Information on EC 2.3.2.23 - E2 ubiquitin-conjugating enzyme and Organism(s) Mus musculus

for references in articles please use BRENDA:EC2.3.2.23
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Mus musculus


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria


The taxonomic range for the selected organisms is: Mus musculus

EC NUMBER
COMMENTARY hide
2.3.2.23
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RECOMMENDED NAME
GeneOntology No.
E2 ubiquitin-conjugating enzyme
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
protein ubiquitination
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SYSTEMATIC NAME
IUBMB Comments
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself. In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
Ube2J1-/- mice have reduced viability and fail to thrive early after birth. Male Ube2J1-/- mice are sterile due to a defect in late spermatogenesis. Removal of the cytoplasm is incomplete in Ube2J1-/- elongating spermatids, compromising the release of mature elongate spermatids into the lumen of the seminiferous tubule
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
[ubiquitin-activating protein E1]-S-ubiquitinyl-L-cysteine + [ubiquitin carrier protein UbcH7]-L-cysteine
[ubiquitin-activating protein E1]-L-cysteine + [ubiquitin carrier protein UbcH7]-S-ubiquitinyl-L-cysteine
show the reaction diagram
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?
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expresion in Escherichia coli