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Information on EC 2.1.2.2 - phosphoribosylglycinamide formyltransferase 1 and Organism(s) Taeniopygia guttata

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EC Tree
IUBMB Comments
Two enzymes are known to catalyse the third step in de novo purine biosynthesis. This enzyme utilizes 10-formyltetrahydrofolate as the formyl donor, while the other enzyme, EC 6.3.1.21, phosphoribosylglycinamide formyltransferase 2, utilizes formate. In vertebrates this activity is catalysed by a trifunctional enzyme that also catalyses the activities of EC 6.3.4.13, phosphoribosylamine---glycine ligase and EC 6.3.3.1, phosphoribosylformylglycinamidine cyclo-ligase.
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Taeniopygia guttata
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Word Map
The taxonomic range for the selected organisms is: Taeniopygia guttata
The enzyme appears in selected viruses and cellular organisms
Synonyms
glycinamide ribonucleotide formyltransferase, glycinamide ribonucleotide transformylase, garft, gar tfase, gar transformylase, garftase, phosphoribosylglycinamide formyltransferase, glycinamide ribonucleotide formyl transferase, gar formyltransferase, gartfase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-amino-N-ribosylacetamide 5'-phosphate transformylase
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5'-phosphoribosylglycinamide transformylase
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5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase
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ADE8
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GAR formyltransferase
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GAR TFase
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GAR transformylase
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GART
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glycinamide ribonucleotide transformylase
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PurN
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
formyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase
Two enzymes are known to catalyse the third step in de novo purine biosynthesis. This enzyme utilizes 10-formyltetrahydrofolate as the formyl donor, while the other enzyme, EC 6.3.1.21, phosphoribosylglycinamide formyltransferase 2, utilizes formate. In vertebrates this activity is catalysed by a trifunctional enzyme that also catalyses the activities of EC 6.3.4.13, phosphoribosylamine---glycine ligase and EC 6.3.3.1, phosphoribosylformylglycinamidine cyclo-ligase.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-02-4
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A674GJW5_TAEGU
1003
0
106977
TrEMBL
other Location (Reliability: 4)
A0A674GJ19_TAEGU
1007
0
106941
TrEMBL
other Location (Reliability: 5)
A0A674GQR8_TAEGU
1001
0
106807
TrEMBL
other Location (Reliability: 4)
A0A674H3D8_TAEGU
1050
0
112174
TrEMBL
Mitochondrion (Reliability: 3)
H0YQC2_TAEGU
1038
0
110128
TrEMBL
Mitochondrion (Reliability: 5)
A0A674HGX0_TAEGU
998
0
106424
TrEMBL
other Location (Reliability: 4)
A0A674H706_TAEGU
1000
0
106665
TrEMBL
other Location (Reliability: 4)