Disease on EC 2.3.2.23 - E2 ubiquitin-conjugating enzyme and Organism(s) Homo sapiens
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Acquired Immunodeficiency Syndrome
Identification of New Lead Molecules Against UBE2NL Enzyme for Cancer Therapy.
Acquired Immunodeficiency Syndrome
The E2-25K ubiquitin-associated (UBA) domain aids in polyubiquitin chain synthesis and linkage specificity.
Adenocarcinoma
cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin-conjugating enzyme.
Adenocarcinoma
Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice.
Adenocarcinoma
Expression of UbcH10 in pancreatic ductal adenocarcinoma and its correlation with prognosis.
Adenocarcinoma
Identification of potential crucial genes associated with the pathogenesis and prognosis of pancreatic adenocarcinoma.
Adenocarcinoma
Inhibitors of the Cdc34 acidic loop: A computational investigation integrating molecular dynamics, virtual screening and docking approaches.
Adenocarcinoma
Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.
Adenocarcinoma
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
Adenocarcinoma
UbcH10 expression provides a useful tool for the prognosis and treatment of non-small cell lung cancer.
Adenocarcinoma
UBE2C induces EMT through Wnt/??catenin and PI3K/Akt signaling pathways by regulating phosphorylation levels of Aurora-A.
Adenocarcinoma
UBE2C mRNA expression controlled by miR-300 and HuR determines its oncogenic role in gastric cancer.
Adenocarcinoma
Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-?B activation.
Adenocarcinoma of Lung
Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis.
Adenocarcinoma of Lung
Elevated TOP2A and UBE2C expressions correlate with poor prognosis in patients with surgically resected lung adenocarcinoma: a study based on immunohistochemical analysis and bioinformatics.
Adenocarcinoma of Lung
Expression of UBE2C in lung adenocarcinoma based on database analysis and its clinical significance.
Adenocarcinoma of Lung
High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.
Adenocarcinoma of Lung
UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma.
Adenocarcinoma of Lung
UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells.
Adenocarcinoma of Lung
UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma.
Adenocarcinoma of Lung
UBE2V2 Positively Correlates With PD-L1 Expression and Confers Poor Patient Survival in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Ubiquitin Conjugating Enzyme E2 H (UBE2H) Is Linked to Poor Outcomes and Metastasis in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers.
African Swine Fever
African swine fever virus encodes for an E2-ubiquitin conjugating enzyme that is mono- and di-ubiquitinated and required for viral replication cycle.
Alzheimer Disease
Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7).
Alzheimer Disease
High ubiquitin conjugating enzyme E2 T mRNA expression and its prognostic significance in lung adenocarcinoma: A study based on the TCGA database.
Alzheimer Disease
Predictive Potential of Circulating Ube2h mRNA as an E2 Ubiquitin-Conjugating Enzyme for Diagnosis or Treatment of Alzheimer's Disease.
Alzheimer Disease
Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2).
Alzheimer Disease
Sumoylation of amyloid precursor protein negatively regulates Abeta aggregate levels.
Anemia
Hereditary poikilocytic anemia associated with the co-inheritance of two alpha spectrin abnormalities.
Anemia
RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence.
Anemia, Hemolytic
Combination of two mutant alpha spectrin alleles underlies a severe spherocytic hemolytic anemia.
Anemia, Hemolytic
Hereditary poikilocytic anemia associated with the co-inheritance of two alpha spectrin abnormalities.
Arthritis
Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from ?-Santonin Derivatives.
Arthritis, Experimental
SUMO-Conjugating Enzyme UBC9 Promotes Proliferation and Migration of Fibroblast-like Synoviocytes in Rheumatoid Arthritis.
Arthritis, Rheumatoid
SUMO-Conjugating Enzyme UBC9 Promotes Proliferation and Migration of Fibroblast-like Synoviocytes in Rheumatoid Arthritis.
Arthritis, Rheumatoid
The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes.
Asthma
Identification of critical genes associated with the development of asthma by co-expression modules construction.
Astrocytoma
Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors.
Atherosclerosis
Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach.
Atrial Fibrillation
Identification of Co-expressed Genes Between Atrial Fibrillation and Stroke.
Autoimmune Diseases
Effect of UBE2L3 genotype on regulation of the linear ubiquitin chain assembly complex in systemic lupus erythematosus.
Autoimmune Diseases
Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c.
Autoimmune Diseases
The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes.
Autoimmune Diseases
UBE2L3 Polymorphism Amplifies NF-?B Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases.
Autoimmune Diseases
Variants on the UBE2L3-YDJC autoimmune disease risk haplotype increase UBE2L3 gene expression by modulating CTCF and YY1 binding.
Azoospermia
A functional variant in the UBE2B gene promoter is associated with idiopathic azoospermia.
Bacterial Infections
Legionella pneumophila inhibits immune signalling via MavC-mediated transglutaminase-induced ubiquitination of UBE2N.
Bacterial Infections
The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1? Secretion by Inflammasomes.
Bile Duct Diseases
The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma.
Biliary Tract Diseases
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Blast Crisis
De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways.
Brain Injuries, Traumatic
Downregulation of UBE2Q1 is associated with neuronal apoptosis in rat brain cortex following traumatic brain injury.
Breast Neoplasms
A High-Throughput Screening Strategy for Development of RNF8-Ubc13 Protein-Protein Interaction Inhibitors.
Breast Neoplasms
Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma.
Breast Neoplasms
AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.
Breast Neoplasms
Combination of multiple mRNA markers (PTTG1, Survivin, UbcH10 and TK1) in the diagnosis of Taiwanese patients with breast cancer by membrane array.
Breast Neoplasms
Derlin-1 exhibits oncogenic activities and indicates an unfavorable prognosis in breast cancer.
Breast Neoplasms
Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides.
Breast Neoplasms
Downregulation of Ubiquitin-conjugating Enzyme UBE2D3 Promotes Telomere Maintenance and Radioresistance of Eca-109 Human Esophageal Carcinoma Cells.
Breast Neoplasms
Erratum to: UBE2S is associated with malignant characteristics of breast cancer cells.
Breast Neoplasms
Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells.
Breast Neoplasms
Exceptionally high UBE2C expression is a unique phenomenon in basal-like type breast cancer and is regulated by BRCA1.
Breast Neoplasms
Exosomes Mediated Transfer of Circ_UBE2D2 Enhances the Resistance of Breast Cancer to Tamoxifen by Binding to MiR-200a-3p.
Breast Neoplasms
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Breast Neoplasms
Free ISG15 triggers an antitumor immune response against breast cancer: a new perspective.
Breast Neoplasms
Incorporating prior biological knowledge for network-based differential gene expression analysis using differentially weighted graphical LASSO.
Breast Neoplasms
Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue.
Breast Neoplasms
Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity.
Breast Neoplasms
Inhibition of ubiquitin conjugating enzyme UBE2C reduces proliferation and sensitizes breast cancer cells to radiation, doxorubicin, tamoxifen and letrozole.
Breast Neoplasms
ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells.
Breast Neoplasms
Knockdown of UbcH10 Enhances the Chemosensitivity of Dual Drug Resistant Breast Cancer Cells to Epirubicin and Docetaxel.
Breast Neoplasms
Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer.
Breast Neoplasms
MicroRNA-196a post-transcriptionally upregulates the UBE2C proto-oncogene and promotes cell proliferation in breast cancer.
Breast Neoplasms
Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo.
Breast Neoplasms
Mutation screening of the RNF8, UBC13 and MMS2 genes in Northern Finnish breast cancer families.
Breast Neoplasms
Prognostic significance of UBE2C mRNA expression in high-risk early breast cancer. A Hellenic Cooperative Oncology Group (HeCOG) Study.
Breast Neoplasms
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer.
Breast Neoplasms
RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence.
Breast Neoplasms
Regulatory network reconstruction of five essential microRNAs for survival analysis in breast cancer by integrating miRNA and mRNA expression datasets.
Breast Neoplasms
RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis.
Breast Neoplasms
Slug-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination.
Breast Neoplasms
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data.
Breast Neoplasms
The clinicopathological significance of ubiquitin-conjugating enzyme E2C, leucine-rich repeated-containing G protein-coupled receptor, WW domain-containing oxidoreductase, and vasculogenic mimicry in invasive breast carcinoma.
Breast Neoplasms
UBE2C Overexpression Aggravates Patient Outcome by Promoting Estrogen-Dependent/Independent Cell Proliferation in Early Hormone Receptor-Positive and HER2-Negative Breast Cancer.
Breast Neoplasms
UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
Breast Neoplasms
UBE2Q1 in a Human Breast Carcinoma Cell Line: Overexpression and Interaction with p53.
Breast Neoplasms
UBE2S is associated with malignant characteristics of breast cancer cells.
Breast Neoplasms
UBE2T promotes proliferation, invasion and glycolysis of breast cancer cells by regualting the PI3K/AKT signaling pathway.
Breast Neoplasms
Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-[cyrillic small letter ka]B mediated matrix metalloproteinase-1 gene regulation.
Breast Neoplasms
Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers.
Breast Neoplasms
Ubiquitin-Conjugating Enzyme E2T is an Independent Prognostic Factor and Promotes Gastric Cancer Progression.
Breast Neoplasms
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.
Breast Neoplasms
Ubiquitin-Conjugating Enzyme UBE2C Is Highly Expressed in Breast Microcalcification Lesions.
Breast Neoplasms
Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.
Breast Neoplasms
Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway.
Breast Neoplasms
Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway.
Breast Neoplasms
Validation of UBE2C protein as a prognostic marker in node-positive breast cancer.
Calcinosis
Ubiquitin-Conjugating Enzyme UBE2C Is Highly Expressed in Breast Microcalcification Lesions.
Carcinogenesis
A monoclonal antibody against a potential cancer biomarker, human ubiquitin-conjugating enzyme E2.
Carcinogenesis
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Carcinogenesis
Association of clinicopathological features with UbcH10 expression in colorectal cancer.
Carcinogenesis
Bioinformatic analysis identifies potentially key differentially expressed genes in oncogenesis and progression of clear cell renal cell carcinoma.
Carcinogenesis
Combined elevation of AURKB and UBE2C predicts severe outcomes and therapy resistance in glioma.
Carcinogenesis
Depletion of UBE2C reduces ovarian cancer malignancy and reverses cisplatin resistance via downregulating CDK1.
Carcinogenesis
Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer.
Carcinogenesis
Epstein-Barr Virus Latent Membrane Protein-1 Induces the Expression of SUMO-1 and SUMO-2/3 in LMP1-positive Lymphomas and Cells.
Carcinogenesis
Expression of ubiquitin-conjugating enzyme E2T in colorectal cancers and clinical implications.
Carcinogenesis
Hepatitis C Virus Downregulates Ubiquitin-Conjugating Enzyme E2S Expression To Prevent Proteasomal Degradation of NS5A, Leading to Host Cells More Sensitive to DNA Damage.
