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S-(5'-adenosyl)-L-methionine-d3 disulfate salt + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-(d3-methyl)mercaptopurine
-
-
-
-
?
S-adenosyl-L-methionine + 2-aminothiophenol
S-adenosyl-L-homocysteine + 2-methylsulfanylphenylamine
-
-
-
-
?
S-adenosyl-L-methionine + 2-bromothiophenol
S-adenosyl-L-homocysteine + 1-bromo-2-methylsulfanylbenzene
-
-
-
-
?
S-adenosyl-L-methionine + 2-mercaptoethanol
S-adenosyl-L-homocysteine + 2-methylmercaptoethanol
-
-
-
-
?
S-adenosyl-L-methionine + 2-methoxythiophenol
S-adenosyl-L-homocysteine + 1-methoxy-2-methylsulfanylbenzene
-
-
-
-
?
S-adenosyl-L-methionine + 2-thiouracil
S-adenosyl-L-homocysteine + thiouracil-2-S-methylether
-
-
-
-
?
S-adenosyl-L-methionine + 3-methoxythiophenol
S-adenosyl-L-homocysteine + 1-methylsulfanyl-3-methoxybenzene
-
-
-
-
?
S-adenosyl-L-methionine + 4-(aminomethoxy)thiophenol
S-adenosyl-L-homocysteine + 1-aminomethoxy-4-methylsulfanylbenzene
-
-
-
-
?
S-adenosyl-L-methionine + 4-bromothiophenol
S-adenosyl-L-homocysteine + 1-bromo-4-methylsulfanylbenzene
-
-
-
-
?
S-adenosyl-L-methionine + 4-chlorothiophenol
S-adenosyl-L-homocysteine + 1-chloro-4-methylsulfanylbenzene
-
-
-
-
?
S-adenosyl-L-methionine + 4-fluorothiophenol
S-adenosyl-L-homocysteine + 1-fluoro-4-methylsulfanylbenzene
-
-
-
-
?
S-adenosyl-L-methionine + 4-methoxythiophenol
S-adenosyl-L-homocysteine + 1-methoxy-4-methylsulfanylbenzene
-
-
-
-
?
S-adenosyl-L-methionine + 4-methylthiophenol
S-adenosyl-L-homocysteine + 1-methyl-4-methylsulfanylbenzene
-
-
-
-
?
S-adenosyl-L-methionine + 4-nitrothiophenol
S-adenosyl-L-homocysteine + 1-methylsulfanyl-4-nitrobenzene
-
-
-
-
?
S-adenosyl-L-methionine + 4-thiobenzoate
S-adenosyl-L-homocysteine + 4-methylsulfanyl benzoate
-
-
-
-
?
S-adenosyl-L-methionine + 6-hydroxy-8-mercaptopurine
S-adenosyl-L-homocysteine + 6-hydroxy-8-methylmercaptopurine
-
-
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
?
-
-
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine
S-adenosyl-L-methionine + 6-mercaptopurine nucleoside
S-adenosyl-L-homocysteine + 6-methylmercaptopurine nucleoside
-
inactivation
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine-riboside
S-adenosyl-L-homocysteine + 6-methylmercaptopurine-riboside
-
-
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine-riboside-5'-monophosphate
S-adenosyl-L-homocysteine + 6-methylmercaptopurine-riboside-5'-monophosphate
-
-
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine-riboside-5'-triphosphate
S-adenosyl-L-homocysteine + 6-methylmercaptopurine-riboside-5'-triphosphate
-
-
-
-
?
S-adenosyl-L-methionine + 6-selenoguanine-riboside
S-adenosyl-L-homocysteine + 6-methylselenoguanine-riboside
-
-
-
-
?
S-adenosyl-L-methionine + 6-selenopurine
S-adenosyl-L-homocysteine + 6-methylselenopurine
-
-
-
-
?
S-adenosyl-L-methionine + 6-selenopurine-riboside
S-adenosyl-L-homocysteine + 6-methylselenopurine-riboside
-
-
-
-
?
S-adenosyl-L-methionine + 6-thiodeoxyguanosine
S-adenosyl-L-homocysteine + 6-thiodeoxyguanosine S-methylether
-
-
-
-
r
S-adenosyl-L-methionine + 6-thiodeoxyguanosine monophosphate
S-adenosyl-L-homocysteine + 6-methylthiodeoxyguanosine monophosphate
-
-
-
-
?
