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Information on EC 2.3.1.41 - beta-ketoacyl-[acyl-carrier-protein] synthase I and Organism(s) Pseudomonas aeruginosa

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EC Tree
IUBMB Comments
This enzyme is responsible for the chain-elongation step of dissociated (type II) fatty-acid biosynthesis, i.e. the addition of two C atoms to the fatty-acid chain. Escherichia coli mutants that lack this enzyme are deficient in unsaturated fatty acids. The enzyme can use fatty acyl thioesters of ACP (C2 to C16) as substrates, as well as fatty acyl thioesters of Co-A (C4 to C16) . The substrate specificity is very similar to that of EC 2.3.1.179, beta-ketoacyl-ACP synthase II, with the exception that the latter enzyme is far more active with palmitoleoyl-ACP (C16Delta9) as substrate, allowing the organism to regulate its fatty-acid composition with changes in temperature [4,5].
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Pseudomonas aeruginosa
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The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
condensing enzyme, beta-ketoacyl synthase, kas i, beta-ketoacyl-acp synthase, beta-ketoacyl synthetase, 3-ketoacyl-acyl carrier protein synthase, 3-ketoacyl-acp synthase, beta-ketoacyl-acp synthase i, beta-ketoacyl-acyl carrier protein synthase i, fatty acid condensing enzyme, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-ketoacyl-acyl carrier protein synthase
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3-oxoacyl-[acyl-carrier-protein] synthase
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acyl-malonyl(acyl-carrier-protein)-condensing enzyme
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beta-ketoacyl acyl carrier protein synthase
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beta-ketoacyl synthetase
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beta-ketoacyl-ACP synthetase
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beta-ketoacyl-acyl carrier protein synthetase
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beta-ketoacyl-[acyl carrier protein] synthase
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beta-ketoacylsynthase
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condensing enzyme
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fatty acid condensing enzyme
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synthase, 3-oxoacyl-[acyl-carrier-protein]
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating)
This enzyme is responsible for the chain-elongation step of dissociated (type II) fatty-acid biosynthesis, i.e. the addition of two C atoms to the fatty-acid chain. Escherichia coli mutants that lack this enzyme are deficient in unsaturated fatty acids. The enzyme can use fatty acyl thioesters of ACP (C2 to C16) as substrates, as well as fatty acyl thioesters of Co-A (C4 to C16) [4]. The substrate specificity is very similar to that of EC 2.3.1.179, beta-ketoacyl-ACP synthase II, with the exception that the latter enzyme is far more active with palmitoleoyl-ACP (C16Delta9) as substrate, allowing the organism to regulate its fatty-acid composition with changes in temperature [4,5].
CAS REGISTRY NUMBER
COMMENTARY hide
9077-10-5
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A485HSM0_PSEAI
109
0
11427
TrEMBL
-
A0A8F9JJI7_PSEAI
405
0
42895
TrEMBL
-
A0A485EL80_PSEAI
338
0
35968
TrEMBL
-
A0A0A8RKY8_PSEAI
405
0
42865
TrEMBL
-
A0A4P0UD28_PSEAI
123
0
12439
TrEMBL
-
A0A0A8RBG4_PSEAI
345
0
36391
TrEMBL
-
A0A485FK73_PSEAI
227
0
24040
TrEMBL
-
A0A0F6RTE0_PSEAI
405
0
42864
TrEMBL
-
A0A4P0UDN3_PSEAI
189
0
20127
TrEMBL
-
A0A8G3M3E7_PSEAI
418
0
43801
TrEMBL
-
A0A6A9JNM1_PSEAI
405
0
42895
TrEMBL
-
A0A2R3IS94_PSEAI
405
0
42893
TrEMBL
-
A0A8F9NYG8_PSEAI
405
0
42909
TrEMBL
-
A0A0F6U8S9_PSEAI
345
0
36353
TrEMBL
-
A0A659BGM0_PSEAI
345
0
36410
TrEMBL
-
A0A4P0TK37_PSEAI
68
0
7095
TrEMBL
-
A0A4P0TIB5_PSEAI
76
0
8069
TrEMBL
-
A0A4U9RHV0_PSEAI
345
0
36410
TrEMBL
-
A0A071L2X6_PSEAI
405
0
42879
TrEMBL
-