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Information on EC 2.3.1.12 - dihydrolipoyllysine-residue acetyltransferase and Organism(s) Sus scrofa

for references in articles please use BRENDA:EC2.3.1.12

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EC Tree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.12 dihydrolipoyllysine-residue acetyltransferase

IUBMB Comments

A multimer (24-mer or 60-mer, depending on the source) of this enzyme forms the core of the pyruvate dehydrogenase multienzyme complex, and binds tightly both EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively acetylated by EC 1.2.4.1, and the only observed direction catalysed by EC 2.3.1.12 is that where the acetyl group is passed to coenzyme A.

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Sus scrofa

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2.3.1.12
lipoylated
multienzyme
stearothermophilus
thiamin
azotobacter
vinelandii
subcomplexes
subunit-binding
lipoyl-lysine
e3-binding
icosahedral
pdc-e2
1.2.4.1
lipoyl-bearing
dodecahedron
alpha2beta2
pentagonal
e1alpha
e1beta
2-14cpyruvate
molecular biology
degradation

The taxonomic range for the selected organisms is: Sus scrofa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Reaction Schemes

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acetyl-CoA

enzyme N6-(dihydrolipoyl)lysine

CoA

enzyme N6-(S-acetyldihydrolipoyl)lysine

Synonyms

dihydrolipoamide acetyltransferase, dihydrolipoyl transacetylase, lipoate acetyltransferase, dihydrolipoyl acetyltransferase, dhlta, dihydrolipoyl acetyl transferase, dihydrolipoyllysine-residue acetyltransferase, show all synonyms

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acetyltransferase, lipoate

DHLTA

dihydrolipoate acetyltransferase

dihydrolipoic transacetylase

dihydrolipoyl acetyltransferase

E2p

lipoate acetyltransferase

lipoate transacetylase

lipoic acetyltransferase

lipoic acid acetyltransferase

lipoic transacetylase

lipoylacetyltransferase

myelin-proteolipid O-palmitoyltransferase

palmitoyl-CoA:myelin-proteolipid O-palmitoyltransferase

thioltransacetylase A

transacetylase X

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Acyl group transfer

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BRENDA

acetyl CoA biosynthesis, oxidative decarboxylation of pyruvate

KEGG

Biosynthesis of secondary metabolites, Citrate cycle (TCA cycle), Glycolysis / Gluconeogenesis, Microbial metabolism in diverse environments, Pyruvate metabolism

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acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase

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9032-29-5

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dihydrolipoamide + acetyl-CoA

S-acetyldihydrolipoamide + CoA

2 entries

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dihydrolipoamide + acetyl-CoA

S-acetyldihydrolipoamide + CoA

2 entries

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19.7

All organisms
Arabidopsis thaliana
Azotobacter vinelandii
Bacillus subtilis
Bos taurus
Brassica oleracea
Brassica oleracea var. botrytis
Chlorella sp. MM3
Columba sp.
Escherichia coli
Geobacillus stearothermophilus
Hansenula miso
Homo sapiens
Mammalia
Mus musculus
Mycoplasma hyopneumoniae
Neisseria meningitidis
Neurospora crassa
Rattus norvegicus
Rhodospirillum rubrum
Saccharomyces cerevisiae
Salmonella enterica subsp. enterica serovar Typhimurium
Solanum tuberosum
Sus scrofa
Syntrophotalea carbinolica
Zea mays