S-adenosyl-L-methionine + 6-thiodeoxyinosine
S-adenosyl-L-homocysteine + 6-thiodeoxyinosine S-methylether
-
-
-
-
r
S-adenosyl-L-methionine + 6-thiodeoxyinosine monophosphate
S-adenosyl-L-homocysteine + 6-methyl thiodeoxyinosine monophosphate
-
-
-
-
?
S-adenosyl-L-methionine + 6-thioguanine
?
-
-
-
-
?
S-adenosyl-L-methionine + 6-thioguanine
S-adenosyl-L-homocysteine + 6-methylthioguanine
S-adenosyl-L-methionine + 6-thioguanine monophosphate
S-adenosyl-L-homocysteine + 6-methylthioguanine monophosphate
-
-
-
-
?
S-adenosyl-L-methionine + 6-thioguanine-riboside
S-adenosyl-L-homocysteine + 6-methylthioguanine-riboside
-
-
-
-
?
S-adenosyl-L-methionine + 6-thioguanine-riboside-5'-monophosphate
S-adenosyl-L-homocysteine + 6-methylthioguanine-riboside-5'-monophosphate
-
-
-
-
?
S-adenosyl-L-methionine + 6-thioguanosine monophosphate
S-adenosyl-L-homocysteine + 6-methyl thioguanosine monophosphate
-
-
-
-
?
S-adenosyl-L-methionine + 6-thioinosine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine riboside
-
-
-
-
?
S-adenosyl-L-methionine + 6-thioinosine 5'-monophosphate
S-adenosyl-L-homocysteine + 6-methylmercaptopurine ribonucleotide
-
-
-
-
?
S-adenosyl-L-methionine + 6-thioinosine diphosphate
S-adenosyl-L-homocysteine + 6-methylthioinosine diphosphate
-
-
-
-
?
S-adenosyl-L-methionine + 6-thioinosine monophosphate
S-adenosyl-L-homocysteine + 6-methyl thioinosine monophosphate
-
-
-
-
?
S-adenosyl-L-methionine + 6-thioinosine monophosphate
S-adenosyl-L-homocysteine + 6-methylthioinosine monophosphate
-
-
-
-
?
S-adenosyl-L-methionine + 6-thioinosine triphosphate
S-adenosyl-L-homocysteine + 6-methylthioinosine triphosphate
-
-
-
-
?
S-adenosyl-L-methionine + 6-thioinosine-monophosphate
S-adenosyl-L-homocysteine + 6-methylmercaptopurine-ribonucleotide
-
-
consisting of 6-methyl-thioinosine-monophosphate, -diphosphate and triphosphate
-
?
S-adenosyl-L-methionine + 6-thiopurine
S-adenosyl-L-homocysteine + 6-methylthiopurine
-
-
-
-
?
S-adenosyl-L-methionine + 7-methyl-6-mercaptopurine
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + 8-hydroxy-6-mercaptopurine
S-adenosyl-L-homocysteine + 8-hydroxy-6-methylmercaptopurine
-
-
-
-
?
S-adenosyl-L-methionine + 9(n-propyl)6-thioguanine
S-adenosyl-L-homocysteine + 9(n-propyl)6-methylthioguanine
-
-
-
-
?
S-adenosyl-L-methionine + 9-(n-butyl)-6-mercaptopurine
S-adenosyl-L-homocysteine + 9-(n-butyl)-6-methylmercaptopurine
-
-
-
-
?
S-adenosyl-L-methionine + 9-ethyl-6-mercaptopurine
S-adenosyl-L-homocysteine + 9-ethyl-6-methylmercaptopurine
-
-
-
-
?
S-adenosyl-L-methionine + a thiopurine
S-adenosyl-L-homocysteine + a thiopurine S-methylether
S-adenosyl-L-methionine + azathioprine
?
-
-
-
-
?
S-adenosyl-L-methionine + azathioprine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
S-adenosyl-L-methionine + azathioprine
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + mercaptopurine
S-adenosyl-L-homocysteine + methylmercaptopurine
-
-
-
-
?
S-adenosyl-L-methionine + thioguanine nucleotide
S-adenosyl-L-homocysteine + methylthioguanine
-
-
-
-
?
S-adenosyl-L-methionine + thioinosine monophosphate
S-adenosyl-L-homocysteine + methylthioinosine monophosphate
-
-
-
-
?
