Reference on EC 2.3.1.13 - glycine N-acyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nandi, D.L.; Lucas, S.V.; Webster, L.T.
Benzoyl-coenzyme A:glycine N-acyltransferase and phenylacetyl-coenzyme A:glycine N-acyltransferase from bovine liver mitochondria. Purification and characterization
J. Biol. Chem.
254
7230-7237
1979
Bos taurus
Webster, L.T.; Siddiqui, U.A.; Lucas, S.V.; Strong, J.M.; Mieyal, J.J.
Identification of separate acyl-CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man
J. Biol. Chem.
251
3352-3358
1976
Homo sapiens, Macaca mulatta
James, M.O.; Bend, J.R.
A radiochemical assay for glycine N-acyltransferase activity. Some properties of the enzyme in rat and rabbit
Biochem. J.
172
285-291
1978
BRENDA: Oryctolagus cuniculus, Rattus norvegicus
Textmining: Rattus
Koelvraa, AS.; Gregersen, N.
Acyl-CoA: glycine N-acyltransferase: organelle localization and affinity toward straight- and branched-chained acyl-CoA esters in rat liver
Biochem. Med. Metab. Biol.
36
98-105
1986
BRENDA: Rattus norvegicus
Textmining: Rattus, Homo sapiens
Webster, L.T.
Benzoyl-CoA: amino acid and phenylacetyl-CoA: amino acid N-acyltransferases
Methods Enzymol.
77
301-308
1981
Bos taurus
Kelley, M.; Vessey, D.A.
Isolation and characterization of mitochondrial acyl-CoA: glycine N-acyltransferase from kidney
J. Biochem. Toxicol.
8
65-69
1993
Bos taurus
-
Mawal, Y.R.; Qureshi, I.A.
An immunodetection method for the quantitation of human acyl CoA: glycine N-acyltransferase in biological samples
Biochem. Mol. Biol. Int.
34
595-601
1994
Ovis aries, Homo sapiens
Mawal, Y.R.; Qureshi, I.A.
Purification to homogeneity of mitochondrial acyl CoA: glycine N-acyltransferase from human liver
Biochem. Biophys. Res. Commun.
205
1373-1379
1994
Ovis aries, Homo sapiens
Mawal, Y.; Paradis, K.; Qureshi, I.A.
Developmental profile of mitochondrial glycine N-acyltransferase in human liver
J. Pediatr.
130
1003-1007
1997
Homo sapiens
Van der Westhuizen, F.H.; Pretorius, P.J.; Erasmus, E.
The utilization of alanine, glutamic acid, and serine as amino acid substrates for glycine N-acyltransferase
J. Biochem. Mol. Toxicol.
14
102-109
2000
Bos taurus, Homo sapiens
Kelley, M.; Vessey, D.A.
Isolation and characterization of mitochondrial acyl-CoA: glycine N-acyltransferases from kidney
J. Biochem. Toxicol.
8
63-69
1993
Bos taurus
Zhang, H.; Lang, Q.; Li, J.; Zhong, Z.; Xie, F.; Ye, G.; Wan, B.; Yu, L.
Molecular cloning and characterization of a novel human glycine-N-acyltransferase gene GLYATL1, which activates transcriptional activity of HSE pathway
Int. J. Mol. Sci.
8
433-444
2007
Homo sapiens (Q969I3)
-
Yamamoto, A.; Nonen, S.; Fukuda, T.; Yamazaki, H.; Azuma, J.
Genetic polymorphisms of glycine N-acyltransferase in Japanese individuals
Drug Metab. Pharmacokinet.
24
114-117
2009
Homo sapiens (Q6IB77)
Matsuo, M.; Terai, K.; Kameda, N.; Matsumoto, A.; Kurokawa, Y.; Funase, Y.; Nishikawa, K.; Sugaya, N.; Hiruta, N.; Kishimoto, T.
Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma
Biochem. Biophys. Res. Commun.
420
901-906
2012
Homo sapiens (Q6IB77), Homo sapiens
Badenhorst, C.P.; Jooste, M.; van Dijk, A.A.
Enzymatic characterization and elucidation of the catalytic mechanism of a recombinant bovine glycine N-acyltransferase
Drug Metab. Dispos.
40
346-352
2012
BRENDA: Bos taurus (Q2KIR7), Bos taurus
Textmining: Homo sapiens, Expression vector pColdIII
Waluk, D.P.; Schultz, N.; Hunt, M.C.
Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans
FASEB J.
24
2795-2803
2010
Homo sapiens (Q8WU03)
Badenhorst, C.P.; van der Sluis, R.; Erasmus, E.; van Dijk, A.A.
Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation
Expert. Opin. Drug Metab. Toxicol.
9
1139-1153
2013
BRENDA: Homo sapiens (Q6IB77)
Textmining: Areas
Van der Sluis, R.; Badenhorst, C.; Van der Westhuizen, F.; Van Dijk, A.
