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Information on EC 2.3.1.9 - acetyl-CoA C-acetyltransferase and Organism(s) Arabidopsis thaliana

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EC Tree
IUBMB Comments
The enzyme, found in both eukaryotes and prokaryotes, catalyses the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. In the second step the acyl group is transferred to an acetyl-CoA molecule. cf. EC 2.3.1.16, acetyl-CoA C-acyltransferase.
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Arabidopsis thaliana
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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Synonyms
acetoacetyl-coa thiolase, acetyl-coa acetyltransferase, erg10, acoat, acetyl-coa c-acetyltransferase, cytosolic acetoacetyl-coa thiolase, osat1, 2-methylacetoacetyl-coa thiolase, acetoacetyl coa thiolase, aact2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-methylacetoacetyl-CoA thiolase
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3-oxothiolase
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AACT1
acetoacetyl CoA thiolase
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acetoacetyl-CoA thiolase
acetyl coenzyme A thiolase
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acetyl-CoA acetyltransferase
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acetyl-CoA:N-acetyltransferase
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acetyltransferase, acetyl coenzyme A
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beta-acetoacetyl coenzyme A thiolase
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cytosolic acetoacetyl-CoA thiolase 1
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cytosolic acetoacetyl-CoA thiolase 2
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thiolase II
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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condensation
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thiolytic cleavage
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:acetyl-CoA C-acetyltransferase
The enzyme, found in both eukaryotes and prokaryotes, catalyses the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. In the second step the acyl group is transferred to an acetyl-CoA molecule. cf. EC 2.3.1.16, acetyl-CoA C-acyltransferase.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-46-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
isoform AACT! is highly expressed in root tips, young leaf, top stem and anther
Manually annotated by BRENDA team
isoform AACT! is highly expressed in root tips, young leaf, top stem and anther
Manually annotated by BRENDA team
isoform AACT! is primarily expressed in the vascular system
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
isozyme AACT1, its peroxisomal localisation depends on the presence of a C-terminal peroxisomal targeting sequence, PTS1, motif, Ser-Ala-Leu
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
THIC1_ARATH
403
0
41412
Swiss-Prot
other Location (Reliability: 3)
THIC2_ARATH
415
0
43292
Swiss-Prot
other Location (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene ACT1, DNA and amino acid sequence determination and analysis, expression, expression analysis, phylogenetic analysis, overexpression in transgenic Arabidopsis thaliana plants using transfection with Agrobacterium tumefaciens
gene ACT2, DNA and amino acid sequence determination and analysis, expression analysis, phylogenetic analysis, overexpression in transgenic Arabidopsis thaliana plants using transfection with Agrobacterium tumefaciens
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ahumada, I.; Caira, A.; Hemmerlin, A.; Gonzalez, V.; Pateraki, I.; Bach, T.; Rodriguez-Concepcion, M.; Campos, N.; Boronat, A.
Characterisation of the gene family encoding acetoacetyl-CoA thiolase in Arabidopsis
Funct. Plant Biol.
35
1100-1111
2008
Arabidopsis thaliana (Q8S4Y1), Arabidopsis thaliana (Q9FIK7)
Manually annotated by BRENDA team
Jin, H.; Song, Z.; Nikolau, B.J.
Reverse genetic characterization of two paralogous acetoacetyl CoA thiolase genes in Arabidopsis reveals their importance in plant growth and development
Plant J.
70
1015-1032
2012
Arabidopsis thaliana (Q8S4Y1), Arabidopsis thaliana (Q9FIK7)
Manually annotated by BRENDA team