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Information on EC 2.3.1.199 - very-long-chain 3-oxoacyl-CoA synthase and Organism(s) Taeniopygia guttata

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EC Tree
IUBMB Comments
This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids [6,7]. For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate , while CER6 from the same plant prefers substrates with chain length of C22 to C32 [4,8]. cf. EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase
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Taeniopygia guttata
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Word Map
The taxonomic range for the selected organisms is: Taeniopygia guttata
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
fatty acid elongase, elovl1, elovl7, 3-ketoacyl-coa synthase, fatty acid elongase 1, acyl-coa elongase, beta-ketoacyl-coa synthase, fa elongase, fae1 kcs, fatty acid elongation1, more
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
malonyl-CoA:very-long-chain acyl-CoA malonyltransferase (decarboxylating and thioester-hydrolysing)
This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids [6,7]. For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate [5], while CER6 from the same plant prefers substrates with chain length of C22 to C32 [4,8]. cf. EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase
CAS REGISTRY NUMBER
COMMENTARY hide
88414-92-0
-
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A674GY01_TAEGU
293
7
34771
TrEMBL
other Location (Reliability: 5)
B5G3Z4_TAEGU
297
7
34747
TrEMBL
other Location (Reliability: 4)
A0A674G9L9_TAEGU
265
6
31169
TrEMBL
other Location (Reliability: 4)
A0A674HE01_TAEGU
315
8
36747
TrEMBL
Secretory Pathway (Reliability: 2)
H0ZNY9_TAEGU
475
9
55735
TrEMBL
other Location (Reliability: 1)
B5G3Z3_TAEGU
297
7
34761
TrEMBL
other Location (Reliability: 4)
A0A674G8R2_TAEGU
265
7
31364
TrEMBL
other Location (Reliability: 4)
H0Z1C1_TAEGU
283
6
32956
TrEMBL
other Location (Reliability: 4)
A0A674GJ08_TAEGU
314
7
36764
TrEMBL
other Location (Reliability: 2)
A0A674GGR7_TAEGU
282
7
33055
TrEMBL
Secretory Pathway (Reliability: 1)
A0A674GRD0_TAEGU
316
7
36996
TrEMBL
other Location (Reliability: 5)
H1A4V4_TAEGU
272
7
32157
TrEMBL
other Location (Reliability: 5)
A0A674G7G6_TAEGU
332
7
38995
TrEMBL
other Location (Reliability: 2)
H0Z5V4_TAEGU
280
6
32761
TrEMBL
Secretory Pathway (Reliability: 1)
A0A674G8A7_TAEGU
278
6
32846
TrEMBL
Mitochondrion (Reliability: 4)
A0A674HGI9_TAEGU
400
7
46473
TrEMBL
Mitochondrion (Reliability: 4)
H0ZRK3_TAEGU
275
7
32599
TrEMBL
other Location (Reliability: 5)
H0Z9Z4_TAEGU
288
7
33805
TrEMBL
other Location (Reliability: 5)
A0A674GLS5_TAEGU
270
6
31497
TrEMBL
Secretory Pathway (Reliability: 1)
A0A674GXQ5_TAEGU
297
7
35239
TrEMBL
other Location (Reliability: 5)
H0YWT7_TAEGU
281
7
33474
TrEMBL
other Location (Reliability: 5)
A0A674H7L5_TAEGU
317
7
37273
TrEMBL
Secretory Pathway (Reliability: 3)