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Disease on EC 2.3.2.23 - E2 ubiquitin-conjugating enzyme

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Identification of New Lead Molecules Against UBE2NL Enzyme for Cancer Therapy.
The E2-25K ubiquitin-associated (UBA) domain aids in polyubiquitin chain synthesis and linkage specificity.
Adenocarcinoma
cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin-conjugating enzyme.
Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice.
Expression of UbcH10 in pancreatic ductal adenocarcinoma and its correlation with prognosis.
Identification of potential crucial genes associated with the pathogenesis and prognosis of pancreatic adenocarcinoma.
Inhibitors of the Cdc34 acidic loop: A computational investigation integrating molecular dynamics, virtual screening and docking approaches.
Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
UbcH10 expression provides a useful tool for the prognosis and treatment of non-small cell lung cancer.
UBE2C induces EMT through Wnt/??catenin and PI3K/Akt signaling pathways by regulating phosphorylation levels of Aurora-A.
UBE2C mRNA expression controlled by miR-300 and HuR determines its oncogenic role in gastric cancer.
Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-?B activation.
Adenocarcinoma of Lung
Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis.
Elevated TOP2A and UBE2C expressions correlate with poor prognosis in patients with surgically resected lung adenocarcinoma: a study based on immunohistochemical analysis and bioinformatics.
Expression of UBE2C in lung adenocarcinoma based on database analysis and its clinical significance.
High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.
Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis.
Targeting Ubc9 for cancer therapy.
UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma.
UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells.
UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma.
UBE2V2 Positively Correlates With PD-L1 Expression and Confers Poor Patient Survival in Lung Adenocarcinoma.
Ubiquitin Conjugating Enzyme E2 H (UBE2H) Is Linked to Poor Outcomes and Metastasis in Lung Adenocarcinoma.
Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers.
Adenoma
UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.
African Swine Fever
African swine fever virus encodes for an E2-ubiquitin conjugating enzyme that is mono- and di-ubiquitinated and required for viral replication cycle.
Albuminuria
Chronic kidney disease: novel insights from genome-wide association studies.
Alzheimer Disease
Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7).
High ubiquitin conjugating enzyme E2 T mRNA expression and its prognostic significance in lung adenocarcinoma: A study based on the TCGA database.
Predictive Potential of Circulating Ube2h mRNA as an E2 Ubiquitin-Conjugating Enzyme for Diagnosis or Treatment of Alzheimer's Disease.
Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2).
Sumoylation of amyloid precursor protein negatively regulates Abeta aggregate levels.
Anemia
Hereditary poikilocytic anemia associated with the co-inheritance of two alpha spectrin abnormalities.
RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence.
Red blood cell membrane disorders.
Three Novel Spectrin Variants in Jaundiced Neonates.
Anemia, Diamond-Blackfan
Inherited bone marrow failure syndromes.
Anemia, Hemolytic
Combination of two mutant alpha spectrin alleles underlies a severe spherocytic hemolytic anemia.
Hereditary poikilocytic anemia associated with the co-inheritance of two alpha spectrin abnormalities.
Arthritis
Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from ?-Santonin Derivatives.
Arthritis, Experimental
SUMO-Conjugating Enzyme UBC9 Promotes Proliferation and Migration of Fibroblast-like Synoviocytes in Rheumatoid Arthritis.
Arthritis, Rheumatoid
SUMO-Conjugating Enzyme UBC9 Promotes Proliferation and Migration of Fibroblast-like Synoviocytes in Rheumatoid Arthritis.
The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes.
Asthma
Identification of critical genes associated with the development of asthma by co-expression modules construction.
Astrocytoma
Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors.
Expression of ubiquitin-conjugating enzyme E2C/UbcH10 in astrocytic tumors.
Atherosclerosis
Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach.
Atrial Fibrillation
Identification of Co-expressed Genes Between Atrial Fibrillation and Stroke.
Autoimmune Diseases
Effect of UBE2L3 genotype on regulation of the linear ubiquitin chain assembly complex in systemic lupus erythematosus.
Emerging roles of Lys63-linked polyubiquitylation in immune responses.
New developments in genetics of myositis.
Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c.
The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes.
UBE2L3 Polymorphism Amplifies NF-?B Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases.
Variants on the UBE2L3-YDJC autoimmune disease risk haplotype increase UBE2L3 gene expression by modulating CTCF and YY1 binding.
Azoospermia
A functional variant in the UBE2B gene promoter is associated with idiopathic azoospermia.
Bacterial Infections
Legionella pneumophila inhibits immune signalling via MavC-mediated transglutaminase-induced ubiquitination of UBE2N.
The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1? Secretion by Inflammasomes.
Bile Duct Diseases
The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma.
Biliary Tract Diseases
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Blast Crisis
De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways.
Brain Injuries, Traumatic
Downregulation of UBE2Q1 is associated with neuronal apoptosis in rat brain cortex following traumatic brain injury.
Breast Diseases
UbcH10 is overexpressed in malignant breast carcinomas.
Breast Neoplasms
A High-Throughput Screening Strategy for Development of RNF8-Ubc13 Protein-Protein Interaction Inhibitors.
Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma.
AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.
Clinicopathological relevance of UbcH10 in breast cancer.
Combination of multiple mRNA markers (PTTG1, Survivin, UbcH10 and TK1) in the diagnosis of Taiwanese patients with breast cancer by membrane array.
Derlin-1 exhibits oncogenic activities and indicates an unfavorable prognosis in breast cancer.
Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides.
Downregulation of Ubiquitin-conjugating Enzyme UBE2D3 Promotes Telomere Maintenance and Radioresistance of Eca-109 Human Esophageal Carcinoma Cells.
Erratum to: UBE2S is associated with malignant characteristics of breast cancer cells.
Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells.
Exceptionally high UBE2C expression is a unique phenomenon in basal-like type breast cancer and is regulated by BRCA1.
Exosomes Mediated Transfer of Circ_UBE2D2 Enhances the Resistance of Breast Cancer to Tamoxifen by Binding to MiR-200a-3p.
Expression of the novel human gene, UBE2Q1, in breast tumors.
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Free ISG15 triggers an antitumor immune response against breast cancer: a new perspective.
Genomic Correlates of DNA Damage in Breast Cancer Subtypes.
Incorporating prior biological knowledge for network-based differential gene expression analysis using differentially weighted graphical LASSO.
Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue.
Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity.
Inhibition of ubiquitin conjugating enzyme UBE2C reduces proliferation and sensitizes breast cancer cells to radiation, doxorubicin, tamoxifen and letrozole.
ISG15 as a novel tumor biomarker for drug sensitivity.
ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells.
Knockdown of UbcH10 Enhances the Chemosensitivity of Dual Drug Resistant Breast Cancer Cells to Epirubicin and Docetaxel.
Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin.
Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer.
MicroRNA-196a post-transcriptionally upregulates the UBE2C proto-oncogene and promotes cell proliferation in breast cancer.
Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo.
Mutation screening of the RNF8, UBC13 and MMS2 genes in Northern Finnish breast cancer families.
Overexpression of the novel human gene, UBE2Q2, in breast cancer.
Prognostic significance of UBE2C mRNA expression in high-risk early breast cancer. A Hellenic Cooperative Oncology Group (HeCOG) Study.
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer.
RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence.
Rad6B is a positive regulator of beta-catenin stabilization.
Regulatory network reconstruction of five essential microRNAs for survival analysis in breast cancer by integrating miRNA and mRNA expression datasets.
RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis.
Slug-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination.
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data.
The clinicopathological significance of ubiquitin-conjugating enzyme E2C, leucine-rich repeated-containing G protein-coupled receptor, WW domain-containing oxidoreductase, and vasculogenic mimicry in invasive breast carcinoma.
UbcH10 expression in human lymphomas.
UbcH10 is overexpressed in malignant breast carcinomas.
UBE2C Overexpression Aggravates Patient Outcome by Promoting Estrogen-Dependent/Independent Cell Proliferation in Early Hormone Receptor-Positive and HER2-Negative Breast Cancer.
UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
UBE2Q1 in a Human Breast Carcinoma Cell Line: Overexpression and Interaction with p53.
UBE2S is associated with malignant characteristics of breast cancer cells.
UBE2T promotes proliferation, invasion and glycolysis of breast cancer cells by regualting the PI3K/AKT signaling pathway.
Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-[cyrillic small letter ka]B mediated matrix metalloproteinase-1 gene regulation.
Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers.
Ubiquitin-Conjugating Enzyme E2T is an Independent Prognostic Factor and Promotes Gastric Cancer Progression.
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.
Ubiquitin-Conjugating Enzyme UBE2C Is Highly Expressed in Breast Microcalcification Lesions.
Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.
Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway.
Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway.
Validation of UBE2C protein as a prognostic marker in node-positive breast cancer.
Calcinosis
Ubiquitin-Conjugating Enzyme UBE2C Is Highly Expressed in Breast Microcalcification Lesions.
Carcinogenesis
A monoclonal antibody against a potential cancer biomarker, human ubiquitin-conjugating enzyme E2.
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Association of clinicopathological features with UbcH10 expression in colorectal cancer.
Bioinformatic analysis identifies potentially key differentially expressed genes in oncogenesis and progression of clear cell renal cell carcinoma.
Combined elevation of AURKB and UBE2C predicts severe outcomes and therapy resistance in glioma.
Depletion of UBE2C reduces ovarian cancer malignancy and reverses cisplatin resistance via downregulating CDK1.
Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer.
Epstein-Barr Virus Latent Membrane Protein-1 Induces the Expression of SUMO-1 and SUMO-2/3 in LMP1-positive Lymphomas and Cells.
Expression of ubiquitin-conjugating enzyme E2C/UbcH10 in astrocytic tumors.
