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Information on EC 2.3.1.199 - very-long-chain 3-oxoacyl-CoA synthase and Organism(s) Gallus gallus

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EC Tree
IUBMB Comments
This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids [6,7]. For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate , while CER6 from the same plant prefers substrates with chain length of C22 to C32 [4,8]. cf. EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase
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Gallus gallus
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Word Map
The taxonomic range for the selected organisms is: Gallus gallus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
fatty acid elongase, elovl1, elovl7, 3-ketoacyl-coa synthase, fatty acid elongase 1, acyl-coa elongase, beta-ketoacyl-coa synthase, fa elongase, fae1 kcs, fatty acid elongation1, more
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
malonyl-CoA:very-long-chain acyl-CoA malonyltransferase (decarboxylating and thioester-hydrolysing)
This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids [6,7]. For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate [5], while CER6 from the same plant prefers substrates with chain length of C22 to C32 [4,8]. cf. EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase
CAS REGISTRY NUMBER
COMMENTARY hide
88414-92-0
-
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ELOV6_CHICK
265
6
31268
Swiss-Prot
other Location (Reliability: 4)
R4GLY7_CHICK
252
6
29918
TrEMBL
other Location (Reliability: 5)
E7E8G6_CHICK
252
6
30017
TrEMBL
Secretory Pathway (Reliability: 5)
E3VVM5_CHICK
290
7
33890
TrEMBL
other Location (Reliability: 5)
E3VVZ8_CHICK
295
7
35182
TrEMBL
other Location (Reliability: 4)
A0A3Q2U4A2_CHICK
143
0
17219
TrEMBL
other Location (Reliability: 3)
E3VVZ9_CHICK
265
6
31268
TrEMBL
other Location (Reliability: 4)
Q5F345_CHICK
266
7
31075
TrEMBL
Secretory Pathway (Reliability: 1)
E1BYE9_CHICK
297
7
34633
TrEMBL
other Location (Reliability: 5)
E3VVZ7_CHICK
314
7
36761
TrEMBL
other Location (Reliability: 2)
E1C102_CHICK
279
7
33195
TrEMBL
other Location (Reliability: 4)
A0A3Q2U2S5_CHICK
494
6
54752
TrEMBL
other Location (Reliability: 3)