Carcinogenesis
High expression of UBE2T predicts poor prognosis and survival in multiple myeloma.
Carcinogenesis
Homology modeling and virtual screening of ubiquitin conjugation enzyme E2A for designing a novel selective antagonist against cancer.
Carcinogenesis
Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Carcinogenesis
Identification of Biomarkers Based on Bioinformatics Analysis: The Expression of Ubiquitin-Conjugating Enzyme E2T (UBE2T) in the Carcinogenesis and Progression of Hepatocellular Carcinoma.
Carcinogenesis
Molecular subtyping and functional validation of TTK, TPX2, UBE2C, and LRP8 in sensitivity of TNBC to paclitaxel.
Carcinogenesis
Overexpression of ubiquitin-conjugating enzyme E2 L3 in hepatocellular carcinoma potentiates apoptosis evasion by inhibiting the GSK3?/p65 pathway.
Carcinogenesis
Role of ubiquitin-conjugating enzyme E2T in the carcinogenesis and progression of pancreatic cancer.
Carcinogenesis
SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T.
Carcinogenesis
Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.
Carcinogenesis
Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis.
Carcinogenesis
The clinical significance of UBE2C gene in progression of renal cell carcinoma.
Carcinogenesis
The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome.
Carcinogenesis
UbcH10 Expression in Benign, Hyperplastic, and Malignant Endometrial Curetted Materials: A Tissue Microarray Study.
Carcinogenesis
UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas.
Carcinogenesis
UbcH10 expression provides a useful tool for the prognosis and treatment of non-small cell lung cancer.
Carcinogenesis
UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.
Carcinogenesis
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma.
Carcinogenesis
UBE2C Is a Potential Biomarker of Intestinal-Type Gastric Cancer With Chromosomal Instability.
Carcinogenesis
UBE2C is overexpressed in ESCC tissues and its abrogation attenuates the malignant phenotype of ESCC cell lines.
Carcinogenesis
UBE2C, Directly Targeted by miR-548e-5p, Increases the Cellular Growth and Invasive Abilities of Cancer Cells Interacting with the EMT Marker Protein Zinc Finger E-box Binding Homeobox 1/2 in NSCLC.
Carcinogenesis
Ube2s expression is elevated in hepatocellular carcinoma and predicts poor prognosis of the patients.
Carcinogenesis
UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3?/?-catenin pathway.
Carcinogenesis
UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma.
Carcinogenesis
Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-[cyrillic small letter ka]B mediated matrix metalloproteinase-1 gene regulation.
Carcinogenesis
Ubiquitin-Conjugating Enzyme E2T is an Independent Prognostic Factor and Promotes Gastric Cancer Progression.
Carcinogenesis
Ubiquitin-conjugating enzyme E2T knockdown suppresses hepatocellular tumorigenesis via inducing cell cycle arrest and apoptosis.
Carcinogenesis
Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker.
Carcinogenesis
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Carcinogenesis
Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.
Carcinogenesis
Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway.
Carcinogenesis
Up-regulation of miR-455-5p by the TGF-?-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B.
Carcinoma
Alterations of ubiquitylation and sumoylation in conventional renal cell carcinomas after the Chernobyl accident: a comparison with Spanish cases.
Carcinoma
Comparative proteomic profiling of triple-negative breast cancer reveals that up-regulation of RhoGDI-2 is associated to the inhibition of caspase 3 and caspase 9.
Carcinoma
Downregulation of Ubiquitin-conjugating Enzyme UBE2D3 Promotes Telomere Maintenance and Radioresistance of Eca-109 Human Esophageal Carcinoma Cells.
Carcinoma
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Carcinoma
Gene expression patterns in the histopathological classification of epithelial ovarian cancer.
Carcinoma
High UBCH10 protein expression as a marker of poor prognosis in esophageal squamous cell carcinoma.
Carcinoma
Induction of cell proliferation, clonogenicity and cell accumulation in S phase as a consequence of human UBE2Q1 overexpression.
Carcinoma
Inhibiting ubiquitin conjugating enzyme E2 N by microRNA-590-3p reduced cell growth of cervical carcinoma.
Carcinoma
LncRNA MALAT1 Regulating Lung Carcinoma Progression via the miR-491-5p/UBE2C Axis.
Carcinoma
Multicenter validation of cyclin D1, MCM7, TRIM29, and UBE2C as prognostic protein markers in non-muscle-invasive bladder cancer.
Carcinoma
Overexpression of UBE2C in esophageal squamous cell carcinoma tissues and molecular analysis.
Carcinoma
Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin.
Carcinoma
Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.
Carcinoma
Preventive effect of oral hangeshashinto (TJ-14) on the development of reflux-induced esophageal cancer.
Carcinoma
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
Carcinoma
UbcH10 expression can predict prognosis and sensitivity to the antineoplastic treatment for colorectal cancer patients.
Carcinoma
UbcH10 Expression in Benign, Hyperplastic, and Malignant Endometrial Curetted Materials: A Tissue Microarray Study.
Carcinoma
UbcH10 expression provides a useful tool for the prognosis and treatment of non-small cell lung cancer.
Carcinoma
UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status.
Carcinoma
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR.
Carcinoma
UBE2C is a marker of unfavorable prognosis in bladder cancer after radical cystectomy.
Carcinoma
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma.
Carcinoma
UBE2C is involved in the functions of ECRG4 on esophageal squamous cell carcinoma.
Carcinoma
UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma.
Carcinoma
UBE2QL1 is Disrupted by a Constitutional Translocation Associated with Renal Tumour Predisposition and is a Novel Candidate Renal Tumour Suppressor Gene.
Carcinoma
UBE2T promotes proliferation and regulates PI3K/Akt signaling in renal cell carcinoma.
Carcinoma
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Carcinoma
Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-? through p38 MAPK and JNK signaling pathways in human lung carcinoma.
Carcinoma, Ductal
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Carcinoma, Hepatocellular
Enhanced expression of mRNAs of antisecretory factor-1, gp96, DAD1 and CDC34 in human hepatocellular carcinomas.
Carcinoma, Hepatocellular
Gain of UBE2D1 facilitates hepatocellular carcinoma progression and is associated with DNA damage caused by continuous IL-6.
Carcinoma, Hepatocellular
Identification of Biomarkers Based on Bioinformatics Analysis: The Expression of Ubiquitin-Conjugating Enzyme E2T (UBE2T) in the Carcinogenesis and Progression of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases.
Carcinoma, Hepatocellular
Inhibitors of the Cdc34 acidic loop: A computational investigation integrating molecular dynamics, virtual screening and docking approaches.
Carcinoma, Hepatocellular
MicroRNA miR-147b promotes tumor growth via targeting UBE2N in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Prognostic value of ubiquitin-conjugating enzyme E2 S overexpression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes.
Carcinoma, Hepatocellular
SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T.
Carcinoma, Hepatocellular
The interplay of UBE2T and Mule in regulating Wnt/?-catenin activation to promote hepatocellular carcinoma progression.
Carcinoma, Hepatocellular
UBE2C functions as a potential oncogene by enhancing cell proliferation, migration, invasion, and drug resistance in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
UBE2I promotes metastasis and correlates with poor prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
UBE2J2 promotes hepatocellular carcinoma cell epithelial-mesenchymal transition and invasion
Carcinoma, Hepatocellular
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
Carcinoma, Hepatocellular
UBE2S enhances the ubiquitination of p53 and exerts oncogenic activities in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Ube2s expression is elevated in hepatocellular carcinoma and predicts poor prognosis of the patients.
Carcinoma, Hepatocellular
UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development.
Carcinoma, Hepatocellular
UBE2T promotes hepatocellular carcinoma cell growth via ubiquitination of p53.
Carcinoma, Hepatocellular
UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma.
Carcinoma, Hepatocellular
UBE2T: A new molecular regulator of cancer stemness in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through ?-catenin-EGFR-PI3K-Akt-mTOR signaling pathway.
Carcinoma, Hepatocellular
Upregulation of ubiquitin-conjugating enzyme E2T (UBE2T) predicts poor prognosis and promotes hepatocellular carcinoma progression.
Carcinoma, Hepatocellular
[UbcH10 expression in hepatocellular carcinoma and its clinicopathological significance].
Carcinoma, Intraductal, Noninfiltrating
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Carcinoma, Non-Small-Cell Lung
KIAA0101 and UbcH10 interact to regulate non-small cell lung cancer cell proliferation by disrupting the function of the spindle assembly checkpoint.
Carcinoma, Non-Small-Cell Lung
The Relationship Between UBE2C and AGGF1 Overexpression and Tumor Angiogenesis in Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
UbcH10 expression provides a useful tool for the prognosis and treatment of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
UBE2C, Directly Targeted by miR-548e-5p, Increases the Cellular Growth and Invasive Abilities of Cancer Cells Interacting with the EMT Marker Protein Zinc Finger E-box Binding Homeobox 1/2 in NSCLC.
Carcinoma, Non-Small-Cell Lung
Ube2S regulates Wnt/?-catenin signaling and promotes the progression of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation.
Carcinoma, Non-Small-Cell Lung
UBE2T silencing inhibited non-small cell lung cancer cell proliferation and invasion by suppressing the wnt/?-catenin signaling pathway.
Carcinoma, Non-Small-Cell Lung
Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway.
Carcinoma, Ovarian Epithelial
Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Gene expression patterns in the histopathological classification of epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Increased Expression of UBE2T Predicting Poor Survival of Epithelial Ovarian Cancer: Based on Comprehensive Analysis of UBE2s, Clinical Samples, and the GEO Database.
Carcinoma, Ovarian Epithelial
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
Carcinoma, Renal Cell
Alterations of ubiquitylation and sumoylation in conventional renal cell carcinomas after the Chernobyl accident: a comparison with Spanish cases.
Carcinoma, Renal Cell
Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.
Carcinoma, Renal Cell
UBE2QL1 is Disrupted by a Constitutional Translocation Associated with Renal Tumour Predisposition and is a Novel Candidate Renal Tumour Suppressor Gene.
Carcinoma, Renal Cell
UBE2T promotes proliferation and regulates PI3K/Akt signaling in renal cell carcinoma.
Carcinoma, Squamous Cell
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Carcinoma, Squamous Cell
UbcH10 expression provides a useful tool for the prognosis and treatment of non-small cell lung cancer.
Carcinoma, Squamous Cell
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR.
Carcinoma, Squamous Cell
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
UBE2C promotes the progression of head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
Carcinoma, Squamous Cell
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Cataract
Whole exome sequencing reveals putatively novel associations in retinopathies and drusen formation.
Cerebral Infarction
E2-25K SUMOylation inhibits proteasome for cell death during cerebral ischemia/reperfusion.
Chikungunya Fever
Ubiquitin-Conjugating Enzyme E2 L3 is Downregulated by the Chikungunya Virus nsP2 Protease.
