Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.3.1.48 - histone acetyltransferase and Organism(s) Arabidopsis thaliana

for references in articles please use BRENDA:EC2.3.1.48
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.48 histone acetyltransferase
IUBMB Comments
A group of enzymes acetylating histones. Several of the enzymes can also acetylate lysines in other proteins [3,4].
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Arabidopsis thaliana
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
clock, histone acetyltransferase, n-acetyltransferase, tip60, histone acetyltransferases, cbp/p300, creb-binding protein, ep300, crebbp, creb binding protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acetyltransferase, histone
-
-
-
-
ELONGATA3
component of the elongator complex
enhancer-of-asymmetric leaves-two1
-
factor acetyltransferase
-
enzyme form A is also able to acetylate nonhistone proteins, mostly transcription factors, overview
FAT
-
when acetylating nonhistone transcription factor proteins, factor specific, overview
general control non-repressed protein5
-
-
histone acetokinase
-
-
-
-
histone acetylase
-
-
-
-
histone acetyltransferase
-
-
histone acetyltransferase AtGCN5
-
-
histone transacetylase
-
-
-
-
nucleosome-histone acetyltransferase
-
-
-
-
additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:[protein]-L-lysine acetyltransferase
A group of enzymes acetylating histones. Several of the enzymes can also acetylate lysines in other proteins [3,4].
CAS REGISTRY NUMBER
COMMENTARY hide
9054-51-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + histone
CoA + acetylhistone
show the reaction diagram
acetyl-CoA + histone H
CoA + acetylhistone H
show the reaction diagram
-
histone acetyltransferase AtGCN5 is required to regulate the floral meristem activity through the WUS/AG pathway
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
show the reaction diagram
acetyl-CoA + histone H4
CoA + acetylhistone H4
show the reaction diagram
acetyl-CoA + [histone H3]-L-lysine14
CoA + [histone H3]-N6-acetyl-L-lysine14
show the reaction diagram
-
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine9
CoA + [histone H3]-N6-acetyl-L-lysine9
show the reaction diagram
-
-
-
-
?
histone + acetyl-CoA
acetyl-histone + CoA
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + histone
CoA + acetylhistone
show the reaction diagram
-
histone H3 is the preferred substrate
-
r
acetyl-CoA + histone H
CoA + acetylhistone H
show the reaction diagram
-
histone acetyltransferase AtGCN5 is required to regulate the floral meristem activity through the WUS/AG pathway
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
show the reaction diagram
-
acetylation at Lys9
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
show the reaction diagram
-
acetylation at Lys14
-
-
?
acetyl-CoA + [histone H3]-L-lysine14
CoA + [histone H3]-N6-acetyl-L-lysine14
show the reaction diagram
-
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine9
CoA + [histone H3]-N6-acetyl-L-lysine9
show the reaction diagram
-
-
-
-
?
histone + acetyl-CoA
acetyl-histone + CoA
show the reaction diagram
-
histone acetylation is an important posttranslational modification correlated with gene activation, the HAC1 is involved in the regulation of flowering time via repression of flowering locus C, the enzyme participates in many physiological processes, including proliferation, differentiation, and apoptosis
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
gamma-butyrolactone
-
MB-3
