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(R)-chloroquine
-
50% inhibition at 0.018 mM, liver enzyme, 50% inhibition at 0.0022 mM, brain enzyme
(S)-chloroquine
-
50% inhibition at 0.005 mM, liver enzyme, 50% inhibition at 0.007 mM, brain enzyme
2-(4-hydroperoxyphenyl)-6-methyl-4H-chromen-4-one
-
-
3,6-dimethyl-2-phenyl-4H-chromen-4-one
-
-
3-bromo-6-chloro-2-phenyl-4H-chromen-4-one
-
-
3-bromo-6-methyl-2-phenyl-4H-chromen-4-one
-
-
3-chloro-6-methyl-2-phenyl-4H-chromen-4-one
-
-
6-chloro-2-phenyl-4H-chromen-4-one
-
-
6-methyl-2-phenyl-4H-chromen-4-one
-
-
8-bromo-6-chloro-2-phenyl-4H-chromen-4-one
-
-
8-bromo-6-methyl-2-phenyl-4H-chromen-4-one
-
-
diphenhydramine
potent HNMT inhibitor, occupies the histamine-binding site, thus blocks access to the enzymes active site
Metoprine
potent HNMT inhibitor, occupies the histamine-binding site, thus blocks access to the enzymes active site
N-[2(benzhydryloxy)ethyl] N N-dimethylamine
-
diphenhydramine, competitive inhibitor
S-adenosylhomocysteine
-
-
amodiaquine
potent HNMT inhibitor, occupies the histamine-binding site, thus blocks access to the enzymes active site
amodiaquine
inhibits the reaction with BI 187004
tacrine
-
50% inhibition at 0.00046 mM for enzyme of embryonic kidney, at 0.0007 mM for recombinant brain enzyme
tacrine
potent HNMT inhibitor, occupies the histamine-binding site, thus blocks access to the enzymes active site
additional information
-
not inhibitory: S-adenosyl-L-methionine
-
additional information
-
not inhibitory: galanthamine up to 0.001 mM
-
additional information
near the N-terminus of HNMT, several aromatic residues (Phe9, Tyr15, and Phe19) adopt different rotamer conformations or become disordered in the enzyme-inhibitor complexes, accommodating the diverse, rigid hydrophobic groups of the inhibitors, maximized shape complementarity between the protein aromatic side-chains and aromatic rings of the inhibitors are responsible for the tight binding of the different inhibitors
-
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Adenoma
Decreased histamine catabolism in the colonic mucosa of patients with colonic adenoma.
Alzheimer Disease
No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.
Amyotrophic Lateral Sclerosis
Determining the Effect of the HNMT, STK39, and NMD3 Polymorphisms on the Incidence of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Multiple System Atrophy in Chinese Populations.
Arthus Reaction
Biogenic amines in the Arthus reaction.
Arthus Reaction
Histamine metabolism in the Arthus reaction.
Asthma
Association of the histamine N-methyltransferase C314T (Thr105Ile) polymorphism with atopic dermatitis in Caucasian children.
Asthma
Genetic variation within the histamine pathway among patients with asthma - a pilot study.
Asthma
Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma.
Asthma
Implications of pharmacogenomics in the current and future treatment of asthma.
Asthma
Lack of association between atopic asthma and polymorphisms of the histamine H1 receptor, histamine H2 receptor, and histamine N-methyltransferase genes.
Asthma
Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population.
Asthma
No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.
Asthma
No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations.
Asthma
Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis.
Asthma
Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study.
Asthma
Theoretical 3D model of histamine N-methyltransferase: insights into the effects of a genetic polymorphism on enzymatic activity and thermal stability.
Brain Diseases
Histamine N-Methyltransferase in the Brain.
Breast Neoplasms
Associations of polymorphisms in histidine decarboxylase, histamine N-methyltransferase and histamine receptor H3 genes with breast cancer.