Characterisation of the influence of genetic variations on the enzyme activity of a recombinant human glycine N-acyltransferase
Gene
515
447-453
2013
Homo sapiens (Q6IB77), Homo sapiens
van der Sluis, R.; Badenhorst, C.P.; Erasmus, E.; van Dyk, E.; van der Westhuizen, F.H.; van Dijk, A.A.
Conservation of the coding regions of the glycine N-acyltransferase gene further suggests that glycine conjugation is an essential detoxification pathway
Gene
571
126-134
2015
Homo sapiens (Q6IB77), Homo sapiens
Dempsey, D.R.; Bond, J.D.; Carpenter, A.M.; Rodriguez Ospina, S.; Merkler, D.J.
Expression, purification, and characterization of mouse glycine N-acyltransferase in Escherichia coli
Protein Expr. Purif.
97
23-28
2014
BRENDA: Mus musculus (Q91XE0), Mus musculus
Textmining: Escherichia coli, Homo sapiens, Bos taurus
van der Sluis, R.; Ungerer, V.; Nortje, C.; A van Dijk, A.; Erasmus, E.
New insights into the catalytic mechanism of human glycine N-acyltransferase
J. Biochem. Mol. Toxicol.
31
e21963
2017
Homo sapiens (Q6IB77), Homo sapiens
Jeffries, K.A.; Dempsey, D.R.; Farrell, E.K.; Anderson, R.L.; Garbade, G.J.; Gurina, T.S.; Gruhonjic, I.; Gunderson, C.A.; Merkler, D.J.
Glycine N-acyltransferase-like 3 is responsible for long-chain N-acylglycine formation in N18TG2 cells
J. Lipid Res.
57
781-790
2016
Mus musculus, Mus musculus (E9Q5L8)
Eich, M.L.; Chandrashekar, D.S.; Rodriguez Pen A, M.D.C.; Robinson, A.D.; Siddiqui, J.; Daignault-Newton, S.; Chakravarthi, B.V.S.K.; Kunju, L.P.; Netto, G.J.; Varambally, S.
Characterization of glycine-N-acyltransferase like 1 (GLYATL1) in prostate cancer
Prostate
79
1629-1639
2019
Homo sapiens
Leung, K.Y.; De Castro, S.C.P.; Santos, C.; Savery, D.; Prunty, H.; Gold-Diaz, D.; Bennett, S.; Heales, S.; Copp, A.J.; Greene, N.D.E.
Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia
J. Inherit. Metab. Dis.
43
1186-1198
2020
Mus sp.
Qureshi, IA; Ratnakumari, L; Michalak, A; Giguère, R; Cyr, D; Butterworth, RF
A profile of cerebral and hepatic carnitine, ammonia, and energy metabolism in a model of organic aciduria: BALB/cByJ mouse with short-chain acyl-CoA dehydrogenase deficiency.
Biochem Med Metab Biol
50
145-58
1993
Mus musculus, Mus sp., Metazoa, animal
Qureshi, IA; Lebel, S; Letarte, J
Development and inducibility of the hepatic and renal hippurate-synthesizing system in sparse-fur (spf) mutant mice with ornithine transcarbamylase deficiency.
Biochem Int
19
657-66
1989
Mus sp.
James, MO; Bend, JR
Perinatal development of, and effect of chemical pretreatment on, glycine N-acyltransferase activities in liver and kidney of rabbit and rat.
Biochem J
172
293-9
1978
Oryctolagus cuniculus, Rattus, Rattus norvegicus
Marniemi, J; Vainio, H; Parkki, M
Drug conjugation in Gunn rats: reduced UDP-glucuronosyl transferase and UDP-glucosyl transferase activities with increased glycine-N-acyltransferase activity.
Pharmacology
13
492-501
1975
Rattus norvegicus
Badawy, AA
The effects of acetate, metal cations, phenobarbitone, porphyrogens and substrates of glycine acyltransferase on the utilization of haem by rat liver apo-(tryptophan pyrrolase).
Biochem J
164
431-8
1977
Rattus
Gregersen, N; Kølvraa, S; Mortensen, PB
Acyl-CoA: glycine N-acyltransferase: in vitro studies on the glycine conjugation of straight- and branched-chained acyl-CoA esters in human liver.
Biochem Med Metab Biol
35
210-8
1986
Homo sapiens
Tephly, TR; Condie, LW; Piper, WN
The role of substrates for glycine acyltransferase, and the role of sulfanilamide and acetate in the reversal of chemically-induced porphyria in the rat.
Enzyme
16
187-95
1973
Rattus, Porphyria
Tremblay, C; Melançon, SB; Dallaire, L
[Physiological limitation of benzoic acid detoxification by glycine-n-acylase in the normal human being (child and adult)]
Union Med Can
103
703-7
1974
Homo sapiens
Imamura, T; Baldwin, TO; Riggs, A
The amino acid sequence of the monomeric hemoglobin component from the bloodworm, Glyat liver.