S-adenosyl-L-methionine + thioinosine triphosphate
S-adenosyl-L-homocysteine + methylthioinosine triphosphate
-
-
-
-
?
S-adenosyl-L-methionine + thiopurine
S-adenosyl-L-homocysteine + methylthiopurine
-
-
-
-
?
additional information
?
-
S-adenosyl-L-methionine + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
-
485516, 485520, 485521, 485522, 485524, 485525, 485526, 485527, 485528, 485529, 657544, 684266, 685852, 686157, 686161, 686184, 686189, 686326, 686328, 686351, 686505, 686507, 686574, 687982, 687983, 688126, 688415, 688777, 689358, 689362, 689365, 689368, 689369, 690115, 690118, 702159, 703355, 704818, 706091, 706093, 706816, 718804, 718942, 720181, 720847, 755922, 756145, 756499, 756597, 757309, 757473 -
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
-
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
-
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
-
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
immunosuppressant medication
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
inactivation
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT
-
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
TPMT deactivates 6-mercaptopurine by methylation
-
-
?
S-adenosyl-L-methionine + 6-thioguanine
S-adenosyl-L-homocysteine + 6-methylthioguanine
-
-
485516, 485519, 485520, 485521, 485522, 485523, 485526, 485527, 485528, 485529, 657749, 658654, 659566, 685852, 686161, 686189, 686351, 686505, 688415, 689358, 689365, 689369, 690115, 701941, 703564, 756145, 756597, 757473 -
-
?
S-adenosyl-L-methionine + 6-thioguanine
S-adenosyl-L-homocysteine + 6-methylthioguanine
-
-
-
?
S-adenosyl-L-methionine + 6-thioguanine
S-adenosyl-L-homocysteine + 6-methylthioguanine
-
-
-
-
?
S-adenosyl-L-methionine + a thiopurine
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
-
485516, 485518, 485519, 485520, 485521, 485522, 485523, 485524, 485525, 485526, 485527, 485528, 485529, 684265, 684266, 684267, 684275, 684276, 684279, 684733, 685037, 685852, 686157, 686161, 686167, 686184, 686189, 686326, 686328, 686351, 686503, 686505, 686507, 686574, 687195, 687982, 687983, 688415, 688777, 688807, 689358, 689362, 689365, 689368, 689369, 690115, 690118, 756597, 757473 -
-
?
S-adenosyl-L-methionine + a thiopurine
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
-
-
?
S-adenosyl-L-methionine + a thiopurine
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
-
-
-
?
S-adenosyl-L-methionine + a thiopurine
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
-
-
?
S-adenosyl-L-methionine + a thiopurine
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
enzyme plays an important role in metabolism of heterocyclic sulfhydryl drugs such as 6-thiopurine and 6-thioguanine
-
-
?
S-adenosyl-L-methionine + a thiopurine
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
S-methylation, enzyme of major catabolic pathway of thiopurines
-
-
?
S-adenosyl-L-methionine + azathioprine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
-
-
-
?
S-adenosyl-L-methionine + azathioprine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
-
-
?
S-adenosyl-L-methionine + azathioprine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT
684266, 686161, 686189, 686326, 686574, 688126, 688415, 688777, 689358, 689362, 689368, 690115, 690118 -
-
?
S-adenosyl-L-methionine + azathioprine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT
-
-
?
S-adenosyl-L-methionine + azathioprine
S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT
-
-
?
additional information
?
-
-
aliphatic thiol compounds are poor substrates or not methylated, dithiothreitol is no substrate
-
-
?
additional information
?
-
-
S-adenosyl-L-methionine and sinefungin prevent degradation of TPMT by stabilizing ist native structure
-
-
?
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Agranulocytosis
[Significance of thiopurine s-methyltransferase gene test in a clinical case].
Anemia
Expressing thiopurine S-methyltransferase activity as units per litre of whole-blood overcomes misleading high results in patients with anaemia.
Anemia, Aplastic
Aplastic anemia secondary to azathioprine in systemic lupus erythematosus: report of a case with normal thiopurine S-methyltransferase enzyme activity and review of the literature.
Arthritis, Rheumatoid
Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Comprehensive screening of the thiopurine methyltransferase polymorphisms by denaturing high-performance liquid chromatography.
Arthritis, Rheumatoid
High frequency of mutant thiopurine S-methyltransferase genotypes in Mexican patients with systemic lupus erythematosus and rheumatoid arthritis.
