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Information on EC 2.3.1.51 - 1-acylglycerol-3-phosphate O-acyltransferase and Organism(s) Rattus norvegicus
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2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferaseIUBMB Comments
Acyl-[acyl-carrier protein] can also act as an acyl donor. The animal enzyme is specific for the transfer of unsaturated fatty acyl groups.
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Word Map
- 2.3.1.51
- adipose
- triacylglycerols
- triglyceride
- lipodystrophy
- phospholipid
- acyl-coas
- lipase
- diacylglycerol
- droplet
- adipocytes
-
berardinelli-seip
-
lipolysis
- glycerolipids
- agpats
- glycerophospholipids
-
chanarin-dorfman
- hypertriglyceridemia
- lysophospholipids
-
seipin
- ichthyosis
-
perilipins
-
acanthosis
-
ichthyosiform
-
nigricans
- erythroderma
-
identification-58
-
kennedy
-
acyl-acyl
-
endophilins
-
lipoatrophy
-
acyl-coa-dependent
- medicine
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
Synonyms
abhd5, agpat2, lpaat, lysophosphatidic acid acyltransferase, lpaat-beta, agpat1, 1-acylglycerol-3-phosphate o-acyltransferase, agpat3, agpat4, lpa acyltransferase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1-acyl-sn-glycero-3-phosphate acyltransferase
-
-
-
-
1-acyl-sn-glycerol 3-phosphate acyltransferase
-
-
-
-
1-acylglycero-3-phosphate acyltransferase
-
-
-
-
1-acylglycerolphosphate acyltransferase
-
-
-
-
1-acylglycerophosphate acyltransferase
-
-
-
-
acyltransferase, 1-acylglycerol phosphate
-
-
-
-
lysophosphatidic acid-acyltransferase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
Acyl-[acyl-carrier protein] can also act as an acyl donor. The animal enzyme is specific for the transfer of unsaturated fatty acyl groups.
CAS REGISTRY NUMBER
COMMENTARY
51901-16-7
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 1-arachidonoyl-sn-glycerol 3-phosphate
CoA + 1-arachidonoyl-2-acyl-sn-glycerol 3-phosphate
acyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 2-acyl-1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + 1-palmitoyl-sn-glycerol 3-phosphate
CoA + 1-palmitoyl-2-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + 1-stearoyl-sn-glycerol 3-phosphate
CoA + 1-stearoyl-2-acyl-sn-glycerol 3-phosphate
arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate
lauroyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-lauroyl-sn-glycerol 3-phosphate
linoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-linoleoyl-sn-glycerol 3-phosphate
myristoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-myristoyl-sn-glycerol 3-phosphate
palmitoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoleoyl-sn-glycerol 3-phosphate
palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
stearoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-stearoyl-sn-glycerol 3-phosphate
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
i.e. phosphatidic acid
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
i.e. phosphatidic acid
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
C-14 to C-22
-
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
acyl-donors are saturated and unsaturated fatty acyl-CoAs
-
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
omega-3 and omega-6 polyunsaturated fatty acyl-CoAs
-
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
1 to 6 double bonds
i.e. phosphatidic acid
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
with 1 to 5 double bonds
-
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
with 1 to 5 double bonds
i.e. phosphatidic acid
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
unsaturated preferred
i.e. phosphatidic acid
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
monoenic and dienic acyl-CoA thioesters
i.e. phosphatidic acid
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
C-16, C-18, C-20 acyl-CoAs and C-22 acyl-CoA
i.e. phosphatidic acid
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
involved in phospholipid biosynthesis
-
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
involved in phospholipid biosynthesis
-
?
acyl-CoA + 1-arachidonoyl-sn-glycerol 3-phosphate
CoA + 1-arachidonoyl-2-acyl-sn-glycerol 3-phosphate
-
less efficient than 1-acyl-sn-glycerol 3-phosphate
-
?
acyl-CoA + 1-arachidonoyl-sn-glycerol 3-phosphate
CoA + 1-arachidonoyl-2-acyl-sn-glycerol 3-phosphate
-
less efficient than 1-acyl-sn-glycerol 3-phosphate
-
?
acyl-CoA + 1-stearoyl-sn-glycerol 3-phosphate
CoA + 1-stearoyl-2-acyl-sn-glycerol 3-phosphate
-
less efficient than 1-acyl-sn-glycerol 3-phosphate
-
?
acyl-CoA + 1-stearoyl-sn-glycerol 3-phosphate
CoA + 1-stearoyl-2-acyl-sn-glycerol 3-phosphate
-
less efficient than 1-acyl-sn-glycerol 3-phosphate
-
?
arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
arachidonoyl-CoA is a poor substrate
-
?
arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
arachidonoyl-CoA is a poor substrate
-
?
lauroyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-lauroyl-sn-glycerol 3-phosphate
-
-
-
?
lauroyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-lauroyl-sn-glycerol 3-phosphate
-
lauroyl-CoA is a poor substrate
-
?
lauroyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-lauroyl-sn-glycerol 3-phosphate
-
lauroyl-CoA is a poor substrate
-
?
linoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-linoleoyl-sn-glycerol 3-phosphate
-
-
-
?
linoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-linoleoyl-sn-glycerol 3-phosphate
-
-
-
?
linoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-linoleoyl-sn-glycerol 3-phosphate
-
-
-
?
linoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-linoleoyl-sn-glycerol 3-phosphate
-
linoleoyl-CoA is a good substrate but is utilized less efficiently than oleoyl-CoA
-
?
myristoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-myristoyl-sn-glycerol 3-phosphate
-
myristoyl-CoA is a poor substrate
-
?
myristoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-myristoyl-sn-glycerol 3-phosphate
-
myristoyl-CoA is a poor substrate
-
?
oleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-oleoyl-sn-glycerol 3-phosphate
-
is the most effective acyl donor
-
?
palmitoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoleoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoleoyl-sn-glycerol 3-phosphate
-
palmitoleoyl-CoA is a good substrate but is utilized less efficiently than oleoyl-CoA
-
?
palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
-
palmitoyl-CoA is a poor substrate
-
?
stearoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-stearoyl-sn-glycerol 3-phosphate
-
stearoyl-CoA is a poor substrate
-
?
stearoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-stearoyl-sn-glycerol 3-phosphate
-
stearoyl-CoA is a poor substrate
-
?
additional information
?
-
-
no acceptors are 1-acyl-sn-glycero-3-phosphoethanolamine, 1-acyl-sn-glycero-3-phosphomonomethylethanolamine, 1-acyl-sn-glycero-3-phosphodimethylethanolamine or 1-acyl-sn-glycero-3-phosphocholine
-
-
?
additional information
?
-
-
the enzyme exhibits a considerable selectivity for monoenoic and dienoic fatty acyl-CoA thioesters
-
-
?
additional information
?
-
-
the enzyme system shows relatively broad specificity for saturated and unsaturated fatty acids, with 14- to 20-carbon chains. Time courses fo the acylations of 1-acyl-glycerophosphate in the presence of equimolar mixtures of oleoyl-CoA and arachidonoyl-CoA
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
involved in phospholipid biosynthesis
-
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
involved in phospholipid biosynthesis
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
no inhibition by sulfhydryl reagents, 1-acylglycerol 3-phosphoethanol, 1-acylglycerol 3-phosphoethanolamine, 1-acylglycerol 3-phosphodimethylethanolamine, 1-acylglycerol 3-choline
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
bovine serum albumin
-
induces T-lymphocyte enzyme activity in the presence of palmitoyl-CoA but not oleoyl-CoA
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.125
1-acyl-sn-glycerol 3-phosphate
-
in the incorporation of palmitate and linoleate
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
pH profiles of the platelet and liver enzyme systems
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ABHD5_RAT
351
0
39104
Swiss-Prot
other Location (Reliability: 1)
GPAT2_RAT
801
0
88969
Swiss-Prot
other Location (Reliability: 2)
GPAT3_RAT
457
2
51012
Swiss-Prot
Secretory Pathway (Reliability: 1)
MBOA2_RAT
519
5
59001
Swiss-Prot
Secretory Pathway (Reliability: 2)
PLCD_RAT
378
3
43794
Swiss-Prot
Secretory Pathway (Reliability: 1)
PCAT1_RAT
534
1
59762
Swiss-Prot
Mitochondrion (Reliability: 2)
PCAT2_RAT
544
1
59829
Swiss-Prot
other Location (Reliability: 3)
Q6MG85_RAT
284
2
31698
TrEMBL
Secretory Pathway (Reliability: 1)
F7EQT9_RAT
322
3
36012
TrEMBL
other Location (Reliability: 2)
D4AC45_RAT
265
3
29456
TrEMBL
Secretory Pathway (Reliability: 4)
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
using solubilization with Triton X-100 and gel filtration, separation from EC 2.3.1.23
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bell, R.M.; Coleman, R.A.
Enzymes of triacylglycerol formation in mammals
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
16
87-111
1983
Rattus norvegicus
-
Yamashita, S.; Hosaka, K.; Miki, Y.; Numa, S.
Glycerolipid acyltransferases from rat liver: 1-acylglycerophosphate acyltransferase, 1-acylglycerophosphorylcholine acyltransferase, and diacylglycerol acyltransferase
Methods Enzymol.
71
528-536
1981
Rattus norvegicus
Hill, E.E.; Lands, W.E.M.
Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine
Biochim. Biophys. Acta
152
645-648
1968
Rattus norvegicus
Yamashita, S.; Nakaya, N.; Miki, Y.; Numa, S.
Separation of 1-acylglycerolphosphate acyltransferase and 1-acylglycerolphosphorylcholine acyltransferase of rat liver microsomes
Proc. Natl. Acad. Sci. USA
72
600-603
1975
Rattus norvegicus
Miki, Y.; Hosaka, K.; Yamashita, S.; Handa, H.; Numa, S.
Acyl-acceptor specificities of 1-acylglycerolphosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase resolved from rat liver microsomes
Eur. J. Biochem.
81
433-441
1977
Rattus norvegicus
Waku, K.; Hayakawa, F.; Nakazawa, Y.
Regulation of the fatty acid pattern of phospholipids in rabbit sarcoplasmic reticulum. Specificity of glycerophosphate, 1-acylglycerophosphate and 2-acylglycerophosphorylcholine acyltransferase systems
J. Biochem.
82
671-677
1977
Oryctolagus cuniculus, Rattus norvegicus
Inoue, M.; Murase, S.; Okuyama, H.
Acyl coenzyme A:phospholipid acyltransferases in porcine platelets discriminate between omega-3 and omega-6 unsaturated fatty acids
Arch. Biochem. Biophys.
231
29-37
1984
Rattus norvegicus, Sus scrofa
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