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Information on EC 2.3.2.2 - gamma-glutamyltransferase and Organism(s) Pseudomonas aeruginosa

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.2 gamma-glutamyltransferase
IUBMB Comments
The mammlian enzyme is part of the cell antioxidant defense mechanism. It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH levels. The protein also has EC 3.4.19.13 (glutathione hydrolase) activity [3-4]. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide. The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions [3-4].
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Pseudomonas aeruginosa
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Word Map
The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
ggt, gamma-glutamyl transpeptidase, gamma-glutamyltransferase, gamma-glutamyltranspeptidase, gamma-gtp, gamma glutamyl transferase, glutamyl transpeptidase, gamma-glutamyl-transpeptidase, gammagt, blggt, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alpha-glutamyl transpeptidase
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gamma-glutamyl peptidyltransferase
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gamma-glutamyl transpeptidase
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gamma-GPT
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gamma-GT
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gamma-GTP
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glutamyl transpeptidase
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glutamyltransferase, gamma-
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L-gamma-glutamyl transpeptidase
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L-gamma-glutamyltransferase
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L-glutamyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aminoacyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase
The mammlian enzyme is part of the cell antioxidant defense mechanism. It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH levels. The protein also has EC 3.4.19.13 (glutathione hydrolase) activity [3-4]. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide. The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions [3-4].
CAS REGISTRY NUMBER
COMMENTARY hide
9046-27-9
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A8G3JIW9_PSEAI
577
0
62060
TrEMBL
-
A0A8G3J1A1_PSEAI
557
0
59902
TrEMBL
-
A0A2R3IWC9_PSEAI
557
0
59859
TrEMBL
-
A0A8G2VBF0_PSEAI
577
0
62031
TrEMBL
-
A0A8G5QFM0_PSEAI
577
0
62047
TrEMBL
-
A0A8G3VI48_PSEAI
577
0
62032
TrEMBL
-
A0A8G3Q713_PSEAI
557
0
59932
TrEMBL
-
A0A8F9V7N7_PSEAI
577
0
62028
TrEMBL
-
A0A8G4TSN8_PSEAI
557
0
59846
TrEMBL
-
A0A8G3TFB4_PSEAI
577
0
61941
TrEMBL
-
A0A8G3W3Q6_PSEAI
577
0
61973
TrEMBL
-
A0A8F9JSE5_PSEAI
557
0
59902
TrEMBL
-