Arthritis, Rheumatoid
Is thiopurine methyltransferase genetic polymorphism a major factor for withdrawal of azathioprine in rheumatoid arthritis patients?
Arthritis, Rheumatoid
Reduced thiopurine methyltransferase activity and development of side effects of azathioprine treatment in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Systematic review of thiopurine methyltransferase genotype and enzymatic testing strategies.
Aspergillosis
Severe pancytopenia and aspergillosis caused by thioguanine in a thiopurine S-methyltransferase deficient patient: a case report.
Autoimmune Diseases
Allelic variants of the thiopurine methyltransferase (TPMT) gene in the Colombian population.
Autoimmune Diseases
Assessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs.
Autoimmune Diseases
Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis.
Autoimmune Diseases
Ethnic differences in thiopurine methyltransferase pharmacogenetics: evidence for allele specificity in Caucasian and Kenyan individuals.
Autoimmune Diseases
Frequency of thiopurine S-methyltransferase mutant alleles in indigenous and admixed Guatemalan patients with acute lymphoblastic leukemia.
Autoimmune Diseases
Genetic polymorphism of thiopurine S-methyltransferase in Argentina.
Autoimmune Diseases
Genetic polymorphisms of thiopurine S-methyltransferase in a cohort of patients with systemic autoimmune diseases.
Autoimmune Diseases
Genotyping of thiopurine methyltransferase using pyrosequencing.
Autoimmune Diseases
In Vitro Protein Stability of Two Naturally Occurring Thiopurine S-Methyltransferase Variants: Biophysical Characterization of TPMT*6 and TPMT*8.
Autoimmune Diseases
Red Blood cell IMPDH activity in adults and children with or without azathioprine: Relationship between thiopurine metabolites, ITPA and TPMT activities.
Autoimmune Diseases
The use of denaturing high-pressure liquid chromatography for the detection of mutations in thiopurine methyltransferase.
Autoimmune Diseases
Thiopurine S-methytransferase Gene Polymorphism in Rheumatoid Arthritis.
Autoimmune Diseases
[Significance of thiopurine s-methyltransferase gene test in a clinical case].
beta-Thalassemia
Arrayed primer extension: a robust and reliable genotyping platform for the diagnosis of single gene disorders: beta-thalassemia and thiopurine methyltransferase deficiency.
Brain Neoplasms
High incidence of secondary brain tumours after radiotherapy and antimetabolites.
Breast Neoplasms
Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer.
Breast Neoplasms
Misinterpretation of TPMT by a DTC Genetic Testing Company.
Carcinoma
Human thiopurine methyltransferase: molecular cloning and expression of T84 colon carcinoma cell cDNA.
Cardiotoxicity
Acute lymphoblastic leukemia.
Cholangitis, Sclerosing
Autoimmune hepatitis with sclerosing cholangitis in a patient with thiopurine methyltransferase deficiency: case presentation.
Colitis, Ulcerative
Allelic variants of the thiopurine S-methyltransferase deficiency in patients with ulcerative colitis and in healthy controls.
Colitis, Ulcerative
Whole-Blood Thiopurine S-Methyltransferase Genotype and Phenotype Concordance in Iranian Kurdish Ulcerative Colitis (UC) Patients.
Colorectal Neoplasms
A personalized approach to cancer treatment: how biomarkers can help.
Crohn Disease
5-aminosalicylate therapy is associated with higher 6-thioguanine levels in adults and children with inflammatory bowel disease in remission on 6-mercaptopurine or azathioprine.
Crohn Disease
Analysis of thiopurine S-methyltransferase phenotype-genotype in a Tunisian population with Crohn's disease.
Crohn Disease
Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study.
Crohn Disease
Azathioprine-associated acute myeloid leukemia in a patient with Crohn's disease and thiopurine S-methyltransferase deficiency.
Crohn Disease
Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease.
Crohn Disease
Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy.
Crohn Disease
Interaction between azathioprine and aminosalicylates: an in vivo study in patients with Crohn's disease.
Crohn Disease
Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine.
Crohn Disease
Normal thiopurine methyltransferase phenotype testing in a Crohn disease patient with azathioprine induced myelosuppression.
Crohn Disease
NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease.
Crohn Disease
Safe treatment of thiopurine S-methyltransferase deficient Crohn's disease patients with azathioprine.
Crohn Disease
Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy.
