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1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X
2-acyl-sn-glycero-3-phosphocholine + lipid X
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA
2-acyl-sn-glycero-3-phosphocholine + lipid IVB
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-oleoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + hexa-acyl lipid A
2-oleoyl-sn-glycero-3-phosphoethanolamine + hepta-acyl lipid A
1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphoserine + hexa-acyl lipid A
2-palmitoyl-sn-glycero-3-phosphoserine + hepta-acyl lipid A
additional information
?
-
1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X
2-acyl-sn-glycero-3-phosphocholine + lipid X
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X
2-acyl-sn-glycero-3-phosphocholine + lipid X
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X
2-acyl-sn-glycero-3-phosphocholine + lipid X
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA
2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA
2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA
2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA
2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-oleoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-oleoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + hexa-acyl lipid A
2-oleoyl-sn-glycero-3-phosphoethanolamine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + hexa-acyl lipid A
2-oleoyl-sn-glycero-3-phosphoethanolamine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphoserine + hexa-acyl lipid A
2-palmitoyl-sn-glycero-3-phosphoserine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphoserine + hexa-acyl lipid A
2-palmitoyl-sn-glycero-3-phosphoserine + hepta-acyl lipid A
-
-
-
?
additional information
?
-
enzyme from Bordetella bronchiseptica transfers palmitates to the lipid A C-3' positions
-
-
?
additional information
?
-
enzyme from Bordetella bronchiseptica transfers palmitates to the lipid A C-3' positions
-
-
?
additional information
?
-
enzyme from Bordetella parapertussis transfers palmitates to the lipid A C-2 and C-3' positions
-
-
?
additional information
?
-
PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine
-
-
?
additional information
?
-
PagP measures the palmitoyl group with an internal hydrocarbon ruler that is formed in the interior of the eightstranded antiparallel beta barrel. Phospholipid access occurs at the crenel present between strands F and G so the phospholipid head group can remain exposed to the cell exterior while the lipid acyl chain remains in a predominantly hydrophobic environment as it translocates to the protein interior
-
-
?
additional information
?
-
enzyme from Pseudomonas aeruginosa transfers palmitates to the lipid A C-3' positions
-
-
?
additional information
?
-
-
enzyme from Pseudomonas aeruginosa transfers palmitates to the lipid A C-3' positions
-
-
?
additional information
?
-
PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine
-
-
?
additional information
?
-
PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X
2-acyl-sn-glycero-3-phosphocholine + lipid X
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA
2-acyl-sn-glycero-3-phosphocholine + lipid IVB
additional information
?
-
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X
2-acyl-sn-glycero-3-phosphocholine + lipid X
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X
2-acyl-sn-glycero-3-phosphocholine + lipid X
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X
2-acyl-sn-glycero-3-phosphocholine + lipid X
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA
2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA
2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
-
-
?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA
2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
-
-
?
additional information
?
-
enzyme from Bordetella bronchiseptica transfers palmitates to the lipid A C-3' positions
-
-
?
additional information
?
-
enzyme from Bordetella bronchiseptica transfers palmitates to the lipid A C-3' positions
-
-
?
additional information
?
-
enzyme from Bordetella parapertussis transfers palmitates to the lipid A C-2 and C-3' positions
-
-
?
additional information
?
-
PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine
-
-
?
additional information
?
-
PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine
-
-
?
additional information
?
-
PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
18.2
substrate 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphoserine, pH 8.0, temperature not specified in the publication
18.2
substrate 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphoserine, pH 8.0, temperature not specified in the publication
23.3
substrate 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication
23.3
substrate 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication
29.6
substrate 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication
29.6
substrate 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication
7.2
substrate 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine, pH 8.0, temperature not specified in the publication
7.2
substrate 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine, pH 8.0, temperature not specified in the publication
9.7
substrate 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication
9.7
substrate 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Iyer, B.R.; Mahalakshmi, R.
Residue-dependent thermodynamic cost and barrel plasticity balances activity in the PhoPQ-activated enzyme PagP of Salmonella typhimurium
Biochemistry
22
5712-5722
2015
Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli (P37001)
brenda
Bishop, R.E.; Gibbons, H.S.; Guina, T.; Trent, M.S.; Miller, S.I.; Raetz, C.R.
Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria
EMBO J.
19
5071-5080
2000
Escherichia coli (P37001), Salmonella enterica subsp. enterica serovar Typhimurium (Q8ZR06), Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (Q8ZR06)
brenda
Hittle, L.E.; Jones, J.W.; Hajjar, A.M.; Ernst, R.K.; Preston, A.
Bordetella parapertussis PagP mediates the addition of two palmitates to the lipopolysaccharide lipid A
J. Bacteriol.
197
572-580
2015
Bordetella parapertussis (Q7W4D1)
brenda
Kawasaki, K.; Ernst, R.K.; Miller, S.I.
Purification and characterization of deacylated and/or palmitoylated lipid A species unique to Salmonella enterica serovar Typhimurium
J. Endotoxin Res.
11
57-61
2005
Salmonella enterica subsp. enterica serovar Typhimurium
brenda
Preston, A.; Maxim, E.; Toland, E.; Pishko, E.J.; Harvill, E.T.; Caroff, M.; Maskell, D.J.
Bordetella bronchiseptica PagP is a Bvg-regulated lipid A palmitoyl transferase that is required for persistent colonization of the mouse respiratory tract
Mol. Microbiol.
48
725-736
2003
Bordetella bronchiseptica (Q7WFT9), Bordetella bronchiseptica ATCC BAA-588 (Q7WFT9)
brenda
Thaipisuttikul, I.; Hittle, L.E.; Chandra, R.; Zangari, D.; Dixon, C.L.; Garrett, T.A.; Rasko, D.A.; Dasgupta, N.; Moskowitz, S.M.; Malmstroem, L.; Goodlett, D.R.; Miller, S.I.; Bishop, R.E.; Ernst, R.K.
A divergent Pseudomonas aeruginosa palmitoyltransferase essential for cystic fibrosis-specific lipid A
Mol. Microbiol.
91
158-174
2014
Pseudomonas aeruginosa (Q9I401), Pseudomonas aeruginosa
brenda
Hwang, P.M.; Choy, W.Y.; Lo, E.I.; Chen, L.; Forman-Kay, J.D.; Raetz, C.R.; Prive, G.G.; Bishop, R.E.; Kay, L.E.
Solution structure and dynamics of the outer membrane enzyme PagP by NMR
Proc. Natl. Acad. Sci. USA
99
13560-13565
2002
Escherichia coli (P37001)
brenda
Cuesta-Seijo, J.A.; Neale, C.; Khan, M.A.; Moktar, J.; Tran, C.D.; Bishop, R.E.; Pomes, R.; Prive, G.G.
PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler
Structure
18
1210-1219
2010
Escherichia coli (P37001)
brenda