Cholangiocarcinoma
The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma.
Cholangiocarcinoma
Ubiquitin-conjugating enzyme E2T regulates cell proliferation and migration in cholangiocarcinoma.
Colitis
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Colitis, Ulcerative
Cutting Edge: Hypoxia-Induced Ubc9 Promoter Hypermethylation Regulates IL-17 Expression in Ulcerative Colitis.
Colitis, Ulcerative
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Colonic Neoplasms
Bioinformatics Analysis of Prognostic miRNA Signature and Potential Critical Genes in Colon Cancer.
Colonic Neoplasms
Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH.
Colonic Neoplasms
IMP-1 Displays Cross-Talk with K-Ras and Modulates Colon Cancer Cell Survival through the Novel Proapoptotic Protein CYFIP2.
Colonic Neoplasms
Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue.
Colonic Neoplasms
Overexpression of UbcH10 alternates the cell cycle profile and accelerate the tumor proliferation in colon cancer.
Colonic Neoplasms
Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-?B activation.
Colorectal Neoplasms
Association of clinicopathological features with UbcH10 expression in colorectal cancer.
Colorectal Neoplasms
Bortezomib stabilizes mitotic cyclins and prevents cell cycle progression via inhibition of UBE2C in colorectal carcinoma.
Colorectal Neoplasms
Comprehensive analysis of differentially expressed genes reveals the promotive effects of UBE2T on colorectal cancer cell proliferation.
Colorectal Neoplasms
Expression of ubiquitin-conjugating enzyme E2T in colorectal cancers and clinical implications.
Colorectal Neoplasms
Expression Status of UBE2Q2 in Colorectal Primary Tumors and Cell Lines.
Colorectal Neoplasms
Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.
Colorectal Neoplasms
Induction of cell proliferation, clonogenicity and cell accumulation in S phase as a consequence of human UBE2Q1 overexpression.
Colorectal Neoplasms
Inhibition of Ubiquitin-conjugating Enzyme E2 May Activate the Degradation of Hypoxia-inducible Factors and, thus, Overcome Cellular Resistance to Radiation in Colorectal Cancer.
Colorectal Neoplasms
Promoter Methylation Status of Two Novel Human Genes, UBE2Q1 and UBE2Q2, in Colorectal Cancer: a New Finding in Iranian Patients.
Colorectal Neoplasms
RNA INTERFERENCE-MEDIATED SILENCING OF UBCH10 GENE INHIBITS COLORECTAL CANCER CELL GROWTH IN VITRO AND IN VIVO.
Colorectal Neoplasms
RNA interference-mediated silencing of UBCH10 gene inhibits colorectal cancer cell growth in vitro and in vivo.
Colorectal Neoplasms
Spatial UBE2N protein expression indicates genomic instability in colorectal cancers.
Colorectal Neoplasms
UbcH10 expression can predict prognosis and sensitivity to the antineoplastic treatment for colorectal cancer patients.
Colorectal Neoplasms
UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status.
Colorectal Neoplasms
UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.
Colorectal Neoplasms
UbcH10 overexpression is less pronounced in older colorectal cancer patients.
Colorectal Neoplasms
Ube2s stabilizes ?-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development.
Colorectal Neoplasms
Ubiquitin-conjugating enzyme E2T(UBE2T) promotes colorectal cancer progression by facilitating ubiquitination and degradation of p53.
Colorectal Neoplasms
Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-?B activation.
Coronary Artery Disease
Evaluating the association of common UBE2Z variants with coronary artery disease in an Iranian population.
COVID-19
An integrative analysis identifying transcriptional features and key genes involved in COVID-19.
Crohn Disease
Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease.
Crohn Disease
Genome-Wide Association Study of Ulcerative Colitis in Koreans Suggests Extensive Overlapping of Genetic Susceptibility With Caucasians.
Crohn Disease
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Dehydration
Cowpea and abiotic stresses: identification of reference genes for transcriptional profiling by qPCR.
Dehydration
Selection of Reference Genes for qRT-PCR Analysis in Medicinal Plant Glycyrrhiza under Abiotic Stresses and Hormonal Treatments.
Diabetes Mellitus
Association between UBE2E2 variant rs7612463 and type 2 diabetes mellitus in a Chinese Han population.
Diabetes Mellitus
Lack of association between UBE2E2 gene polymorphism (rs7612463) and type 2 diabetes mellitus in a Saudi population.
Diabetes Mellitus
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetes Mellitus, Type 2
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.
Diabetes Mellitus, Type 2
Association between the UBE2Z rs46522 and TCF7L2 rs7903146 polymorphisms with type 2 diabetes in south western Iran.
Diabetes Mellitus, Type 2
Association between UBE2E2 variant rs7612463 and type 2 diabetes mellitus in a Chinese Han population.
Diabetes Mellitus, Type 2
Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals.
Diabetes Mellitus, Type 2
Impact of KCNQ1, CDKN2A/2B, CDKAL1, HHEX, MTNR1B, SLC30A8, TCF7L2, and UBE2E2 on risk of developing type 2 diabetes in Thai population.
Diabetes Mellitus, Type 2
Lack of association between UBE2E2 gene polymorphism (rs7612463) and type 2 diabetes mellitus in a Saudi population.
Diabetes Mellitus, Type 2
Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes.
Diabetes Mellitus, Type 2
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetes Mellitus, Type 2
Type 2 Diabetes Risk Allele UBE2E2 Is Associated With Decreased Glucose-Stimulated Insulin Release in Elderly Chinese Han Individuals.
Diabetes, Gestational
Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus.
e2 ubiquitin-conjugating enzyme deficiency
A novel UBE2A mutation in a Chinese family with X-linked intellectual disability.
e2 ubiquitin-conjugating enzyme deficiency
Adjunctive use of the ketogenic diet in a young adult with UBE2A deficiency syndrome and super-refractory status epilepticus.
e2 ubiquitin-conjugating enzyme deficiency
An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression.
e2 ubiquitin-conjugating enzyme deficiency
Delineation of Clinical Manifestations of the Inherited Xq24 Microdeletion Segregating with sXCI in Mothers: Two Novel Cases with Distinct Phenotypes Ranging from UBE2A Deficiency Syndrome to Recurrent Pregnancy Loss.
e2 ubiquitin-conjugating enzyme deficiency
Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase.
e2 ubiquitin-conjugating enzyme deficiency
RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration.
e2 ubiquitin-conjugating enzyme deficiency
Refinement of the clinical and mutational spectrum of UBE2A deficiency syndrome.
e2 ubiquitin-conjugating enzyme deficiency
The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair.
e2 ubiquitin-conjugating enzyme deficiency
The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
e2 ubiquitin-conjugating enzyme deficiency
Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells.
e2 ubiquitin-conjugating enzyme deficiency
UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.
e2 ubiquitin-conjugating enzyme deficiency
UBE2A deficiency in two siblings: A novel splicing variant inherited from a maternal germline mosaicism.
e2 ubiquitin-conjugating enzyme deficiency
UBE2A deficiency syndrome: a report of two unrelated cases with large Xq24 deletions encompassing UBE2A gene.
e2 ubiquitin-conjugating enzyme deficiency
UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients.
Elliptocytosis, Hereditary
A novel mobile element inserted in the alpha spectrin gene: spectrin dayton. A truncated alpha spectrin associated with hereditary elliptocytosis.
Elliptocytosis, Hereditary
Clinical expression of alpha spectrin mutants in hereditary elliptocytosis.
Elliptocytosis, Hereditary
Four different mutations in codon 28 of alpha spectrin are associated with structurally and functionally abnormal spectrin alpha I/74 in hereditary elliptocytosis.
Elliptocytosis, Hereditary
Genetic basis of the polymorphisms of the alphaI domain of spectrin.
Elliptocytosis, Hereditary
SP alpha I/65 hereditary elliptocytosis in Calabria (southern Italy).
Elliptocytosis, Hereditary
Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway.
Elliptocytosis, Hereditary
Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis.
Elliptocytosis, Hereditary
Unique alpha-spectrin mutant in a kindred with common hereditary elliptocytosis.
Endometrial Neoplasms
Combining Bioinformatics and Experiments to Identify and Verify Key Genes with Prognostic Values in Endometrial Carcinoma.
Endometrial Neoplasms
UbcH10 Expression in Benign, Hyperplastic, and Malignant Endometrial Curetted Materials: A Tissue Microarray Study.
Endometrial Neoplasms
UBE2C Is Upregulated by Estrogen and Promotes Epithelial-Mesenchymal Transition via p53 in Endometrial Cancer.
Endometrial Neoplasms
UBE2S mediates tumor progression via SOX6/?-Catenin signaling in endometrial cancer.
Endometrial Neoplasms
Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/AKT pathway.
Epilepsy
An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression.
Epilepsy, Generalized
Adjunctive use of the ketogenic diet in a young adult with UBE2A deficiency syndrome and super-refractory status epilepticus.
Escherichia coli Infections
High ubiquitin conjugating enzyme E2 T mRNA expression and its prognostic significance in lung adenocarcinoma: A study based on the TCGA database.
Esophageal Neoplasms
Overexpression of UBE2C in esophageal squamous cell carcinoma tissues and molecular analysis.
Esophageal Neoplasms
UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
Esophageal Neoplasms
UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer.
Esophageal Neoplasms
UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells.
Esophageal Neoplasms
[Screening and identification of anoikis-resistant gene UBCH7 in esophageal cancer cells].
Esophageal Squamous Cell Carcinoma
High UBCH10 protein expression as a marker of poor prognosis in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Overexpression of UBE2C in esophageal squamous cell carcinoma tissues and molecular analysis.
Esophageal Squamous Cell Carcinoma
Preventive effect of oral hangeshashinto (TJ-14) on the development of reflux-induced esophageal cancer.
Esophageal Squamous Cell Carcinoma
UBE2C is involved in the functions of ECRG4 on esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
UBE2T Contributes to the Prognosis of Esophageal Squamous Cell Carcinoma.
Esotropia
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Fanconi Anemia
Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.
Fanconi Anemia
AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.
Fanconi Anemia
Deficiency of the Fanconi anemia E2 ubiqitin conjugase UBE2T only partially abrogates Alu-mediated recombination in a new model of homology dependent recombination.
Fanconi Anemia
Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.
Fanconi Anemia
High expression of UBE2T predicts poor prognosis and survival in multiple myeloma.
Fanconi Anemia
Homozygous missense variant in UBE2T is associated with mild Fanconi anemia phenotype.
Fanconi Anemia
Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links.
Fanconi Anemia
Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex.
Fanconi Anemia
Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T.
Fanconi Anemia
Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair.
Fanconi Anemia
Mind the metal: a fragment library-derived zinc impurity binds the E2 ubiquitin-conjugating enzyme Ube2T and induces structural rearrangements.
Fanconi Anemia
Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.
Fanconi Anemia
The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair.