Chronic Urticaria
Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria.
Colitis, Ulcerative
Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene.
Cough
Enzymatic modulation of bronchoconstriction, gland secretion, plasma extravasation and cough.
Cystic Fibrosis
Diets high in heat-treated soybean meal reduce the histamine-induced epithelial response in the colon of weaned piglets and increase epithelial catabolism of histamine.
Decompression Sickness
Comparison of the acyl chain specificities of human myristoyl-CoA synthetase and human myristoyl-CoA:protein N-myristoyltransferase.
Dermatitis, Atopic
Association of the histamine N-methyltransferase C314T (Thr105Ile) polymorphism with atopic dermatitis in Caucasian children.
Dermatitis, Atopic
Involvement of human histamine N-methyltransferase gene polymorphisms in susceptibility to atopic dermatitis in korean children.
Dermatitis, Atopic
MicroRNA-223 is involved in the pathogenesis of atopic dermatitis by affecting histamine-N-methyltransferase.
Down Syndrome
Human brain cytosolic histamine-N-methyltransferase is decreased in Down syndrome and increased in Pick's disease.
Duodenal Ulcer
C314T polymorphism in histamine N-methyltransferase gene and susceptibility to duodenal ulcer in Chinese population.
Duodenal Ulcer
Gastric mucosal histamine and histamine methyltransferase in patients with duodenal ulcer.
Duodenal Ulcer
Gastric mucosal histamine and histamine methytltransferase in patients with duodenal ulcer.
Duodenal Ulcer
Histamine and duodenal ulcer: effect of omeprazole on gastric histamine in patients with duodenal ulcer.
Duodenal Ulcer
Histamine and duodenal ulceration in renal transplant recipients.
Duodenal Ulcer
Histamine and peptic ulcer disease: histamine methyltransferase activity in gastric mucosa of control subjects and duodenal ulcer patients before and after surgical treatment.
Duodenal Ulcer
[Histamine and its role in peptic gastric diseases: the discovery of histamine-H2-receptor antagonists]
Epilepsy
Histamine-N-methyl transferase polymorphism and risk for migraine.
Epilepsy, Reflex
Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats.
Essential Tremor
Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.
Essential Tremor
No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.
Essential Tremor
The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor.
Food Hypersensitivity
Both catabolic pathways of histamine via histamine-N-methyltransferase and diamine oxidase are diminished in the colonic mucosa of patients with food allergy.
Heart Failure
Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure.
Hepatitis
Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice.
histamine n-methyltransferase deficiency
Histamine N-methyltransferase regulates aggression and the sleep-wake cycle.
histamine n-methyltransferase deficiency
[Analysis of brain histamine clearance using genetically engineered mice].
Hydronephrosis
Induction of histamine methyltransferase during experimental hydronephrosis: a mechanism of adaptation for histamine homeostasis in rabbit kidney.
Hypersensitivity
Association of diamine oxidase and histamine N-methyltransferase polymorphisms with presence of migraine in a group of Mexican mothers of children with allergies.
Hypersensitivity
Expression of histidine decarboxylase messenger RNA and histamine N-methyltransferase messenger RNA in nasal allergy.
Hypersensitivity
Histamine N-methyltransferase modulates histamine- and antigen-induced bronchoconstriction in guinea pigs in vivo.
Hypertension
Histamine, histidine decarboxylase and histamine-N-methyltransferase in brain areas of spontaneously hypertensive rats.
Hypertension
The effect of intrahypothalamic injection of homodimaprit on blood pressure.
Hypotension
Cardiac and regional haemodynamic effects of histamine N-methyltransferase inhibitor metoprine in haemorrhage-shocked rats.
Hypotension
Endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats--studies with histamine N-methyltransferase inhibitor SKF 91488.
Hypotension
Endogenous central histamine-induced reversal of critical hemorrhagic hypotension in rats: studies with L-histidine.