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
HAM1 or the HAM2 genes display an overlapping expression pattern, mainly in growing organs such as shoots and flower buds
Manually annotated by BRENDA team
HAM1 or the HAM2 genes display an overlapping expression pattern, mainly in growing organs such as shoots and flower buds
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
the Arabidopsis genome contains 12 histone acetyltransferase genes
malfunction
-
loss of function of the Arabidopsis histone acetyltransferase GCN5 results in serious defects in terms of thermotolerance, and considerably impairs the transcriptional activation of heat stress-responsive genes. The expression of several key regulators such as the heat stress transcription factors HSFA2 and HSFA3, multiprotein bridging factor 1c (MBF1c) and UV-hypersensitive 6 (UVH6) is downregulated in the gcn5 mutant under heat stress compared with the wild-type. The GCN5 mutation affects H3K9 and H3K14 acetylation of HSFA3 and UVH6 genes under heat stress. Overexpression of the Triticum aestivum TaGCN5 gene restores thermotolerance in Arabidopsis gcn5 mutant plants
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HAC12_ARATH
1706
0
190272
Swiss-Prot
Mitochondrion (Reliability: 5)
HAC1_ARATH
1697
0
190045
Swiss-Prot
Chloroplast (Reliability: 4)
HAC2_ARATH
1367
0
155772
Swiss-Prot
other Location (Reliability: 4)
HAC4_ARATH
1470
0
166802
Swiss-Prot
Chloroplast (Reliability: 3)
HAC5_ARATH
1670
0
188188
Swiss-Prot
Mitochondrion (Reliability: 5)
MCC1_ARATH
247
0
28306
Swiss-Prot
other Location (Reliability: 2)
GCN5_ARATH
568
0
63124
Swiss-Prot
Chloroplast (Reliability: 2)
MYST1_ARATH
445
0
51438
Swiss-Prot
other Location (Reliability: 5)
MYST2_ARATH
445
0
51367
Swiss-Prot
Chloroplast (Reliability: 4)
HATB_ARATH
467
0
52738
Swiss-Prot
other Location (Reliability: 4)
MBD9_ARATH
2176
0
240431
Swiss-Prot
other Location (Reliability: 2)
Q8LFM6_ARATH
128
0
14475
TrEMBL
other Location (Reliability: 2)
A0A178VL29_ARATH
568
0
63124
TrEMBL
Chloroplast (Reliability: 2)
A0A654GE09_ARATH
445
0
51438
TrEMBL
other Location (Reliability: 5)
F4I4I8_ARATH
1677
0
187091
TrEMBL
Mitochondrion (Reliability: 5)
A0A654ECF9_ARATH
128
0
14475
TrEMBL
other Location (Reliability: 2)
A0A7G2E5X7_ARATH
1834
0
204762
TrEMBL
Chloroplast (Reliability: 4)
A0A1I9LPG3_ARATH
1589
0
179302
TrEMBL
other Location (Reliability: 3)
A0A7G2FKH0_ARATH
467
0
52688
TrEMBL
other Location (Reliability: 4)
A0A178W5M6_ARATH
1680
0
187454
TrEMBL
Mitochondrion (Reliability: 5)
A0A178UIX7_ARATH
270
0
30835
TrEMBL
other Location (Reliability: 5)
A0A5S9WVM3_ARATH
1697
0
190022
TrEMBL
Chloroplast (Reliability: 4)
A0A5S9WMR7_ARATH
1470
0
166817
TrEMBL
Chloroplast (Reliability: 2)
A0A1I9LNJ6_ARATH
177
0
20218
TrEMBL
Secretory Pathway (Reliability: 3)
A0A654F6L1_ARATH
1670
0
188188
TrEMBL
Mitochondrion (Reliability: 5)
A0A1P8ARV7_ARATH
1641
0
183631
TrEMBL
Mitochondrion (Reliability: 5)
A0A178WJZ4_ARATH
1697
0
190045
TrEMBL
Chloroplast (Reliability: 4)
A0A178UAU6_ARATH
445
0
51437
TrEMBL
Chloroplast (Reliability: 5)
Q6NLS5_ARATH
270
0
30835
TrEMBL
other Location (Reliability: 5)
A0A1P8ARV8_ARATH
1680
0
187425
TrEMBL
Mitochondrion (Reliability: 5)
A0A654FZP0_ARATH
445
0
51357
TrEMBL
Chloroplast (Reliability: 4)
A0A7G2E4A1_ARATH
1387
0
157474
TrEMBL
other Location (Reliability: 2)
A0A178VBT3_ARATH
265
0
30241
TrEMBL
other Location (Reliability: 2)
Q9LFD8_ARATH
273
0
31318
TrEMBL
other Location (Reliability: 5)
A0A654EIU4_ARATH
1456
0
165000
TrEMBL
Chloroplast (Reliability: 2)
A0A1P8AQG0_ARATH
1456
0
165070
