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Information on EC 2.2.1.1 - transketolase and Organism(s) Arabidopsis thaliana

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EC Tree
     2 Transferases
         2.2 Transferring aldehyde or ketonic groups
             2.2.1 Transketolases and transaldolases
                2.2.1.1 transketolase
IUBMB Comments
A thiamine-diphosphate protein. Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO2 and R-CHOH-CO-CH2OH. The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
transketolase, tktl1, transketolase a, transketolase-like 1, tktl-1, transketolase-like-1, tktl2, transketolase-like enzyme 1, transketolase-like-2, tkt10, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycolaldehydetransferase
-
-
-
-
transketolase-1
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
keto group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase
A thiamine-diphosphate protein. Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO2 and R-CHOH-CO-CH2OH. The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.
CAS REGISTRY NUMBER
COMMENTARY hide
9014-48-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate
erythrose 4-phosphate + D-xylulose 5-phosphate
show the reaction diagram
-
-
-
-
?
D-ribose 5-phosphate + D-xylulose 5-phosphate
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
show the reaction diagram
-
-
-
r
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
D-ribose 5-phosphate + D-xylulose 5-phosphate
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate
erythrose 4-phosphate + D-xylulose 5-phosphate
show the reaction diagram
-
-
-
-
?
D-ribose 5-phosphate + D-xylulose 5-phosphate
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
show the reaction diagram
-
-
-
r
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
D-ribose 5-phosphate + D-xylulose 5-phosphate
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
thiamine diphosphate
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl)oxy]-N-[1-(4-ethyl-6-hydroxypyrimidin-2-yl)-4-(furan-2-yl)-1H-pyrrol-2-yl]acetamide
-
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3-(2,4-dichlorophenoxy)-N-[3-(furan-2-yl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl]propanamide
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-
alpha-terthienyl
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N-[1-(3-chloro-5-methylpyridin-2-yl)-3-(furan-2-yl)-1H-pyrazol-5-yl]-3-phenoxypropanamide
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-
ZINC12007063
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i.e. 2-[(2,2-dimethyl-3H-benzofuran-7-yl)oxy]-N-[2-(4-ethyl]-6-oxo-1H-pyrimidin-2-yl)-5-(2-furyl)pyrazol-3
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.4
isoelectric focusing
5.9
calculated from amino acid sequence
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
increased transketolase activity causes reduced growth and results in leaf chlorosis
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
TKTC1_ARATH
741
0
79968
Swiss-Prot
Chloroplast (Reliability: 1)
TKTC2_ARATH
741
0
79922
Swiss-Prot
Chloroplast (Reliability: 1)
A0A5S9X788_ARATH
741
0
79922
TrEMBL
Chloroplast (Reliability: 1)
A0A178VEI0_ARATH
741
0
79968
TrEMBL
Chloroplast (Reliability: 1)
A0A654F253_ARATH
741
0
79980
TrEMBL
Chloroplast (Reliability: 1)
A0A7G2EIA1_ARATH
738
0
79705
TrEMBL
Chloroplast (Reliability: 1)
F4JBY2_ARATH
740
0
79839
TrEMBL
Chloroplast (Reliability: 1)
A0A178VQH8_ARATH
741
0
79950
TrEMBL
Chloroplast (Reliability: 1)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Nicotiana tabacum cultivar Samsun
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Khozaei, M.; Fisk, S.; Lawson, T.; Gibon, Y.; Sulpice, R.; Stitt, M.; Lefebvre, S.C.; Raines, C.A.
Overexpression of plastid transketolase in tobacco results in a thiamine auxotrophic phenotype
Plant Cell
27
432-447
2015
Arabidopsis thaliana
Manually annotated by BRENDA team
Huo, J.; Zhao, B.; Zhang, Z.; Xing, J.; Zhang, J.; Dong, J.; Fan, Z.
Structure-based discovery and synthesis of potential transketolase inhibitors
Molecules
23
2116
2018
Arabidopsis thaliana
Manually annotated by BRENDA team
Zhao, B.; Huo, J.; Liu, N.; Zhang, J.; Dong, J.
Transketolase is identified as a target of herbicidal substance alpha-terthienyl by proteomics
Toxins
10
41
2018
Arabidopsis thaliana (F4JBY2)
Manually annotated by BRENDA team