Expression of ubiquitin-conjugating enzyme E2T in colorectal cancers and clinical implications.
Hepatitis C Virus Downregulates Ubiquitin-Conjugating Enzyme E2S Expression To Prevent Proteasomal Degradation of NS5A, Leading to Host Cells More Sensitive to DNA Damage.
High expression of UBE2T predicts poor prognosis and survival in multiple myeloma.
Homology modeling and virtual screening of ubiquitin conjugation enzyme E2A for designing a novel selective antagonist against cancer.
Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Identification of Biomarkers Based on Bioinformatics Analysis: The Expression of Ubiquitin-Conjugating Enzyme E2T (UBE2T) in the Carcinogenesis and Progression of Hepatocellular Carcinoma.
Molecular subtyping and functional validation of TTK, TPX2, UBE2C, and LRP8 in sensitivity of TNBC to paclitaxel.
Overexpression of ubiquitin-conjugating enzyme E2 L3 in hepatocellular carcinoma potentiates apoptosis evasion by inhibiting the GSK3?/p65 pathway.
Role of ubiquitin-conjugating enzyme E2T in the carcinogenesis and progression of pancreatic cancer.
SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T.
Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.
Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis.
The clinical significance of UBE2C gene in progression of renal cell carcinoma.
The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome.
UbcH10 and Its Emerging Role in Systemic Carcinogenesis.
UbcH10 Expression in Benign, Hyperplastic, and Malignant Endometrial Curetted Materials: A Tissue Microarray Study.
UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas.
UbcH10 expression provides a useful tool for the prognosis and treatment of non-small cell lung cancer.
UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme.
UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma.
UBE2C Is a Potential Biomarker of Intestinal-Type Gastric Cancer With Chromosomal Instability.
UBE2C is overexpressed in ESCC tissues and its abrogation attenuates the malignant phenotype of ESCC cell lines.
UBE2C promotes the progression of head and neck squamous cell carcinoma.
UBE2C, Directly Targeted by miR-548e-5p, Increases the Cellular Growth and Invasive Abilities of Cancer Cells Interacting with the EMT Marker Protein Zinc Finger E-box Binding Homeobox 1/2 in NSCLC.
Ube2s expression is elevated in hepatocellular carcinoma and predicts poor prognosis of the patients.
UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3?/?-catenin pathway.
UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma.
Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-[cyrillic small letter ka]B mediated matrix metalloproteinase-1 gene regulation.
Ubiquitin-Conjugating Enzyme E2T is an Independent Prognostic Factor and Promotes Gastric Cancer Progression.
Ubiquitin-conjugating enzyme E2T knockdown suppresses hepatocellular tumorigenesis via inducing cell cycle arrest and apoptosis.
Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker.
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.
Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway.
Up-regulation of miR-455-5p by the TGF-?-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B.
Carcinoma
Alterations of ubiquitylation and sumoylation in conventional renal cell carcinomas after the Chernobyl accident: a comparison with Spanish cases.
Comparative proteomic profiling of triple-negative breast cancer reveals that up-regulation of RhoGDI-2 is associated to the inhibition of caspase 3 and caspase 9.
Downregulation of Ubiquitin-conjugating Enzyme UBE2D3 Promotes Telomere Maintenance and Radioresistance of Eca-109 Human Esophageal Carcinoma Cells.
Elevated expression of UBE2T in lung cancer tumors and cell lines.
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Gene expression patterns in the histopathological classification of epithelial ovarian cancer.
High UBCH10 protein expression as a marker of poor prognosis in esophageal squamous cell carcinoma.
Induction of cell proliferation, clonogenicity and cell accumulation in S phase as a consequence of human UBE2Q1 overexpression.
Inhibiting ubiquitin conjugating enzyme E2 N by microRNA-590-3p reduced cell growth of cervical carcinoma.
LncRNA MALAT1 Regulating Lung Carcinoma Progression via the miR-491-5p/UBE2C Axis.
Multicenter validation of cyclin D1, MCM7, TRIM29, and UBE2C as prognostic protein markers in non-muscle-invasive bladder cancer.
Overexpression of the novel human gene, UBE2Q2, in breast cancer.
Overexpression of UBE2C in esophageal squamous cell carcinoma tissues and molecular analysis.
Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin.
Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.
Preventive effect of oral hangeshashinto (TJ-14) on the development of reflux-induced esophageal cancer.
Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis.
Targeting Ubc9 for cancer therapy.
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
UbcH10 expression can predict prognosis and sensitivity to the antineoplastic treatment for colorectal cancer patients.
UbcH10 Expression in Benign, Hyperplastic, and Malignant Endometrial Curetted Materials: A Tissue Microarray Study.
UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas.
UbcH10 expression provides a useful tool for the prognosis and treatment of non-small cell lung cancer.
UbcH10 is overexpressed in malignant breast carcinomas.
UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status.
UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR.
UBE2C is a marker of unfavorable prognosis in bladder cancer after radical cystectomy.
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma.
UBE2C is involved in the functions of ECRG4 on esophageal squamous cell carcinoma.
UBE2C promotes rectal carcinoma via miR-381.
UBE2C promotes the progression of head and neck squamous cell carcinoma.
UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma.
UBE2QL1 is Disrupted by a Constitutional Translocation Associated with Renal Tumour Predisposition and is a Novel Candidate Renal Tumour Suppressor Gene.
UBE2T Contributes to the Prognosis of Esophageal Squamous Cell Carcinoma.
UBE2T promotes proliferation and regulates PI3K/Akt signaling in renal cell carcinoma.
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-? through p38 MAPK and JNK signaling pathways in human lung carcinoma.
Carcinoma, Ductal
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Carcinoma, Hepatocellular
Enhanced expression of mRNAs of antisecretory factor-1, gp96, DAD1 and CDC34 in human hepatocellular carcinomas.
Gain of UBE2D1 facilitates hepatocellular carcinoma progression and is associated with DNA damage caused by continuous IL-6.
Identification of Biomarkers Based on Bioinformatics Analysis: The Expression of Ubiquitin-Conjugating Enzyme E2T (UBE2T) in the Carcinogenesis and Progression of Hepatocellular Carcinoma.
Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases.
Inhibitors of the Cdc34 acidic loop: A computational investigation integrating molecular dynamics, virtual screening and docking approaches.
MicroRNA miR-147b promotes tumor growth via targeting UBE2N in hepatocellular carcinoma.
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Prognostic value of ubiquitin-conjugating enzyme E2 S overexpression in hepatocellular carcinoma.
Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes.
SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T.
The interplay of UBE2T and Mule in regulating Wnt/?-catenin activation to promote hepatocellular carcinoma progression.
UBE2C functions as a potential oncogene by enhancing cell proliferation, migration, invasion, and drug resistance in hepatocellular carcinoma cells.
UBE2I promotes metastasis and correlates with poor prognosis in hepatocellular carcinoma.
UBE2J2 promotes hepatocellular carcinoma cell epithelial-mesenchymal transition and invasion
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
UBE2S enhances the ubiquitination of p53 and exerts oncogenic activities in hepatocellular carcinoma.
Ube2s expression is elevated in hepatocellular carcinoma and predicts poor prognosis of the patients.
UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development.
UBE2T promotes hepatocellular carcinoma cell growth via ubiquitination of p53.
UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma.
UBE2T: A new molecular regulator of cancer stemness in hepatocellular carcinoma.
Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through ?-catenin-EGFR-PI3K-Akt-mTOR signaling pathway.
Upregulation of ubiquitin-conjugating enzyme E2T (UBE2T) predicts poor prognosis and promotes hepatocellular carcinoma progression.
[UbcH10 expression in hepatocellular carcinoma and its clinicopathological significance].
Carcinoma, Intraductal, Noninfiltrating
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Carcinoma, Non-Small-Cell Lung
KIAA0101 and UbcH10 interact to regulate non-small cell lung cancer cell proliferation by disrupting the function of the spindle assembly checkpoint.
The Relationship Between UBE2C and AGGF1 Overexpression and Tumor Angiogenesis in Non-Small Cell Lung Cancer.
UbcH10 expression provides a useful tool for the prognosis and treatment of non-small cell lung cancer.
UBE2C, Directly Targeted by miR-548e-5p, Increases the Cellular Growth and Invasive Abilities of Cancer Cells Interacting with the EMT Marker Protein Zinc Finger E-box Binding Homeobox 1/2 in NSCLC.
Ube2S regulates Wnt/?-catenin signaling and promotes the progression of non-small cell lung cancer.
UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation.
UBE2T silencing inhibited non-small cell lung cancer cell proliferation and invasion by suppressing the wnt/?-catenin signaling pathway.
Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway.
Carcinoma, Ovarian Epithelial
Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer.
Gene expression patterns in the histopathological classification of epithelial ovarian cancer.
Increased Expression of UBE2T Predicting Poor Survival of Epithelial Ovarian Cancer: Based on Comprehensive Analysis of UBE2s, Clinical Samples, and the GEO Database.
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
Carcinoma, Renal Cell
Alterations of ubiquitylation and sumoylation in conventional renal cell carcinomas after the Chernobyl accident: a comparison with Spanish cases.
Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.
UBE2QL1 is Disrupted by a Constitutional Translocation Associated with Renal Tumour Predisposition and is a Novel Candidate Renal Tumour Suppressor Gene.
UBE2T promotes proliferation and regulates PI3K/Akt signaling in renal cell carcinoma.
Carcinoma, Small Cell
Elevated expression of UBE2T in lung cancer tumors and cell lines.
Carcinoma, Squamous Cell
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
UbcH10 expression provides a useful tool for the prognosis and treatment of non-small cell lung cancer.
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR.
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma.
UBE2C promotes the progression of head and neck squamous cell carcinoma.
UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma.
UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Cataract
Whole exome sequencing reveals putatively novel associations in retinopathies and drusen formation.