Fanconi Anemia
The SH3 domain of alphaII spectrin is a target for the Fanconi anemia protein, FANCG.
Fanconi Anemia
Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia.
Fanconi Anemia
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.
Fanconi Anemia
UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells.
Fanconi Anemia
UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.
Fanconi Anemia
UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2.
Fatty Liver
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Fractures, Spontaneous
Identification of potential target genes and related regulatory transcription factors in spontaneous hairline fracture induced by hypervitaminosis A.
Gallbladder Neoplasms
Erratum: Identification of UBE2T as an independent prognostic biomarker for gallbladder cancer.
Gallbladder Neoplasms
Identification of UBE2T as an independent prognostic biomarker for gallbladder cancer.
Gastroesophageal Reflux
Preventive effect of oral hangeshashinto (TJ-14) on the development of reflux-induced esophageal cancer.
Glioblastoma
Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors.
Glioblastoma
High expression of UBE2C is associated with the aggressive progression and poor outcome of malignant glioma.
Glioblastoma
Molecular and Clinical Characterization of UBE2S in Glioma as a Biomarker for Poor Prognosis and Resistance to Chemo-Radiotherapy.
Glioblastoma
Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin.
Glioblastoma
SUMOylation Regulator-Related Molecules Can Be Used as Prognostic Biomarkers for Glioblastoma.
Glioblastoma
UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy.
Glioblastoma
UBE2T promotes glioblastoma invasion and migration via stabilizing GRP78 and regulating EMT.
Glioma
Combined elevation of AURKB and UBE2C predicts severe outcomes and therapy resistance in glioma.
Glioma
Forkhead Box M1 positively regulates UBE2C and protects glioma cells from autophagic death.
Glioma
High expression of UBE2C is associated with the aggressive progression and poor outcome of malignant glioma.
Glioma
Knockdown of ubiquitin-conjugating enzyme E2C/UbcH10 expression by RNA interference inhibits glioma cell proliferation and enhances cell apoptosis in vitro.
Glioma
Molecular and Clinical Characterization of UBE2S in Glioma as a Biomarker for Poor Prognosis and Resistance to Chemo-Radiotherapy.
Glioma
SUMOylation of PUM2 promotes the vasculogenic mimicry of glioma cells via regulating CEBPD.
Glioma
UBE2D3 Activates SHP-2 Ubiquitination to Promote Glycolysis and Proliferation of Glioma via Regulating STAT3 Signaling Pathway.
Glioma
UBE2T promotes glioblastoma invasion and migration via stabilizing GRP78 and regulating EMT.
Glioma
Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker.
Graves Disease
The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population.
Head and Neck Neoplasms
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Heart Defects, Congenital
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Hematologic Neoplasms
Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker.
Hematuria
UBE2C cell-free RNA in urine can discriminate between bladder cancer and hematuria.
Hemochromatosis
UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis.
Hepatitis
Gain of UBE2D1 facilitates hepatocellular carcinoma progression and is associated with DNA damage caused by continuous IL-6.
Hepatitis
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Hepatitis
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
Hepatitis B
Aberrant methylation of UBE2Q1 promoter is associated with poor prognosis of acute-on-chronic hepatitis B pre-liver failure.
Hepatitis B
Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Hepatitis B, Chronic
Aberrant methylation of UBE2Q1 promoter is associated with poor prognosis of acute-on-chronic hepatitis B pre-liver failure.
Hepatitis B, Chronic
Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Hepatitis B, Chronic
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
Hepatoblastoma
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Herpes Simplex
Functional characterization of residues required for the herpes simplex virus 1 E3 ubiquitin ligase ICP0 to interact with the cellular E2 ubiquitin-conjugating enzyme UBE2D1 (UbcH5a).
Herpes Simplex
Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity.
Herpes Simplex
Herpes simplex virus type 1 regulatory protein ICP0 does not protect cyclins D1 and D3 from degradation during infection.
Herpes Simplex
The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a.
Herpes Simplex
The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity.
Hirsutism
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Hirsutism
UBE2A deficiency in two siblings: A novel splicing variant inherited from a maternal germline mosaicism.
Hirsutism
UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients.
Huntington Disease
The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
Huntington Disease
Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases.
Hypersensitivity
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.
Hypersensitivity
Arabidopsis UBC13 differentially regulates two programmed cell death pathways in responses to pathogen and low-temperature stress.
Hypersensitivity
Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites.
Hypersensitivity
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.
Hypersensitivity
RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response.
Hypersensitivity
UBE2V2 (MMS2) is not required for effective immunoglobulin gene conversion or DNA damage tolerance in DT40.
Hypertelorism
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Hypervitaminosis A
Identification of potential target genes and related regulatory transcription factors in spontaneous hairline fracture induced by hypervitaminosis A.
Immune System Diseases
The E2 ubiquitin-conjugating enzyme UbcH5c: an emerging target in cancer and immune disorders.
Infarction, Middle Cerebral Artery
E2-25K SUMOylation inhibits proteasome for cell death during cerebral ischemia/reperfusion.
Infections
A functional variant in UBE2L3 contributes to HBV infection and maintains cccDNA stability by inducing degradation of APOBEC3A protein.
Infections
Antitumor effects of hsa?miR661?3p on non?small cell lung cancer in vivo and in vitro.
Infections
Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators.
Infections
E2 ubiquitin-conjugating enzyme UBE2L6 promotes Senecavirus A proliferation by stabilizing the viral RNA polymerase.
Infections
Echinococcus multilocularis infection induces UBE2N suppression via exosomal emu-miR-4989.
Infections
Evaluation of a SUMO E2 Conjugating Enzyme Involved in Resistance to Clavibacter michiganensis Subsp. michiganensis in Solanum peruvianum, Through a Tomato Mottle Virus VIGS Assay.
Infections
Herpes simplex virus type 1 regulatory protein ICP0 does not protect cyclins D1 and D3 from degradation during infection.
Infections
High ubiquitin conjugating enzyme E2 T mRNA expression and its prognostic significance in lung adenocarcinoma: A study based on the TCGA database.
Infections
Host genetic variants influencing the clinical course of hepatitis B virus infection.
Infections
ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells.
Infections
ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis.
Infections
Large-Scale Arrayed Analysis of Protein Degradation Reveals Cellular Targets for HIV-1 Vpu.
Infections
Legionella pneumophila regulates the activity of UBE2N by deamidase-mediated deubiquitination.
Infections
Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response.
Infections
Proteasome inhibition attenuates coxsackievirus-induced myocardial damage in mice.
Infections
Structural basis for the recognition of Ubc13 by the Shigella flexneri effector OspI.
Infections
The deubiquitinase OTUB1 augments NF-?B-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
Infections
The stability of HSV-1 ICP0 early after infection is defined by the RING finger and the UL13 protein kinase.
Infections
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
Infections
Ubiquitin-Conjugating Enzyme E2 L3 is Downregulated by the Chikungunya Virus nsP2 Protease.
Infections
Ubiquitin-conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection.
Infections
[Screening and identification of anoikis-resistant gene UBCH7 in esophageal cancer cells].
Infertility
Genetic association of UBE2B variants with susceptibility to male infertility in a Northeast Chinese population.
Infertility
Loss of the E2 SUMO-conjugating enzyme Ube2i in oocytes during ovarian folliculogenesis causes infertility in mice.
Infertility
UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men.
Infertility, Female
Loss of the E2 SUMO-conjugating enzyme Ube2i in oocytes during ovarian folliculogenesis causes infertility in mice.
Infertility, Male
Genetic association of UBE2B variants with susceptibility to male infertility in a Northeast Chinese population.
Infertility, Male
Spermatid nuclear and sperm periaxonemal anomalies in the mouse Ube2b null mutant.
Infertility, Male
UBE2W down-regulation promotes cell apoptosis and correlates with hypospermatogenesis.
Inflammatory Bowel Diseases
Expression Quantitative Trait Loci Analysis Identifies Associations Between Genotype and Gene Expression in Human Intestine.
Inflammatory Bowel Diseases
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Inflammatory Bowel Diseases
SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease.
Influenza in Birds
SUMO1 modification of the non-structural protein 1 of influenza A virus.
Influenza, Human
Reliable reference genes for the quantification of mRNA in human T-cells and PBMCs stimulated with live influenza virus.
Insulin Resistance
Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis.
Insulin Resistance
Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity.
Insulin Resistance
[Identification and bioinformatics analysis of differentially expressed microRNAs in mice liver tissues with a high fat diet-induced insulin resistance].
Intellectual Disability
A novel 47.2 Mb duplication on chromosomal bands Xq21.1-25 associated with mental retardation.
Intellectual Disability
A novel missense mutation in the UBE2A gene causes intellectual disability in the large X-linked family.
Intellectual Disability
A novel splice site mutation in the UBE2A gene leads to aberrant mRNA splicing in a Chinese patient with X-linked intellectual disability type Nascimento.
Intellectual Disability
A novel UBE2A mutation causes X-linked intellectual disability type Nascimento.
Intellectual Disability
A novel UBE2A mutation in a Chinese family with X-linked intellectual disability.
Intellectual Disability
Adjunctive use of the ketogenic diet in a young adult with UBE2A deficiency syndrome and super-refractory status epilepticus.
Intellectual Disability
An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression.
Intellectual Disability
KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and Lysosome-Mediated Degradation.
Intellectual Disability
Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability.
Intellectual Disability
Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy.
Intellectual Disability
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Intellectual Disability
Refinement of the clinical and mutational spectrum of UBE2A deficiency syndrome.
Intellectual Disability
The Role of the Reanalysis of Genetic Test Results in the Diagnosis of Dysmorphic Syndrome Caused by Inherited xq24 Deletion including the UBE2A and CXorf56 Genes.
Intellectual Disability
UBE2A deficiency in two siblings: A novel splicing variant inherited from a maternal germline mosaicism.
Intellectual Disability
UBE2A deficiency syndrome: a report of two unrelated cases with large Xq24 deletions encompassing UBE2A gene.
Intellectual Disability
UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients.
Intellectual Disability
X-linked intellectual disability type Nascimento is a clinically distinct, probably underdiagnosed entity.
Iron Deficiencies
A lysine-63-linked ubiquitin chain-forming conjugase, UBC13, promotes the developmental responses to iron deficiency in Arabidopsis roots.
Keratitis
ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis.
Learning Disabilities
Whole exome sequencing reveals putatively novel associations in retinopathies and drusen formation.
Leukemia
Differential regulation of PML-RAR? stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.
Leukemia
Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm.
Leukemia
Expression and localization of the CDC34 ubiquitin-conjugating enzyme in pediatric acute lymphoblastic leukemia.
Leukemia
Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia.
Leukemia
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Leukemia
Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies.
Leukemia
Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
Leukemia
Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha.
Leukemia
The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a.
