Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.3.2.26 - HECT-type E3 ubiquitin transferase and Organism(s) Danio rerio

for references in articles please use BRENDA:EC2.3.2.26
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.26 HECT-type E3 ubiquitin transferase
IUBMB Comments
In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. cf. EC 2.3.2.27, RING-type E3 ubiquitin transferase and EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Danio rerio
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
hide
The taxonomic range for the selected organisms is: Danio rerio
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-lysine
=
[E2 ubiquitin-conjugating enzyme]-L-cysteine
+
[acceptor protein]-N6-ubiquitinyl-L-lysine
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-lysine
=
[E2 ubiquitin-conjugating enzyme]-L-cysteine
+
[acceptor protein]-N6-ubiquitinyl-L-lysine
Synonyms
nedd4, smurf1, smurf2, huwe1, nedd4l, nedd4-1, e6-ap, ube3c, trp120, trip12, more
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming)
In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. cf. EC 2.3.2.27, RING-type E3 ubiquitin transferase and EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
TRIPC_DANRE
2026
0
223044
Swiss-Prot
Mitochondrion (Reliability: 4)
SMUF2_DANRE
765
0
87464
Swiss-Prot
Mitochondrion (Reliability: 4)
HACE1_DANRE
904
0
102165
Swiss-Prot
Mitochondrion (Reliability: 4)
Q7SXZ7_DANRE
994
0
113719
TrEMBL
other Location (Reliability: 3)
Q6DGP5_DANRE
163
0
18062
TrEMBL
other Location (Reliability: 4)
E9QIB6_DANRE
1411
0
158223
TrEMBL
Mitochondrion (Reliability: 3)
A0A2R8Q4R9_DANRE
1190
0
134273
TrEMBL
other Location (Reliability: 4)
F1R4B5_DANRE
857
0
97571
TrEMBL
other Location (Reliability: 2)
Q1LY19_DANRE
1081
0
123695
TrEMBL
other Location (Reliability: 3)
A0A2R8QHN5_DANRE
1384
0
155736
TrEMBL
Mitochondrion (Reliability: 3)
Q32PW2_DANRE
170
0
19181
TrEMBL
other Location (Reliability: 4)
A0A8M1NV16_DANRE
2794
0
308375
TrEMBL
other Location (Reliability: 1)
X1WEK3_DANRE
820
0
92741
TrEMBL
other Location (Reliability: 3)
A0A2R8PW57_DANRE
2570
0
284425
TrEMBL
other Location (Reliability: 4)
A0A2R8QU86_DANRE
1390
0
156343
TrEMBL
Mitochondrion (Reliability: 3)
F1QP93_DANRE
988
0
113237
TrEMBL
other Location (Reliability: 1)
Q8JFV5_DANRE
2576
0
285225
TrEMBL
other Location (Reliability: 4)
F1QL68_DANRE
4474
0
488244
TrEMBL
other Location (Reliability: 3)
A0A8M1P8Z2_DANRE
388
0
43030
TrEMBL
other Location (Reliability: 1)
U6C7R6_DANRE
867
0
99450
TrEMBL
other Location (Reliability: 3)
A2VCZ7_DANRE
866
0
98308
TrEMBL
other Location (Reliability: 4)
A0A2R8Q4L4_DANRE
857
0
98235
TrEMBL
other Location (Reliability: 5)
K7DYG3_DANRE
248
0
28375
TrEMBL
other Location (Reliability: 2)
Q5EAZ8_DANRE
395
0
43757
TrEMBL
other Location (Reliability: 1)
F1Q632_DANRE
1011
0
115650
TrEMBL
other Location (Reliability: 1)
F1Q7U1_DANRE
388
0
43030
TrEMBL
other Location (Reliability: 1)
A0A8M1PCX7_DANRE
1081
0
123695
TrEMBL
other Location (Reliability: 3)
E7EYK8_DANRE
4830
0
528562
TrEMBL
other Location (Reliability: 4)
A0A2R8Q6F8_DANRE
2111
0
232446
TrEMBL
Mitochondrion (Reliability: 4)
F1QEG9_DANRE
731
0
83272
TrEMBL
Mitochondrion (Reliability: 4)
Q8AW58_DANRE
706
0
80229
TrEMBL
other Location (Reliability: 2)
A0A2R8RTJ0_DANRE
583
0
68224
TrEMBL
other Location (Reliability: 5)
F6NW03_DANRE
976
0
111875
TrEMBL
other Location (Reliability: 3)
A1L204_DANRE
499
0
54205
TrEMBL
other Location (Reliability: 4)
F6P346_DANRE
867
0
98395
TrEMBL
other Location (Reliability: 4)
A0A8M1P0Z6_DANRE
851
0
97494
TrEMBL
other Location (Reliability: 3)
A0A286YBF5_DANRE
903
0
102692
TrEMBL
other Location (Reliability: 5)
A0A2R8QLH9_DANRE
873
0
100022
TrEMBL
other Location (Reliability: 5)
A0A8M1NTE1_DANRE
1552
0
175283
TrEMBL
other Location (Reliability: 3)
Q6PCR3_DANRE
731
0
83242
TrEMBL
Mitochondrion (Reliability: 4)
Q3KRP0_DANRE
910
0
105883
TrEMBL
other Location (Reliability: 1)
A0A0R4IDE6_DANRE
787
0
91565
TrEMBL
other Location (Reliability: 1)
A7E274_DANRE
832
0
91249
TrEMBL
other Location (Reliability: 4)
A0A0R4IBD8_DANRE
842
0
96455
TrEMBL
other Location (Reliability: 3)
A0A2R8QGM9_DANRE
1438
0
163187
TrEMBL
Mitochondrion (Reliability: 3)
A0A8M1P4D4_DANRE
2053
0
226053
TrEMBL
Mitochondrion (Reliability: 4)
A2BGM8_DANRE
1069
0
122543
TrEMBL
other Location (Reliability: 4)
A0A286Y9W2_DANRE
1475
0
165165
TrEMBL
Mitochondrion (Reliability: 3)
F1Q529_DANRE
2053
0
226053
TrEMBL
Mitochondrion (Reliability: 4)
A0A0R4IGL6_DANRE
2509
0
277341
TrEMBL
other Location (Reliability: 4)
A0A8N1YZY7_DANRE
1069
0
122543
TrEMBL
other Location (Reliability: 4)
A0A2R8QEV4_DANRE
988
0
113205
TrEMBL
other Location (Reliability: 1)
A0A286Y9V7_DANRE
805
0
92281
TrEMBL
other Location (Reliability: 5)
A0A8M1NAZ3_DANRE
854
0
96967
TrEMBL
other Location (Reliability: 2)
Q5U398_DANRE
857
0
97541
TrEMBL
other Location (Reliability: 2)
A0A8M1NTA5_DANRE
1046
0
115855
TrEMBL
other Location (Reliability: 3)
A0A8M1N0I1_DANRE
2576
0
285225
TrEMBL
other Location (Reliability: 4)
U6C7X6_DANRE
851
0
97494
TrEMBL
other Location (Reliability: 3)
A0A2R8Q9I7_DANRE
1508
0
169021
TrEMBL
Mitochondrion (Reliability: 3)
Q1LYI3_DANRE
1552
0
175283
TrEMBL
other Location (Reliability: 3)