Cerebral Infarction
E2-25K SUMOylation inhibits proteasome for cell death during cerebral ischemia/reperfusion.
Chikungunya Fever
Ubiquitin-Conjugating Enzyme E2 L3 is Downregulated by the Chikungunya Virus nsP2 Protease.
Cholangiocarcinoma
The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma.
Ubiquitin-conjugating enzyme E2T regulates cell proliferation and migration in cholangiocarcinoma.
Classical Swine Fever
[Ubiquitin-proteasome pathway and virus infection]
Colitis
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Colitis, Ulcerative
Cutting Edge: Hypoxia-Induced Ubc9 Promoter Hypermethylation Regulates IL-17 Expression in Ulcerative Colitis.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Colonic Neoplasms
Bioinformatics Analysis of Prognostic miRNA Signature and Potential Critical Genes in Colon Cancer.
Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH.
IMP-1 Displays Cross-Talk with K-Ras and Modulates Colon Cancer Cell Survival through the Novel Proapoptotic Protein CYFIP2.
Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue.
Overexpression of UbcH10 alternates the cell cycle profile and accelerate the tumor proliferation in colon cancer.
Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-?B activation.
Colorectal Neoplasms
Association of clinicopathological features with UbcH10 expression in colorectal cancer.
Bortezomib stabilizes mitotic cyclins and prevents cell cycle progression via inhibition of UBE2C in colorectal carcinoma.
Comprehensive analysis of differentially expressed genes reveals the promotive effects of UBE2T on colorectal cancer cell proliferation.
Expression of ubiquitin-conjugating enzyme E2T in colorectal cancers and clinical implications.
Expression Status of UBE2Q2 in Colorectal Primary Tumors and Cell Lines.
Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.
Induction of cell proliferation, clonogenicity and cell accumulation in S phase as a consequence of human UBE2Q1 overexpression.
Inhibition of Ubiquitin-conjugating Enzyme E2 May Activate the Degradation of Hypoxia-inducible Factors and, thus, Overcome Cellular Resistance to Radiation in Colorectal Cancer.
Promoter Methylation Status of Two Novel Human Genes, UBE2Q1 and UBE2Q2, in Colorectal Cancer: a New Finding in Iranian Patients.
RNA INTERFERENCE-MEDIATED SILENCING OF UBCH10 GENE INHIBITS COLORECTAL CANCER CELL GROWTH IN VITRO AND IN VIVO.
RNA interference-mediated silencing of UBCH10 gene inhibits colorectal cancer cell growth in vitro and in vivo.
Spatial UBE2N protein expression indicates genomic instability in colorectal cancers.
UbcH10 expression can predict prognosis and sensitivity to the antineoplastic treatment for colorectal cancer patients.
UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status.
UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.
UbcH10 overexpression is less pronounced in older colorectal cancer patients.
UBE2Q1 expression in human colorectal tumors and cell lines.
Ube2s stabilizes ?-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development.
Ubiquitin-conjugating enzyme E2T(UBE2T) promotes colorectal cancer progression by facilitating ubiquitination and degradation of p53.
Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-?B activation.
Congenital Bone Marrow Failure Syndromes
Inherited bone marrow failure syndromes.
Coronary Artery Disease
Evaluating the association of common UBE2Z variants with coronary artery disease in an Iranian population.
COVID-19
An integrative analysis identifying transcriptional features and key genes involved in COVID-19.
Crohn Disease
Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease.
Genome-Wide Association Study of Ulcerative Colitis in Koreans Suggests Extensive Overlapping of Genetic Susceptibility With Caucasians.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Dehydration
Cowpea and abiotic stresses: identification of reference genes for transcriptional profiling by qPCR.
Selection of Reference Genes for qRT-PCR Analysis in Medicinal Plant Glycyrrhiza under Abiotic Stresses and Hormonal Treatments.
Diabetes Mellitus
Association between UBE2E2 variant rs7612463 and type 2 diabetes mellitus in a Chinese Han population.
Lack of association between UBE2E2 gene polymorphism (rs7612463) and type 2 diabetes mellitus in a Saudi population.
Signals regulating accelerated muscle protein catabolism in uremia.
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetes Mellitus, Type 2
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.
Association between the UBE2Z rs46522 and TCF7L2 rs7903146 polymorphisms with type 2 diabetes in south western Iran.
Association between UBE2E2 variant rs7612463 and type 2 diabetes mellitus in a Chinese Han population.
Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals.
Impact of KCNQ1, CDKN2A/2B, CDKAL1, HHEX, MTNR1B, SLC30A8, TCF7L2, and UBE2E2 on risk of developing type 2 diabetes in Thai population.
Lack of association between UBE2E2 gene polymorphism (rs7612463) and type 2 diabetes mellitus in a Saudi population.
Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes.
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Type 2 Diabetes Risk Allele UBE2E2 Is Associated With Decreased Glucose-Stimulated Insulin Release in Elderly Chinese Han Individuals.
Diabetes, Gestational
Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus.
e2 ubiquitin-conjugating enzyme deficiency
A novel UBE2A mutation in a Chinese family with X-linked intellectual disability.
Adjunctive use of the ketogenic diet in a young adult with UBE2A deficiency syndrome and super-refractory status epilepticus.
An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression.
Delineation of Clinical Manifestations of the Inherited Xq24 Microdeletion Segregating with sXCI in Mothers: Two Novel Cases with Distinct Phenotypes Ranging from UBE2A Deficiency Syndrome to Recurrent Pregnancy Loss.
Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase.
RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration.
Refinement of the clinical and mutational spectrum of UBE2A deficiency syndrome.
The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair.
The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells.
UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.
UBE2A deficiency in two siblings: A novel splicing variant inherited from a maternal germline mosaicism.
UBE2A deficiency syndrome: a report of two unrelated cases with large Xq24 deletions encompassing UBE2A gene.
UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients.
Elliptocytosis, Hereditary
A novel mobile element inserted in the alpha spectrin gene: spectrin dayton. A truncated alpha spectrin associated with hereditary elliptocytosis.
Clinical expression of alpha spectrin mutants in hereditary elliptocytosis.
Four different mutations in codon 28 of alpha spectrin are associated with structurally and functionally abnormal spectrin alpha I/74 in hereditary elliptocytosis.
Genetic basis of the polymorphisms of the alphaI domain of spectrin.
SP alpha I/65 hereditary elliptocytosis in Calabria (southern Italy).
Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway.
Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis.
Unique alpha-spectrin mutant in a kindred with common hereditary elliptocytosis.
Endometrial Neoplasms
Combining Bioinformatics and Experiments to Identify and Verify Key Genes with Prognostic Values in Endometrial Carcinoma.
UbcH10 Expression in Benign, Hyperplastic, and Malignant Endometrial Curetted Materials: A Tissue Microarray Study.
UBE2C Is Upregulated by Estrogen and Promotes Epithelial-Mesenchymal Transition via p53 in Endometrial Cancer.
UBE2S mediates tumor progression via SOX6/?-Catenin signaling in endometrial cancer.
Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/AKT pathway.
Epilepsy
An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression.
Epilepsy, Generalized
Adjunctive use of the ketogenic diet in a young adult with UBE2A deficiency syndrome and super-refractory status epilepticus.
Escherichia coli Infections
High ubiquitin conjugating enzyme E2 T mRNA expression and its prognostic significance in lung adenocarcinoma: A study based on the TCGA database.
Esophageal Neoplasms
Overexpression of UBE2C in esophageal squamous cell carcinoma tissues and molecular analysis.
UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer.
UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells.
[Screening and identification of anoikis-resistant gene UBCH7 in esophageal cancer cells].
Esophageal Squamous Cell Carcinoma
High UBCH10 protein expression as a marker of poor prognosis in esophageal squamous cell carcinoma.
Overexpression of UBE2C in esophageal squamous cell carcinoma tissues and molecular analysis.
Preventive effect of oral hangeshashinto (TJ-14) on the development of reflux-induced esophageal cancer.
UBE2C is involved in the functions of ECRG4 on esophageal squamous cell carcinoma.
UBE2T Contributes to the Prognosis of Esophageal Squamous Cell Carcinoma.
Esotropia
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Fanconi Anemia
Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.
AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.
Deficiency of the Fanconi anemia E2 ubiqitin conjugase UBE2T only partially abrogates Alu-mediated recombination in a new model of homology dependent recombination.
Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.
High expression of UBE2T predicts poor prognosis and survival in multiple myeloma.
Homozygous missense variant in UBE2T is associated with mild Fanconi anemia phenotype.
Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links.
Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex.
Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T.
Inherited bone marrow failure syndromes.
Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair.
Mind the metal: a fragment library-derived zinc impurity binds the E2 ubiquitin-conjugating enzyme Ube2T and induces structural rearrangements.
Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.
The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair.
The SH3 domain of alphaII spectrin is a target for the Fanconi anemia protein, FANCG.
Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia.
UBE2T Contributes to the Prognosis of Esophageal Squamous Cell Carcinoma.
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.
UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells.
UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.
UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2.
Fatty Liver
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Fractures, Spontaneous
Identification of potential target genes and related regulatory transcription factors in spontaneous hairline fracture induced by hypervitaminosis A.
Gallbladder Neoplasms
Erratum: Identification of UBE2T as an independent prognostic biomarker for gallbladder cancer.
Identification of UBE2T as an independent prognostic biomarker for gallbladder cancer.
Gastroesophageal Reflux
Preventive effect of oral hangeshashinto (TJ-14) on the development of reflux-induced esophageal cancer.
Glioblastoma
Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors.
High expression of UBE2C is associated with the aggressive progression and poor outcome of malignant glioma.
Molecular and Clinical Characterization of UBE2S in Glioma as a Biomarker for Poor Prognosis and Resistance to Chemo-Radiotherapy.
Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin.
SUMOylation Regulator-Related Molecules Can Be Used as Prognostic Biomarkers for Glioblastoma.
UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy.
UBE2T promotes glioblastoma invasion and migration via stabilizing GRP78 and regulating EMT.
Glioma
Combined elevation of AURKB and UBE2C predicts severe outcomes and therapy resistance in glioma.
Forkhead Box M1 positively regulates UBE2C and protects glioma cells from autophagic death.
High expression of UBE2C is associated with the aggressive progression and poor outcome of malignant glioma.
Knockdown of ubiquitin-conjugating enzyme E2C/UbcH10 expression by RNA interference inhibits glioma cell proliferation and enhances cell apoptosis in vitro.
Molecular and Clinical Characterization of UBE2S in Glioma as a Biomarker for Poor Prognosis and Resistance to Chemo-Radiotherapy.
SUMOylation of PUM2 promotes the vasculogenic mimicry of glioma cells via regulating CEBPD.
UBE2D3 Activates SHP-2 Ubiquitination to Promote Glycolysis and Proliferation of Glioma via Regulating STAT3 Signaling Pathway.
UBE2T promotes glioblastoma invasion and migration via stabilizing GRP78 and regulating EMT.
Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker.
Goiter
UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.
Graves Disease
The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population.
Head and Neck Neoplasms
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Heart Defects, Congenital
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Hematologic Neoplasms
Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker.
Hematuria
UBE2C cell-free RNA in urine can discriminate between bladder cancer and hematuria.
Hemochromatosis
UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis.
Hemosiderosis
Transplantation studies in mice with congenital hemolytic anemia.
Hepatitis
Gain of UBE2D1 facilitates hepatocellular carcinoma progression and is associated with DNA damage caused by continuous IL-6.
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
Hepatitis B
Aberrant methylation of UBE2Q1 promoter is associated with poor prognosis of acute-on-chronic hepatitis B pre-liver failure.
Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Hepatitis B, Chronic
Aberrant methylation of UBE2Q1 promoter is associated with poor prognosis of acute-on-chronic hepatitis B pre-liver failure.
Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
Hepatoblastoma
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Herpes Simplex
Functional characterization of residues required for the herpes simplex virus 1 E3 ubiquitin ligase ICP0 to interact with the cellular E2 ubiquitin-conjugating enzyme UBE2D1 (UbcH5a).
Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity.
Herpes simplex virus type 1 regulatory protein ICP0 does not protect cyclins D1 and D3 from degradation during infection.
The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a.
The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity.
Hirsutism
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
UBE2A deficiency in two siblings: A novel splicing variant inherited from a maternal germline mosaicism.
UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients.
Hodgkin Disease
UbcH10 expression in human lymphomas.
Huntington Disease
The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases.
Hypersensitivity
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.
Arabidopsis UBC13 differentially regulates two programmed cell death pathways in responses to pathogen and low-temperature stress.
Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites.
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.
RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response.
UBE2V2 (MMS2) is not required for effective immunoglobulin gene conversion or DNA damage tolerance in DT40.
Hypertelorism
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Hypertriglyceridemia
Association of genetic variants with dyslipidemia.
Hypervitaminosis A
Identification of potential target genes and related regulatory transcription factors in spontaneous hairline fracture induced by hypervitaminosis A.
Immune System Diseases
The E2 ubiquitin-conjugating enzyme UbcH5c: an emerging target in cancer and immune disorders.
UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling.
Infarction, Middle Cerebral Artery
E2-25K SUMOylation inhibits proteasome for cell death during cerebral ischemia/reperfusion.
Infections
A functional variant in UBE2L3 contributes to HBV infection and maintains cccDNA stability by inducing degradation of APOBEC3A protein.
Antitumor effects of hsa?miR661?3p on non?small cell lung cancer in vivo and in vitro.
Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators.
E2 ubiquitin-conjugating enzyme UBE2L6 promotes Senecavirus A proliferation by stabilizing the viral RNA polymerase.
Echinococcus multilocularis infection induces UBE2N suppression via exosomal emu-miR-4989.
Evaluation of a SUMO E2 Conjugating Enzyme Involved in Resistance to Clavibacter michiganensis Subsp. michiganensis in Solanum peruvianum, Through a Tomato Mottle Virus VIGS Assay.
Herpes simplex virus type 1 regulatory protein ICP0 does not protect cyclins D1 and D3 from degradation during infection.
High ubiquitin conjugating enzyme E2 T mRNA expression and its prognostic significance in lung adenocarcinoma: A study based on the TCGA database.
Host genetic variants influencing the clinical course of hepatitis B virus infection.
ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells.
ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis.
Large-Scale Arrayed Analysis of Protein Degradation Reveals Cellular Targets for HIV-1 Vpu.
Legionella pneumophila regulates the activity of UBE2N by deamidase-mediated deubiquitination.
Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response.
New loci associated with chronic hepatitis B virus infection in Han Chinese.
Proteasome inhibition attenuates coxsackievirus-induced myocardial damage in mice.
Structural basis for the recognition of Ubc13 by the Shigella flexneri effector OspI.
The deubiquitinase OTUB1 augments NF-?B-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
The stability of HSV-1 ICP0 early after infection is defined by the RING finger and the UL13 protein kinase.
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
Ubiquitin-Conjugating Enzyme E2 L3 is Downregulated by the Chikungunya Virus nsP2 Protease.
Ubiquitin-conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection.
[Screening and identification of anoikis-resistant gene UBCH7 in esophageal cancer cells].
Infertility
Function of RAD6B and RNF8 in spermatogenesis.
Genetic association of UBE2B variants with susceptibility to male infertility in a Northeast Chinese population.
Loss of the E2 SUMO-conjugating enzyme Ube2i in oocytes during ovarian folliculogenesis causes infertility in mice.
UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men.
Infertility, Female
Loss of the E2 SUMO-conjugating enzyme Ube2i in oocytes during ovarian folliculogenesis causes infertility in mice.
Infertility, Male
Genetic association of UBE2B variants with susceptibility to male infertility in a Northeast Chinese population.
Novel variants in UBE2B gene and idiopathic male infertility.
Spermatid nuclear and sperm periaxonemal anomalies in the mouse Ube2b null mutant.
UBE2W down-regulation promotes cell apoptosis and correlates with hypospermatogenesis.
[UBE2B gene and male infertility: an update].
Inflammatory Bowel Diseases
Expression Quantitative Trait Loci Analysis Identifies Associations Between Genotype and Gene Expression in Human Intestine.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease.
Influenza in Birds
SUMO1 modification of the non-structural protein 1 of influenza A virus.
Influenza, Human
Reliable reference genes for the quantification of mRNA in human T-cells and PBMCs stimulated with live influenza virus.
Insulin Resistance
Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis.
Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity.
[Identification and bioinformatics analysis of differentially expressed microRNAs in mice liver tissues with a high fat diet-induced insulin resistance].
Intellectual Disability
A novel 47.2 Mb duplication on chromosomal bands Xq21.1-25 associated with mental retardation.
A novel missense mutation in the UBE2A gene causes intellectual disability in the large X-linked family.
A novel splice site mutation in the UBE2A gene leads to aberrant mRNA splicing in a Chinese patient with X-linked intellectual disability type Nascimento.
A novel UBE2A mutation causes X-linked intellectual disability type Nascimento.
A novel UBE2A mutation in a Chinese family with X-linked intellectual disability.
Adjunctive use of the ketogenic diet in a young adult with UBE2A deficiency syndrome and super-refractory status epilepticus.
An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression.
KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and Lysosome-Mediated Degradation.
Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability.
Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy.
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Refinement of the clinical and mutational spectrum of UBE2A deficiency syndrome.
The Role of the Reanalysis of Genetic Test Results in the Diagnosis of Dysmorphic Syndrome Caused by Inherited xq24 Deletion including the UBE2A and CXorf56 Genes.
UBE2A deficiency in two siblings: A novel splicing variant inherited from a maternal germline mosaicism.
UBE2A deficiency syndrome: a report of two unrelated cases with large Xq24 deletions encompassing UBE2A gene.
UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients.
X-linked intellectual disability type Nascimento is a clinically distinct, probably underdiagnosed entity.
Iron Deficiencies
A lysine-63-linked ubiquitin chain-forming conjugase, UBC13, promotes the developmental responses to iron deficiency in Arabidopsis roots.
Jaundice, Neonatal
Three Novel Spectrin Variants in Jaundiced Neonates.
Keratitis
ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis.
Learning Disabilities
Whole exome sequencing reveals putatively novel associations in retinopathies and drusen formation.
Leukemia
Differential regulation of PML-RAR? stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.
Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm.
Expression and localization of the CDC34 ubiquitin-conjugating enzyme in pediatric acute lymphoblastic leukemia.
Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia.
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies.
Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha.
Physical and functional interactions between ZIP kinase and UbcH5.
The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a.
Leukemia, Erythroblastic, Acute
Biosynthesis of spectrin and its assembly into the cytoskeletal system of Friend erythroleukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways.
Leukemia, Myeloid, Acute
De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways.
Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways.
Leukemia, Promyelocytic, Acute
Differential regulation of PML-RAR? stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.
Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
Leukemia, T-Cell
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.
Lipodystrophy
Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy-causing mutations.
Lipodystrophy, Familial Partial
Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy-causing mutations.
Liver Cirrhosis
Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Liver Diseases
Aberrant methylation of UBE2Q1 promoter is associated with poor prognosis of acute-on-chronic hepatitis B pre-liver failure.
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Targeted deep sequencing of plasma circulating cell-free DNA reveals Vimentin and Fibulin 1 as potential epigenetic biomarkers for hepatocellular carcinoma.
Liver Neoplasms
Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on pathways and biological functions affecting the survival time of liver cancer.
Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases.
Upregulated expression of ubiquitin-conjugating enzyme E2Q1 (UBE2Q1) is associated with enhanced cell proliferation and poor prognosis in human hapatocellular carcinoma.
Lung Neoplasms
Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer.
Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression.
Effects of ubiquitin-conjugating enzyme 2C on invasion, proliferation and cell cycling of lung cancer cells.
Elevated expression of UBE2T in lung cancer tumors and cell lines.
KIAA0101 and UbcH10 interact to regulate non-small cell lung cancer cell proliferation by disrupting the function of the spindle assembly checkpoint.
Knockdown of UBE2T Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion by Suppressing the PI3K/Akt Signaling Pathway.
Lung Cancer and DNA Repair Genes: Multilevel Association Analysis from the International Lung Cancer Consortium.
miRNAs deregulation in serum of mice is associated with lung cancer related pathway deregulation induced by PM2.5.
Targeting CDC34 E2 ubiquitin conjugating enzyme for lung cancer therapy.
The miR 495-UBE2C-ABCG2/ERCC1 axis reverses cisplatin resistance by downregulating drug resistance genes in cisplatin-resistant non-small cell lung cancer cells.
The Relationship Between UBE2C and AGGF1 Overexpression and Tumor Angiogenesis in Non-Small Cell Lung Cancer.
UbcH10 expression provides a useful tool for the prognosis and treatment of non-small cell lung cancer.
UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status.
UBE2C, Directly Targeted by miR-548e-5p, Increases the Cellular Growth and Invasive Abilities of Cancer Cells Interacting with the EMT Marker Protein Zinc Finger E-box Binding Homeobox 1/2 in NSCLC.
Ube2S regulates Wnt/?-catenin signaling and promotes the progression of non-small cell lung cancer.
UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma.
UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation.
UBE2T silencing inhibited non-small cell lung cancer cell proliferation and invasion by suppressing the wnt/?-catenin signaling pathway.
Ubiquitin conjugating enzyme E2 L3 promoted tumor growth of NSCLC through accelerating p27kip1 ubiquitination and degradation.
Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway.
Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers.
Ubiquitin-Conjugating Enzyme E2T is an Independent Prognostic Factor and Promotes Gastric Cancer Progression.
Lupus Erythematosus, Systemic
A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus.
Effect of UBE2L3 genotype on regulation of the linear ubiquitin chain assembly complex in systemic lupus erythematosus.
The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes.
UBE2L3 Polymorphism Amplifies NF-?B Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases.
Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in Chinese population.
Lymphatic Metastasis
Association of clinicopathological features with UbcH10 expression in colorectal cancer.
Expression of UbcH10 in pancreatic ductal adenocarcinoma and its correlation with prognosis.
Overexpression of UBE2C correlates with poor prognosis in gastric cancer patients.
Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data.
The clinicopathological significance of ubiquitin-conjugating enzyme E2C, leucine-rich repeated-containing G protein-coupled receptor, WW domain-containing oxidoreductase, and vasculogenic mimicry in invasive breast carcinoma.
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
The Relationship Between UBE2C and AGGF1 Overexpression and Tumor Angiogenesis in Non-Small Cell Lung Cancer.
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma.
Ube2S regulates Wnt/?-catenin signaling and promotes the progression of non-small cell lung cancer.
UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation.
Lymphoma
Furosine Induced Apoptosis by the Regulation of STAT1/STAT2 and UBA7/UBE2L6 Genes in HepG2 Cells.
UbcH10 expression in human lymphomas.
Lymphoma, B-Cell
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Lymphoma, Non-Hodgkin
UbcH10 expression in human lymphomas.
Malaria
Identification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for Malaria Venture Malaria Box active in blood and liver stage Plasmodium falciparum parasites.
Red blood cell membrane disorders.
Malaria, Cerebral
Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children.
Medulloblastoma
Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene.
Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway.
Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/AKT pathway.
[WGCNA screening of prognostic markers in medulloblastoma].
Melanoma
Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization.
Comprehensive Investigation into the Role of Ubiquitin-Conjugating Enzyme E2S in Melanoma Development.
Differential UBE2C and HOXA1 expression in melanocytic nevi and melanoma.
RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/?-Catenin Signaling.
Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis.
Targeting Ubc9 for cancer therapy.
UBE2C overexpression in melanoma and its essential role in G2/M transition.
UBE2N plays a pivotal role in maintaining melanoma malignancy.
UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling.
Meningioma
A study of UbcH10 expression and its association with recurrence of meningiomas.
RIZ1 negatively regulates ubiquitin-conjugating enzyme E2C/UbcH10 via targeting c-Myc in meningioma.
Mental Retardation, X-Linked
Delineation of Clinical Manifestations of the Inherited Xq24 Microdeletion Segregating with sXCI in Mothers: Two Novel Cases with Distinct Phenotypes Ranging from UBE2A Deficiency Syndrome to Recurrent Pregnancy Loss.
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Novel missense mutations in the ubiquitination-related gene UBE2A cause a recognizable X-linked mental retardation syndrome.
UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome.
Metabolic Diseases
Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity.
Metabolic Syndrome
Association analysis of genetic variants with metabolic syndrome components in the Moroccan population.
Mouth Neoplasms
Cancer Stem Cell based molecular predictors of tumor recurrence in Oral squamous cell carcinoma.
UBE2C promotes the progression of head and neck squamous cell carcinoma.
UBE2S associated with OSCC proliferation by promotion of P21 degradation via the ubiquitin-proteasome system.
Up-regulation of miR-455-5p by the TGF-?-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B.
Multiple Myeloma
Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma.
Blockade of ubiquitin-conjugating enzyme CDC34 enhances anti-myeloma activity of Bortezomib/Proteasome inhibitor PS-341.
High expression of UBE2T predicts poor prognosis and survival in multiple myeloma.
hsa-miR-631 resensitizes bortezomib-resistant multiple myeloma cell lines by inhibiting UbcH10.
Muscle Hypotonia
The Role of the Reanalysis of Genetic Test Results in the Diagnosis of Dysmorphic Syndrome Caused by Inherited xq24 Deletion including the UBE2A and CXorf56 Genes.
Muscular Atrophy
Effects of ornithine alpha-ketoglutarate on protein metabolism in Yoshida sarcoma-bearing rats.
UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension.
UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin.
Myocardial Infarction
The rs46522 Polymorphism of the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with Abnormal Metabolic Parameters in Patients with Myocardial Infarction: The Genetics of Atherosclerosis Disease Mexican Study.
Nasopharyngeal Carcinoma
Epigenetic downregulation of the ISG15-conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma.
High expression of ubiquitin-conjugating enzyme 2C (UBE2C) correlates with nasopharyngeal carcinoma progression.
UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3?/?-catenin pathway.
Ubiquitin-conjugating enzyme E2 B regulates the ubiquitination of O6-methylguanine-DNA methyltransferase and BCNU sensitivity in human nasopharyngeal carcinoma cells.
Neoplasm Metastasis
A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis.
Association of clinicopathological features with UbcH10 expression in colorectal cancer.
Characterization of KRAS Rearrangements in Metastatic Prostate Cancer.
Comprehensive Investigation into the Role of Ubiquitin-Conjugating Enzyme E2S in Melanoma Development.
Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression.
Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH.
Downregulated genes by silencing MYC pathway identified with RNA-SEQ analysis as potential prognostic biomarkers in gastric adenocarcinoma.
Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer.
Expression of UbcH10 in pancreatic ductal adenocarcinoma and its correlation with prognosis.
Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays.
Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Oncogenic Activities Of UBE2S Mediated By VHL/HIF-1?/STAT3 Signal Via The Ubiquitin-Proteasome System In PDAC.
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer.
Prognostic value of ubiquitin-conjugating enzyme E2 S overexpression in hepatocellular carcinoma.
RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/?-Catenin Signaling.
RIZ1 negatively regulates ubiquitin-conjugating enzyme E2C/UbcH10 via targeting c-Myc in meningioma.
Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.
Slug-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination.
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data.
The clinicopathological significance of ubiquitin-conjugating enzyme E2C, leucine-rich repeated-containing G protein-coupled receptor, WW domain-containing oxidoreductase, and vasculogenic mimicry in invasive breast carcinoma.
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
The interplay of UBE2T and Mule in regulating Wnt/?-catenin activation to promote hepatocellular carcinoma progression.
The Relationship Between UBE2C and AGGF1 Overexpression and Tumor Angiogenesis in Non-Small Cell Lung Cancer.
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma.
UBE2C, Directly Targeted by miR-548e-5p, Increases the Cellular Growth and Invasive Abilities of Cancer Cells Interacting with the EMT Marker Protein Zinc Finger E-box Binding Homeobox 1/2 in NSCLC.
UBE2I promotes metastasis and correlates with poor prognosis in hepatocellular carcinoma.
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development.
UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/?-catenin signaling pathway.
Ube2S regulates Wnt/?-catenin signaling and promotes the progression of non-small cell lung cancer.
UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3?/?-catenin pathway.
UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation.
Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy.
Ubiquitin Conjugating Enzyme E2 H (UBE2H) Is Linked to Poor Outcomes and Metastasis in Lung Adenocarcinoma.
Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-[cyrillic small letter ka]B mediated matrix metalloproteinase-1 gene regulation.
Ubiquitin-conjugating enzyme E2T(UBE2T) promotes colorectal cancer progression by facilitating ubiquitination and degradation of p53.
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.
Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway.
Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway.
Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-?B activation.
Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through ?-catenin-EGFR-PI3K-Akt-mTOR signaling pathway.
Neoplasms
A Complex Regulatory Network Coordinating Cell Cycles During Caenorhabditis elegans Development Is Revealed by a Genome-Wide RNAi Screen.