Crohn Disease
Severe pancytopenia from thiopurine methyltransferase deficiency: a preventable complication of 6-mercaptopurine therapy in children with Crohn disease.
Crohn Disease
The Current Relevance of Pharmacogenetics in Immunomodulation Treatment for Crohn's Disease.
Crohn Disease
The Identification of a Novel Thiopurine S-Methyltransferase Allele, TPMT*45, in Korean Patient with Crohn's Disease.
Crohn Disease
Thiopurine methyltransferase genotype distribution in patients with Crohn's disease.
Crohn Disease
Thiopurines in the Management of Crohn's Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity-A Retrospective Study.
Crohn Disease
[Significance of thiopurine s-methyltransferase gene test in a clinical case].
Cystic Fibrosis
Ubiquitin-mediated proteasomal degradation of ABC transporters: a new aspect of genetic polymorphisms and clinical impacts.
Dermatitis, Atopic
A retrospective evaluation of azathioprine in severe childhood atopic eczema, using thiopurine methyltransferase levels to exclude patients at high risk of myelosuppression.
Dermatitis, Atopic
Azathioprine as a treatment for severe atopic eczema in children with a partial thiopurine methyl transferase (TPMT) deficiency.
Dermatitis, Atopic
Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind, randomised controlled trial.
Dermatitis, Atopic
Life threatening myelotoxicity secondary to azathioprine in a patient with atopic eczema and normal thiopurine methyltransferase activity.
Dermatitis, Atopic
[Safety of azathioprine therapy adjusted to thiopurine methyltransferase activity in the treatment of infantile atopic dermatitis. Report on 7 cases]
Drug-Related Side Effects and Adverse Reactions
A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study.
Drug-Related Side Effects and Adverse Reactions
Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).
Drug-Related Side Effects and Adverse Reactions
Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis.
Drug-Related Side Effects and Adverse Reactions
Association between thiopurine S-methyltransferase polymorphisms and thiopurine-induced adverse drug reactions in patients with inflammatory bowel disease: a meta-analysis.
Drug-Related Side Effects and Adverse Reactions
Automation of the Whole-Blood Thiopurine S-Methyltransferase (TPMT) Phenotyping Assay Using the Biomek NXP and Biomek i5 Liquid-Handling Workstations.
Drug-Related Side Effects and Adverse Reactions
Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism.
Drug-Related Side Effects and Adverse Reactions
Determination of ITPase activity in erythrocyte lysates obtained for determination of TPMT activity.
Drug-Related Side Effects and Adverse Reactions
Genotype-guided thiopurine dosing does not lead to additional costs in patients with inflammatory bowel disease.
Drug-Related Side Effects and Adverse Reactions
Microfluidic platform for single nucleotide polymorphism genotyping of the thiopurine S-methyltransferase gene to evaluate risk for adverse drug events.
Drug-Related Side Effects and Adverse Reactions
No induction of thiopurine methyltransferase during thiopurine treatment in inflammatory bowel disease.
Drug-Related Side Effects and Adverse Reactions
Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation.
Drug-Related Side Effects and Adverse Reactions
Pre-analytic and analytic sources of variations in thiopurine methyltransferase activity measurement in patients prescribed thiopurine-based drugs: A systematic review.
Drug-Related Side Effects and Adverse Reactions
Predicting drug response and toxicity based on gene polymorphisms.
Drug-Related Side Effects and Adverse Reactions
Relationships between thiopurine S-methyltransferase polymorphism and azathioprine-related adverse drug reactions in Chinese renal transplant recipients.
Drug-Related Side Effects and Adverse Reactions
Relevance of pharmacogenetic aspects of mercaptopurine metabolism in the treatment of interstitial lung disease.
Drug-Related Side Effects and Adverse Reactions
Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy.
Drug-Related Side Effects and Adverse Reactions
The impact of thiopurine-S-methyltransferase genotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases.
Drug-Related Side Effects and Adverse Reactions
Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease.
Drug-Related Side Effects and Adverse Reactions
Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment.
Drug-Related Side Effects and Adverse Reactions
Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease.
Drug-Related Side Effects and Adverse Reactions
Thiopurine S-methyltransferase testing for averting drug toxicity in patients receiving thiopurines: a systematic review.
Drug-Related Side Effects and Adverse Reactions
Thiopurine S-methyltransferase testing for averting drug toxicity: a meta-analysis of diagnostic test accuracy.
