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Information on EC 2.1.2.2 - phosphoribosylglycinamide formyltransferase 1 and Organism(s) Drosophila melanogaster

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EC Tree
IUBMB Comments
Two enzymes are known to catalyse the third step in de novo purine biosynthesis. This enzyme utilizes 10-formyltetrahydrofolate as the formyl donor, while the other enzyme, EC 6.3.1.21, phosphoribosylglycinamide formyltransferase 2, utilizes formate. In vertebrates this activity is catalysed by a trifunctional enzyme that also catalyses the activities of EC 6.3.4.13, phosphoribosylamine---glycine ligase and EC 6.3.3.1, phosphoribosylformylglycinamidine cyclo-ligase.
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Drosophila melanogaster
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The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
glycinamide ribonucleotide formyltransferase, glycinamide ribonucleotide transformylase, garft, gar tfase, gar transformylase, garftase, glycinamide ribonucleotide formyl transferase, phosphoribosylglycinamide formyltransferase, gar formyltransferase, gartfase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-amino-N-ribosylacetamide 5'-phosphate transformylase
-
-
-
-
5'-phosphoribosylglycinamide transformylase
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-
-
-
5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase
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-
-
-
ADE8
-
-
-
-
GAR formyltransferase
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-
-
-
GAR TFase
-
-
-
-
GAR transformylase
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-
-
-
GART
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-
-
-
GART synthetase
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-
glycinamide ribonucleotide transformylase
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-
-
-
PurN
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
formyl group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase
Two enzymes are known to catalyse the third step in de novo purine biosynthesis. This enzyme utilizes 10-formyltetrahydrofolate as the formyl donor, while the other enzyme, EC 6.3.1.21, phosphoribosylglycinamide formyltransferase 2, utilizes formate. In vertebrates this activity is catalysed by a trifunctional enzyme that also catalyses the activities of EC 6.3.4.13, phosphoribosylamine---glycine ligase and EC 6.3.3.1, phosphoribosylformylglycinamidine cyclo-ligase.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-02-4
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
show the reaction diagram
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
10-Acetyl-5,8-dideazafolate
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-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PUR2_DROME
1353
0
144448
Swiss-Prot
Mitochondrion (Reliability: 5)
F3YDH3_DROME
1353
0
144572
TrEMBL
Mitochondrion (Reliability: 5)
X2J516_DROME
1353
0
144525
TrEMBL
Mitochondrion (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Daubner, S.C.; Schrimsher, J.L.; Schendel, F.J.; Young, M.; Henikoff, S.; Patterson, D.; Stubbe, J.; Benkovic, S.J.
A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis
Biochemistry
24
7059-7062
1985
Drosophila melanogaster, Gallus gallus, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Manually annotated by BRENDA team
Chen, P.; Schulze-Gahmen, U.; Stura, E.A.; Inglese, J.; Johnson, D.L.; Marolewski, A.; Benkovic, S.J.; Wilson, I.A.
Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution
J. Mol. Biol.
227
283-292
1992
Bacillus subtilis, Drosophila melanogaster, Escherichia coli, Homo sapiens, Mus musculus, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Inglese, J.; Johnson, D.L.; Shiau, A.; Smith, J.M.; Benkovic, S.J.
Subcloning, characterization, and affinity labeling of Escherichia coli glycinamide ribonucleotide transformylase
Biochemistry
29
1436-1443
1990
Bacillus subtilis, Cricetulus griseus, Drosophila melanogaster, Escherichia coli, Gallus gallus, Homo sapiens, Mus musculus, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Caperelli, C.A.
Mammalian glycinamide ribonucleotide transformylase. Kinetic mechanism and associated de novo purine biosynthesis activities
J. Biol. Chem.
264
5053-5057
1989
Gallus gallus, Drosophila melanogaster, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Warren, M.S.; Marolewski, A.E.; Benkovic, S.J.
A rapid screen of active site mutants in glycinamide ribonucleotide transformylase
Biochemistry
35
8855-8862
1996
Bacillus subtilis, Saccharomyces cerevisiae, Gallus gallus, Drosophila melanogaster, Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
McMorran, B.J.; Kumara, H.M.C.S.; Sullivan, K.; Lamont, I.L.
Involvement of a transformylase enzyme in siderophore synthesis in Pseudomonas aeruginosa
Microbiology
147
1517-1524
2001
Arabidopsis thaliana, Bacillus subtilis, Saccharomyces cerevisiae, Drosophila melanogaster, Escherichia coli, Pseudomonas aeruginosa
Manually annotated by BRENDA team