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Information on EC 2.3.2.26 - HECT-type E3 ubiquitin transferase and Organism(s) Bos taurus

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.26 HECT-type E3 ubiquitin transferase
IUBMB Comments
In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. cf. EC 2.3.2.27, RING-type E3 ubiquitin transferase and EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
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Bos taurus
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-lysine
=
[E2 ubiquitin-conjugating enzyme]-L-cysteine
+
[acceptor protein]-N6-ubiquitinyl-L-lysine
Synonyms
nedd4, smurf1, smurf2, huwe1, nedd4l, nedd4-1, e6-ap, ube3c, trp120, trip12, more
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming)
In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. cf. EC 2.3.2.27, RING-type E3 ubiquitin transferase and EC 2.3.2.31, RBR-type E3 ubiquitin transferase.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
TRIPC_BOVIN
1992
0
220390
Swiss-Prot
other Location (Reliability: 5)
UBE3D_BOVIN
389
0
43392
Swiss-Prot
other Location (Reliability: 5)
HACE1_BOVIN
909
0
102053
Swiss-Prot
Mitochondrion (Reliability: 4)
A0A3Q1LSM9_BOVIN
4356
0
480406
TrEMBL
other Location (Reliability: 4)
E1BNY9_BOVIN
4375
0
482191
TrEMBL
other Location (Reliability: 3)
E1BLD1_BOVIN
2610
0
289338
TrEMBL
other Location (Reliability: 4)
A0A3Q1LJ39_BOVIN
738
0
85222
TrEMBL
other Location (Reliability: 3)
A4IFN7_BOVIN
875
0
100358
TrEMBL
other Location (Reliability: 3)
A0A3Q1MLU3_BOVIN
1425
0
158270
TrEMBL
other Location (Reliability: 1)
F1MLS5_BOVIN
731
0
83265
TrEMBL
Mitochondrion (Reliability: 4)
A0A3Q1LFY0_BOVIN
1085
0
121526
TrEMBL
other Location (Reliability: 5)
A0A3Q1MN84_BOVIN
854
0
98137
TrEMBL
other Location (Reliability: 2)
F1MGQ5_BOVIN
862
0
98641
TrEMBL
other Location (Reliability: 2)
A0A3Q1LHC1_BOVIN
2549
0
282290
TrEMBL
other Location (Reliability: 4)
E1BCU1_BOVIN
1068
0
122958
TrEMBL
Mitochondrion (Reliability: 3)
G3MXP2_BOVIN
1440
0
160674
TrEMBL
other Location (Reliability: 1)
A0A3Q1MXC6_BOVIN
877
0
99443
TrEMBL
other Location (Reliability: 3)
A0A3Q1MH88_BOVIN
1235
0
138218
TrEMBL
other Location (Reliability: 5)
A0A3Q1MNT7_BOVIN
355
0
39772
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1M231_BOVIN
1255
0
140070
TrEMBL
other Location (Reliability: 5)
Q32PG0_BOVIN
921
0
104558
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1MU15_BOVIN
400
0
44878
TrEMBL
Mitochondrion (Reliability: 5)
A0A3Q1MHU5_BOVIN
1151
0
128949
TrEMBL
other Location (Reliability: 5)
A0A3Q1N8W0_BOVIN
837
0
94804
TrEMBL
other Location (Reliability: 2)
F1N645_BOVIN
1571
0
175692
TrEMBL
Mitochondrion (Reliability: 2)
A2VE03_BOVIN
862
0
98642
TrEMBL
other Location (Reliability: 2)
A0A3Q1MJ08_BOVIN
1237
0
138159
TrEMBL
other Location (Reliability: 5)
F1MJ10_BOVIN
1321
0
148903
TrEMBL
Mitochondrion (Reliability: 4)
F1MJ09_BOVIN
856
0
99333
TrEMBL
other Location (Reliability: 1)
Q32PG4_BOVIN
527
0
61666
TrEMBL
other Location (Reliability: 5)
F1N3W8_BOVIN
738
0
85295
TrEMBL
Secretory Pathway (Reliability: 4)
A0A3Q1LR68_BOVIN
851
0
97358
TrEMBL
other Location (Reliability: 2)
E1B782_BOVIN
4837
0
527046
TrEMBL
other Location (Reliability: 2)
A0A3Q1NIL1_BOVIN
793
0
90308
TrEMBL
other Location (Reliability: 3)
A0A3Q1LWC5_BOVIN
1067
0
121108
TrEMBL
other Location (Reliability: 2)
A0A3Q1M409_BOVIN
1967
0
217592
TrEMBL
other Location (Reliability: 5)
A3KMV3_BOVIN
870
0
98696
TrEMBL
Mitochondrion (Reliability: 3)
A0A3Q1LT33_BOVIN
901
0
104268
TrEMBL
other Location (Reliability: 2)
F1N0L0_BOVIN
1574
0
174957
TrEMBL
Mitochondrion (Reliability: 4)
A0A3Q1MJH3_BOVIN
1050
0
119219
TrEMBL
other Location (Reliability: 3)
F1N703_BOVIN
1085
0
123385
TrEMBL
other Location (Reliability: 3)
A0A3Q1NEU5_BOVIN
999
0
114674
TrEMBL
other Location (Reliability: 2)