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Information on EC 2.1.1.8 - histamine N-methyltransferase and Organism(s) Bos taurus

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.8 histamine N-methyltransferase
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This record set is specific for:
Bos taurus
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
hnmt, histamine n-methyltransferase, histamine-n-methyltransferase, histamine methyltransferase, ntau-methyltransferase, histamine-methylating enzyme, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
histamine 1-methyltransferase
-
-
-
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histamine methyltransferase
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-
-
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histamine-methylating enzyme
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-
-
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imidazole methyltransferase
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-
-
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imidazole N-methyltransferase
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-
-
-
imidazolemethyltransferase
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-
-
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methyltransferase, histamine
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-
-
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S-adenosylmethionine-histamine N-methyltransferase
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-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Ntau-methylhistamine
show the reaction diagram
ordered steady state mechanism with S-adenosylmethionine being the first substrate to bind to the enzyme and N-methylhistamine being the first product to dissociate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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-
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N-methylation
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-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:histamine N-tele-methyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9029-80-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + histamine
S-adenosyl-L-homocysteine + Ntau-methylhistamine
show the reaction diagram
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
amodiaquine
-
-
histamine
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not
Metoprine
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.517
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HNMT_BOVIN
292
0
33646
Swiss-Prot
Mitochondrion (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
33200
-
x * 33200, SDS-PAGE
34800
-
gel filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 33200, SDS-PAGE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nishibori, M.; Oishi, R.; Itoh, Y.; Saeki, K.
Purification and partial characterization of histamine N-methyltransferase from bovine brain
Neurochem. Int.
19
135-141
1991
Bos taurus
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Manually annotated by BRENDA team
Gitomer, W.L.; Tipton, K.F.
Purification and kinetic properties of ox brain histamine N-methyltransferase
Biochem. J.
233
669-676
1986
Bos taurus
Manually annotated by BRENDA team