_DANRE
364
0
38786
Swiss-Prot
other Location (Reliability: 2)
SH3R1_DANRE
867
0
91632
Swiss-Prot
other Location (Reliability: 2)
SIAH1_DANRE
282
0
31080
Swiss-Prot
Mitochondrion (Reliability: 3)
SIAH2_DANRE
331
0
34494
Swiss-Prot
Mitochondrion (Reliability: 5)
CHFR_DANRE
637
0
71730
Swiss-Prot
other Location (Reliability: 1)
MKRN1_DANRE
439
0
49700
Swiss-Prot
other Location (Reliability: 2)
MKRN2_DANRE
414
0
46480
Swiss-Prot
Mitochondrion (Reliability: 5)
RING2_DANRE
336
0
37539
Swiss-Prot
other Location (Reliability: 2)
RN185_DANRE
194
2
20520
Swiss-Prot
other Location (Reliability: 4)
MARH5_DANRE
289
2
32106
Swiss-Prot
other Location (Reliability: 1)
MYLIA_DANRE
472
0
53434
Swiss-Prot
other Location (Reliability: 1)
MYLIB_DANRE
464
0
52661
Swiss-Prot
other Location (Reliability: 2)
NSE1_DANRE
239
0
27205
Swiss-Prot
other Location (Reliability: 5)
TRI33_DANRE
1163
0
128198
Swiss-Prot
other Location (Reliability: 1)
UHRF1_DANRE
776
0
87091
Swiss-Prot
other Location (Reliability: 3)
KCMF1_DANRE
383
0
42048
Swiss-Prot
other Location (Reliability: 2)
RAG1_DANRE
1057
0
121247
Swiss-Prot
other Location (Reliability: 2)
RN181_DANRE
156
0
18033
Swiss-Prot
other Location (Reliability: 2)
A0A2R8PY29_DANRE
1016
0
116663
TrEMBL
other Location (Reliability: 2)
Q6DGJ4_DANRE
578
0
65725
TrEMBL
other Location (Reliability: 4)
F1QIM8_DANRE
318
0
36099
TrEMBL
other Location (Reliability: 2)
F1QMP3_DANRE
331
0
36447
TrEMBL
other Location (Reliability: 1)
A9JR95_DANRE
492
0
54415
TrEMBL
other Location (Reliability: 1)
Q1LXV6_DANRE
991
0
109936
TrEMBL
other Location (Reliability: 3)
E7EXH5_DANRE
575
0
65148
TrEMBL
other Location (Reliability: 1)
A9C4A6_DANRE
397
0
44118
TrEMBL
other Location (Reliability: 3)
A0A8N7UZ20_DANRE
551
0
61173
TrEMBL
other Location (Reliability: 1)
A0A8N7V037_DANRE
312
1
34120
TrEMBL
other Location (Reliability: 5)
F1Q8K3_DANRE
287
0
33374
TrEMBL
other Location (Reliability: 2)
Q7ZTZ6_DANRE
284
0
32985
TrEMBL
other Location (Reliability: 2)
F1QJY3_DANRE
352
2
40203
TrEMBL
Secretory Pathway (Reliability: 3)
A0A8M1P9U9_DANRE
477
0
53475
TrEMBL
other Location (Reliability: 2)
A0A2R8QKX2_DANRE
474
0
53157
TrEMBL
other Location (Reliability: 3)
F1QU48_DANRE
440
0
49380
TrEMBL
other Location (Reliability: 1)
A0A0R4IZ61_DANRE
263
1
29935
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8N7V009_DANRE
479
0
54946
TrEMBL
other Location (Reliability: 1)
B7ZDA3_DANRE
1713
0
194621
TrEMBL
other Location (Reliability: 2)
E7FBW3_DANRE
655
0
71780
TrEMBL
other Location (Reliability: 2)
F1QUJ1_DANRE
384
0
42915
TrEMBL
other Location (Reliability: 2)
A2BGH5_DANRE
441
0
50212
TrEMBL
other Location (Reliability: 2)