Drug-Related Side Effects and Adverse Reactions
Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphism.
Eczema, Dyshidrotic
Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase.
Eczema, Dyshidrotic
Detection of a Novel Single Nucleotide Polymorphism of the Human Thiopurine S-Methyltransferase gene in a Chinese Individual.
Febrile Neutropenia
Acute lymphoblastic leukemia.
Hearing Loss
Association of candidate pharmacogenetic markers with platinum-induced ototoxicity: PanCareLIFE dataset.
Hearing Loss
Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts.
Hearing Loss
Usefulness of current candidate genetic markers to identify childhood cancer patients at risk for platinum-induced ototoxicity: Results of the European PanCareLIFE cohort study.
Hematologic Neoplasms
Consequences of binding an S-adenosylmethionine analogue on the structure and dynamics of the thiopurine methyltransferase protein backbone.
Hematologic Neoplasms
Structural and functional impact of missense mutations in TPMT: An integrated computational approach.
Hematologic Neoplasms
Tertiary structure of thiopurine methyltransferase from Pseudomonas syringae, a bacterial orthologue of a polymorphic, drug-metabolizing enzyme.
Hematologic Neoplasms
Understanding thiopurine methyltransferase polymorphisms for the targeted treatment of hematologic malignancies.
Hepatic Veno-Occlusive Disease
TPMT and MTHFR genotype is not associated with altered risk of thioguanine-related sinusoidal obstruction syndrome in pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group.
Hepatitis, Autoimmune
Autoimmune hepatitis with sclerosing cholangitis in a patient with thiopurine methyltransferase deficiency: case presentation.
Hepatitis, Autoimmune
Azathioprine metabolite measurements are not useful in following treatment of autoimmune hepatitis in Alaska Native and other non-Caucasian people.
Hepatitis, Autoimmune
Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.
Hepatitis, Autoimmune
Characterisation and utility of thiopurine methyltransferase and thiopurine metabolite measurements in autoimmune hepatitis.
Hepatitis, Autoimmune
Cost-effectiveness of pharmacotherapy for autoimmune hepatitis.
Hepatitis, Autoimmune
NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis.
Hepatitis, Autoimmune
Thiopurine methyltransferase deficiency and azathioprine intolerance in autoimmune hepatitis.
Hepatitis, Autoimmune
Thiopurine methyltransferase phenotype and genotype in relation to azathioprine therapy in autoimmune hepatitis.
Hepatitis, Autoimmune
Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis.
Hepatitis, Autoimmune
[Thiopurine methyltransferase activity in patients with autoimmune hepatitis]
Hypersensitivity
Azathioprine hypersensitivity syndrome: a case report.
Hypersensitivity
Azathioprine hypersensitivity syndrome: report of two cases with cutaneous manifestations.
Hypersensitivity
Methodological and statistical issues in pharmacogenomics.
Hypersensitivity
Overview of the pharmacoeconomics of pharmacogenetics.
Idiopathic Pulmonary Fibrosis
Erratum to: Thiopurine S-Methyltransferase Testing in Idiopathic Pulmonary Fibrosis: A Pharmacogenetic Cost-Effectiveness Analysis.
Infections
Association Between Thiopurine S-Methyltransferase (TPMT) Genetic Variants and Infection in Pediatric Heart Transplant Recipients Treated With Azathioprine: A Multi-Institutional Analysis.
Infections
Systemic treatment of pediatric atopic dermatitis with azathioprine and mycophenolate mofetil.
Inflammatory Bowel Diseases
A Practical Non-Extraction Direct Liquid Chromatography Method for Determination of Thiopurine S-Methyltransferase Activity in Inflammatory Bowel Disease.
Inflammatory Bowel Diseases
A Simple Method for TPMT and ITPA Genotyping Using Multiplex HRMA for Patients Treated with Thiopurine Drugs.
Inflammatory Bowel Diseases
Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
Allele frequency of thiopurine methyltransferase and inosine triphosphate pyrophosphatase gene polymorphisms in Korean patients with inflammatory bowel diseases.
Inflammatory Bowel Diseases
Analysis of thiopurine S-methyltransferase genotypes in Japanese patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
Association between thiopurine S-methyltransferase polymorphisms and thiopurine-induced adverse drug reactions in patients with inflammatory bowel disease: a meta-analysis.
Inflammatory Bowel Diseases
Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism.
