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Information on EC 2.3.1.225 - protein S-acyltransferase and Organism(s) Drosophila melanogaster

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.225 protein S-acyltransferase
IUBMB Comments
The enzyme catalyses the posttranslational protein palmitoylation that plays a role in protein-membrane interactions, protein trafficking, and enzyme activity. Palmitoylation increases the hydrophobicity of proteins or protein domains and contributes to their membrane association.
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This record set is specific for:
Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
hip14, dhhc3, palmitoyl acyltransferase, dhhc5, zdhhc5, dhhc2, akr1p, zdhhc3, protein acyltransferase, dhhc protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
protein acyl transferase
-
-
protein acyltransferase
-
-
SYSTEMATIC NAME
IUBMB Comments
palmitoyl-CoA:[protein]-L-cysteine S-palmitoyltransferase
The enzyme catalyses the posttranslational protein palmitoylation that plays a role in protein-membrane interactions, protein trafficking, and enzyme activity. Palmitoylation increases the hydrophobicity of proteins or protein domains and contributes to their membrane association.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
palmitoyl-CoA + [protein]-L-cysteine
[protein]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
additional information
?
-
-
in the absence of cellular factors, palmitoyl-CoA is capable of spontaneously S-acylating cysteinyl thiols, overview
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
palmitoyl-CoA + [protein]-L-cysteine
[protein]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
additional information
?
-
-
in the absence of cellular factors, palmitoyl-CoA is capable of spontaneously S-acylating cysteinyl thiols, overview
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-Bromopalmitate
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
enzyme class II
Manually annotated by BRENDA team
-
enzyme class I
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
additional information
-
one enzyme family is lysosomal and is involved in protein degradation. The second is cytosolic and removes palmitoyl moieties preferentially from proteins associated with membranes. PAT activity requires detergent, e.g. Triton X-100, for solubilization
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
APP_DROME
693
5
75008
Swiss-Prot
other Location (Reliability: 4)
ZDHC8_DROME
934
4
99717
Swiss-Prot
Secretory Pathway (Reliability: 1)
HIP14_DROME
637
6
71299
Swiss-Prot
other Location (Reliability: 2)
Q8SWX8_DROME
395
3
45552
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0B4KH44_DROME
253
3
29649
TrEMBL
other Location (Reliability: 3)
Q8MKK7_DROME
198
3
23048
TrEMBL
Secretory Pathway (Reliability: 1)
X2J6Q6_DROME
343
6
38439
TrEMBL
Mitochondrion (Reliability: 4)
Q9W3M8_DROME
199
0
22419
TrEMBL
other Location (Reliability: 5)
Q0IGS7_DROME
284
4
33223
TrEMBL
Secretory Pathway (Reliability: 1)
E1JIY0_DROME
251
3
29256
TrEMBL
other Location (Reliability: 4)
A0A0B4LF16_DROME
452
4
51574
TrEMBL
Secretory Pathway (Reliability: 1)
Q960T3_DROME
320
2
35816
TrEMBL
other Location (Reliability: 4)
Q9U722_DROME
444
4
50444
TrEMBL
other Location (Reliability: 5)
Q9VBM5_DROME
283
4
33147
TrEMBL
Secretory Pathway (Reliability: 5)
E8NHB0_DROME
381
4
43730
TrEMBL
Mitochondrion (Reliability: 2)
A1Z833_DROME
443
4
50561
TrEMBL
Secretory Pathway (Reliability: 1)
A1ZAR2_DROME
338
4
40056
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0B4KF56_DROME
352
4
41371
TrEMBL
Secretory Pathway (Reliability: 1)
Q9W251_DROME
278
5
32167
TrEMBL
Secretory Pathway (Reliability: 1)
Q4V6Z4_DROME
395
2
42257
TrEMBL
Mitochondrion (Reliability: 5)
E2QCN5_DROME
227
3
26868
TrEMBL
Secretory Pathway (Reliability: 1)
Q9VBM7_DROME
290
4
33713
TrEMBL
Secretory Pathway (Reliability: 5)
Q9I7L7_DROME
300
4
35597
TrEMBL
Secretory Pathway (Reliability: 1)
A0A499GVI2_DROME
589
3
66469
TrEMBL
Mitochondrion (Reliability: 5)
Q4V6X2_DROME
165
2
19381
TrEMBL
Mitochondrion (Reliability: 5)
Q4V6X7_DROME
360
4
42721
TrEMBL
Mitochondrion (Reliability: 4)
M9PFE4_DROME
655
6
73379
TrEMBL
other Location (Reliability: 2)
A0A4D6K4L3_DROME
613
3
69073
TrEMBL
other Location (Reliability: 2)
D3PFF3_DROME
211
3
24467
TrEMBL
Secretory Pathway (Reliability: 1)
Q95S28_DROME
237
3
27287
TrEMBL
Mitochondrion (Reliability: 2)
Q9VG80_DROME
427
4
49200
TrEMBL
Secretory Pathway (Reliability: 3)
Q9VKB1_DROME
585
3
65975
TrEMBL
Mitochondrion (Reliability: 5)
Q9XTL3_DROME
277
3
31691
TrEMBL
Secretory Pathway (Reliability: 1)
M9PFJ4_DROME
132
1
15281
TrEMBL
Secretory Pathway (Reliability: 2)
Q9VPM2_DROME
968
4
105490
TrEMBL
other Location (Reliability: 3)
Q9VBM6_DROME
276
4
32196
TrEMBL
other Location (Reliability: 5)
Q9VQK9_DROME
420
5
47014
TrEMBL
other Location (Reliability: 3)
Q8MSL3_DROME
435
3
50316
TrEMBL
Secretory Pathway (Reliability: 2)
C3KGN8_DROME
247
3
28809
TrEMBL
other Location (Reliability: 5)
A0A0B4LEL6_DROME
449
4
51347
TrEMBL
Secretory Pathway (Reliability: 1)
Q9VB73_DROME
381
4
43802
TrEMBL
Mitochondrion (Reliability: 2)
Q9VBM8_DROME
299
4
34423
TrEMBL
Secretory Pathway (Reliability: 5)
Q9VKN8_DROME
276
4
31529
TrEMBL
Secretory Pathway (Reliability: 1)
Q7K3T4_DROME
293
4
33380
TrEMBL
other Location (Reliability: 4)
Q9VBM4_DROME
302
4
35790
TrEMBL
Mitochondrion (Reliability: 1)
A0A0B4LF00_DROME
440
4
50334
TrEMBL
Secretory Pathway (Reliability: 1)
Q6NLJ6_DROME
410
4
45134
TrEMBL
Secretory Pathway (Reliability: 3)
Q7K2V5_DROME
338
4
39774
TrEMBL
Secretory Pathway (Reliability: 1)
Q9VTV6_DROME
755
5
82257
TrEMBL
other Location (Reliability: 4)
Q9VSV3_DROME
435
3
50457
TrEMBL
Secretory Pathway (Reliability: 2)
Q8IQN9_DROME
288
4
33598
TrEMBL
Secretory Pathway (Reliability: 3)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Linder, M. E.; Deschenes, R. J.
New insights into the mechanisms of protein palmitoylation
Biochemistry
42
4311-4320
2003
Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Mitchell, D. A.; Vasudevan, A.; Linder, M. E.; Deschenes, R. J.
Protein palmitoylation by a family of DHHC protein S-acyltransferases
J. Lipid Res.
47
1118-1127
2006
Drosophila melanogaster, Homo sapiens, Homo sapiens (Q8IUH5), Homo sapiens (Q9Y397), Saccharomyces cerevisiae
Manually annotated by BRENDA team