Q801W6_DANRE
681
0
76698
TrEMBL
Secretory Pathway (Reliability: 4)
A0A0R4IPD0_DANRE
334
0
36900
TrEMBL
Mitochondrion (Reliability: 4)
F6PCP5_DANRE
502
0
58096
TrEMBL
Mitochondrion (Reliability: 5)
A5PLF8_DANRE
352
2
40139
TrEMBL
Secretory Pathway (Reliability: 3)
Q803J9_DANRE
377
1
42063
TrEMBL
Secretory Pathway (Reliability: 1)
Q6TGT1_DANRE
453
0
51249
TrEMBL
other Location (Reliability: 2)
A4QP91_DANRE
79
0
8916
TrEMBL
Secretory Pathway (Reliability: 3)
A0A2R8RZZ9_DANRE
564
0
62040
TrEMBL
other Location (Reliability: 2)
Q5U376_DANRE
913
0
101174
TrEMBL
other Location (Reliability: 3)
A2RV40_DANRE
309
0
34060
TrEMBL
other Location (Reliability: 4)
A0A8M1N1B0_DANRE
573
0
65608
TrEMBL
Mitochondrion (Reliability: 4)
X1WG91_DANRE
967
0
106466
TrEMBL
other Location (Reliability: 1)
F1Q745_DANRE
1759
0
199215
TrEMBL
other Location (Reliability: 2)
F1RED7_DANRE
238
2
26836
TrEMBL
other Location (Reliability: 2)
B3DJ74_DANRE
566
0
61277
TrEMBL
Mitochondrion (Reliability: 4)
A0A2R8QL76_DANRE
594
0
66325
TrEMBL
other Location (Reliability: 3)
E7EYM0_DANRE
167
0
18773
TrEMBL
other Location (Reliability: 3)
F1QIN7_DANRE
525
0
57810
TrEMBL
other Location (Reliability: 2)
B2GQH3_DANRE
439
0
49700
TrEMBL
other Location (Reliability: 2)
A0A8M1P8S1_DANRE
1183
0
134144
TrEMBL
other Location (Reliability: 5)
Q5BLF4_DANRE
442
0
48350
TrEMBL
other Location (Reliability: 4)
A0A8N1TYI4_DANRE
330
0
34422
TrEMBL
Mitochondrion (Reliability: 5)
F8W4R2_DANRE
414
0
47589
TrEMBL
other Location (Reliability: 3)
F8W2S5_DANRE
287
0
31944
TrEMBL
other Location (Reliability: 1)
B7ZVH3_DANRE
554
0
60832
TrEMBL
other Location (Reliability: 2)
A8DZI0_DANRE
1098
0
120961
TrEMBL
Secretory Pathway (Reliability: 5)
Q6NY39_DANRE
371
0
42429
TrEMBL
other Location (Reliability: 2)
A0A8M1N256_DANRE
656
3
76246
TrEMBL
Secretory Pathway (Reliability: 1)
A0A286YBY1_DANRE
697
0
77921
TrEMBL
other Location (Reliability: 1)
A0A2H4T2C3_DANRE
522
0
60063
TrEMBL
Mitochondrion (Reliability: 4)
F1QLH7_DANRE
951
0
106704
TrEMBL
other Location (Reliability: 3)
E7FEA4_DANRE
242
0
26882
TrEMBL
Mitochondrion (Reliability: 2)
A0A2R8Q6U1_DANRE
335
2
36583
TrEMBL
other Location (Reliability: 1)
A0A8M1P220_DANRE
363
0
39709
TrEMBL
other Location (Reliability: 2)
F1R0M2_DANRE
566
0
61307
TrEMBL
Mitochondrion (Reliability: 4)
B3DIT8_DANRE
880
0
93102
TrEMBL
other Location (Reliability: 1)
F1R926_DANRE
1013
0
115622
TrEMBL
other Location (Reliability: 2)
F1QD74_DANRE
1057
0
121161
TrEMBL
other Location (Reliability: 2)
A0A0R4IR19_DANRE
236
0
27076
TrEMBL
Mitochondrion (Reliability: 5)
A0A0R4IAC5_DANRE
602
0
62903
TrEMBL
Secretory Pathway (Reliability: 3)
Q5RFW5_DANRE
