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Information on EC 2.3.2.23 - E2 ubiquitin-conjugating enzyme and Organism(s) Dictyostelium discoideum

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.23 E2 ubiquitin-conjugating enzyme
IUBMB Comments
The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself. In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage.
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This record set is specific for:
Dictyostelium discoideum
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Word Map
The taxonomic range for the selected organisms is: Dictyostelium discoideum
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
+
[E2 ubiquitin-conjugating enzyme]-L-cysteine
=
[E1 ubiquitin-activating enzyme]-L-cysteine
+
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
Synonyms
ube2c, cdc34, ubc13, ube2t, ubch10, e2 enzyme, ube2s, ubch7, e2 ubiquitin-conjugating enzyme, ube2l3, more
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself. In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
UBE2S_DICDI
215
0
23617
Swiss-Prot
other Location (Reliability: 2)
UBE2W_DICDI
149
0
16818
Swiss-Prot
other Location (Reliability: 2)
UBCX_DICDI
149
0
17011
Swiss-Prot
other Location (Reliability: 1)
UBE2N_DICDI
154
0
17380
Swiss-Prot
other Location (Reliability: 3)
UB2J2_DICDI
241
1
27154
Swiss-Prot
other Location (Reliability: 2)
UB2JL_DICDI
170
0
19335
Swiss-Prot
other Location (Reliability: 1)
UBC2_DICDI
151
0
17155
Swiss-Prot
Mitochondrion (Reliability: 4)
UBE2C_DICDI
153
0
17473
Swiss-Prot
other Location (Reliability: 2)
UBCB_DICDI
148
0
16809
Swiss-Prot
other Location (Reliability: 2)