Information on EC 2.1.4.1 - glycine amidinotransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
2.1.4.1
-
RECOMMENDED NAME
GeneOntology No.
glycine amidinotransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
L-arginine + glycine = L-ornithine + guanidinoacetate
show the reaction diagram
canavanine can act instead of arginine
-
-
-
L-arginine + glycine = L-ornithine + guanidinoacetate
show the reaction diagram
reaction and kinetic mechanisms, overview
-
L-arginine + glycine = L-ornithine + guanidinoacetate
show the reaction diagram
reaction and kinetic mechanisms, overview
-
-
PATHWAY
KEGG Link
MetaCyc Link
Arginine and proline metabolism
-
creatine biosynthesis
-
Glycine, serine and threonine metabolism
-
Metabolic pathways
-
SYSTEMATIC NAME
IUBMB Comments
L-arginine:glycine amidinotransferase
Canavanine can act instead of arginine.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
AGAT
-
-
AGAT
-
-
AGAT
P50442
-
AGAT
-
-
AGAT
Q9IAJ6
-
arginine-glycine amidinotransferase
-
-
-
-
arginine-glycine transamidinase
-
-
-
-
arginine:glycine amidinotransferase
-
-
arginine:glycine amidinotransferase
-
-
arginine:glycine amidinotransferase
P50442
-
arginine:glycine amidinotransferase
-
-
CyrA
B0LI36
gene name; gene name
-
EC 2.6.2.1
-
-
formerly
-
GAT
Rattus norvegicus Wistar
-
-
-
glycine amidinotransferase
Q0GU46
-
glycine amidinotransferase
-
-
glycine amidinotransferase
-
-
glycine amidinotransferase
P50442
-
glycine aminotransferase
Q9IAJ6
-
glycine transamidinase
-
-
-
-
L-arginine:glycine amidinotransferase
-
-
L-arginine:glycine amidinotransferase
Q9IAJ6
-
CAS REGISTRY NUMBER
COMMENTARY
9027-35-4
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
cow
-
-
Manually annotated by BRENDA team
Felis domestica
cat
-
-
Manually annotated by BRENDA team
cDNA clone, sequence of the chicken AT gene, GenBank
SwissProt
Manually annotated by BRENDA team
chicken; white leghorn
-
-
Manually annotated by BRENDA team
soybean
-
-
Manually annotated by BRENDA team
cytosolic enzyme, DDBJ/EMBL/GenBank database, cDNA sequence; mitochondrial enzyme, DDBJ/EMBL/GenBank database, cDNA sequence
SwissProt
Manually annotated by BRENDA team
Lacerta sp.
lizard
-
-
Manually annotated by BRENDA team
lamprey
-
-
Manually annotated by BRENDA team
mouse
-
-
Manually annotated by BRENDA team
no activity in Leuconostoc mesenteroides
-
-
-
Manually annotated by BRENDA team
no activity in Streptomyces sp.
-
-
-
Manually annotated by BRENDA team
cDNA sequence, EMBL accession number
SwissProt
Manually annotated by BRENDA team
rat; strain Sprague-Dawley
-
-
Manually annotated by BRENDA team
rat; strain Wistar
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
strain Sprague-Dawley
-
-
Manually annotated by BRENDA team
Rattus norvegicus Wistar
strain Wistar
-
-
Manually annotated by BRENDA team
7 to 8-d-old piglets, milk from lactating sows
-
-
Manually annotated by BRENDA team
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
875
-
glycine
-
per active site, pH 8.5, 30C
875
-
L-arginine
-
per active site, pH 8.5, 30C
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
30
45
-
different optima for wild-type and mutant CyrAs, above 40C activity decreases rapidly for all enzymes, including the S247M variant, which shows 18% of maximal activity at 45C
32
40
-
20% of maximal activity at 40C, maximal activity at 32C
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5.1
-
-
sequence calculation, native enzyme
5.6
-
-
sequence calculation, His6-tagged enzyme
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.5
-
-
purified recombinant enzyme, maximally stable at