378
2
41834
TrEMBL
Secretory Pathway (Reliability: 5)
A0A8N1Z010_DANRE
157
0
17479
TrEMBL
other Location (Reliability: 2)
E7F6B0_DANRE
728
0
78089
TrEMBL
Secretory Pathway (Reliability: 3)
A0A2R8QDY9_DANRE
586
0
64276
TrEMBL
other Location (Reliability: 2)
A0A2R8QKK6_DANRE
1111
0
123561
TrEMBL
other Location (Reliability: 5)
A0A8N1YZZ5_DANRE
465
1
51447
TrEMBL
Secretory Pathway (Reliability: 1)
Q7SYN2_DANRE
605
0
67962
TrEMBL
other Location (Reliability: 2)
A0A8M1NGH3_DANRE
664
13
74342
TrEMBL
Secretory Pathway (Reliability: 2)
Q6J0N1_DANRE
221
0
25315
TrEMBL
other Location (Reliability: 1)
F1Q4N1_DANRE
1028
0
113962
TrEMBL
other Location (Reliability: 3)
A0AR23_DANRE
999
0
109475
TrEMBL
other Location (Reliability: 2)
A2BGH2_DANRE
524
0
59003
TrEMBL
other Location (Reliability: 2)
A0A2R8QKJ5_DANRE
574
0
63082
TrEMBL
other Location (Reliability: 2)
Q7ZUQ8_DANRE
406
0
45090
TrEMBL
other Location (Reliability: 2)
A0A0A0MPK2_DANRE
751
1
81960
TrEMBL
other Location (Reliability: 2)
A0A8M1PBP9_DANRE
287
0
33374
TrEMBL
other Location (Reliability: 2)
A9JRD3_DANRE
499
0
57763
TrEMBL
other Location (Reliability: 5)
F1R959_DANRE
360
0
40105
TrEMBL
other Location (Reliability: 2)
A0A0U3RBN1_DANRE
545
0
59704
TrEMBL
other Location (Reliability: 3)
A0A8M1PDZ7_DANRE
475
0
52417
TrEMBL
other Location (Reliability: 2)
Q08CR1_DANRE
562
0
63983
TrEMBL
other Location (Reliability: 1)
B0JZJ6_DANRE
529
0
58164
TrEMBL
other Location (Reliability: 2)
F1R6A7_DANRE
934
0
104833
TrEMBL
other Location (Reliability: 5)
Q5RGV4_DANRE
475
0
52417
TrEMBL
other Location (Reliability: 2)
B0UXK1_DANRE
551
0
61173
TrEMBL
other Location (Reliability: 1)
A0A0H2UKD5_DANRE
286
0
31584
TrEMBL
other Location (Reliability: 2)
A0A1D5NT10_DANRE
171
0
19456
TrEMBL
other Location (Reliability: 3)
Q4G0B5_DANRE
290
0
32627
TrEMBL
other Location (Reliability: 2)
A0A0R4I9G0_DANRE
414
0
46453
TrEMBL
Mitochondrion (Reliability: 5)
Q6NZX0_DANRE
699
0
77514
TrEMBL
other Location (Reliability: 1)
A0A0R4ID58_DANRE
1004
0
115401
TrEMBL
other Location (Reliability: 1)
A4FVG6_DANRE
291
0
32864
TrEMBL
other Location (Reliability: 5)
X1WFS5_DANRE
542
0
61338
TrEMBL
other Location (Reliability: 1)
E9QJH6_DANRE
53
0
5686
TrEMBL
other Location (Reliability: 1)
A0A0R4IVV6_DANRE
135
0
15349
TrEMBL
other Location (Reliability: 2)
F1QI34_DANRE
704
0
75167
TrEMBL
Secretory Pathway (Reliability: 3)
B0R0S8_DANRE
475
0
52787
TrEMBL
other Location (Reliability: 1)
A0A0G2KTY5_DANRE
306
0
33564
TrEMBL
other Location (Reliability: 4)
E7F4X3_DANRE
342
2
38478
TrEMBL
Mitochondrion (Reliability: 2)
H9KUX0_DANRE
185
0
20609
TrEMBL
other Location (Reliability: 2)
A4FVN0_DANRE
369
0
40835
