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Information on EC 2.3.1.199 - very-long-chain 3-oxoacyl-CoA synthase and Organism(s) Bos taurus

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EC Tree
IUBMB Comments
This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids [6,7]. For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate , while CER6 from the same plant prefers substrates with chain length of C22 to C32 [4,8]. cf. EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
fatty acid elongase, elovl1, elovl7, 3-ketoacyl-coa synthase, fatty acid elongase 1, acyl-coa elongase, beta-ketoacyl-coa synthase, fa elongase, fae1 kcs, fatty acid elongation1, more
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
malonyl-CoA:very-long-chain acyl-CoA malonyltransferase (decarboxylating and thioester-hydrolysing)
This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids [6,7]. For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate [5], while CER6 from the same plant prefers substrates with chain length of C22 to C32 [4,8]. cf. EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase
CAS REGISTRY NUMBER
COMMENTARY hide
88414-92-0
-
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ELOV5_BOVIN
299
7
35377
Swiss-Prot
other Location (Reliability: 5)
ELOV7_BOVIN
281
7
33639
Swiss-Prot
other Location (Reliability: 3)
A4FUF2_BOVIN
294
7
34328
TrEMBL
other Location (Reliability: 4)
Q3T120_BOVIN
279
7
32683
TrEMBL
other Location (Reliability: 5)
E1BBR7_BOVIN
270
6
31637
TrEMBL
other Location (Reliability: 3)
A6QNQ7_BOVIN
264
6
31282
TrEMBL
other Location (Reliability: 5)
A0A3Q1MIU0_BOVIN
587
7
66243
TrEMBL
other Location (Reliability: 2)
F6QT14_BOVIN
314
7
36527
TrEMBL
Secretory Pathway (Reliability: 4)
A5PKE6_BOVIN
314
7
36626
TrEMBL
other Location (Reliability: 2)
E1BBK7_BOVIN
212
6
24522
TrEMBL
Secretory Pathway (Reliability: 3)