Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
6-aminopenicillanate acyltransferase
-
-
-
-
6-aminopenicillanic acid acyltransferase
-
-
-
-
6-aminopenicillinanic acid phenylacetyltransferase
-
-
-
-
6-aminopenicillinanic acylase
-
-
-
-
acyl coA:isopenicillin N-acyltransferase
-
acyl coenzyme A: isopenicillin N acyltransferase
-
-
acyl coenzyme A:6-aminopenicillanic acid acyltransferase
-
-
-
-
acyl-CoA:6-aminopenicillanate acyltransferase
-
-
-
-
acyl-CoA:6-APA acyltransferase
-
-
-
-
acyl-CoA:isopenicillin N acyltransferase
-
-
-
-
acyl-coenzyme A: IPN acyltransferase
-
-
acyl-coenzyme A:isopenicillin N acyltransferase
-
-
-
-
acyl-coenzyme A:isopenicillin N-acyltransferase
-
-
-
-
acyltransferase, 6-aminopenicillanate
-
-
-
-
isopenicillin N acyltransferase
isopenicillin N:acyl CoA acyltransferase
-
-
isopenicillin N:acyl-CoA: acyltransferase
-
-
-
-
isopenicillin-N N-acyltransferase
-
-
aatA
-
-
aatA
-
gene encoding isopenicillin N acyltransferase
aatB
-
-
aatB
-
AN6775.3, gene encoding a penicillin V producing activity, which, in contrast to aatA, does not encode a peroxisomal targeting signal PTS1. aatB homologues also exist in non-penicillin-producing fungi and is suggested to be a paralogue of aatA.
IAT
-
-
isopenicillin N acyltransferase
-
-
-
-
isopenicillin N acyltransferase
-
-
isopenicillin N acyltransferase
-
-
isopenicillin N acyltransferase
-
isopenicillin N acyltransferase
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
phenoxyacetyl-CoA + isopenicillin N + H2O
CoA + penicillin V + L-2-aminohexanedioate
phenylacetyl-CoA + 6-aminopenicillanic acid + H2O
CoA + benzylpenicillin
phenylacetyl-CoA + isopenicillin N + H2O
CoA + benzylpenicillin + L-2-aminohexanedioate
phenylacetyl-CoA + isopenicillin N + H2O
CoA + penicillin G + L-2-aminohexanedioate
phenoxyacetyl-CoA + isopenicillin N + H2O
CoA + penicillin V + L-2-aminohexanedioate
-
-
-
-
?
phenoxyacetyl-CoA + isopenicillin N + H2O
CoA + penicillin V + L-2-aminohexanedioate
-
-
-
-
?
phenylacetyl-CoA + 6-aminopenicillanic acid + H2O
CoA + benzylpenicillin
-
-
-
?
phenylacetyl-CoA + 6-aminopenicillanic acid + H2O
CoA + benzylpenicillin
-
acyl-CoA:6-aminopenicillanate acyltransferase activity
-
?
phenylacetyl-CoA + 6-aminopenicillanic acid + H2O
CoA + benzylpenicillin
-
-
-
?
phenylacetyl-CoA + isopenicillin N + H2O
CoA + benzylpenicillin + L-2-aminohexanedioate
-
-
-
?
phenylacetyl-CoA + isopenicillin N + H2O
CoA + benzylpenicillin + L-2-aminohexanedioate
-
acyl-coenzyme A:isopenicillin N acyltransferase activity, S309 is involved in substrate acylation
-
?
phenylacetyl-CoA + isopenicillin N + H2O
CoA + penicillin G + L-2-aminohexanedioate
-
-
-
-
?
phenylacetyl-CoA + isopenicillin N + H2O
CoA + penicillin G + L-2-aminohexanedioate
-
-
-
?
phenylacetyl-CoA + isopenicillin N + H2O
CoA + penicillin G + L-2-aminohexanedioate
IAT substitutes the alpha-aminoadipic acid side chain of isopenicillin N by a phenylacetic acid phenolate group from phenylacetyl-CoA
-
-
?
phenylacetyl-CoA + isopenicillin N + H2O
CoA + penicillin G + L-2-aminohexanedioate
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Tobin, M.B.; Baldwin, J.E.; Cole, S.C.J.; Miller, J.R.; Skatrud, P.L.; Sutherland, J.D.
The requirement for subunit interaction in the production of Penicillium chrysogenum acyl-coenzyme A:isopenicillin N acyltransferase in Escherichia coli
Gene
132
199-206
1993
Penicillium chrysogenum
brenda
Fernandez, F.J.; Gutierrez, S.; Velasco, J.; Montenegro, E.; Marcos, A.T.; Martin, J.F.
Molecular characterization of three loss-of-function mutations in the isopenicillin N-acyltransferase gene (penDE) of Penicillium chrysogenum
J. Bacteriol.
176
4941-4948
1994
Penicillium chrysogenum, Penicillium chrysogenum WIS 54-1255
brenda
Tobin, M.B.; Cole, S.C.J.; Kovacevic, S.; Miller, J.R.; Baldwin, J.E.; Sutherland, J.D.
Acyl-coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum: effect of amino acid substitutions at Ser227, Ser230 and Ser309 on proenzyme cleavage and activity
FEMS Microbiol. Lett.
121
39-46
1994
Penicillium chrysogenum
brenda
Nielsen, J.; Jorgensen, H.S.
Metabolic control analysis of the penicillin biosynthetic pathway in a high-yielding strain of Penicillium chrysogenum
Biotechnol. Prog.