Leukemia, Erythroblastic, Acute
Biosynthesis of spectrin and its assembly into the cytoskeletal system of Friend erythroleukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways.
Leukemia, Myeloid, Acute
De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways.
Leukemia, Myeloid, Acute
Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways.
Leukemia, Promyelocytic, Acute
Differential regulation of PML-RAR? stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.
Leukemia, Promyelocytic, Acute
Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
Leukemia, T-Cell
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Leukemia, T-Cell
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.
Lipodystrophy
Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy-causing mutations.
Lipodystrophy, Familial Partial
Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy-causing mutations.
Liver Cirrhosis
Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Liver Cirrhosis
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Liver Diseases
Aberrant methylation of UBE2Q1 promoter is associated with poor prognosis of acute-on-chronic hepatitis B pre-liver failure.
Liver Diseases
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Liver Diseases
Targeted deep sequencing of plasma circulating cell-free DNA reveals Vimentin and Fibulin 1 as potential epigenetic biomarkers for hepatocellular carcinoma.
Liver Neoplasms
Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on pathways and biological functions affecting the survival time of liver cancer.
Liver Neoplasms
Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases.
Liver Neoplasms
Upregulated expression of ubiquitin-conjugating enzyme E2Q1 (UBE2Q1) is associated with enhanced cell proliferation and poor prognosis in human hapatocellular carcinoma.
Lung Neoplasms
Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer.
Lung Neoplasms
Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression.
Lung Neoplasms
Effects of ubiquitin-conjugating enzyme 2C on invasion, proliferation and cell cycling of lung cancer cells.
Lung Neoplasms
KIAA0101 and UbcH10 interact to regulate non-small cell lung cancer cell proliferation by disrupting the function of the spindle assembly checkpoint.
Lung Neoplasms
Knockdown of UBE2T Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion by Suppressing the PI3K/Akt Signaling Pathway.
Lung Neoplasms
Lung Cancer and DNA Repair Genes: Multilevel Association Analysis from the International Lung Cancer Consortium.
Lung Neoplasms
miRNAs deregulation in serum of mice is associated with lung cancer related pathway deregulation induced by PM2.5.
Lung Neoplasms
The miR 495-UBE2C-ABCG2/ERCC1 axis reverses cisplatin resistance by downregulating drug resistance genes in cisplatin-resistant non-small cell lung cancer cells.
Lung Neoplasms
The Relationship Between UBE2C and AGGF1 Overexpression and Tumor Angiogenesis in Non-Small Cell Lung Cancer.
Lung Neoplasms
UbcH10 expression provides a useful tool for the prognosis and treatment of non-small cell lung cancer.
Lung Neoplasms
UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status.
Lung Neoplasms
UBE2C, Directly Targeted by miR-548e-5p, Increases the Cellular Growth and Invasive Abilities of Cancer Cells Interacting with the EMT Marker Protein Zinc Finger E-box Binding Homeobox 1/2 in NSCLC.
Lung Neoplasms
Ube2S regulates Wnt/?-catenin signaling and promotes the progression of non-small cell lung cancer.
Lung Neoplasms
UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma.
Lung Neoplasms
UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation.
Lung Neoplasms
UBE2T silencing inhibited non-small cell lung cancer cell proliferation and invasion by suppressing the wnt/?-catenin signaling pathway.
Lung Neoplasms
Ubiquitin conjugating enzyme E2 L3 promoted tumor growth of NSCLC through accelerating p27kip1 ubiquitination and degradation.
Lung Neoplasms
Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway.
Lung Neoplasms
Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers.
Lung Neoplasms
Ubiquitin-Conjugating Enzyme E2T is an Independent Prognostic Factor and Promotes Gastric Cancer Progression.
Lupus Erythematosus, Systemic
A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Effect of UBE2L3 genotype on regulation of the linear ubiquitin chain assembly complex in systemic lupus erythematosus.
Lupus Erythematosus, Systemic
The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes.
Lupus Erythematosus, Systemic
UBE2L3 Polymorphism Amplifies NF-?B Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases.
Lupus Erythematosus, Systemic
Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in Chinese population.
Lymphatic Metastasis
Association of clinicopathological features with UbcH10 expression in colorectal cancer.
Lymphatic Metastasis
Expression of UbcH10 in pancreatic ductal adenocarcinoma and its correlation with prognosis.
Lymphatic Metastasis
Overexpression of UBE2C correlates with poor prognosis in gastric cancer patients.
Lymphatic Metastasis
Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.
Lymphatic Metastasis
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data.
Lymphatic Metastasis
The clinicopathological significance of ubiquitin-conjugating enzyme E2C, leucine-rich repeated-containing G protein-coupled receptor, WW domain-containing oxidoreductase, and vasculogenic mimicry in invasive breast carcinoma.
Lymphatic Metastasis
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
Lymphatic Metastasis
The Relationship Between UBE2C and AGGF1 Overexpression and Tumor Angiogenesis in Non-Small Cell Lung Cancer.
Lymphatic Metastasis
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma.
Lymphatic Metastasis
Ube2S regulates Wnt/?-catenin signaling and promotes the progression of non-small cell lung cancer.
Lymphatic Metastasis
UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation.
Lymphoma
Furosine Induced Apoptosis by the Regulation of STAT1/STAT2 and UBA7/UBE2L6 Genes in HepG2 Cells.
Lymphoma, B-Cell
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Malaria
Identification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for Malaria Venture Malaria Box active in blood and liver stage Plasmodium falciparum parasites.
Malaria, Cerebral
Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children.
Medulloblastoma
Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene.
Medulloblastoma
Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway.
Medulloblastoma
Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/AKT pathway.
Melanoma
Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization.
Melanoma
Comprehensive Investigation into the Role of Ubiquitin-Conjugating Enzyme E2S in Melanoma Development.
Melanoma
RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/?-Catenin Signaling.
Meningioma
A study of UbcH10 expression and its association with recurrence of meningiomas.
Meningioma
RIZ1 negatively regulates ubiquitin-conjugating enzyme E2C/UbcH10 via targeting c-Myc in meningioma.
Mental Retardation, X-Linked
Delineation of Clinical Manifestations of the Inherited Xq24 Microdeletion Segregating with sXCI in Mothers: Two Novel Cases with Distinct Phenotypes Ranging from UBE2A Deficiency Syndrome to Recurrent Pregnancy Loss.
Mental Retardation, X-Linked
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Mental Retardation, X-Linked
Novel missense mutations in the ubiquitination-related gene UBE2A cause a recognizable X-linked mental retardation syndrome.
Mental Retardation, X-Linked
UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome.
Metabolic Diseases
Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity.
Metabolic Syndrome
Association analysis of genetic variants with metabolic syndrome components in the Moroccan population.
Mouth Neoplasms
Cancer Stem Cell based molecular predictors of tumor recurrence in Oral squamous cell carcinoma.
Mouth Neoplasms
UBE2S associated with OSCC proliferation by promotion of P21 degradation via the ubiquitin-proteasome system.
Mouth Neoplasms
Up-regulation of miR-455-5p by the TGF-?-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B.
Multiple Myeloma
Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma.
Multiple Myeloma
Blockade of ubiquitin-conjugating enzyme CDC34 enhances anti-myeloma activity of Bortezomib/Proteasome inhibitor PS-341.
Multiple Myeloma
High expression of UBE2T predicts poor prognosis and survival in multiple myeloma.
Multiple Myeloma
hsa-miR-631 resensitizes bortezomib-resistant multiple myeloma cell lines by inhibiting UbcH10.
Muscle Hypotonia
The Role of the Reanalysis of Genetic Test Results in the Diagnosis of Dysmorphic Syndrome Caused by Inherited xq24 Deletion including the UBE2A and CXorf56 Genes.
Muscular Atrophy
Effects of ornithine alpha-ketoglutarate on protein metabolism in Yoshida sarcoma-bearing rats.
Muscular Atrophy
UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension.
Muscular Atrophy
UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin.
Myocardial Infarction
The rs46522 Polymorphism of the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with Abnormal Metabolic Parameters in Patients with Myocardial Infarction: The Genetics of Atherosclerosis Disease Mexican Study.
Nasopharyngeal Carcinoma
Epigenetic downregulation of the ISG15-conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
High expression of ubiquitin-conjugating enzyme 2C (UBE2C) correlates with nasopharyngeal carcinoma progression.
Nasopharyngeal Carcinoma
UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3?/?-catenin pathway.
Nasopharyngeal Carcinoma
Ubiquitin-conjugating enzyme E2 B regulates the ubiquitination of O6-methylguanine-DNA methyltransferase and BCNU sensitivity in human nasopharyngeal carcinoma cells.
Neoplasm Metastasis
A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis.
Neoplasm Metastasis
Association of clinicopathological features with UbcH10 expression in colorectal cancer.
Neoplasm Metastasis
Comprehensive Investigation into the Role of Ubiquitin-Conjugating Enzyme E2S in Melanoma Development.
Neoplasm Metastasis
Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression.
Neoplasm Metastasis
Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH.
Neoplasm Metastasis
Downregulated genes by silencing MYC pathway identified with RNA-SEQ analysis as potential prognostic biomarkers in gastric adenocarcinoma.
Neoplasm Metastasis
Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer.
Neoplasm Metastasis
Expression of UbcH10 in pancreatic ductal adenocarcinoma and its correlation with prognosis.
Neoplasm Metastasis
Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays.
Neoplasm Metastasis
Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Neoplasm Metastasis
Oncogenic Activities Of UBE2S Mediated By VHL/HIF-1?/STAT3 Signal Via The Ubiquitin-Proteasome System In PDAC.
Neoplasm Metastasis
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer.
Neoplasm Metastasis
Prognostic value of ubiquitin-conjugating enzyme E2 S overexpression in hepatocellular carcinoma.
Neoplasm Metastasis
RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/?-Catenin Signaling.
Neoplasm Metastasis
RIZ1 negatively regulates ubiquitin-conjugating enzyme E2C/UbcH10 via targeting c-Myc in meningioma.
Neoplasm Metastasis
Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.
Neoplasm Metastasis
Slug-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination.
Neoplasm Metastasis
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data.
Neoplasm Metastasis
The clinicopathological significance of ubiquitin-conjugating enzyme E2C, leucine-rich repeated-containing G protein-coupled receptor, WW domain-containing oxidoreductase, and vasculogenic mimicry in invasive breast carcinoma.
Neoplasm Metastasis
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
Neoplasm Metastasis
The interplay of UBE2T and Mule in regulating Wnt/?-catenin activation to promote hepatocellular carcinoma progression.
Neoplasm Metastasis
The Relationship Between UBE2C and AGGF1 Overexpression and Tumor Angiogenesis in Non-Small Cell Lung Cancer.
Neoplasm Metastasis
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma.
Neoplasm Metastasis
UBE2C, Directly Targeted by miR-548e-5p, Increases the Cellular Growth and Invasive Abilities of Cancer Cells Interacting with the EMT Marker Protein Zinc Finger E-box Binding Homeobox 1/2 in NSCLC.
