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Information on EC 2.3.1.181 - lipoyl(octanoyl) transferase and Organism(s) Pseudomonas aeruginosa

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EC Tree
IUBMB Comments
This is the first committed step in the biosynthesis of lipoyl cofactor. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein. Examples of such lipoylated proteins include pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [2,3]. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the true substrate . The other enzyme involved in the biosynthesis of lipoyl cofactor is EC 2.8.1.8, lipoyl synthase. An alternative lipoylation pathway involves EC 6.3.1.20, lipoate---protein ligase, which can lipoylate apoproteins using exogenous lipoic acid (or its analogues).
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Pseudomonas aeruginosa
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Word Map
The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
lipoyltransferase, lipt2, lipb octanoyltransferase, lipoyl(octanoyl) transferase 2, atlip2p2, octanoyltransferase lipm, lipoyl (octanoyl)-acyl carrier protein:protein transferase, octanoyl (lipoyl) n-octanoyl (lipoyl) transferase, lipoyl(octanoyl)transferase, lip2p2, more
PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
octanoyl-[acyl-carrier protein]:protein N-octanoyltransferase
This is the first committed step in the biosynthesis of lipoyl cofactor. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein. Examples of such lipoylated proteins include pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [2,3]. Lipoyl-ACP can also act as a substrate [4] although octanoyl-ACP is likely to be the true substrate [6]. The other enzyme involved in the biosynthesis of lipoyl cofactor is EC 2.8.1.8, lipoyl synthase. An alternative lipoylation pathway involves EC 6.3.1.20, lipoate---protein ligase, which can lipoylate apoproteins using exogenous lipoic acid (or its analogues).
CAS REGISTRY NUMBER
COMMENTARY hide
392687-64-8
-
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A069Q518_PSEAI
217
0
23857
TrEMBL
-
A0A509JKK8_PSEAI
217
0
23869
TrEMBL
-
A0A367LVY0_PSEAI
115
0
12435
TrEMBL
-
A0A8G7C156_PSEAI
217
0
23839
TrEMBL
-
A0A8G2S555_PSEAI
217
0
23816
TrEMBL
-
A0A0A8RAE4_PSEAI
217
0
23773
TrEMBL
-
A0A8B4Z9X4_PSEAI
217
0
23846
TrEMBL
-
A0A8G7C0T6_PSEAI
217
0
23827
TrEMBL
-