Hypotension
Influence of SKF 91488, histamine N-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats.
Hypotension
Involvement of arginine vasopressin in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.
Hypotension
Involvement of proopiomenalocortin-derived peptides in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.
Hypotension
Involvement of the renin-angiotensin system in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.
Hypotension
Involvement of the sympathetic nervous system in the reversal of critical haemorrhagic hypotension by endogenous central histamine in rats.
Infections
Airway hyperresponsiveness to histamine in mycoplasmal infection: role of histamine N-methyltransferase.
Infections
The response of histamine degrading enzymes to nematode infection.
Infections
Viral respiratory infection causes airway hyperresponsiveness and decreases histamine N-methyltransferase activity in guinea pigs.
Intellectual Disability
Adult male patient with severe intellectual disability caused by a homozygous mutation in the HNMT gene.
Intellectual Disability
Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability.
Intellectual Disability
Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability.
Intestinal Diseases
Histamine N-methyltransferase and diamine oxidase gene polymorphisms in patients with inflammatory and neoplastic intestinal diseases.
Leukemia, Erythroblastic, Acute
A comparative analysis of the kinetic mechanism and peptide substrate specificity of human and Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase.
Melanoma
Autonomous histamine metabolism in human melanoma cells.
Migraine Disorders
Association of diamine oxidase and histamine N-methyltransferase polymorphisms with presence of migraine in a group of Mexican mothers of children with allergies.
Migraine Disorders
Histamine-N-methyl transferase polymorphism and risk for migraine.
Movement Disorders
The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor.
Multiple Sclerosis
Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis.
Multiple System Atrophy
Determining the Effect of the HNMT, STK39, and NMD3 Polymorphisms on the Incidence of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Multiple System Atrophy in Chinese Populations.
Myasthenia Gravis
Association of myasthenia gravis with polymorphisms in the gene of histamine N-methyltransferase.
Neoplasms
Causal relationship between a tumour growth and the changes in histamine metabolism in tissues of sarcoma-bearing rat.
Neoplasms
Histamine and its metabolizing enzymes in tissues of primary ductal breast cancer.
Neoplasms
Metabolism of histamine in tissues of primary ductal breast cancer.
Neoplasms
[A study on activity of beta-glucuronidase in serum and secretion from upper respiratory tract in patients with head and neck malignant tumors]
Parkinson Disease
Association Analyses of SNAP25, HNMT, FCHSD1, and DBH Single-Nucleotide Polymorphisms with Parkinson's Disease in a Northern Chinese Population.
Parkinson Disease
Association of Histamine N-Methyltransferase Thr105Ile Polymorphism with Parkinson's Disease and Schizophrenia in Han Chinese: A Case-Control Study.
Parkinson Disease
Determining the Effect of the HNMT, STK39, and NMD3 Polymorphisms on the Incidence of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Multiple System Atrophy in Chinese Populations.
Parkinson Disease
Histamine N-Methyltransferase in the Brain.
Parkinson Disease
Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.
Parkinson Disease
Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease.
Parkinson Disease
No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.
Parkinson Disease
The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor.
Parkinson Disease
Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: A PRISMA-compliant systematic review and meta-analysis.
Peptic Ulcer
Histamine and peptic ulcer disease: histamine methyltransferase activity in gastric mucosa of control subjects and duodenal ulcer patients before and after surgical treatment.
Pick Disease of the Brain
Human brain cytosolic histamine-N-methyltransferase is decreased in Down syndrome and increased in Pick's disease.
Rhinitis
Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis.
Rhinitis, Allergic
Association of the histamine N-methyltransferase C314T (Thr105Ile) polymorphism with atopic dermatitis in Caucasian children.
Seizures
Differences in activity in cerebral methyltransferases and monoamine oxidases between audiogenic seizure susceptible and resistant mice and deermice.
Seizures
Role of histaminergic neurons in development of epileptic seizures in EL mice.