Neoplasm Metastasis
UBE2I promotes metastasis and correlates with poor prognosis in hepatocellular carcinoma.
Neoplasm Metastasis
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
Neoplasm Metastasis
UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development.
Neoplasm Metastasis
UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/?-catenin signaling pathway.
Neoplasm Metastasis
Ube2S regulates Wnt/?-catenin signaling and promotes the progression of non-small cell lung cancer.
Neoplasm Metastasis
UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3?/?-catenin pathway.
Neoplasm Metastasis
UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation.
Neoplasm Metastasis
Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy.
Neoplasm Metastasis
Ubiquitin Conjugating Enzyme E2 H (UBE2H) Is Linked to Poor Outcomes and Metastasis in Lung Adenocarcinoma.
Neoplasm Metastasis
Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-[cyrillic small letter ka]B mediated matrix metalloproteinase-1 gene regulation.
Neoplasm Metastasis
Ubiquitin-conjugating enzyme E2T(UBE2T) promotes colorectal cancer progression by facilitating ubiquitination and degradation of p53.
Neoplasm Metastasis
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.
Neoplasm Metastasis
Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway.
Neoplasm Metastasis
Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway.
Neoplasm Metastasis
Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-?B activation.
Neoplasm Metastasis
Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through ?-catenin-EGFR-PI3K-Akt-mTOR signaling pathway.
Neoplasms
A Complex Regulatory Network Coordinating Cell Cycles During Caenorhabditis elegans Development Is Revealed by a Genome-Wide RNAi Screen.
Neoplasms
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.
Neoplasms
A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissue.
Neoplasms
A molecular basis for stabilization of the von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase.
Neoplasms
A monoclonal antibody against a potential cancer biomarker, human ubiquitin-conjugating enzyme E2.
Neoplasms
All-trans retinoic acid treatment of Wilms tumor cells reverses expression of genes associated with high risk and relapse in vivo.
Neoplasms
Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.
Neoplasms
AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.
Neoplasms
Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene.
Neoplasms
Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors.
Neoplasms
Antitumor effects of hsa?miR661?3p on non?small cell lung cancer in vivo and in vitro.
Neoplasms
Association of clinicopathological features with UbcH10 expression in colorectal cancer.
Neoplasms
Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer.
Neoplasms
Cancer Stem Cell based molecular predictors of tumor recurrence in Oral squamous cell carcinoma.
Neoplasms
CCI-779 Inhibits Cell-Cycle G2-M Progression and Invasion of Castration-Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability.
Neoplasms
Cell division cycle 34 is highly expressed in hepatitis C virus-positive hepatocellular carcinoma with favorable phenotypes.
Neoplasms
Changes in the transcriptome of bovine ovarian cortex during follicle activation in vitro.
Neoplasms
Chromenopyrimidinone Controls Stemness and Malignancy by suppressing CD133 Expression in Hepatocellular Carcinoma.
Neoplasms
Clinical implications of gene dosage and gene expression patterns in diploid breast carcinoma.
Neoplasms
Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer.
Neoplasms
Combined elevation of AURKB and UBE2C predicts severe outcomes and therapy resistance in glioma.
Neoplasms
Comprehensive Investigation into the Role of Ubiquitin-Conjugating Enzyme E2S in Melanoma Development.
Neoplasms
Constitutional trisomy 8p11.21-q11.21 mosaicism: a germline alteration predisposing to myeloid leukaemia.
Neoplasms
Depletion of UBE2C reduces ovarian cancer malignancy and reverses cisplatin resistance via downregulating CDK1.
Neoplasms
Deregulation of Rb-E2F1 axis causes chromosomal instability by engaging the transactivation function of Cdc20-anaphase-promoting complex/cyclosome.
Neoplasms
Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression.
Neoplasms
Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH.
Neoplasms
Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling.
Neoplasms
Differentially expressed genes in hormone refractory prostate cancer: association with chromosomal regions involved with genetic aberrations.
Neoplasms
DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables.
Neoplasms
Downregulation of UBE2E2 in rat liver cells after hepatocarcinogen treatment facilitates cell proliferation and slowing down of DNA damage response in GST-P-expressing preneoplastic lesions.
Neoplasms
Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer.
Neoplasms
Elevated TOP2A and UBE2C expressions correlate with poor prognosis in patients with surgically resected lung adenocarcinoma: a study based on immunohistochemical analysis and bioinformatics.
Neoplasms
Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
Neoplasms
Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.
Neoplasms
Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer.
Neoplasms
Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients.
Neoplasms
Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma.
Neoplasms
Expression of UbcH10 in pancreatic ductal adenocarcinoma and its correlation with prognosis.
Neoplasms
Expression of UBE2C in lung adenocarcinoma based on database analysis and its clinical significance.
Neoplasms
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Neoplasms
Expression of ubiquitin-conjugating enzyme E2T in colorectal cancers and clinical implications.
Neoplasms
Gain of UBE2D1 facilitates hepatocellular carcinoma progression and is associated with DNA damage caused by continuous IL-6.
Neoplasms
Gene expression patterns in the histopathological classification of epithelial ovarian cancer.
Neoplasms
Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy.
Neoplasms
Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays.
Neoplasms
Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma.
Neoplasms
Global analysis of gene expression signature and diagnostic/prognostic biomarker identification of hepatocellular carcinoma.
Neoplasms
HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases.
Neoplasms
High Expression of UBE2B as a Poor Prognosis Factor in Patients With Rectal Cancer Following Chemoradiotherapy.
Neoplasms
High expression of UBE2C is associated with the aggressive progression and poor outcome of malignant glioma.
Neoplasms
High ubiquitin conjugating enzyme E2 T mRNA expression and its prognostic significance in lung adenocarcinoma: A study based on the TCGA database.
Neoplasms
Homology modeling and virtual screening of ubiquitin conjugation enzyme E2A for designing a novel selective antagonist against cancer.
Neoplasms
HP1? Sensitizes Cervical Cancer Cells to Cisplatin through the Suppression of UBE2L3.
Neoplasms
Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Neoplasms
Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T.
Neoplasms
Identification of a novel microRNA-mRNA regulatory biomodule in human prostate cancer.
Neoplasms
Identification of a potential tumor suppressor gene, UBL3, in non-small cell lung cancer.
Neoplasms
Identification of biomarkers correlated with diagnosis and prognosis of endometrial cancer using bioinformatics analysis.
Neoplasms
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Neoplasms
Identification of epigenetically downregulated Tmem70 and Ube2e2 in rat liver after 28-day treatment with hepatocarcinogenic thioacetamide showing gene product downregulation in hepatocellular preneoplastic and neoplastic lesions produced by tumor promotion.
Neoplasms
Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis.
Neoplasms
Identification of hub genes involved in the occurrence and development of hepatocellular carcinoma via bioinformatics analysis.
Neoplasms
Identification of Novel Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma using Bioinformatics Analysis.
Neoplasms
Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression.
Neoplasms
Identification of small molecule inhibitors against UBE2C by using docking studies.
Neoplasms
Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases.
Neoplasms
Identification of UBE2T as an independent prognostic biomarker for gallbladder cancer.
Neoplasms
Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agents.
Neoplasms
Increased Expression of UBE2T Predicting Poor Survival of Epithelial Ovarian Cancer: Based on Comprehensive Analysis of UBE2s, Clinical Samples, and the GEO Database.
Neoplasms
Induction of cell proliferation, clonogenicity and cell accumulation in S phase as a consequence of human UBE2Q1 overexpression.
Neoplasms
Inhibition of UBE2N-dependent CDK6 protein degradation by miR-934 promotes human bladder cancer cell growth.
Neoplasms
Integrated clinicopathological features and gene microarray analysis of pancreatic neuroendocrine tumors.
Neoplasms
Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3.
Neoplasms
Involvement of ubiquitin-conjugating enzyme E2C in proliferation and invasion of prostate carcinoma cells.
Neoplasms
KIAA0101 and UbcH10 interact to regulate non-small cell lung cancer cell proliferation by disrupting the function of the spindle assembly checkpoint.
Neoplasms
Knockdown of UbcH10 Enhances the Chemosensitivity of Dual Drug Resistant Breast Cancer Cells to Epirubicin and Docetaxel.
Neoplasms
Knockdown of UBE2T Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion by Suppressing the PI3K/Akt Signaling Pathway.
Neoplasms
Lentivirus-mediated RNA interference targeting UbcH10 reduces cell growth and invasion of human osteosarcoma cells via inhibition of Ki-67 and matrix metalloproteinases.
Neoplasms
LncRNA MALAT1 Regulating Lung Carcinoma Progression via the miR-491-5p/UBE2C Axis.
Neoplasms
Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer.
Neoplasms
MicroRNA miR-147b promotes tumor growth via targeting UBE2N in hepatocellular carcinoma.
Neoplasms
Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo.
Neoplasms
MiR-525-5p Repressed Metastasis and Anoikis Resistance in Cervical Cancer via Blocking UBE2C/ZEB1/2 Signal Axis.
Neoplasms
miRNA?101?3p.1 as an independent diagnostic biomarker aggravates chronic obstructive pulmonary disease via activation of the EGFR/PI3K/AKT signaling pathway.
Neoplasms
Molecular and Clinical Characterization of UBE2S in Glioma as a Biomarker for Poor Prognosis and Resistance to Chemo-Radiotherapy.
Neoplasms
Molecular characterization of central neurocytomas: Potential markers for tumor typing and progression.
Neoplasms
Niclosamide Induces Cell Cycle Arrest in G1 Phase in Head and Neck Squamous Cell Carcinoma Through Let-7d/CDC34 Axis.
Neoplasms
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
Neoplasms
Oncogenic Activities Of UBE2S Mediated By VHL/HIF-1?/STAT3 Signal Via The Ubiquitin-Proteasome System In PDAC.
Neoplasms
Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9.
Neoplasms
Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.
Neoplasms
Overexpression of UbcH10 alternates the cell cycle profile and accelerate the tumor proliferation in colon cancer.
Neoplasms
Overexpression of ubiquitin-conjugating enzyme E2 L3 in hepatocellular carcinoma potentiates apoptosis evasion by inhibiting the GSK3?/p65 pathway.
Neoplasms
Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin.
Neoplasms
Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.
Neoplasms
Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.
Neoplasms
Prognostic significance of UBE2C mRNA expression in high-risk early breast cancer. A Hellenic Cooperative Oncology Group (HeCOG) Study.
Neoplasms
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer.
Neoplasms
Prognostic value of ubiquitin-conjugating enzyme E2 S overexpression in hepatocellular carcinoma.
Neoplasms
Promoter Methylation Status of Two Novel Human Genes, UBE2Q1 and UBE2Q2, in Colorectal Cancer: a New Finding in Iranian Patients.
Neoplasms
Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality.