TrEMBL
Chloroplast (Reliability: 3)
Q9FWQ4_ARATH
238
0
27025
TrEMBL
other Location (Reliability: 2)
A0A178VGI0_ARATH
1410
0
158220
TrEMBL
Mitochondrion (Reliability: 5)
D6BJH9_ARATH
107
0
12285
TrEMBL
other Location (Reliability: 3)
A0A1P8BFL5_ARATH
432
0
48910
TrEMBL
other Location (Reliability: 1)
A0A654EAH3_ARATH
1680
0
187395
TrEMBL
Mitochondrion (Reliability: 5)
A0A178U8L6_ARATH
445
0
51367
TrEMBL
Chloroplast (Reliability: 4)
F4IDH2_ARATH
1741
0
195169
TrEMBL
Chloroplast (Reliability: 4)
A0A178UGY7_ARATH
273
0
31318
TrEMBL
other Location (Reliability: 5)
A0A178W519_ARATH
1470
0
166803
TrEMBL
Chloroplast (Reliability: 2)
A0A178VE69_ARATH
282
0
32631
TrEMBL
Secretory Pathway (Reliability: 4)
A0A178UNR1_ARATH
467
0
52724
TrEMBL
other Location (Reliability: 4)
A0A7G2EF59_ARATH
527
0
59427
TrEMBL
other Location (Reliability: 3)
A0A178UHL7_ARATH
236
0
27195
TrEMBL
other Location (Reliability: 5)
A0A178WQ25_ARATH
1178
0
135060
TrEMBL
other Location (Reliability: 4)
A0A7G2EPQ0_ARATH
1620
0
182247
TrEMBL
Mitochondrion (Reliability: 5)
A0A654GBT7_ARATH
467
0
52766
TrEMBL
other Location (Reliability: 4)
A0A7G2E0J1_ARATH
1285
0
146779
TrEMBL
other Location (Reliability: 4)
A0A7G2DWK0_ARATH
1695
0
189345
TrEMBL
Mitochondrion (Reliability: 5)
A0A654EXH5_ARATH
1367
0
155756
TrEMBL
other Location (Reliability: 4)
F4I4I6_ARATH
129
0
14603
TrEMBL
other Location (Reliability: 2)
Q1JPN3_ARATH
467
0
52738
TrEMBL
other Location (Reliability: 4)
F4KFH9_ARATH
236
0
27195
TrEMBL
other Location (Reliability: 5)
A0A1P8ARU4_ARATH
1470
0
163539
TrEMBL
Mitochondrion (Reliability: 5)
A0A1P8ATA1_ARATH
1673
0
187333
TrEMBL
Chloroplast (Reliability: 4)
A0A5S9WSQ6_ARATH
1367
0
155772
TrEMBL
other Location (Reliability: 4)
A0A5S9X9P5_ARATH
247
0
28306
TrEMBL
other Location (Reliability: 2)
A0A654FFS2_ARATH
568
0
63134
TrEMBL
Chloroplast (Reliability: 2)
A0A654F157_ARATH
1741
0
195169
TrEMBL
Chloroplast (Reliability: 4)
A0A7G2F698_ARATH
445
0
51393
TrEMBL
Chloroplast (Reliability: 4)
A0A5S9YEL8_ARATH
467
0
52738
TrEMBL
other Location (Reliability: 4)
IDM1_ARATH
1189
0
131329
Swiss-Prot
-
ELP3_ARATH
565
0
63694
Swiss-Prot
-
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
GCN5 phosphorylated by activities in cellular extracts can be dephosphorylated by AtPP2C-6-6 in vitro
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C732W
mutation abolishes the binding to histone H3
C740W
mutation abolishes the binding to histone H3
D924A
mutation in conserved residues in the histone acetyltransferase domain, abolishes the in vitro acetyltransferase activity
E451Stop
mutation results in the silencing of 35S-NPTII but not the RD29A-LUC transgene
E941Q
mutation in conserved residues in the histone acetyltransferase domain, abolishes the in vitro acetyltransferase activity
M942A
mutation in conserved residues in the histone acetyltransferase domain, diminishes the in vitro acetyltransferase activity
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed as a His-tagged fusion protein in Escherichia coli
-
expression in insect cells
gene hac1, genetic regulation analysis
-
HAM1 promoter analysis, expression pattern, phylogenetic analysis of MYST proteins, overview
HAM2 promoter analysis, expression pattern, phylogenetic analysis of MYST proteins, overview
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme GCN5 is upregulated by heat stress
-
quantitative RT-PCR analysis of the expression of HAT family genes in response to hest stress, overview
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hasan, S.; Hottiger, M.O.