A0A485FXF1_PSEAI
577
0
62138
TrEMBL
-
A0A8G2UWB1_PSEAI
577
0
62031
TrEMBL
-
A0A5F1BI81_PSEAI
556
0
59759
TrEMBL
-
A0A8F9JJ40_PSEAI
557
0
59846
TrEMBL
-
A0A8G5ZGG1_PSEAI
577
0
61967
TrEMBL
-
A0A8G5JDU6_PSEAI
577
0
61972
TrEMBL
-
A0A8G4E6E8_PSEAI
577
0
62016
TrEMBL
-
A0A7M2ZYM5_PSEAI
577
0
62031
TrEMBL
-
A0A659BNI3_PSEAI
557
0
59904
TrEMBL
-
A0A643ERW8_PSEAI
577
0
61973
TrEMBL
-
A0A8G6WQH3_PSEAI
577
0
61959
TrEMBL
-
A0A485GTE7_PSEAI
261
0
27300
TrEMBL
-
A0A3S3W547_PSEAI
557
0
59860
TrEMBL
-
A0A4P0TDX4_PSEAI
478
0
52334
TrEMBL
-
A0A5E5QVV7_PSEAI
557
0
59890
TrEMBL
-
A0A8G3YMA8_PSEAI
577
0
61969
TrEMBL
-
A0A8G5J0M2_PSEAI
557
0
59874
TrEMBL
-
A0A8G2Z906_PSEAI
557
0
59963
TrEMBL
-
A0A2R3IU24_PSEAI
577
0
62138
TrEMBL
-
A0A3M5E4V0_PSEAI
478
0
52380
TrEMBL
-
A0A8G5NCR9_PSEAI
577
0
62043
TrEMBL
-
A0A8G3J8Z0_PSEAI
577
0
61989
TrEMBL
-
A0A3S0J129_PSEAI
557
0
59889
TrEMBL
-
A0A8G2QF00_PSEAI
557
0
59902
TrEMBL
-
A0A8H2FFM8_PSEAI
557
0
59900
TrEMBL
-
A0A0F7QWE3_PSEAI
557
0
59874
TrEMBL
-
A0A7M3B105_PSEAI
577
0
62036
TrEMBL
-
A0A8G7PYW1_PSEAI
557
0
59904
TrEMBL
-
A0A8F8R2R5_PSEAI
577
0
62069
TrEMBL
-
A0A485G327_PSEAI
538
0
58352
TrEMBL
-
A0A8G7CQV3_PSEAI
577
0
62009
TrEMBL
-
A0A0F6U876_PSEAI
577
0
62002
TrEMBL
-
A0A8G4M6F2_PSEAI
557
0
59847
TrEMBL
-
A0A6A9K0V7_PSEAI
557
0
59876
TrEMBL
-
A0A431XHD1_PSEAI
577
0
62136
TrEMBL
-
A0A8G6SED2_PSEAI
557
0
59902
TrEMBL
-
A0A233SZX2_PSEAI
577
0
62011
TrEMBL
-
A0A8G1Q8E2_PSEAI
577
0
62011
TrEMBL
-
A0A8G6UD36_PSEAI
577
0
62076
TrEMBL
-
A0A8G7FUQ3_PSEAI
577
0
62030
TrEMBL
-
A0A8G6E9M0_PSEAI
577
0
62017
TrEMBL
-
A0A8G2VWB4_PSEAI
557
0
59845
TrEMBL
-
A0A8G2WYE5_PSEAI
557
0
59816
TrEMBL
-
A0A485GXX9_PSEAI
192
0
20977
TrEMBL
-
A0A8B4ZIJ5_PSEAI
557
0
59930
TrEMBL
-
A0A8G3ANC3_PSEAI
577
0
62105
TrEMBL
-
A0A080VRF4_PSEAI
577
0
62091
TrEMBL
-
A0A7M3AYZ0_PSEAI
557
0
59901
TrEMBL
-
A0A8G2QJR6_PSEAI
577
0
62030
TrEMBL
-
A0A3S3TLK5_PSEAI
577
0
61995
TrEMBL
-
A0A8G5KQX3_PSEAI
557
0
59914
TrEMBL
-
A0A8G3UVR4_PSEAI
557
0
59816
TrEMBL
-
A0A8G6X5Q3_PSEAI
557
0
59903
TrEMBL
-
A0A6B1Y3P4_PSEAI
557
0
59904
TrEMBL
-
A0A8G3QDA5_PSEAI
528
0
56735
TrEMBL
-
A0A8G6L5G3_PSEAI
577
0
61956
TrEMBL
-
A0A8G2RLU6_PSEAI
577
0
62005
TrEMBL
-
A0A241XGQ9_PSEAI
577
0
62017
TrEMBL
-
A0A8G5Q9X1_PSEAI
577
0
62017
TrEMBL
-
A0A0A8RKH7_PSEAI
557
0
59888
TrEMBL
-
A0A0K3A9L5_PSEAI
577
0
62061
TrEMBL
-
A0A8G6RDF9_PSEAI
557
0
59888
TrEMBL
-
A0A8G3ZI40_PSEAI
577
0
62119
TrEMBL
-
A0A8B5AZ36_PSEAI
557
0
59873
TrEMBL
-
A0A8G7K6Y8_PSEAI
577
0
61968
TrEMBL
-
A0A8G7A7E0_PSEAI
577
0
62017
TrEMBL
-
A0A8G3PKI0_PSEAI
577
0
62045
TrEMBL
-
A0A5F1BU95_PSEAI
577
0
62003
TrEMBL
-
A0A8G4HQ28_PSEAI
577
0
61929
TrEMBL
-
A0A8G6LGE0_PSEAI
577
0
61987
TrEMBL
-
A0A8G6TA92_PSEAI
557
0
59820
TrEMBL
-
A0A8H0X6J9_PSEAI
577
0
61984
TrEMBL
-
A0A8F9KCW0_PSEAI
577
0
61954
TrEMBL
-
A0A6A9JUE1_PSEAI
577
0
61987
TrEMBL
-