Neoplasms
Quantitative SWATH-Based Proteomic Profiling for Identification of Mechanism-Driven Diagnostic Biomarkers Conferring in the Progression of Metastatic Prostate Cancer.
Neoplasms
RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/?-Catenin Signaling.
Neoplasms
Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition.
Neoplasms
RNA INTERFERENCE-MEDIATED SILENCING OF UBCH10 GENE INHIBITS COLORECTAL CANCER CELL GROWTH IN VITRO AND IN VIVO.
Neoplasms
RNA interference-mediated silencing of UBCH10 gene inhibits colorectal cancer cell growth in vitro and in vivo.
Neoplasms
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Neoplasms
RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity that is Essential for DNA Double-Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.
Neoplasms
Role of ubiquitin-conjugating enzyme E2T in the carcinogenesis and progression of pancreatic cancer.
Neoplasms
SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T.
Neoplasms
Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.
Neoplasms
Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10.
Neoplasms
Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification.
Neoplasms
Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors.
Neoplasms
Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis.
Neoplasms
Targeting the ubiquitin-conjugating enzyme E2D4 for cancer drug discovery-a structure-based approach.
Neoplasms
The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.
Neoplasms
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data.
Neoplasms
The clinicopathological significance of ubiquitin-conjugating enzyme E2C, leucine-rich repeated-containing G protein-coupled receptor, WW domain-containing oxidoreductase, and vasculogenic mimicry in invasive breast carcinoma.
Neoplasms
The E2 ubiquitin-conjugating enzyme UbcH5c: an emerging target in cancer and immune disorders.
Neoplasms
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
Neoplasms
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.
Neoplasms
The interplay of UBE2T and Mule in regulating Wnt/?-catenin activation to promote hepatocellular carcinoma progression.
Neoplasms
The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.
Neoplasms
The Relationship Between UBE2C and AGGF1 Overexpression and Tumor Angiogenesis in Non-Small Cell Lung Cancer.
Neoplasms
The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization.
Neoplasms
Tissue Effects in a Randomized Controlled Trial of Short-term Finasteride in Early Prostate Cancer.
Neoplasms
Transcript Levels of Androgen Receptor Variant 7 and Ubiquitin-Conjugating Enzyme 2C in Hormone Sensitive Prostate Cancer and Castration-Resistant Prostate Cancer.
Neoplasms
Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China.
Neoplasms
Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia.
Neoplasms
Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade.
Neoplasms
Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105.
Neoplasms
Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors.
Neoplasms
UbcH10 a Major Actor in Cancerogenesis and a Potential Tool for Diagnosis and Therapy.
Neoplasms
UbcH10 Expression in Benign, Hyperplastic, and Malignant Endometrial Curetted Materials: A Tissue Microarray Study.
Neoplasms
UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status.
Neoplasms
UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.
Neoplasms
UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis.
Neoplasms
UBE2C cell-free RNA in urine can discriminate between bladder cancer and hematuria.
Neoplasms
UBE2C functions as a potential oncogene by enhancing cell proliferation, migration, invasion, and drug resistance in hepatocellular carcinoma cells.
Neoplasms
UBE2C is a marker of unfavorable prognosis in bladder cancer after radical cystectomy.
Neoplasms
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma.
Neoplasms
UBE2C Is a Potential Biomarker of Intestinal-Type Gastric Cancer With Chromosomal Instability.
Neoplasms
UBE2C is involved in the functions of ECRG4 on esophageal squamous cell carcinoma.
Neoplasms
UBE2C is overexpressed in ESCC tissues and its abrogation attenuates the malignant phenotype of ESCC cell lines.
Neoplasms
UBE2C Overexpression Aggravates Patient Outcome by Promoting Estrogen-Dependent/Independent Cell Proliferation in Early Hormone Receptor-Positive and HER2-Negative Breast Cancer.
Neoplasms
UBE2C, Directly Targeted by miR-548e-5p, Increases the Cellular Growth and Invasive Abilities of Cancer Cells Interacting with the EMT Marker Protein Zinc Finger E-box Binding Homeobox 1/2 in NSCLC.
Neoplasms
UBE2D3 Activates SHP-2 Ubiquitination to Promote Glycolysis and Proliferation of Glioma via Regulating STAT3 Signaling Pathway.
Neoplasms
UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer.
Neoplasms
UBE2I promotes metastasis and correlates with poor prognosis in hepatocellular carcinoma.
Neoplasms
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
Neoplasms
UBE2QL1 is Disrupted by a Constitutional Translocation Associated with Renal Tumour Predisposition and is a Novel Candidate Renal Tumour Suppressor Gene.
Neoplasms
UBE2S enhances the ubiquitination of p53 and exerts oncogenic activities in hepatocellular carcinoma.
Neoplasms
UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1.
Neoplasms
Ube2s expression is elevated in hepatocellular carcinoma and predicts poor prognosis of the patients.
Neoplasms
UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development.
Neoplasms
UBE2S mediates tumor progression via SOX6/?-Catenin signaling in endometrial cancer.
Neoplasms
UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells.
Neoplasms
Ube2S regulates Wnt/?-catenin signaling and promotes the progression of non-small cell lung cancer.
Neoplasms
Ube2s stabilizes ?-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development.
Neoplasms
UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma.
Neoplasms
UBE2T promotes glioblastoma invasion and migration via stabilizing GRP78 and regulating EMT.
Neoplasms
UBE2T promotes proliferation and regulates PI3K/Akt signaling in renal cell carcinoma.
Neoplasms
UBE2T promotes proliferation, invasion and glycolysis of breast cancer cells by regualting the PI3K/AKT signaling pathway.
Neoplasms
UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation.
Neoplasms
UBE2T silencing inhibited non-small cell lung cancer cell proliferation and invasion by suppressing the wnt/?-catenin signaling pathway.
Neoplasms
UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells.
Neoplasms
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
Neoplasms
Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy.
Neoplasms
UBE2V2 Positively Correlates With PD-L1 Expression and Confers Poor Patient Survival in Lung Adenocarcinoma.
Neoplasms
Ubiquitin conjugating enzyme E2 L3 promoted tumor growth of NSCLC through accelerating p27kip1 ubiquitination and degradation.
Neoplasms
Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-[cyrillic small letter ka]B mediated matrix metalloproteinase-1 gene regulation.
Neoplasms
Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway.
Neoplasms
Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers.
Neoplasms
Ubiquitin-Conjugating Enzyme E2T is an Independent Prognostic Factor and Promotes Gastric Cancer Progression.
Neoplasms
Ubiquitin-conjugating enzyme E2T knockdown suppresses hepatocellular tumorigenesis via inducing cell cycle arrest and apoptosis.
Neoplasms
Ubiquitin-conjugating enzyme E2T regulates cell proliferation and migration in cholangiocarcinoma.
Neoplasms
Ubiquitin-conjugating enzyme E2T(UBE2T) promotes colorectal cancer progression by facilitating ubiquitination and degradation of p53.
Neoplasms
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.
Neoplasms
Ubiquitin-conjugating enzyme UbcH10 promotes gastric cancer growth and is a potential biomarker for gastric cancer.
Neoplasms
Ubiquitin-Conjugating Enzyme UBE2C Is Highly Expressed in Breast Microcalcification Lesions.
Neoplasms
Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker.
Neoplasms
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Neoplasms
Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation.
Neoplasms
Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway.
Neoplasms
Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-?B activation.
Neoplasms
Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-? through p38 MAPK and JNK signaling pathways in human lung carcinoma.
Neoplasms
Up-regulation of miR-455-5p by the TGF-?-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B.
Neoplasms
Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through ?-catenin-EGFR-PI3K-Akt-mTOR signaling pathway.
Neoplasms
Upregulation of ubiquitin-conjugating enzyme E2T (UBE2T) predicts poor prognosis and promotes hepatocellular carcinoma progression.
Neoplasms
Upregulation of ubiquitin-conjugating enzyme E2Z is associated with human hepatocellular carcinoma.
Neoplasms
Validation of UBE2C protein as a prognostic marker in node-positive breast cancer.
Neoplasms
WITHDRAWN: Production of a novel UBE2S anti-body and significance of its expression in some tumors.
Neoplasms
Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/AKT pathway.
Neuroblastoma
A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways.
Neurodegenerative Diseases
Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.
Neurodegenerative Diseases
D: -Serine exposure resulted in gene expression changes implicated in neurodegenerative disorders and neuronal dysfunction in male Fischer 344 rats.
Neurodegenerative Diseases
Expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveals modest age-dependent decreases in specific neurons.
Neurodegenerative Diseases
Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models.
Neurodegenerative Diseases
The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
Neurofibrosarcoma
Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.
Obesity
Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis.
Obesity
GWA-based pleiotropic analysis identified potential SNPs and genes related to type 2 diabetes and obesity.
Obesity
Identification of a loss-of-function mutation in Ube2l6 associated with obesity resistance.
Obesity
Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity.
Obesity, Morbid
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Oligospermia
UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men.
Oligospermia
UBE2W down-regulation promotes cell apoptosis and correlates with hypospermatogenesis.
Osteoarthritis
MicroRNA-101a-3p could be involved in the pathogenesis of temporomandibular joint osteoarthritis by mediating UBE2D1 and FZD4.
Osteoporosis
Gene co-expression network analysis identifies BRCC3 as a key regulator in osteogenic differentiation of osteoblasts through a ?-catenin signaling dependent pathway.
Osteosarcoma
Downregulation of UBE2T can enhance the radiosensitivity of osteosarcoma in vitro and in vivo.
Osteosarcoma
Knockdown of UBE2T Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion by Suppressing the PI3K/Akt Signaling Pathway.
Osteosarcoma
Lentivirus-mediated RNA interference targeting UbcH10 reduces cell growth and invasion of human osteosarcoma cells via inhibition of Ki-67 and matrix metalloproteinases.
Osteosarcoma
Screening and Interaction Analysis of Key Genes in miR-542-3p Over- Expressed Osteosarcoma Cells by Bioinformatics.
Osteosarcoma
Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation.
Ovarian Neoplasms
Depletion of UBE2C reduces ovarian cancer malignancy and reverses cisplatin resistance via downregulating CDK1.
Ovarian Neoplasms
Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer.
Ovarian Neoplasms
Functional transcriptomic annotation and protein-protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer.
Ovarian Neoplasms
Gene expression patterns in the histopathological classification of epithelial ovarian cancer.
Ovarian Neoplasms
Increased Expression of UBE2T Predicting Poor Survival of Epithelial Ovarian Cancer: Based on Comprehensive Analysis of UBE2s, Clinical Samples, and the GEO Database.
Ovarian Neoplasms
Integrated bioinformatic analysis identifies UBE2Q1 as a potential prognostic marker for high grade serous ovarian cancer.
Ovarian Neoplasms
Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer.
Ovarian Neoplasms
The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer.
Ovarian Neoplasms
The lncRNA 'UCA1' modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels.