Sepsis
Blood histamine concentrations are not elevated in humans with septic shock.
Shock, Septic
Blood histamine concentrations are not elevated in humans with septic shock.
Skin Diseases
Pathogenesis of lupus dermatoses in autoimmune mice. X. Evaluation of histamine-N-methyltransferase activity in the skin of autoimmune.
Stomach Ulcer
Single nucleotide polymorphisms and haplotypes of histamine N-methyltransferase in patients with gastric ulcer.
Synucleinopathies
Determining the Effect of the HNMT, STK39, and NMD3 Polymorphisms on the Incidence of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Multiple System Atrophy in Chinese Populations.
Tachycardia
Influence of SKF 91488, histamine N-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats.
Tachycardia
The effect of intrahypothalamic injection of homodimaprit on blood pressure.
Teratoma
A SEER database study of malignant teratomas in the head and neck region.
Tinnitus
Heidelberg Neuro-Music Therapy Enhances Task-Negative Activity in Tinnitus Patients.
Tinnitus
Heidelberg Neuro-Music Therapy Restores Attention-Related Activity in the Angular Gyrus in Chronic Tinnitus Patients.
Tremor
The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor.
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C314T
-
PCR reaction-restriction fragment length polymorphism assay is used to identify the polymorphism of the point mutation C314T of HNMT gene of 498 Chinese patients with duodenal ulcer and 151 healthy individuals. In normal controls, the allele frequency of HNMT T314 is 3.3%, which is significantly lower than American Caucasians. The HNMT T314 allele is detected in 3.5% of the duodenal ulcer patients. In cases and controls, the frequency of C/C genotypes are 93.0% and 93.4%, respectively. The HNMT T/T genotype is not found in this population. No significant differences is seen in both genotype frequencies and allele frequencies between duodenal ulcer groups and controls
L208D
mutant is severely compromised in its stability
L208F
21% of wild-type activtiy, Michaelis-Menten parameters for SAM and histamine similar to wild-type
L208H
mutant is severely compromised in its stability
L208K
substantial loss of enzymatic activity and binding affinity for histamine
L208N
mutant is severely compromised in its stability
L208R
substantial loss of enzymatic activity and binding affinity for histamine
L208T
mutant is severely compromised in its stability
L208V
48% of wild-type activity, Michaelis-Menten parameters for SAM and histamine similar to wild-type
additional information
-
the A939G polymorphism is significantly associated with the aspirin intolerant chronic urticaria phenotype, while no association is found with the C314T polymorphism, the 939A allele gives lower levels of HNMT mRNA stability, HNMT protein expression, and HNMT enzymatic activity and higher histamine release than the 939G allele, patients with the 939A allele have lower HNMT activity in red blood cell lysates and higher histamine release from their basophils
T105I
-
functional polymorphism, about 50% reduction of enzyme activity
T105I
common threonine-isoleucine polymorphism at residue 105, showing decreased activity and lower protein levels than the 105T protein. Molecular dynamic simulations at 37°C indicate that replacing Thr with the larger Ile residue leads to greater burial of residue 105 and heightened intramolecular interactions between residue 105 and residues within helix R3 and strand a3. This altered, tighter packing is translated to the active site, resulting in the reorientation of several cosubstrate-binding residues
T105I
-
Thr105Ile polymorphism is analyzed whether it is associated with alcoholism in German Caucasians. No significant difference is found in the frequency of the Ile105 allele between alcoholics and controls. Likewise, genotype distributions does not differ significantly. Frequency of the Ile105 allele is significantly lower in male alcoholics with a family history of alcoholism compared to that in male alcoholics without a family history of alcoholism
T105I
-
Thr105Ile polymorphism of the HNMT enzyme is analyzed in patients with essential tremor. Leukocytary DNA from 204 essential tremor patients and a control group of 295 unrelated healthy individuals is studied for the nonsynonymous HNMT Thr105Ile polymorphism by using amplification-restriction analyses. Patients with essential tremor show a higher frequency of homozygous HNMT 105Thr genotypes leading to high metabolic activity with a statistically significant gene-dose effect, as compared to healthy subjects
T105I
an association of the HNMT Thr105Ile polymorphism with Parkinsons disease is observed
T105I
-
naturally occuring mutation, association found with Parkinson's disease
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Francis, D.M.; Thompson, M.F.; Greaves, M.W.