TrEMBL
Secretory Pathway (Reliability: 4)
E7EXX9_DANRE
460
0
51325
TrEMBL
other Location (Reliability: 1)
Q6PBA9_DANRE
283
2
31798
TrEMBL
other Location (Reliability: 2)
Q803L3_DANRE
426
0
47962
TrEMBL
other Location (Reliability: 2)
Q08C70_DANRE
423
0
47719
TrEMBL
Mitochondrion (Reliability: 3)
E7FAU0_DANRE
667
0
74703
TrEMBL
other Location (Reliability: 3)
F1Q5B6_DANRE
926
0
104012
TrEMBL
other Location (Reliability: 5)
A0A0H2UKC6_DANRE
338
0
37799
TrEMBL
other Location (Reliability: 2)
F1Q742_DANRE
939
0
105422
TrEMBL
other Location (Reliability: 5)
A0A8N7V0A8_DANRE
618
5
68077
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8M1NC06_DANRE
281
4
31404
TrEMBL
other Location (Reliability: 1)
A0A8M1P6Z4_DANRE
813
0
89430
TrEMBL
other Location (Reliability: 2)
X1WCS5_DANRE
85
0
9572
TrEMBL
other Location (Reliability: 2)
F1QFP2_DANRE
1168
0
134007
TrEMBL
other Location (Reliability: 2)
A0A0R4I9A5_DANRE
406
0
45549
TrEMBL
other Location (Reliability: 4)
Q803P8_DANRE
410
0
45815
TrEMBL
other Location (Reliability: 1)
A0A8M1NCR2_DANRE
639
0
71408
TrEMBL
other Location (Reliability: 2)
A0A0R4IY71_DANRE
545
0
56428
TrEMBL
Secretory Pathway (Reliability: 3)
A0A240I9X0_DANRE
954
0
107644
TrEMBL
Secretory Pathway (Reliability: 2)
F1QI90_DANRE
913
0
101164
TrEMBL
other Location (Reliability: 3)
A0A0R4IQG6_DANRE
239
0
27231
TrEMBL
other Location (Reliability: 5)
X1WEZ7_DANRE
173
0
19792
TrEMBL
other Location (Reliability: 1)
E7EYR3_DANRE
1694
0
193124
TrEMBL
other Location (Reliability: 2)
Q8UWD2_DANRE
628
0
70098
TrEMBL
other Location (Reliability: 4)
B1H1J3_DANRE
208
0
23145
TrEMBL
other Location (Reliability: 2)
A5PMC1_DANRE
618
5
68077
TrEMBL
Secretory Pathway (Reliability: 2)
F1QQE8_DANRE
401
2
44228
TrEMBL
Secretory Pathway (Reliability: 1)
F1Q9Q8_DANRE
197
1
21609
TrEMBL
other Location (Reliability: 3)
A0A0R4ISP6_DANRE
62
0
5823
TrEMBL
other Location (Reliability: 4)
Q8AW63_DANRE
117
0
12416
TrEMBL
other Location (Reliability: 1)
A2RV08_DANRE
405
0
45593
TrEMBL
other Location (Reliability: 1)
Q0P447_DANRE
248
2
27645
TrEMBL
other Location (Reliability: 2)
A0A8M1P2G6_DANRE
1013
0
115622
TrEMBL
other Location (Reliability: 2)
A0A140LGW2_DANRE
696
0
78557
TrEMBL
other Location (Reliability: 3)
A0A0R4IHW3_DANRE
1038
0
113646
TrEMBL
other Location (Reliability: 4)
B7ZV30_DANRE
909
0
102127
TrEMBL
other Location (Reliability: 1)
A1L1F2_DANRE
721
0
81102
TrEMBL
other Location (Reliability: 4)
A0A8M1P6B6_DANRE
999
0
114763
TrEMBL
other Location (Reliability: 2)
B2KJ26_DANRE
704
0
75113
TrEMBL
Secretory Pathway (Reliability: 3)
A0A2R8QHH9_DANRE
335
2
36524
TrEMBL
other Location (Reliability: 1)
G1K2Q0_DANRE
549