Ovarian Neoplasms
UBE2N Regulates Paclitaxel Sensitivity of Ovarian Cancer via Fos/P53 Axis.
Ovarian Neoplasms
UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/?-catenin signaling pathway.
Pancreatic Neoplasms
Oncogenic Activities Of UBE2S Mediated By VHL/HIF-1?/STAT3 Signal Via The Ubiquitin-Proteasome System In PDAC.
Pancreatic Neoplasms
Role of ubiquitin-conjugating enzyme E2T in the carcinogenesis and progression of pancreatic cancer.
Pancreatic Neoplasms
Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.
Papilloma
Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7.
Parkinson Disease
Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models.
Parkinson Disease
Thyroarytenoid Muscle Gene Expression in a Rat Model of Early-Onset Parkinson's Disease.
Parkinson Disease
Ubiquitin enzymes, ubiquitin and proteasome activity in blood mononuclear cells of MCI, Alzheimer and Parkinson patients.
Persistent Infection
The use of endogenous and exogenous reference RNAs for qualitative and quantitative detection of PRRSV in porcine semen.
Pituitary Neoplasms
Combination of multiple mRNA markers (PTTG1, Survivin, UbcH10 and TK1) in the diagnosis of Taiwanese patients with breast cancer by membrane array.
Pleural Effusion
A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression and localization of the CDC34 ubiquitin-conjugating enzyme in pediatric acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Induction of cell proliferation, clonogenicity and cell accumulation in S phase as a consequence of human UBE2Q1 overexpression.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
UBE2Q1, as a Down Regulated Gene in Pediatric Acute Lymphoblastic Leukemia.
Prostatic Hyperplasia
Identification of key genes and pathways in benign prostatic hyperplasia.
Prostatic Neoplasms
A Hierarchical Machine Learning Model to Discover Gleason Grade-Specific Biomarkers in Prostate Cancer.
Prostatic Neoplasms
A novel prostate cancer therapeutic strategy using icaritin-activated arylhydrocarbon-receptor to co-target androgen receptor and its splice variants.
Prostatic Neoplasms
Anticancer effect of icaritin on prostate cancer via regulating miR-381-3p and its target gene UBE2C.
Prostatic Neoplasms
CCI-779 Inhibits Cell-Cycle G2-M Progression and Invasion of Castration-Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability.
Prostatic Neoplasms
Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer.
Prostatic Neoplasms
Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer.
Prostatic Neoplasms
Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray.
Prostatic Neoplasms
Identification of UBE2C as hub gene in driving prostate cancer by integrated bioinformatics analysis.
Prostatic Neoplasms
Involvement of ubiquitin-conjugating enzyme E2C in proliferation and invasion of prostate carcinoma cells.
Prostatic Neoplasms
Knockdown of UBE2T Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion by Suppressing the PI3K/Akt Signaling Pathway.
Prostatic Neoplasms
KRAS oncogene rearrangements and gene fusions: unexpected rare encounters in late-stage prostate cancers.
Prostatic Neoplasms
Long non-coding RNA LINC01116 acts as an oncogene in prostate cancer cells through regulation of miR-744-5p/UBE2L3 axis.
Prostatic Neoplasms
MED1 mediates androgen receptor splice variant induced gene expression in the absence of ligand.
Prostatic Neoplasms
miR-499a inhibits the proliferation and apoptosis of prostate cancer via targeting UBE2V2.
Prostatic Neoplasms
Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.
Prostatic Neoplasms
Suppression of prostate tumor cell survival by antisense oligonucleotide-mediated inhibition of AR-V7 mRNA synthesis.
Psoriasis
hsa-miR-4516 Mediated Downregulation of STAT3/CDK6/UBE2N Plays a Role in PUVA Induced Apoptosis in Keratinocytes.
Pulmonary Disease, Chronic Obstructive
Screening and Identification of Differentially Expressed Genes Expressed among Left and Right Colon Adenocarcinoma.
Rectal Neoplasms
High Expression of UBE2B as a Poor Prognosis Factor in Patients With Rectal Cancer Following Chemoradiotherapy.
Reperfusion Injury
UBE2D3 contributes to myocardial ischemia-reperfusion injury by regulating autophagy in dependence of p62/SQSTM1.
Retinal Degeneration
[Generation of mouse UBE2W antibody and analysis of UBE2W expression in mouse tissues]
Retinoblastoma
ARI-1, an RBR family ubiquitin-ligase, functions with UBC-18 to regulate pharyngeal development in C. elegans.
Retinoblastoma
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Retinoschisis
Whole exome sequencing reveals putatively novel associations in retinopathies and drusen formation.
Rhinitis, Allergic
miR-338-3p inhibits autophagy in a rat model of allergic rhinitis after PM2.5 exposure through AKT/mTOR signaling by targeting UBE2Q1.
RNA Virus Infections
Ubiquitin-conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection.
Sarcoma
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Sarcoma, Yoshida
Effects of ornithine alpha-ketoglutarate on protein metabolism in Yoshida sarcoma-bearing rats.
Scleroderma, Diffuse
Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population.
Scleroderma, Systemic
Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population.
Seizures
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Seizures
UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients.
Seizures
X-linked intellectual disability type Nascimento is a clinically distinct, probably underdiagnosed entity.
Shock, Septic
Screening of Key Genes of Sepsis and Septic Shock Using Bioinformatics Analysis.
Sickle Cell Trait
Preliminary characterization of a structural defect in homozygous sickled cell alpha spectrin demonstrated by a rabbit autoantibody.
Skin Abnormalities
A novel UBE2A mutation in a Chinese family with X-linked intellectual disability.
Skin Abnormalities
UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients.
Spinocerebellar Ataxias
A key lysine residue in the AXH domain of ataxin-1 is essential for its ubiquitylation.
Spinocerebellar Ataxias
The ubiquitin-conjugating enzyme UbcH6 regulates the transcriptional repression activity of the SCA1 gene product ataxin-1.
Spinocerebellar Ataxias
UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1.
Squamous Cell Carcinoma of Head and Neck
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Squamous Cell Carcinoma of Head and Neck
Robust rank aggregation and cibersort algorithm applied to the identification of key genes in head and neck squamous cell cancer.
Squamous Cell Carcinoma of Head and Neck
UBE2C promotes the progression of head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Starvation
Heat Stress Affects Pi-related Genes Expression and Inorganic Phosphate Deposition/Accumulation in Barley.
Starvation
Identification of transcription factors that bind to the 5'-UTR of the barley PHO2 gene.
Starvation
The ATG12-Conjugating Enzyme ATG10 Is Essential for Autophagic Vesicle Formation in Arabidopsis thaliana.
Starvation
Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway.
Status Epilepticus
Adjunctive use of the ketogenic diet in a young adult with UBE2A deficiency syndrome and super-refractory status epilepticus.
Stomach Neoplasms
A novel UBE2T inhibitor suppresses Wnt/?-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination.
Stomach Neoplasms
Correction: A novel UBE2T inhibitor suppresses Wnt/?-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination.
Stomach Neoplasms
Identification of Potential Biomarkers Involved in Gastric Cancer Through Integrated Analysis of Non-Coding RNA Associated Competing Endogenous RNAs Network.
Stomach Neoplasms
Inhibition of microRNA-17/20a suppresses cell proliferation in gastric cancer by modulating UBE2C expression.
Stomach Neoplasms
Overexpression of UBE2C correlates with poor prognosis in gastric cancer patients.
Stomach Neoplasms
UBE2C induces EMT through Wnt/??catenin and PI3K/Akt signaling pathways by regulating phosphorylation levels of Aurora-A.
Stomach Neoplasms
UBE2C Is a Potential Biomarker of Intestinal-Type Gastric Cancer With Chromosomal Instability.
Stomach Neoplasms
UBE2C mRNA expression controlled by miR-300 and HuR determines its oncogenic role in gastric cancer.
Stomach Neoplasms
Ubiquitin-Conjugating Enzyme E2T is an Independent Prognostic Factor and Promotes Gastric Cancer Progression.
Stomach Neoplasms
Ubiquitin-conjugating enzyme UbcH10 promotes gastric cancer growth and is a potential biomarker for gastric cancer.
Thyroid Carcinoma, Anaplastic
Array-CGH identifies cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma.
Thyroid Carcinoma, Anaplastic
The UbcH10 gene is a novel therapeutic target in anaplastic thyroid carcinoma.
Thyroid Carcinoma, Anaplastic
UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.
Thyroid Diseases
The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population.
Thyroid Neoplasms
Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas.
Thyroid Neoplasms
UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas.
Thyroid Neoplasms
UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.
Thyroiditis
The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population.
Triple Negative Breast Neoplasms
Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer.
Triple Negative Breast Neoplasms
RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence.
Triple Negative Breast Neoplasms
Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib.
Tuberous Sclerosis
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Urinary Bladder Neoplasms
A potential panel of five mRNAs in urinary extracellular vesicles for the detection of bladder cancer.
Urinary Bladder Neoplasms
Knockdown of UBE2T Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion by Suppressing the PI3K/Akt Signaling Pathway.
Urinary Bladder Neoplasms
Multicenter validation of cyclin D1, MCM7, TRIM29, and UBE2C as prognostic protein markers in non-muscle-invasive bladder cancer.
Urinary Bladder Neoplasms
UBE2C cell-free RNA in urine can discriminate between bladder cancer and hematuria.
Urinary Bladder Neoplasms
UBE2C is a marker of unfavorable prognosis in bladder cancer after radical cystectomy.
Urinary Bladder Neoplasms
UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1.
Urinary Bladder Neoplasms
UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells.
Urinary Bladder Neoplasms
[Analysis and verification of the interaction network of differentially expressed genes in invasive bladder cancer.]
Uterine Cervical Neoplasms
Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling.
Uterine Cervical Neoplasms
Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
Uterine Cervical Neoplasms
Expression and clinical significance of UBE2V1 in cervical cancer.
Uterine Cervical Neoplasms
Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy.
Uterine Cervical Neoplasms
HP1? Sensitizes Cervical Cancer Cells to Cisplatin through the Suppression of UBE2L3.
Uterine Cervical Neoplasms
HPV-mediated nuclear export of HP1? drives cervical tumorigenesis by downregulation of p53.
Uterine Cervical Neoplasms
Identification of small molecule inhibitors against UBE2C by using docking studies.
Uterine Cervical Neoplasms
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR.
Uterine Cervical Neoplasms
UHRF1 epigenetically down-regulates UbcH8 to inhibit apoptosis in cervical cancer cells.
Uterine Cervical Neoplasms
Vorinostat targets UBE2C to reverse epithelial-mesenchymal transition and control cervical cancer growth through the ubiquitination pathway.
Virus Diseases
Herpes simplex virus type 1 regulatory protein ICP0 does not protect cyclins D1 and D3 from degradation during infection.
Virus Diseases
Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.