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Information on EC 2.3.2.26 - HECT-type E3 ubiquitin transferase and Organism(s) Caenorhabditis elegans

for references in articles please use BRENDA:EC2.3.2.26
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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.26 HECT-type E3 ubiquitin transferase
IUBMB Comments
In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. cf. EC 2.3.2.27, RING-type E3 ubiquitin transferase and EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
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This record set is specific for:
Caenorhabditis elegans
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Word Map
The taxonomic range for the selected organisms is: Caenorhabditis elegans
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-lysine
=
[E2 ubiquitin-conjugating enzyme]-L-cysteine
+
[acceptor protein]-N6-ubiquitinyl-L-lysine
Synonyms
nedd4, smurf1, smurf2, huwe1, nedd4l, nedd4-1, e6-ap, ube3c, trp120, trip12, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
UBR E3 ubiquitin ligase homolog
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming)
In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. cf. EC 2.3.2.27, RING-type E3 ubiquitin transferase and EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-ubiquitinyl-[Ubc-18]-L-cysteine + [IFY-1]-L-lysine
[Ubc-18]-L-cysteine + N6-ubiquitinyl-[IFY-1]-L-lysine
show the reaction diagram
-
IFY-1 i.e. anaphase inhibitor securin
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
WWP1_CAEEL
794
0
90922
Swiss-Prot
other Location (Reliability: 5)
HECD1_CAEEL
2648
0
292210
Swiss-Prot
other Location (Reliability: 3)
HECW1_CAEEL
1247
0
144050
Swiss-Prot
other Location (Reliability: 1)
ETC1_CAEEL
1001
0
116415
Swiss-Prot
other Location (Reliability: 1)
V6CL75_CAEEL
2613
0
288392
TrEMBL
other Location (Reliability: 3)
U4PBX5_CAEEL
4180
0
465802
TrEMBL
other Location (Reliability: 1)
V6CLC0_CAEEL
2646
0
292009
TrEMBL
other Location (Reliability: 3)
U4PMD1_CAEEL
4182
0
466077
TrEMBL
other Location (Reliability: 1)
Q9BKW4_CAEEL
496
0
57704
TrEMBL
other Location (Reliability: 1)
V6CL74_CAEEL
2611
0
288151
TrEMBL
other Location (Reliability: 3)
U4PES6_CAEEL
4182
0
466044
TrEMBL
other Location (Reliability: 1)
O15979_CAEEL
654
0
73522
TrEMBL
other Location (Reliability: 5)
U4PBJ5_CAEEL
4179
0
465687
TrEMBL
other Location (Reliability: 1)
V6CIS8_CAEEL
2609
0
287949
TrEMBL
other Location (Reliability: 3)
V6CJX7_CAEEL
2644
0
291768
TrEMBL
other Location (Reliability: 3)
Q9GUP2_CAEEL
4177
0
465411
TrEMBL
other Location (Reliability: 1)
V6CLA7_CAEEL
2650
0
292451
TrEMBL
other Location (Reliability: 3)
Q9XXE6_CAEEL
1066
0
120882
TrEMBL
other Location (Reliability: 2)
V6CIS4_CAEEL
2607
0
287708
TrEMBL
other Location (Reliability: 3)
A0A061ACQ8_CAEEL
724
0
82985
TrEMBL
other Location (Reliability: 1)
U4PBK1_CAEEL
4183
0
466159
TrEMBL
other Location (Reliability: 1)
U4PBY0_CAEEL
4185
0
466434
TrEMBL
other Location (Reliability: 1)
U4PRN6_CAEEL
4180
0
465769
TrEMBL
other Location (Reliability: 1)
G5EDT9_CAEEL
2944
0
331071
TrEMBL
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, R.; Kaul, Z.; Ambardekar, C.; Yamamoto, T.G.; Kavdia, K.; Kodali, K.; High, A.A.; Kitagawa, R.
HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans
Development
140
2149-2159
2013
Caenorhabditis elegans
Manually annotated by BRENDA team
Safdar, K.; Gu, A.; Xu, X.; Au, A.; Taylor, J.; Flibotte, S.; Moerman, D.G.; Maine, E.M.
UBR-5, a conserved HECT-type E3 ubiquitin ligase, negatively regulates notch-type signaling in Caenorhabditis elegans
G3 (Bethesda)
6
2125-2134
2016
Caenorhabditis elegans (G5EDT9), Caenorhabditis elegans
Manually annotated by BRENDA team