0
60447
TrEMBL
other Location (Reliability: 2)
B2GT31_DANRE
464
0
52661
TrEMBL
other Location (Reliability: 2)
F1R8W7_DANRE
192
2
20739
TrEMBL
other Location (Reliability: 2)
A0A8M1NBD1_DANRE
310
0
33267
TrEMBL
other Location (Reliability: 2)
I3IRX0_DANRE
531
0
60326
TrEMBL
other Location (Reliability: 1)
A0A8M1N103_DANRE
1176
0
129495
TrEMBL
other Location (Reliability: 1)
F6PED5_DANRE
96
0
10967
TrEMBL
Secretory Pathway (Reliability: 3)
A0A2Q0QGK2_DANRE
607
0
68370
TrEMBL
other Location (Reliability: 1)
A0A8M1P805_DANRE
623
0
69124
TrEMBL
other Location (Reliability: 1)
A0A8M1P379_DANRE
580
2
64395
TrEMBL
other Location (Reliability: 3)
B3DJW1_DANRE
998
0
109416
TrEMBL
other Location (Reliability: 2)
A0A2R8Q6X1_DANRE
354
0
39045
TrEMBL
Mitochondrion (Reliability: 4)
A0A2R8QN70_DANRE
594
0
66202
TrEMBL
other Location (Reliability: 3)
B2GNY0_DANRE
336
0
37539
TrEMBL
other Location (Reliability: 2)
A0A8M1N9B8_DANRE
857
0
90992
TrEMBL
other Location (Reliability: 1)
A0A2R8QJ85_DANRE
547
0
60182
TrEMBL
other Location (Reliability: 2)
G8JL17_DANRE
330
0
34422
TrEMBL
Mitochondrion (Reliability: 5)
A8WGA9_DANRE
663
0
73065
TrEMBL
other Location (Reliability: 2)
Q6DRF1_DANRE
142
0
15904
TrEMBL
other Location (Reliability: 2)
A0A8M1NF66_DANRE
721
0
81887
TrEMBL
other Location (Reliability: 2)
A0A8M1PNX8_DANRE
492
0
57454
TrEMBL
other Location (Reliability: 1)
Q6PH04_DANRE
693
0
78073
TrEMBL
other Location (Reliability: 4)
Q7SXC8_DANRE
290
0
32581
TrEMBL
other Location (Reliability: 2)
A0A8M1P3G5_DANRE
579
0
63202
TrEMBL
other Location (Reliability: 4)
A0A0R4IDT0_DANRE
502
0
56445
TrEMBL
other Location (Reliability: 3)
A0A8M1NUN3_DANRE
1766
0
198095
TrEMBL
other Location (Reliability: 2)
Q7ZV92_DANRE
505
0
54734
TrEMBL
other Location (Reliability: 2)
Q561Z0_DANRE
475
0
52763
TrEMBL
other Location (Reliability: 1)
F1RE02_DANRE
255
2
27924
TrEMBL
other Location (Reliability: 1)
A0A2R8Q620_DANRE
553
0
60911
TrEMBL
other Location (Reliability: 2)
A0A8M1P8W1_DANRE
913
2
97567
TrEMBL
other Location (Reliability: 1)
A0A8M1P9M9_DANRE
589
0
67013
TrEMBL
other Location (Reliability: 2)
E9QBD2_DANRE
1749
0
195703
TrEMBL
Mitochondrion (Reliability: 5)
A0A2R8RV07_DANRE
580
0
63811
TrEMBL
other Location (Reliability: 2)
A0A286YAJ9_DANRE
545
0
61619
TrEMBL
Secretory Pathway (Reliability: 5)
B5DDM1_DANRE
207
0
20613
TrEMBL
Mitochondrion (Reliability: 5)
F1R1Q3_DANRE
421
2
46365
TrEMBL
Secretory Pathway (Reliability: 5)
A0A8M1NCE0_DANRE
309
0
34060
TrEMBL
other Location (Reliability: 4)
A0A0R4ILY2_DANRE
770
0
86840
TrEMBL
other Location (Reliability: 1)
A2RV49_DANRE
871
0
100715
TrEMBL
other Location (Reliability: 3)
A0A8M1NC36_DANRE
