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Information on EC 2.3.1.12 - dihydrolipoyllysine-residue acetyltransferase and Organism(s) Xenopus tropicalis

for references in articles please use BRENDA:EC2.3.1.12
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EC Tree
IUBMB Comments
A multimer (24-mer or 60-mer, depending on the source) of this enzyme forms the core of the pyruvate dehydrogenase multienzyme complex, and binds tightly both EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively acetylated by EC 1.2.4.1, and the only observed direction catalysed by EC 2.3.1.12 is that where the acetyl group is passed to coenzyme A.
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This record set is specific for:
Xenopus tropicalis
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Word Map
The taxonomic range for the selected organisms is: Xenopus tropicalis
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
dihydrolipoamide acetyltransferase, dihydrolipoyl transacetylase, lipoate acetyltransferase, dihydrolipoyl acetyltransferase, dhlta, dihydrolipoyl acetyl transferase, dihydrolipoyllysine-residue acetyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acetyltransferase, lipoate
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DHLTA
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dihydrolipoate acetyltransferase
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dihydrolipoic transacetylase
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dihydrolipoyl acetyltransferase
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E2
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E2p
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lipoate acetyltransferase
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lipoate transacetylase
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lipoic acetyltransferase
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lipoic acid acetyltransferase
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lipoic transacetylase
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lipoylacetyltransferase
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myelin-proteolipid O-palmitoyltransferase
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palmitoyl-CoA:myelin-proteolipid O-palmitoyltransferase
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thioltransacetylase A
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transacetylase X
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase
A multimer (24-mer or 60-mer, depending on the source) of this enzyme forms the core of the pyruvate dehydrogenase multienzyme complex, and binds tightly both EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively acetylated by EC 1.2.4.1, and the only observed direction catalysed by EC 2.3.1.12 is that where the acetyl group is passed to coenzyme A.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-29-5
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
B1H2L3_XENTR
628
0
67109
TrEMBL
Mitochondrion (Reliability: 1)
F6Z0R6_XENTR
628
0
67023
TrEMBL
Mitochondrion (Reliability: 1)