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Information on EC 2.1.1.71 - phosphatidyl-N-methylethanolamine N-methyltransferase and Organism(s) Homo sapiens

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IUBMB Comments
The enzyme also catalyses the transfer of a further methyl group, producing phosphatidylcholine.
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This record set is specific for:
Homo sapiens
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
phospholipid methyltransferase, methyltransferase ii, pemt-l, pemt-s, phosphatidyl-n-methylethanolamine methyltransferase, phosphatidylmonomethylethanolamine methyltransferase, phosphatidylethanolamine methyltransferase i, phosphatidyl-n-methylethanolamine n-methyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyltransferase II
-
-
-
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PEMT-L
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longer isoform of PEMT
PEMT-S
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shorter isoform of PEMT
phosphatidyl-N-methylethanolamine methyltransferase
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-
-
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phosphatidyl-N-monomethylethanolamine methyltransferase
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-
-
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phosphatidylethanolamine methyltransferase I
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-
-
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phosphatidylethanolamine N-methyltransferase
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phosphatidylmonomethylethanolamine methyltransferase
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-
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phospholipid methyltransferase
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-
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PLMT
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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-
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase
The enzyme also catalyses the transfer of a further methyl group, producing phosphatidylcholine.
CAS REGISTRY NUMBER
COMMENTARY hide
67167-73-1
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
show the reaction diagram
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-
-
-
?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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activity of PEMT-S is much higher than of its isoform PEMT-L
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
microvilli
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
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PEMT-L and PEMT-S expression increase the cellular phosphatidylcholine content, whereas the phosphatidylethanolamine content is decreased by PEMT-S expression, but is hardly affected by PEMT-L expression. The cellular content of phosphatidylserine is also reduced by the expression of PEMT-L or PEMT-S
physiological function
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PEMT-L and PEMT-S expression promote the proliferation of HEK-293 cells
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PEMT_HUMAN
199
4
22134
Swiss-Prot
Secretory Pathway (Reliability: 2)
Q71UY0_HUMAN
199
4
22180
TrEMBL
Secretory Pathway (Reliability: 2)
D3YTC7_HUMAN
211
3
22861
TrEMBL
other Location (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
19000
-
SDS-PAGE, PEMT-S
26000
-
SDS-PAGE, PEMT-L
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
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N-glycosylated with high-mannose oligosaccharides
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
stably expressed in human embryonic kidney-293 cells
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the expression level of PEMT-L is 4.4fold higher than that of PEMT-S
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Guan, Z.Z.; Wang, Y.N.; Xiao, K.Q.; Hu, P.S.; Liu, J.L.
Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease
Neurochem. Int.
34
41-47
1999
Homo sapiens
Manually annotated by BRENDA team
Sastry, B.V.R.; Statham, C.N.; Axelrod, J.; Hirata, F.
Evidence for two methyltransferase involved in the conversion of phosphatidylethanolamine to phosphatidylcholine in the rat liver
Arch. Biochem. Biophys.
211
762-773
1981
Bos taurus, Homo sapiens, Neurospora crassa, Rattus norvegicus
Manually annotated by BRENDA team
Morita, S.Y.; Takeuchi, A.; Kitagawa, S.
Functional analysis of two isoforms of phosphatidylethanolamine N-methyltransferase
Biochem. J.
432
387-398
2010
Homo sapiens
Manually annotated by BRENDA team