A Comprehensive Bioinformatics Analysis of UBE2C in Cancers.
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.
A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissue.
A molecular basis for stabilization of the von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase.
A monoclonal antibody against a potential cancer biomarker, human ubiquitin-conjugating enzyme E2.
A study of UbcH10 expression and its association with recurrence of meningiomas.
All-trans retinoic acid treatment of Wilms tumor cells reverses expression of genes associated with high risk and relapse in vivo.
Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.
AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.
Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene.
Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors.
Antitumor effects of hsa?miR661?3p on non?small cell lung cancer in vivo and in vitro.
Association of clinicopathological features with UbcH10 expression in colorectal cancer.
Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer.
Autophagy regulates UBC9 levels during viral-mediated tumorigenesis.
Cancer Stem Cell based molecular predictors of tumor recurrence in Oral squamous cell carcinoma.
CCI-779 Inhibits Cell-Cycle G2-M Progression and Invasion of Castration-Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability.
Cell division cycle 34 is highly expressed in hepatitis C virus-positive hepatocellular carcinoma with favorable phenotypes.
Changes in the transcriptome of bovine ovarian cortex during follicle activation in vitro.
Chromenopyrimidinone Controls Stemness and Malignancy by suppressing CD133 Expression in Hepatocellular Carcinoma.
Clinical implications of gene dosage and gene expression patterns in diploid breast carcinoma.
Clinicopathological relevance of UbcH10 in breast cancer.
Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer.
Combined elevation of AURKB and UBE2C predicts severe outcomes and therapy resistance in glioma.
Comprehensive Investigation into the Role of Ubiquitin-Conjugating Enzyme E2S in Melanoma Development.
Constitutional trisomy 8p11.21-q11.21 mosaicism: a germline alteration predisposing to myeloid leukaemia.
Depletion of UBE2C reduces ovarian cancer malignancy and reverses cisplatin resistance via downregulating CDK1.
Deregulation of Rb-E2F1 axis causes chromosomal instability by engaging the transactivation function of Cdc20-anaphase-promoting complex/cyclosome.
Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression.
Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH.
Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling.
Differentially expressed genes in hormone refractory prostate cancer: association with chromosomal regions involved with genetic aberrations.
DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables.
Downregulation of UBE2E2 in rat liver cells after hepatocarcinogen treatment facilitates cell proliferation and slowing down of DNA damage response in GST-P-expressing preneoplastic lesions.
Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer.
Elevated expression of UBE2T in lung cancer tumors and cell lines.
Elevated TOP2A and UBE2C expressions correlate with poor prognosis in patients with surgically resected lung adenocarcinoma: a study based on immunohistochemical analysis and bioinformatics.
Emerging roles of Lys63-linked polyubiquitylation in immune responses.
Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.
Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer.
Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients.
Expression and clinical significance of UBE2V1 in cervical cancer.
Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma.
Expression of the novel human gene, UBE2Q1, in breast tumors.
Expression of UbcH10 in pancreatic ductal adenocarcinoma and its correlation with prognosis.
Expression of UBE2C in lung adenocarcinoma based on database analysis and its clinical significance.
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Expression of ubiquitin-conjugating enzyme E2C/UbcH10 in astrocytic tumors.
Expression of ubiquitin-conjugating enzyme E2T in colorectal cancers and clinical implications.
Expression Status of UBE2Q2 in Colorectal Primary Tumors and Cell Lines.
FOXP3 Activates SUMO-Conjugating UBC9 Gene in MCF7 Breast Cancer Cells.
Gain of UBE2D1 facilitates hepatocellular carcinoma progression and is associated with DNA damage caused by continuous IL-6.
Gene expression patterns in the histopathological classification of epithelial ovarian cancer.
Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy.
Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays.
Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma.
Genomic profiling of circulating plasma RNA for the analysis of cancer.
Global analysis of gene expression signature and diagnostic/prognostic biomarker identification of hepatocellular carcinoma.
HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases.
High Expression of UBE2B as a Poor Prognosis Factor in Patients With Rectal Cancer Following Chemoradiotherapy.
High expression of UBE2C is associated with the aggressive progression and poor outcome of malignant glioma.
High ubiquitin conjugating enzyme E2 T mRNA expression and its prognostic significance in lung adenocarcinoma: A study based on the TCGA database.
Homology modeling and virtual screening of ubiquitin conjugation enzyme E2A for designing a novel selective antagonist against cancer.
HP1? Sensitizes Cervical Cancer Cells to Cisplatin through the Suppression of UBE2L3.
Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T.
Identification of a novel microRNA-mRNA regulatory biomodule in human prostate cancer.
Identification of a potential tumor suppressor gene, UBL3, in non-small cell lung cancer.
Identification of biomarkers correlated with diagnosis and prognosis of endometrial cancer using bioinformatics analysis.
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Identification of epigenetically downregulated Tmem70 and Ube2e2 in rat liver after 28-day treatment with hepatocarcinogenic thioacetamide showing gene product downregulation in hepatocellular preneoplastic and neoplastic lesions produced by tumor promotion.
Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis.
Identification of hub genes involved in the occurrence and development of hepatocellular carcinoma via bioinformatics analysis.
Identification of New Lead Molecules Against UBE2NL Enzyme for Cancer Therapy.
Identification of Novel Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma using Bioinformatics Analysis.
Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression.
Identification of small molecule inhibitors against UBE2C by using docking studies.
Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases.
Identification of UBE2T as an independent prognostic biomarker for gallbladder cancer.
Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agents.
Increased Expression of UBE2T Predicting Poor Survival of Epithelial Ovarian Cancer: Based on Comprehensive Analysis of UBE2s, Clinical Samples, and the GEO Database.
Induction of cell proliferation, clonogenicity and cell accumulation in S phase as a consequence of human UBE2Q1 overexpression.
Inhibition of UBE2N-dependent CDK6 protein degradation by miR-934 promotes human bladder cancer cell growth.
Integrated clinicopathological features and gene microarray analysis of pancreatic neuroendocrine tumors.
Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3.
Involvement of ubiquitin-conjugating enzyme E2C in proliferation and invasion of prostate carcinoma cells.
ISG15 as a novel tumor biomarker for drug sensitivity.
ISGylation governs the oncogenic function of Ki-Ras in breast cancer.
Ixazomib inhibits myeloma cell proliferation by targeting UBE2K.
KIAA0101 and UbcH10 interact to regulate non-small cell lung cancer cell proliferation by disrupting the function of the spindle assembly checkpoint.
Knockdown of UbcH10 Enhances the Chemosensitivity of Dual Drug Resistant Breast Cancer Cells to Epirubicin and Docetaxel.
Knockdown of UBE2T Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion by Suppressing the PI3K/Akt Signaling Pathway.
Lentivirus-mediated RNA interference targeting UbcH10 reduces cell growth and invasion of human osteosarcoma cells via inhibition of Ki-67 and matrix metalloproteinases.
LncRNA MALAT1 Regulating Lung Carcinoma Progression via the miR-491-5p/UBE2C Axis.
Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer.
MicroRNA miR-147b promotes tumor growth via targeting UBE2N in hepatocellular carcinoma.
MicroRNA-mediated regulation of Ubc9 expression in cancer cells.
Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo.
miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13.
MiR-525-5p Repressed Metastasis and Anoikis Resistance in Cervical Cancer via Blocking UBE2C/ZEB1/2 Signal Axis.
miR-671-5p Inhibits Tumor Proliferation by Blocking Cell Cycle in Osteosarcoma.
miRNA?101?3p.1 as an independent diagnostic biomarker aggravates chronic obstructive pulmonary disease via activation of the EGFR/PI3K/AKT signaling pathway.
Molecular and Clinical Characterization of UBE2S in Glioma as a Biomarker for Poor Prognosis and Resistance to Chemo-Radiotherapy.
Molecular characterization of central neurocytomas: Potential markers for tumor typing and progression.
Niclosamide Induces Cell Cycle Arrest in G1 Phase in Head and Neck Squamous Cell Carcinoma Through Let-7d/CDC34 Axis.
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Oncogenic Activities Of UBE2S Mediated By VHL/HIF-1?/STAT3 Signal Via The Ubiquitin-Proteasome System In PDAC.
Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9.
Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.
Overexpression of the novel human gene, UBE2Q2, in breast cancer.
Overexpression of UbcH10 alternates the cell cycle profile and accelerate the tumor proliferation in colon cancer.
Overexpression of ubiquitin-conjugating enzyme E2 L3 in hepatocellular carcinoma potentiates apoptosis evasion by inhibiting the GSK3?/p65 pathway.
Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin.
Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.
Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.
Prognostic significance of UBE2C mRNA expression in high-risk early breast cancer. A Hellenic Cooperative Oncology Group (HeCOG) Study.
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer.
Prognostic value of ubiquitin-conjugating enzyme E2 S overexpression in hepatocellular carcinoma.
Promoter Methylation Status of Two Novel Human Genes, UBE2Q1 and UBE2Q2, in Colorectal Cancer: a New Finding in Iranian Patients.
Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality.
Quantitative SWATH-Based Proteomic Profiling for Identification of Mechanism-Driven Diagnostic Biomarkers Conferring in the Progression of Metastatic Prostate Cancer.
Rad6B is a positive regulator of beta-catenin stabilization.
RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/?-Catenin Signaling.
Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition.
RNA INTERFERENCE-MEDIATED SILENCING OF UBCH10 GENE INHIBITS COLORECTAL CANCER CELL GROWTH IN VITRO AND IN VIVO.
RNA interference-mediated silencing of UBCH10 gene inhibits colorectal cancer cell growth in vitro and in vivo.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity that is Essential for DNA Double-Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.
Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis.
Role of ubiquitin-conjugating enzyme E2T in the carcinogenesis and progression of pancreatic cancer.
SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T.
Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.
Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10.
Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification.
Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors.
Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis.
Targeting the ubiquitin-conjugating enzyme E2D4 for cancer drug discovery-a structure-based approach.
Targeting Ubc9 for cancer therapy.
The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.
The clinical significance of UBE2C gene in progression of renal cell carcinoma.
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data.
The clinicopathological significance of ubiquitin-conjugating enzyme E2C, leucine-rich repeated-containing G protein-coupled receptor, WW domain-containing oxidoreductase, and vasculogenic mimicry in invasive breast carcinoma.
The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma.
The E2 ubiquitin-conjugating enzyme UbcH5c: an emerging target in cancer and immune disorders.
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.
The interplay of UBE2T and Mule in regulating Wnt/?-catenin activation to promote hepatocellular carcinoma progression.
The PTTG1-Binding Factor (PBF/PTTG1IP) Regulates p53 Activity in Thyroid Cells.
The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.
The Relationship Between UBE2C and AGGF1 Overexpression and Tumor Angiogenesis in Non-Small Cell Lung Cancer.
The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization.
Tissue Effects in a Randomized Controlled Trial of Short-term Finasteride in Early Prostate Cancer.
Transcript Levels of Androgen Receptor Variant 7 and Ubiquitin-Conjugating Enzyme 2C in Hormone Sensitive Prostate Cancer and Castration-Resistant Prostate Cancer.
Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China.
Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia.
Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade.
Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105.
Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors.
Ubc13: the Lys63 ubiquitin chain building machine.
UbcH10 a Major Actor in Cancerogenesis and a Potential Tool for Diagnosis and Therapy.
UbcH10 Expression in Benign, Hyperplastic, and Malignant Endometrial Curetted Materials: A Tissue Microarray Study.
UbcH10 expression in human lymphomas.
UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas.
UbcH10 expression on thyroid fine-needle aspirates.
UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme.
UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status.
UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.
UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis.
UbcH7 regulates 53BP1 stability and DSB repair.
UBE2C cell-free RNA in urine can discriminate between bladder cancer and hematuria.
UBE2C functions as a potential oncogene by enhancing cell proliferation, migration, invasion, and drug resistance in hepatocellular carcinoma cells.
UBE2C is a marker of unfavorable prognosis in bladder cancer after radical cystectomy.
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma.
UBE2C Is a Potential Biomarker of Intestinal-Type Gastric Cancer With Chromosomal Instability.
UBE2C Is a Transcriptional Target of the Cell Cycle Regulator FOXM1.
UBE2C is involved in the functions of ECRG4 on esophageal squamous cell carcinoma.
UBE2C is overexpressed in ESCC tissues and its abrogation attenuates the malignant phenotype of ESCC cell lines.
UBE2C Overexpression Aggravates Patient Outcome by Promoting Estrogen-Dependent/Independent Cell Proliferation in Early Hormone Receptor-Positive and HER2-Negative Breast Cancer.
UBE2C overexpression in melanoma and its essential role in G2/M transition.
UBE2C promotes rectal carcinoma via miR-381.
UBE2C promotes the progression of head and neck squamous cell carcinoma.
UBE2C, Directly Targeted by miR-548e-5p, Increases the Cellular Growth and Invasive Abilities of Cancer Cells Interacting with the EMT Marker Protein Zinc Finger E-box Binding Homeobox 1/2 in NSCLC.
UBE2D3 Activates SHP-2 Ubiquitination to Promote Glycolysis and Proliferation of Glioma via Regulating STAT3 Signaling Pathway.
UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer.
UBE2I promotes metastasis and correlates with poor prognosis in hepatocellular carcinoma.
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
UBE2N plays a pivotal role in maintaining melanoma malignancy.
UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling.
UBE2N Regulates Paclitaxel Sensitivity of Ovarian Cancer via Fos/P53 Axis.
UBE2Q1, as a Down Regulated Gene in Pediatric Acute Lymphoblastic Leukemia.
UBE2QL1 is Disrupted by a Constitutional Translocation Associated with Renal Tumour Predisposition and is a Novel Candidate Renal Tumour Suppressor Gene.
UBE2S enhances the ubiquitination of p53 and exerts oncogenic activities in hepatocellular carcinoma.
UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1.
Ube2s expression is elevated in hepatocellular carcinoma and predicts poor prognosis of the patients.
UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development.
UBE2S mediates tumor progression via SOX6/?-Catenin signaling in endometrial cancer.
UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells.
Ube2S regulates Wnt/?-catenin signaling and promotes the progression of non-small cell lung cancer.
Ube2s stabilizes ?-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development.
UBE2T Contributes to the Prognosis of Esophageal Squamous Cell Carcinoma.
UBE2T knockdown inhibits gastric cancer progression.
UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma.
UBE2T promotes glioblastoma invasion and migration via stabilizing GRP78 and regulating EMT.
UBE2T promotes hepatocellular carcinoma cell growth via ubiquitination of p53.
UBE2T promotes proliferation and regulates PI3K/Akt signaling in renal cell carcinoma.
UBE2T promotes proliferation, invasion and glycolysis of breast cancer cells by regualting the PI3K/AKT signaling pathway.
UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation.
UBE2T silencing inhibited non-small cell lung cancer cell proliferation and invasion by suppressing the wnt/?-catenin signaling pathway.
UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells.
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
UBE2T: A new molecular regulator of cancer stemness in hepatocellular carcinoma.
Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy.
UBE2V2 Positively Correlates With PD-L1 Expression and Confers Poor Patient Survival in Lung Adenocarcinoma.
Ubiquitin conjugating enzyme E2 L3 promoted tumor growth of NSCLC through accelerating p27kip1 ubiquitination and degradation.
Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-[cyrillic small letter ka]B mediated matrix metalloproteinase-1 gene regulation.
Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway.
Ubiquitin-conjugating enzyme E2C: a potential cancer biomarker.
Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers.
Ubiquitin-Conjugating Enzyme E2T is an Independent Prognostic Factor and Promotes Gastric Cancer Progression.
Ubiquitin-conjugating enzyme E2T knockdown suppresses hepatocellular tumorigenesis via inducing cell cycle arrest and apoptosis.
Ubiquitin-conjugating enzyme E2T regulates cell proliferation and migration in cholangiocarcinoma.
Ubiquitin-conjugating enzyme E2T(UBE2T) promotes colorectal cancer progression by facilitating ubiquitination and degradation of p53.
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.
Ubiquitin-conjugating enzyme UbcH10 promotes gastric cancer growth and is a potential biomarker for gastric cancer.
Ubiquitin-Conjugating Enzyme UBE2C Is Highly Expressed in Breast Microcalcification Lesions.
Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker.
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation.
Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway.
Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-?B activation.
Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-? through p38 MAPK and JNK signaling pathways in human lung carcinoma.
Up-regulation of miR-455-5p by the TGF-?-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B.
Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through ?-catenin-EGFR-PI3K-Akt-mTOR signaling pathway.
Upregulation of ubiquitin-conjugating enzyme E2T (UBE2T) predicts poor prognosis and promotes hepatocellular carcinoma progression.
Upregulation of ubiquitin-conjugating enzyme E2Z is associated with human hepatocellular carcinoma.
Validation of UBE2C protein as a prognostic marker in node-positive breast cancer.
WITHDRAWN: Production of a novel UBE2S anti-body and significance of its expression in some tumors.
Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/AKT pathway.
Neuroblastoma
A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways.
Neurodegenerative Diseases
Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.
D: -Serine exposure resulted in gene expression changes implicated in neurodegenerative disorders and neuronal dysfunction in male Fischer 344 rats.
Expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveals modest age-dependent decreases in specific neurons.
Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models.
The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
Neurofibrosarcoma
Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.
Nevus
Differential UBE2C and HOXA1 expression in melanocytic nevi and melanoma.
Nevus, Pigmented
Differential UBE2C and HOXA1 expression in melanocytic nevi and melanoma.
Obesity
Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis.
GWA-based pleiotropic analysis identified potential SNPs and genes related to type 2 diabetes and obesity.
Identification of a loss-of-function mutation in Ube2l6 associated with obesity resistance.
Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity.
Obesity, Morbid
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Oligospermia
UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men.
UBE2W down-regulation promotes cell apoptosis and correlates with hypospermatogenesis.
Osteoarthritis
MicroRNA-101a-3p could be involved in the pathogenesis of temporomandibular joint osteoarthritis by mediating UBE2D1 and FZD4.
Osteoporosis
Gene co-expression network analysis identifies BRCC3 as a key regulator in osteogenic differentiation of osteoblasts through a ?-catenin signaling dependent pathway.
Osteosarcoma
Downregulation of UBE2T can enhance the radiosensitivity of osteosarcoma in vitro and in vivo.
Knockdown of UBE2T Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion by Suppressing the PI3K/Akt Signaling Pathway.
Lentivirus-mediated RNA interference targeting UbcH10 reduces cell growth and invasion of human osteosarcoma cells via inhibition of Ki-67 and matrix metalloproteinases.
Screening and Interaction Analysis of Key Genes in miR-542-3p Over- Expressed Osteosarcoma Cells by Bioinformatics.
Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation.
Ovarian Neoplasms
Depletion of UBE2C reduces ovarian cancer malignancy and reverses cisplatin resistance via downregulating CDK1.
Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer.
Functional transcriptomic annotation and protein-protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer.
Gene expression patterns in the histopathological classification of epithelial ovarian cancer.
Increased Expression of UBE2T Predicting Poor Survival of Epithelial Ovarian Cancer: Based on Comprehensive Analysis of UBE2s, Clinical Samples, and the GEO Database.
Integrated bioinformatic analysis identifies UBE2Q1 as a potential prognostic marker for high grade serous ovarian cancer.
Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer.
The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer.
The lncRNA 'UCA1' modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels.