543
1
61399
TrEMBL
other Location (Reliability: 1)
Q7ZZ86_DANRE
461
0
51258
TrEMBL
other Location (Reliability: 5)
E9QHJ0_DANRE
211
1
23427
TrEMBL
other Location (Reliability: 1)
A0A8M1P6L1_DANRE
482
0
53232
TrEMBL
other Location (Reliability: 1)
A0A0G2KXP0_DANRE
889
0
98688
TrEMBL
other Location (Reliability: 3)
Q6DEG0_DANRE
573
0
65608
TrEMBL
Mitochondrion (Reliability: 4)
Q7SXJ6_DANRE
513
0
56769
TrEMBL
other Location (Reliability: 2)
B3DIY0_DANRE
1078
0
120126
TrEMBL
other Location (Reliability: 5)
A1L254_DANRE
475
0
54820
TrEMBL
other Location (Reliability: 5)
A0A8M1NAI1_DANRE
248
2
27645
TrEMBL
other Location (Reliability: 2)
F1QLY9_DANRE
699
0
77484
TrEMBL
other Location (Reliability: 1)
A0A8M1PAV1_DANRE
338
0
37799
TrEMBL
other Location (Reliability: 2)
Q5XJ27_DANRE
331
0
36492
TrEMBL
other Location (Reliability: 1)
F1QUB4_DANRE
721
0
81086
TrEMBL
other Location (Reliability: 4)
A0A8M1PDJ9_DANRE
364
0
38815
TrEMBL
other Location (Reliability: 2)
A0A8M1NT04_DANRE
282
2
32162
TrEMBL
other Location (Reliability: 3)
A0A8M1PEQ1_DANRE
529
0
58164
TrEMBL
other Location (Reliability: 2)
B3DGQ0_DANRE
1041
0
113724
TrEMBL
other Location (Reliability: 4)
E7F4K2_DANRE
1751
0
195875
TrEMBL
Mitochondrion (Reliability: 5)
A0A0R4ISQ1_DANRE
486
0
53949
TrEMBL
other Location (Reliability: 1)
A0A0R4ILY5_DANRE
532
0
60072
TrEMBL
other Location (Reliability: 3)
A0A0D3QG36_DANRE
866
1
94491
TrEMBL
Secretory Pathway (Reliability: 1)
Q6NX02_DANRE
346
0
38949
TrEMBL
other Location (Reliability: 2)
B0R0J5_DANRE
549
0
60348
TrEMBL
other Location (Reliability: 2)
J9UF94_DANRE
560
0
62752
TrEMBL
other Location (Reliability: 3)
Q58ER5_DANRE
744
0
81232
TrEMBL
other Location (Reliability: 2)
F1QB65_DANRE
266
3
29644
TrEMBL
other Location (Reliability: 4)
A0A8M1NAW6_DANRE
307
0
34436
TrEMBL
other Location (Reliability: 3)
Q5RFZ3_DANRE
843
0
89275
TrEMBL
other Location (Reliability: 1)
F1QX02_DANRE
243
0
27624
TrEMBL
other Location (Reliability: 1)
A0A8M1N0T2_DANRE
428
0
47287
TrEMBL
other Location (Reliability: 2)
A0A8M1NBS7_DANRE
558
0
61483
TrEMBL
other Location (Reliability: 4)
E7F3E1_DANRE
925
0
106630
TrEMBL
other Location (Reliability: 3)
E7FBY1_DANRE
595
0
66265
TrEMBL
other Location (Reliability: 3)
F1QTJ5_DANRE
426
0
47950
TrEMBL
other Location (Reliability: 2)
A0A2R8QTZ8_DANRE
455
1
49200
TrEMBL
other Location (Reliability: 3)
A0A2R8RRT2_DANRE
470
0
52213
TrEMBL
other Location (Reliability: 1)
A0A8M1PAF7_DANRE
554
0
60832
TrEMBL
other Location (Reliability: 2)
B2KJ27_DANRE
566
0
61263
TrEMBL
Mitochondrion (Reliability: 4)
Q6P0H4_DANRE
377
1
42135
TrEMBL
Secretory Pathway (Reliability: 1)
A5PLA6_DANRE
255
2
27925