The kinetic properties and reaction mechanism of histamine methyltransferase from human skin
Biochem. J.
187
819-828
1980
Homo sapiens
brenda
Scott, M.C.; Guerciolini, R.; Szumlanski, C.; Weinshilboum, R.M.
Mouse kidney histamine N-methyltransferase: assay conditions, biochemical properties and strain variation
Agents Actions
32
194-202
1991
Homo sapiens, Mus musculus
brenda
Horton, J.R.; Sawada, K.; Nishibori, M.; Zhang, X.; Cheng, X.
Two polymorphic forms of human histamine methyltransferase. Structural, thermal, and kinetic comparisons
Structure
9
837-849
2001
Homo sapiens (P50135), Homo sapiens
brenda
Yamauchi, K.; Sekizawa, K.; Suzuki, H.; Nakazawa, H.; Ohkawara, Y.; Katayose, D.; Ohtsu, H.; Tamura, G.; Shibahara, S.; et al.
Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway
Am. J. Physiol.
267
L342-L349
1994
Homo sapiens
brenda
Preuss, C.V.; Wood, T.C.; Szumlanski, C.L.; Raftogianis, R.B.; Otterness, D.M.; Girard, B.; Scott, M.C.; Weinshilboum, R.M.
Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity
Mol. Pharmacol.
53
708-717
1998
Homo sapiens
brenda
Donatelli, P.; Marchi, G.; Giuliani, L.; Gustafsson, L.L.; Pacifici, G.M.
Stereoselective inhibition by chloroquine of histamine N-methyltransferase in the human liver and brain
Eur. J. Clin. Pharmacol.
47
345-349
1994
Homo sapiens
brenda
Pang, Y.P.; Zheng, X.E.; Weinshilboum, R.M.
Theoretical 3D model of histamine N-methyltransferase: Insights into the effects of a genetic polymorphism on enzymatic activity and thermal stability
Biochem. Biophys. Res. Commun.
287
204-208
2001
Homo sapiens (P50135), Homo sapiens
brenda
Oroszi, G.; Enoch, M.A.; Chun, J.; Virkkunen, M.; Goldman, D.
Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations
Alcohol. Clin. Exp. Res.
29
303-309
2005
Homo sapiens
brenda
Kuefner, M.A.; Schwelberger, H.G.; Weidenhiller, M.; Hahn, E.G.; Raithel, M.
Both catabolic pathways of histamine via histamine-N-methyl-transferase and diamine oxidase are diminished in the colonic mucosa of patients with food allergy
Inflamm. Res.
53
S31-S32
2004
Homo sapiens
-
brenda
Taraschenko, O.D.; Barnes, W.G.; Herrick-Davis, K.; Yokoyama, Y.; Boyd, D.L.; Hough, L.B.
Actions of tacrine and galanthamine on histamine-N-methyltransferase
Methods Find. Exp. Clin. Pharmacol.
27
161-165
2005
Homo sapiens, Rattus norvegicus
brenda
Horton, J.R.; Sawada, K.; Nishibori, M.; Cheng, X.
Structural basis for inhibition of histamine N-methyltransferase by diverse drugs
J. Mol. Biol.
353
334-344
2005
Homo sapiens (P50135)
brenda
Rutherford, K.; Parson, W.W.; Daggett, V.
The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics
Biochemistry
47
893-901
2008
Homo sapiens (P50135), Homo sapiens
brenda
Cao, H.; Mei, Q.; Zhang, L.; Xu, J.