11
299-305
1995
Penicillium chrysogenum, Penicillium chrysogenum yielding
brenda
Tobin, M.B.; Cole, S.C.J.; Miller, J.R.; Baldwin, J.E.; Sutherland, J.D.
Amino-acid substitutions in the cleavage site of acyl-coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum: effect on proenzyme cleavage and activity
Gene
162
29-35
1995
Penicillium chrysogenum
brenda
Hensgens, C.M.H.; Kroezinga, E.A.; van Montfort, B.A.; van der Laan, J.M.; Sutherland, J.D.; Dijkstra, B.W.
Purification, crystallization and preliminary x-ray diffraction of Cys103Ala acyl coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum
Acta Crystallogr. Sect. D
58
716-718
2002
Penicillium chrysogenum
brenda
Fernandez, F.J.; Cardoza, R.E.; Montenegro, E.; Velasco, J.; Gutierrez, S.; Martin, J.F.
The isopenicillin N acyltransferases of Aspergillus nidulans and Penicillium chrysogenum differ in their ability to maintain the 40-kDa ab heterodimer in an undissociated form
Eur. J. Biochem.
270
1958-1968
2003
Aspergillus nidulans, Penicillium chrysogenum
brenda
Yoshida, H.; Hensgens, C.M.; van der Laan, J.M.; Sutherland, J.D.; Hart, D.J.; Dijkstra, B.W.
An approach to prevent aggregation during the purification and crystallization of wild type acyl coenzyme A: isopenicillin N acyltransferase from Penicillium chrysogenum
Protein Expr. Purif.
41
61-67
2005
Penicillium chrysogenum
brenda
Lamas-Maceiras, M.; Vaca, I.; Rodriguez, E.; Casqueiro, J.; Martin, J.F.
Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N acyltransferase
Biochem. J.
395
147-155
2005
Penicillium chrysogenum
brenda
Ullan, R.V.; Campoy, S.; Casqueiro, J.; Fernandez, F.J.; Martin, J.F.
Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes
Chem. Biol.
14
329-339
2007
Penicillium chrysogenum
brenda
Lutz, M.V.; Bovenberg, R.A.; van der Klei, I.J.; Veenhuis, M.
Synthesis of Penicillium chrysogenum acetyl-CoA:isopenicillin N acyltransferase in Hansenula polymorpha: first step towards the introduction of a new metabolic pathway
FEMS Yeast Res.
5
1063-1067
2005
Penicillium chrysogenum
brenda
Garcia-Estrada, C.; Vaca, I.; Fierro, F.; Sjollema, K.; Veenhuis, M.; Martin, J.F.
The unprocessed preprotein form IATC103S of the isopenicillin N acyltransferase is transported inside peroxisomes and regulates its self-processing
Fungal Genet. Biol.
45
1043-1052
2008
Penicillium chrysogenum
brenda
Kiel, J.A.; van den Berg, M.A.; Fusetti, F.; Poolman, B.; Bovenberg, R.A.; Veenhuis, M.; van der Klei, I.J.
Matching the proteome to the genome: the microbody of penicillin-producing Penicillium chrysogenum cells
Funct. Integr. Genomics
9
167-184
2009
Penicillium chrysogenum
brenda
Sproete, P.; Hynes, M.J.; Hortschansky, P.; Shelest, E.; Scharf, D.H.; Wolke, S.M.; Brakhage, A.A.
Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster
Mol. Microbiol.
70
445-461
2008
Aspergillus nidulans
brenda
Weber, S.S.; Polli, F.; Boer, R.; Bovenberg, R.A.; Driessen, A.J.
Increased penicillin production in Penicillium chrysogenum production strains via balanced overexpression of isopenicillin N acyltransferase
Appl. Environ. Microbiol.
78
7107-7113
2012
Penicillium chrysogenum, Penicillium chrysogenum DS17690
brenda
Moreno-Vargas, L.; Correa-Basurto, J.; Maroun, R.C.; Fernandez, F.J.
Homology modeling of the structure of acyl coA:isopenicillin N-acyltransferase (IAT) from Penicillium chrysogenum. IAT interaction studies with isopenicillin-N, combining molecular dynamics simulations and docking
J. Mol. Model.
18
1189-1205
2012
Penicillium chrysogenum (P15802), Penicillium chrysogenum
brenda
Garcia-Estrada, C.; Barreiro, C.; Jami, M.S.; Martin-Gonzalez, J.; Martin, J.F.
The inducers 1,3-diaminopropane and spermidine cause the reprogramming of metabolism in Penicillium chrysogenum, leading to multiple vesicles and penicillin overproduction
J. Proteomics
85
129-159
2013
Penicillium chrysogenum (Q3HUS0), Penicillium chrysogenum, Penicillium chrysogenum Wisconsin 54-1255 (Q3HUS0)
brenda
Scheckhuber, C.Q.; Veenhuis, M.; van der Klei, I.J.
Improving penicillin biosynthesis in Penicillium chrysogenum by glyoxalase overproduction
Metab. Eng.
18
36-43
2013
Penicillium chrysogenum, Penicillium chrysogenum DS17690
brenda
Cheng, J.S.; Zhao, Y.; Qiao, B.; Lu, H.; Chen, Y.; Yuan, Y.J.
Comprehensive profiling of proteome changes provide insights of industrial Penicillium chrysogenum during pilot and industrial penicillin G fermentation
Appl. Biochem. Biotechnol.
179
788-804
2016
Penicillium chrysogenum (P15802), Penicillium chrysogenum
brenda