UBE2N Regulates Paclitaxel Sensitivity of Ovarian Cancer via Fos/P53 Axis.
UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/?-catenin signaling pathway.
Pancreatic Neoplasms
Oncogenic Activities Of UBE2S Mediated By VHL/HIF-1?/STAT3 Signal Via The Ubiquitin-Proteasome System In PDAC.
Role of ubiquitin-conjugating enzyme E2T in the carcinogenesis and progression of pancreatic cancer.
Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.
Papilloma
Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7.
Parkinson Disease
Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models.
Thyroarytenoid Muscle Gene Expression in a Rat Model of Early-Onset Parkinson's Disease.
Ubiquitin enzymes, ubiquitin and proteasome activity in blood mononuclear cells of MCI, Alzheimer and Parkinson patients.
Persistent Infection
The use of endogenous and exogenous reference RNAs for qualitative and quantitative detection of PRRSV in porcine semen.
Pituitary Neoplasms
Combination of multiple mRNA markers (PTTG1, Survivin, UbcH10 and TK1) in the diagnosis of Taiwanese patients with breast cancer by membrane array.
Pleural Effusion
A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression and localization of the CDC34 ubiquitin-conjugating enzyme in pediatric acute lymphoblastic leukemia.
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Induction of cell proliferation, clonogenicity and cell accumulation in S phase as a consequence of human UBE2Q1 overexpression.
UBE2Q1, as a Down Regulated Gene in Pediatric Acute Lymphoblastic Leukemia.
Prostatic Hyperplasia
Identification of key genes and pathways in benign prostatic hyperplasia.
Prostatic Neoplasms
A Hierarchical Machine Learning Model to Discover Gleason Grade-Specific Biomarkers in Prostate Cancer.
A novel prostate cancer therapeutic strategy using icaritin-activated arylhydrocarbon-receptor to co-target androgen receptor and its splice variants.
Anticancer effect of icaritin on prostate cancer via regulating miR-381-3p and its target gene UBE2C.
CCI-779 Inhibits Cell-Cycle G2-M Progression and Invasion of Castration-Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability.
Characterization of KRAS Rearrangements in Metastatic Prostate Cancer.
Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer.
Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer.
Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray.
Identification of UBE2C as hub gene in driving prostate cancer by integrated bioinformatics analysis.
Involvement of ubiquitin-conjugating enzyme E2C in proliferation and invasion of prostate carcinoma cells.
Knockdown of UBE2T Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion by Suppressing the PI3K/Akt Signaling Pathway.
KRAS oncogene rearrangements and gene fusions: unexpected rare encounters in late-stage prostate cancers.
Long non-coding RNA LINC01116 acts as an oncogene in prostate cancer cells through regulation of miR-744-5p/UBE2L3 axis.
MED1 mediates androgen receptor splice variant induced gene expression in the absence of ligand.
miR-499a inhibits the proliferation and apoptosis of prostate cancer via targeting UBE2V2.
Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.
Suppression of prostate tumor cell survival by antisense oligonucleotide-mediated inhibition of AR-V7 mRNA synthesis.
Psoriasis
hsa-miR-4516 Mediated Downregulation of STAT3/CDK6/UBE2N Plays a Role in PUVA Induced Apoptosis in Keratinocytes.
Pulmonary Disease, Chronic Obstructive
Screening and Identification of Differentially Expressed Genes Expressed among Left and Right Colon Adenocarcinoma.
Rectal Neoplasms
High Expression of UBE2B as a Poor Prognosis Factor in Patients With Rectal Cancer Following Chemoradiotherapy.
Reperfusion Injury
UBE2D3 contributes to myocardial ischemia-reperfusion injury by regulating autophagy in dependence of p62/SQSTM1.
Retinal Degeneration
[Generation of mouse UBE2W antibody and analysis of UBE2W expression in mouse tissues]
Retinoblastoma
ARI-1, an RBR family ubiquitin-ligase, functions with UBC-18 to regulate pharyngeal development in C. elegans.
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Implicating SCF complexes in organogenesis in Caenorhabditis elegans.
Retinoschisis
Whole exome sequencing reveals putatively novel associations in retinopathies and drusen formation.
Rhinitis, Allergic
miR-338-3p inhibits autophagy in a rat model of allergic rhinitis after PM2.5 exposure through AKT/mTOR signaling by targeting UBE2Q1.
RNA Virus Infections
Ubiquitin-conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection.
Sarcoma
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Sarcoma, Yoshida
Effects of ornithine alpha-ketoglutarate on protein metabolism in Yoshida sarcoma-bearing rats.
Scleroderma, Diffuse
Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population.
Scleroderma, Systemic
Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population.
Seizures
A novel UBE2A mutation in a Chinese family with X-linked intellectual disability.
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Refinement of the clinical and mutational spectrum of UBE2A deficiency syndrome.
UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients.
X-linked intellectual disability type Nascimento is a clinically distinct, probably underdiagnosed entity.
Sepsis
Screening of Key Genes of Sepsis and Septic Shock Using Bioinformatics Analysis.
Shock, Septic
Screening of Key Genes of Sepsis and Septic Shock Using Bioinformatics Analysis.
Sickle Cell Trait
Preliminary characterization of a structural defect in homozygous sickled cell alpha spectrin demonstrated by a rabbit autoantibody.
Skin Abnormalities
A novel UBE2A mutation in a Chinese family with X-linked intellectual disability.
UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients.
Spinocerebellar Ataxias
A key lysine residue in the AXH domain of ataxin-1 is essential for its ubiquitylation.
The ubiquitin-conjugating enzyme UbcH6 regulates the transcriptional repression activity of the SCA1 gene product ataxin-1.
UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1.
Squamous Cell Carcinoma of Head and Neck
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Robust rank aggregation and cibersort algorithm applied to the identification of key genes in head and neck squamous cell cancer.
UBE2C promotes the progression of head and neck squamous cell carcinoma.
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Starvation
Heat Stress Affects Pi-related Genes Expression and Inorganic Phosphate Deposition/Accumulation in Barley.
Identification of transcription factors that bind to the 5'-UTR of the barley PHO2 gene.
Regulation of Phosphate Homeostasis by MicroRNA in Arabidopsis.
The ATG12-Conjugating Enzyme ATG10 Is Essential for Autophagic Vesicle Formation in Arabidopsis thaliana.
Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway.
Status Epilepticus
Adjunctive use of the ketogenic diet in a young adult with UBE2A deficiency syndrome and super-refractory status epilepticus.
Stomach Neoplasms
A novel UBE2T inhibitor suppresses Wnt/?-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination.
Correction: A novel UBE2T inhibitor suppresses Wnt/?-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination.
Identification of Potential Biomarkers Involved in Gastric Cancer Through Integrated Analysis of Non-Coding RNA Associated Competing Endogenous RNAs Network.
Inhibition of microRNA-17/20a suppresses cell proliferation in gastric cancer by modulating UBE2C expression.
Overexpression of UBE2C correlates with poor prognosis in gastric cancer patients.
UBE2C induces EMT through Wnt/??catenin and PI3K/Akt signaling pathways by regulating phosphorylation levels of Aurora-A.
UBE2C Is a Potential Biomarker of Intestinal-Type Gastric Cancer With Chromosomal Instability.
UBE2C mRNA expression controlled by miR-300 and HuR determines its oncogenic role in gastric cancer.
UBE2T knockdown inhibits gastric cancer progression.
Ubiquitin-Conjugating Enzyme E2T is an Independent Prognostic Factor and Promotes Gastric Cancer Progression.
Ubiquitin-conjugating enzyme UbcH10 promotes gastric cancer growth and is a potential biomarker for gastric cancer.
Stroke
Identification of Co-expressed Genes Between Atrial Fibrillation and Stroke.
Thyroid Carcinoma, Anaplastic
Array-CGH identifies cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma.
The UbcH10 gene is a novel therapeutic target in anaplastic thyroid carcinoma.
UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.
Thyroid Diseases
The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population.
Thyroid Neoplasms
Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas.
UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas.
UbcH10 expression on thyroid fine-needle aspirates.
UbcH10 is overexpressed in malignant breast carcinomas.
UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.
Thyroiditis
The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population.
Triple Negative Breast Neoplasms
Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer.
RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence.
Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib.
Tuberous Sclerosis
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Urinary Bladder Neoplasms
A potential panel of five mRNAs in urinary extracellular vesicles for the detection of bladder cancer.
Knockdown of UBE2T Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion by Suppressing the PI3K/Akt Signaling Pathway.
Multicenter validation of cyclin D1, MCM7, TRIM29, and UBE2C as prognostic protein markers in non-muscle-invasive bladder cancer.
UBE2C cell-free RNA in urine can discriminate between bladder cancer and hematuria.
UBE2C is a marker of unfavorable prognosis in bladder cancer after radical cystectomy.
UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1.
UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells.
[Analysis and verification of the interaction network of differentially expressed genes in invasive bladder cancer.]
Uterine Cervical Neoplasms
Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling.
Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
Expression and clinical significance of UBE2V1 in cervical cancer.
Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy.
HP1? Sensitizes Cervical Cancer Cells to Cisplatin through the Suppression of UBE2L3.
HPV-mediated nuclear export of HP1? drives cervical tumorigenesis by downregulation of p53.
Identification of small molecule inhibitors against UBE2C by using docking studies.
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR.
UHRF1 epigenetically down-regulates UbcH8 to inhibit apoptosis in cervical cancer cells.
Vorinostat targets UBE2C to reverse epithelial-mesenchymal transition and control cervical cancer growth through the ubiquitination pathway.
Virus Diseases
Herpes simplex virus type 1 regulatory protein ICP0 does not protect cyclins D1 and D3 from degradation during infection.
Ubc13: the Lys63 ubiquitin chain building machine.
Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.