C314T polymorphism in histamine N-methyltransferase gene and susceptibility to duodenal ulcer in Chinese population.
Clin. Chim. Acta
391
130
2008
Homo sapiens
-
brenda
Reuter, M.; Jeste, N.; Klein, T.; Hennig, J.; Goldman, D.; Enoch, M.; Oroszi, G.
Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians
Drug Alcohol Depend.
87
69-75
2007
Homo sapiens
brenda
Ledesma, M.C.; Garcia-Martin, E.; Alonso-Navarro, H.; Martinez, C.; Jimenez-Jimenez, F.J.; Benito-Leon, J.; Puertas, I.; Rubio, L.; Lopez-Alburquerque, T.; Agundez, J.A.
The Nonsynonymous Thr105Ile Polymorphism of the Histamine N-Methyltransferase is Associated to the Risk of Developing Essential Tremor
Neuromolecular Med.
10
356-361
2008
Homo sapiens
brenda
Kim, S.H.; Kang, Y.M.; Kim, S.H.; Cho, B.Y.; Ye, Y.M.; Hur, G.Y.; Park, H.S.
Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria
Allergy
64
213-221
2009
Homo sapiens
brenda
Dave, S.; Rahatgaonkar, A.
Computational evaluation of 2-phenyl-4H-chromen-4-one analogues as antihistamines: Potential histamine N-methyltransferase (HMT) inhibitors
E-J. Chem.
6
1009-1016
2009
Homo sapiens
-
brenda
von Mach-Szczypi?ski, J.; Stanosz, S.; Sieja, K.; Stanosz, M.
Histamine and its metabolizing enzymes in tissues of primary ductal breast cancer
Eur. J. Gynaecol. Oncol.
30
509-511
2009
Homo sapiens
brenda
Agundez, J.; Luengo, A.; Herraez, O.; Martinez, C.; Alonso-Navarro, H.; Jimenez-Jimenez, F.; Garcia-Martin, E.
Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinsons disease
Neuromolecular Med.
10
10-16
2008
Homo sapiens (P50135), Homo sapiens
brenda
Palada, V.; Terzi?, J.; Mazzulli, J.; Bwala, G.; Hagenah, J.; Peterlin, B.; Hung, A.Y.; Klein, C.; Krainc, D.
Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinsons disease
Neurobiol. Aging
33
836.e1-3
2012
Homo sapiens
brenda
Kuefner, M.A.; Feurle, J.; Petersen, J.; Uder, M.; Schwelberger, H.G.
Influence of iodinated contrast media on the activities of histamine inactivating enzymes diamine oxidase and histamine N-methyltransferase in vitro
Allergol. Immunopathol. (Madr.)
42
324-328
2014
Homo sapiens (P50135), Homo sapiens
brenda
Tongsook, C.; Niederhauser, J.; Kronegger, E.; Straganz, G.; Macheroux, P.
Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability
Biochim. Biophys. Acta
1863
188-199
2017
Homo sapiens (P50135), Homo sapiens
brenda
Jia, H.Z.; Liu, S.L.; Zou, Y.F.; Chen, X.F.; Yu, L.; Wan, J.; Zhang, H.Y.; Chen, Q.; Xiong, Y.; Yu, B.; Zhang, W.
MicroRNA-223 is involved in the pathogenesis of atopic dermatitis by affecting histamine-N-methyltransferase
Cell. Mol. Biol. (Noisy-le-grand)
64
103-107
2018
Homo sapiens (P50135), Homo sapiens
brenda
Maw, H.H.; Zeng, X.; Campbell, S.; Taub, M.E.; Teitelbaum, A.M.
N-Methylation of BI 187004 by thiol S-methyltransferase
Drug Metab. Dispos.
46
770-778
2018
Homo sapiens (P50135), Homo sapiens
brenda