Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.1.2.2 - phosphoribosylglycinamide formyltransferase 1 and Organism(s) Bos taurus

for references in articles please use BRENDA:EC2.1.2.2
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
Two enzymes are known to catalyse the third step in de novo purine biosynthesis. This enzyme utilizes 10-formyltetrahydrofolate as the formyl donor, while the other enzyme, EC 6.3.1.21, phosphoribosylglycinamide formyltransferase 2, utilizes formate. In vertebrates this activity is catalysed by a trifunctional enzyme that also catalyses the activities of EC 6.3.4.13, phosphoribosylamine---glycine ligase and EC 6.3.3.1, phosphoribosylformylglycinamidine cyclo-ligase.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Bos taurus
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Synonyms
glycinamide ribonucleotide formyltransferase, glycinamide ribonucleotide transformylase, garft, gar tfase, gar transformylase, garftase, phosphoribosylglycinamide formyltransferase, glycinamide ribonucleotide formyl transferase, gar formyltransferase, gartfase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-amino-N-ribosylacetamide 5'-phosphate transformylase
-
-
-
-
5'-phosphoribosylglycinamide transformylase
-
-
-
-
5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase
-
-
-
-
ADE8
-
-
-
-
GAR formyltransferase
-
-
-
-
GAR TFase
-
-
-
-
GAR transformylase
-
-
-
-
GART
-
-
-
-
glycinamide ribonucleotide formyltransferase
-
glycinamide ribonucleotide transformylase
-
-
-
-
PurN
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
formyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase
Two enzymes are known to catalyse the third step in de novo purine biosynthesis. This enzyme utilizes 10-formyltetrahydrofolate as the formyl donor, while the other enzyme, EC 6.3.1.21, phosphoribosylglycinamide formyltransferase 2, utilizes formate. In vertebrates this activity is catalysed by a trifunctional enzyme that also catalyses the activities of EC 6.3.4.13, phosphoribosylamine---glycine ligase and EC 6.3.3.1, phosphoribosylformylglycinamidine cyclo-ligase.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-02-4
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
fragment
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PUR2_BOVIN
1010
0
107907
Swiss-Prot
Mitochondrion (Reliability: 5)
Q599X3_BOVIN
59
0
6400
TrEMBL
-
Q599X4_BOVIN
177
0
19132
TrEMBL
-
Q599X5_BOVIN
246
0
26111
TrEMBL
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning, chromosomal assignment, genomic organization and the complete sequence of the bovine GART gene
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Woehlke, A.; Droegemueller, C.; Kuiper, H.; Leeb, T.; Distl, O.
Molecular characterization and chromosomal assignment of the bovine glycinamide ribonucleotide formyltransferase (GART) gene on cattle chromosome 1q12.1-q12.2
Gene
348
73-81
2005
Bos taurus (Q599X3), Bos taurus (Q599X4), Bos taurus (Q599X5), Bos taurus
Manually annotated by BRENDA team