Histone acetyl transferases: a role in DNA repair and DNA replication
J. Mol. Med.
80
463-474
2002
Arabidopsis thaliana, Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Mus musculus, Tetrahymena thermophila, Homo sapiens GCN5
Manually annotated by BRENDA team
Bertrand, C.; Bergounioux, C.; Domenichini, S.; Delarue, M.; Zhou, D.X.
Arabidopsis histone acetyltransferase AtGCN5 regulates the floral meristem activity through the WUSCHEL/AGAMOUS pathway
J. Biol. Chem.
278
28246-28251
2003
Arabidopsis thaliana
Manually annotated by BRENDA team
Deng, W.; Liu, C.; Pei, Y.; Deng, X.; Niu, L.; Cao, X.
Involvement of the histone acetyltransferase AtHAC1 in the regulation of flowering time via repression of flowering locus C in Arabidopsis
Plant Physiol.
143
1660-1668
2007
Arabidopsis thaliana
Manually annotated by BRENDA team
Servet, C.; Benhamed, M.; Latrasse, D.; Kim, W.; Delarue, M.; Zhou, D.X.
Characterization of a phosphatase 2C protein as an interacting partner of the histone acetyltransferase GCN5 in Arabidopsis
Biochim. Biophys. Acta
1779
376-382
2008
Arabidopsis thaliana
Manually annotated by BRENDA team
Voss, A.K.; Thomas, T.
MYST family histone acetyltransferases take center stage in stem cells and development
Bioessays
31
1050-1061
2009
Arabidopsis thaliana, Danio rerio, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Danio rerio zMoz
Manually annotated by BRENDA team
Latrasse, D.; Benhamed, M.; Henry, Y.; Domenichini, S.; Kim, W.; Zhou, D.X.; Delarue, M.
The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis
BMC Plant Biol.
8
121
2008
Arabidopsis thaliana (Q9FLF7), Arabidopsis thaliana (Q9LXD7)
Manually annotated by BRENDA team
Kim, W.; Benhamed, M.; Servet, C.; Latrasse, D.; Zhang, W.; Delarue, M.; Zhou, D.X.
Histone acetyltransferase GCN5 interferes with the miRNA pathway in Arabidopsis
Cell Res.
19
899-909
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Cohen, R.; Schocken, J.; Kaldis, A.; Vlachonasios, K.E.; Hark, A.T.; McCain, E.R.
The histone acetyltransferase GCN5 affects the inflorescence meristem and stamen development in Arabidopsis
Planta
230
1207-1221
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Kojima, S.; Iwasaki, M.; Takahashi, H.; Imai, T.; Matsumura, Y.; Fleury, D.; Van Lijsebettens, M.; Machida, Y.; Machida, C.
Asymmetric leaves2 and Elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana
Plant Cell Physiol.
52
1259-1273
2011
Arabidopsis thaliana (Q93ZR1), Arabidopsis thaliana
Manually annotated by BRENDA team
Pavangadkar, K.; Thomashow, M.F.; Triezenberg, S.J.
Histone dynamics and roles of histone acetyltransferases during cold-induced gene regulation in Arabidopsis
Plant Mol. Biol.
74
183-200
2010
Arabidopsis thaliana (Q9AR19)
Manually annotated by BRENDA team
Qian, W.; Miki, D.; Zhang, H.; Liu, Y.; Zhang, X.; Tang, K.; Kan, Y.; La, H.; Li, X.; Li, S.; Zhu, X.; Shi, X.; Zhang, K.; Pontes, O.; Chen, X.; Liu, R.; Gong, Z.; Zhu, J.
A histone acetyltransferase regulates active DNA demethylation in Arabidopsis
Science
336
1445-1448
2012
Arabidopsis thaliana (F4IXE7)
Manually annotated by BRENDA team
Hu, Z.; Song, N.; Zheng, M.; Liu, X.; Liu, Z.; Xing, J.; Ma, J.; Guo, W.; Yao, Y.; Peng, H.; Xin, M.; Zhou, D.X.; Ni, Z.; Sun, Q.
Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis
Plant J.
84
1178-1191
2015
Arabidopsis thaliana
Manually annotated by BRENDA team
Aquea, F.; Timmermann, T.; Herrera-Vasquez, A.
Chemical inhibition of the histone acetyltransferase activity in Arabidopsis thaliana
Biochem. Biophys. Res. Commun.
483
664-668
2017
Arabidopsis thaliana
Manually annotated by BRENDA team