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Information on EC 2.3.2.24 - (E3-independent) E2 ubiquitin-conjugating enzyme and Organism(s) Mus musculus

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.24 (E3-independent) E2 ubiquitin-conjugating enzyme
IUBMB Comments
The enzyme transfers a single ubiquitin directly from an ubiquitinated E1 ubiquitin-activating enzyme to itself, and on to a lysine residue of the acceptor protein without involvement of E3 ubiquitin transferases (cf. EC 2.3.2.26, EC 2.3.2.27). It forms a labile ubiquitin adduct in the presence of E1, ubiquitin, and Mg2+-ATP and catalyses the conjugation of ubiquitin to protein substrates, independently of E3. This transfer has only been observed with small proteins. In vitro a transfer to small acceptors (e.g. L-lysine, N-acetyl-L-lysine methyl ester) has been observed .
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This record set is specific for:
Mus musculus
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Word Map
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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[E1 ubiquitin-activating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-lysine
=
[E1 ubiquitin-activating enzyme]-L-cysteine
+
[acceptor protein]-N6-monoubiquitinyl-L-lysine
[E1 ubiquitin-activating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-lysine
=
[E1 ubiquitin-activating enzyme]-L-cysteine
+
[acceptor protein]-N6-monoubiquitinyl-L-lysine
Synonyms
ube2o, e2-epf ubiquitin carrier protein, e2-230k, ubiquitin carrier protein e2, ubiquitin-conjugating enzyme e2 variant 1, ubiquitin-conjugating enzyme e2 c, ubiquitin-conjugating enzyme e2 n, ubiquitin-conjugating enzyme e2 variant 2, ubiquitin-conjugating enzyme e2 e1, ubiquitin-conjugating enzyme e2 l3, more
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent)
The enzyme transfers a single ubiquitin directly from an ubiquitinated E1 ubiquitin-activating enzyme to itself, and on to a lysine residue of the acceptor protein without involvement of E3 ubiquitin transferases (cf. EC 2.3.2.26, EC 2.3.2.27). It forms a labile ubiquitin adduct in the presence of E1, ubiquitin, and Mg2+-ATP and catalyses the conjugation of ubiquitin to protein substrates, independently of E3. This transfer has only been observed with small proteins. In vitro a transfer to small acceptors (e.g. L-lysine, N-acetyl-L-lysine methyl ester) has been observed [1].
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
UB2E1_MOUSE
193
0
21333
Swiss-Prot
other Location (Reliability: 1)
UBE2H_MOUSE
183
0
20655
Swiss-Prot
other Location (Reliability: 3)
UBE2O_MOUSE
1288
0
140834
Swiss-Prot
other Location (Reliability: 2)
UBE2C_MOUSE
179
0
19606
Swiss-Prot
other Location (Reliability: 4)
UB2D1_MOUSE
147
0
16602
Swiss-Prot
other Location (Reliability: 3)
UB2D2_MOUSE
147
0
16735
Swiss-Prot
other Location (Reliability: 2)
UB2D3_MOUSE
147
0
16687
Swiss-Prot
other Location (Reliability: 2)
UB2R1_MOUSE
235
0
26622
Swiss-Prot
other Location (Reliability: 3)