TrEMBL
other Location (Reliability: 1)
Q90ZZ0_DANRE
264
0
29999
TrEMBL
other Location (Reliability: 2)
Q1LV60_DANRE
1078
0
120126
TrEMBL
other Location (Reliability: 5)
E7FBV5_DANRE
178
0
19394
TrEMBL
other Location (Reliability: 2)
F1R5P0_DANRE
364
0
38815
TrEMBL
other Location (Reliability: 2)
A4QP94_DANRE
694
0
77664
TrEMBL
Mitochondrion (Reliability: 4)
Q6PBS0_DANRE
391
0
44639
TrEMBL
other Location (Reliability: 1)
Q501T3_DANRE
392
1
43478
TrEMBL
other Location (Reliability: 1)
H9GYU5_DANRE
1041
0
113740
TrEMBL
other Location (Reliability: 4)
F1Q974_DANRE
485
0
55297
TrEMBL
other Location (Reliability: 1)
F1QVG3_DANRE
695
0
78233
TrEMBL
other Location (Reliability: 4)
A0A0G2L3N5_DANRE
1058
0
118864
TrEMBL
other Location (Reliability: 5)
A0A2R8Q6C7_DANRE
270
2
30451
TrEMBL
Secretory Pathway (Reliability: 4)
A0A2R8PYP9_DANRE
564
0
62093
TrEMBL
other Location (Reliability: 2)
A0A8M1NHR6_DANRE
502
0
58096
TrEMBL
Mitochondrion (Reliability: 5)
Q6IQJ6_DANRE
524
0
58972
TrEMBL
other Location (Reliability: 2)
A6H8U0_DANRE
589
0
66843
TrEMBL
Mitochondrion (Reliability: 3)
A0A2R8QMJ7_DANRE
866
1
94412
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R4IWB8_DANRE
612
0
66144
TrEMBL
Mitochondrion (Reliability: 4)
Q803C5_DANRE
574
0
64950
TrEMBL
other Location (Reliability: 1)
E7F7U4_DANRE
241
2
26803
TrEMBL
other Location (Reliability: 1)
H0WEV7_DANRE
236
0
25758
TrEMBL
other Location (Reliability: 3)
A0A0J9YIW6_DANRE
96
0
10309
TrEMBL
other Location (Reliability: 2)
I2BJN1_DANRE
256
0
29617
TrEMBL
other Location (Reliability: 2)
F1QAI4_DANRE
464
0
52646
TrEMBL
other Location (Reliability: 2)
F1QXU6_DANRE
1010
0
116020
TrEMBL
other Location (Reliability: 2)
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
2.9 A crystal structure of the ubiquitin ligase CHIP U-box domain complexed with UbcH5a. CHIP binds to UbcH5 and Ubc13 through similar specificity determinants located on the long loops and central helix of the CHIP U-box, and on the N-terminal helix and loops L4 and L7 of its cognate E2 enzymes including a key S-P-A motif. The determinants make different relative contributions to the overall interactions between CHIP and the two E2 enzymes. CHIP undergoes auto-ubiquitination by UbcH5 but not by Ubc13-Uev1a. Instead, CHIP drives the formation of unanchored polyubiquitin by Ubc13-Uev1a. CHIP also interacts productively with the class III E2 enzyme Ube2e2
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Xu, Z.; Kohli, E.; Devlin, K.I.; Bold, M.; Nix, J.C.; Misra, S.
Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes
BMC Struct. Biol.
8
26
2008
Danio rerio (Q7ZTZ6)
Manually annotated by BRENDA team