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Information on EC 2.1.2.9 - methionyl-tRNA formyltransferase and Organism(s) Pseudomonas aeruginosa

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Pseudomonas aeruginosa
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The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
mtfmt, methionyl-trna formyltransferase, methionyl-trna transformylase, mitochondrial methionyl-trna formyltransferase, methionyl-trna-formyltransferase, fmt1p, formyl-methionyl transferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
formylmethionyl-transfer ribonucleic synthetase
-
-
-
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methionyl ribonucleic formyltransferase
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-
-
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methionyl-transfer ribonucleic transformylase
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-
-
-
methionyl-transfer RNA transformylase
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-
-
-
methionyl-tRNA formyltransferase
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-
methionyl-tRNA Met formyltransferase
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-
-
-
methionyl-tRNA transformylase
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-
-
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methyltransferase, methionyl-transfer ribonucleate
-
-
-
-
MTF
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-
-
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N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
formyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9015-76-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O
tetrahydrofolate + N-formylmethionyl-tRNAfMet
show the reaction diagram
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E. coli tRNAFMet
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000086
tRNAfMet
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pH 7.5
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
slow growth of cells when methionyl-tRNA formyltransferase inactive, when enzyme inactive higher transcript titer of MexXY efflux pump
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A8G4GCL2_PSEAI
314
0
33058
TrEMBL
-
A0A8G4DHN1_PSEAI
314
0
32997
TrEMBL
-
A0A8G1K4Y5_PSEAI
314
0
33072
TrEMBL
-
A0A8F9LAR8_PSEAI
314
0
32995
TrEMBL
-
A0A8G6GHL8_PSEAI
314
0
33044
TrEMBL
-
A0A6A9K441_PSEAI
314
0
33032
TrEMBL
-
A0A8G3UIN0_PSEAI
314
0
33041
TrEMBL
-
A0A8G7T927_PSEAI
314
0
33010
TrEMBL
-
A0A509JPN3_PSEAI
314
0
33044
TrEMBL
-
A0A8G3SSM3_PSEAI
314
0
33060
TrEMBL
-
A0A8G7AC89_PSEAI
314
0
33062
TrEMBL
-
A0A8G6UTZ2_PSEAI
314
0
32989
TrEMBL
-
A0A8G8K3S8_PSEAI
314
0
33086
TrEMBL
-
A0A7M2ZRZ0_PSEAI
314
0
33027
TrEMBL
-
A0A8G7CWB2_PSEAI
314
0
32986
TrEMBL
-
A0A8B4ZTB2_PSEAI
314
0
33004
TrEMBL
-
A0A4U9K3Y1_PSEAI
314
0
33014
TrEMBL
-
A0A8G5W3W4_PSEAI
314
0
33032
TrEMBL
-
A0A8G7LFT3_PSEAI
314
0
33028
TrEMBL
-
A0A7M3ARQ4_PSEAI
314
0
33030
TrEMBL
-
A0A8G6Z2U0_PSEAI
314
0
33046
TrEMBL
-
A0A8G6M209_PSEAI
314
0
33053
TrEMBL
-
A0A8G5ZQH9_PSEAI
314
0
33062
TrEMBL
-
A0A8G4JSY7_PSEAI
314
0
33014
TrEMBL
-
A0A367M6V8_PSEAI
312
0
32815
TrEMBL
-
A0A8G3XAQ7_PSEAI
314
0
33044
TrEMBL
-
A0A080VE30_PSEAI
314
0
33000
TrEMBL
-
A0A8F9JZG2_PSEAI
314
0
33044
TrEMBL
-
A0A8G2RS66_PSEAI
314
0
33000
TrEMBL
-
A0A485G6K7_PSEAI
314
0
32909
TrEMBL
-
A0A8G3D2I9_PSEAI
314
0
33030
TrEMBL
-
A0A8G3N4C8_PSEAI
314
0
33032
TrEMBL
-
A0A8G7PMH4_PSEAI
314
0
33025
TrEMBL
-
A0A8G3YEP5_PSEAI
314
0
33014
TrEMBL
-
A0A8G7KTV7_PSEAI
314
0
33000
TrEMBL
-
A0A8H2EXX0_PSEAI
314
0
32990
TrEMBL
-
A0A1Y3LI61_PSEAI
314
0
33055
TrEMBL
-
A0A2R3IYS3_PSEAI
310
0
32509
TrEMBL
-
A0A8G3GHX3_PSEAI
314
0
32978
TrEMBL
-
A0A8G3X5N9_PSEAI
314
0
32990
TrEMBL
-
A0A8G3AT65_PSEAI
314
0
33026
TrEMBL
-
A0A3M5EFQ0_PSEAI
136
0
14694
TrEMBL
-
A0A8G4DRW5_PSEAI
314
0
33044
TrEMBL
-
A0A8G5MMT8_PSEAI
314
0
33013
TrEMBL
-
A0A8G7L8S9_PSEAI
314
0
33072
TrEMBL
-
A0A444LPQ8_PSEAI
314
0
33016
TrEMBL
-
A0A3S0J0V7_PSEAI
314
0
32881
TrEMBL
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
del833
-
inactivated methionyl-tRNA formyltransferase
additional information
-
insertionally inactivated methionyl-tRNA formyltransferase in mutant CDR1 and mutant CDR2
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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fmt gene encoding enzyme is cloned
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Newton, D.T.; Mangroo, D.
Mapping the active site of the Haemophilus influenzae methionyl-tRNA formyltransferase: Residues important for catalysis and tRNA binding
Biochem. J.
339
63-69
1999
Thermus thermophilus, Haemophilus influenzae, Pseudomonas aeruginosa, Rickettsia prowazekii
-
Manually annotated by BRENDA team
Newton, D.T.; Niemkiewicz, M.; Lo, R.Y.; Mangroo, D.
Recognition of the initiator tRNA by the Pseudomonas aeruginosa methionyl-tRNA formyltransferase: importance of the base-base mismatch at the end of the acceptor stem
FEMS Microbiol. Lett.
178
289-298
1999
Escherichia coli, Pseudomonas aeruginosa
Manually annotated by BRENDA team
Caughlan, R.E.; Sriram, S.; Daigle, D.M.; Woods, A.L.; Buco, J.; Peterson, R.L.; Dzink-Fox, J.; Walker, S.; Dean, C.R.
Fmt bypass in Pseudomonas aeruginosa causes induction of MexXY efflux pump expression
Antimicrob. Agents Chemother.
53
5015-5021
2009
Pseudomonas aeruginosa
Manually annotated by BRENDA team