J Biol Chem
247
2785-97
1972
Strongylus vulgaris
Brandt, IK; Simmons, P; Gutfinger, T
Rat liver glycine acyltransferase: partial purification and some properties.
Biochim Biophys Acta
167
196-8
1968
Rattus
Brandt, IK
Glycine acyltransferase activity in developing rat liver.
Biochem Pharmacol
15
994-5
1966
Rattus
MacDermot, KD; Nelson, W; Soutter, V; Towne, D; Schulman, JD
Glycine and benzoate conjugation and glycine acyltransferase activity in the developing and adult rat: possible relationships to nonketotic hyperglycinemia.
Dev Pharmacol Ther
3
150-9
1981
Rattus, Homo sapiens, Metazoa
Ren, P; Li, W; Xue, L
GLYAT regulates JNK-mediated cell death in Drosophila.
Sci Rep
7
5183
2017
Drosophila
Schulke, D; Sass, JO
Frequent sequence variants of human glycine N-acyltransferase (GLYAT) and inborn errors of metabolism.
Biochimie
183
30-34
2021
Homo sapiens, Bacteria
Tian, X; Wu, L; Jiang, M; Zhang, Z; Wu, R; Miao, J; Liu, C; Gao, S
Downregulation of GLYAT Facilitates Tumor Growth and Metastasis and Poor Clinical Outcomes Through the PI3K/AKT/Snail Pathway in Human Breast Cancer.
Front Oncol
11
641399
2021
Homo sapiens, Mus musculus
Waluk, DP; Sucharski, F; Sipos, L; Silberring, J; Hunt, MC
Reversible lysine acetylation regulates the activity of human glycine n-acyltransferase-like 2 (hGLYATL2):Implications for production of glycine-conjugated signalling molecules.
J Biol Chem
2012
Mus musculus, Homo sapiens
Bickhart, DM; Xu, L; Hutchison, JL; Cole, JB; Null, DJ; Schroeder, SG; Song, J; Garcia, JF; Sonstegard, TS; Van Tassell, CP; Schnabel, RD; Taylor, JF; Lewin, HA; Liu, GE
Diversity and population-genetic properties of copy number variations and multicopy genes in cattle.
DNA Res
23
253-62
2016
Bos taurus, Cucumber necrosis virus
Fedry, J; Blais, A; Even, PC; Piedcoq, J; Fromentin, G; Gaudichon, C; Azzout-Marniche, D; Tom, D
Urinary metabolic profile predicts high-fat diet sensitivity in the C57Bl6/J mouse.
J Nutr Biochem
31
88-97
2016
Mus sp.
Merkler, DJ; Merkler, KA; Stern, W; Fleming, FF
Fatty acid amide biosynthesis: a possible new role for peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine N-acyltransferase.
Arch Biochem Biophys
330
430-4
1996
Mammalia
Lino Cardenas, CL; Bourgine, J; Cauffiez, C; Allorge, D; Lo-Guidice, JM; Broly, F; Chevalier, D
Genetic polymorphisms of Glycine N-acyltransferase (GLYAT) in a French Caucasian population.
Xenobiotica
2010
Homo sapiens
Guo, YF; Zhang, LS; Liu, YJ; Hu, HG; Li, J; Tian, Q; Yu, P; Zhang, F; Yang, TL; Guo, Y; Peng, XL; Dai, M; Chen, W; Deng, HW
Suggestion of GLYAT gene underlying variation of bone size and body lean mass as revealed by a bivariate genome-wide association study.
Hum Genet
132
189-99
2013
Annona squamosa
Guan, R; Hong, W; Huang, J; Peng, T; Zhao, Z; Lin, Y; Yu, M; Jian, Z
The expression and prognostic value of GLYATL1 and its potential role in hepatocellular carcinoma.
J Gastrointest Oncol
11
1305-1321
2020
Homo sapiens
Rohwer, JM; Schutte, C; van der Sluis, R
Functional Characterisation of Three Glycine N-Acyltransferase Variants and the Effect on Glycine Conjugation to Benzoyl-CoA.
Int J Mol Sci
22
2021
Homo sapiens
Huckle, KR; Tait, GH; Millburn, P; Hutson, DH
Species variations in the renal and hepatic conjugation of 3-phenoxybenzoic acid with glycine.
Xenobiotica
11
635-44
1981
Mustela putorius furo
Lau, EP; Haley, BE; Barden, RE
Photoaffinity labeling of acyl-coenzyme A:glycine N-acyltransferase with p-azidobenzoyl-coenzyme A.
Biochemistry
16
2581-5
1977
Bos taurus
Gregersen, N; Rosleff, F; Kølvraa, S; Hobolth, N; Rasmussen, K; Lauritzen, R
Non-ketotic C6-C10-dicarboxylic aciduria: biochemical investigations of two cases.
Clin Chim Acta
102
179-89
1980
Homo sapiens
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