Inflammatory Bowel Diseases
Characterisation of novel defective thiopurine S-methyltransferase allelic variants.
Inflammatory Bowel Diseases
Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. A prospective study.
Inflammatory Bowel Diseases
Correlation between Thiopurine S-Methyltransferase Genotype and Adverse Events in Inflammatory Bowel Disease Patients.
Inflammatory Bowel Diseases
Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine drugs.
Inflammatory Bowel Diseases
Cost-effectiveness analysis of genotype screening and therapeutic drug monitoring in patients with inflammatory bowel disease treated with azathioprine therapy: a Chinese healthcare perspective using real-world data.
Inflammatory Bowel Diseases
Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease.
Inflammatory Bowel Diseases
Deletion of Glutathione-S-Transferase M1 Reduces Azathioprine Metabolite Concentrations in Young Patients With Inflammatory Bowel Disease.
Inflammatory Bowel Diseases
Determination of thiopurine S-methyltransferase activity by hydrophilic interaction liquid chromatography hyphenated with mass spectrometry.
Inflammatory Bowel Diseases
Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate.
Inflammatory Bowel Diseases
Dosing azathioprine in thiopurine S-methyltransferase deficient inflammatory bowel disease patients.
Inflammatory Bowel Diseases
Early Assessment of Thiopurine Metabolites Identifies Patients at Risk of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease.
Inflammatory Bowel Diseases
Effects of aminosalicylates on thiopurine S-methyltransferase activity: an ex vivo study in patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
Four human thiopurine s-methyltransferase alleles severely affect protein structure and dynamics.
Inflammatory Bowel Diseases
Frequency of thiopurine methyltransferase mutation in patients of Mediterranean area with inflammatory bowel disease and autoimmune disorders.
Inflammatory Bowel Diseases
High prevalence of polymorphism and low activity of thiopurine methyltransferase in patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
High-resolution melting analysis of the TPMT gene: a study in the Polish population.
Inflammatory Bowel Diseases
Impracticalities of thiopurine S-methyltransferase determination in daily inflammatory bowel disease practice.
Inflammatory Bowel Diseases
Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease: A Retrospective Cohort Study.
Inflammatory Bowel Diseases
Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
Monitoring azathioprine metabolite levels and thiopurine methyl transferase (TPMT) activity in children with inflammatory bowel disease.
Inflammatory Bowel Diseases
Monitoring thiopurine metabolites in korean pediatric patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
No induction of thiopurine methyltransferase during thiopurine treatment in inflammatory bowel disease.
Inflammatory Bowel Diseases
Normal thiopurine methyltransferase levels do not eliminate 6-mercaptopurine or azathioprine toxicity in children with inflammatory bowel disease.
Inflammatory Bowel Diseases
Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism.
Inflammatory Bowel Diseases
Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease.
Inflammatory Bowel Diseases
Pharmacogenetics of drug metabolizing enzyme: thiopurine methyl transferase phenotypes and multidrug resistance 1 gene polymorphism in inflammatory bowel disease.
Inflammatory Bowel Diseases
Pharmacogenomics in inflammatory bowel disease.
Inflammatory Bowel Diseases
Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies.
Inflammatory Bowel Diseases
Prevalence of thiopurine S-methyltransferase gene polymorphisms in patients with inflammatory bowel disease from the island of Crete, Greece.
Inflammatory Bowel Diseases
Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine.
Inflammatory Bowel Diseases
Relevance of thiopurine methyltransferase activity in inflammatory bowel disease patients maintained on low-dose azathioprine.
Inflammatory Bowel Diseases
Review article: thiopurines in inflammatory bowel disease.
Inflammatory Bowel Diseases
Role of Thiopurine Metabolite Testing and Thiopurine Methyltransferase Determination in Pediatric IBD.
Inflammatory Bowel Diseases
Structural and functional impact of missense mutations in TPMT: An integrated computational approach.
Inflammatory Bowel Diseases
Structural Characteristics Determine the Cause of the Low Enzyme Activity of Two Thiopurine S-Methyltransferase Allelic Variants: A Biophysical Characterization of TPMT*2 and TPMT*5.
Inflammatory Bowel Diseases
Systematic review of thiopurine methyltransferase genotype and enzymatic testing strategies.
Inflammatory Bowel Diseases
The Role of Inosine-5'-Monophosphate Dehydrogenase in Thiopurine Metabolism in Patients With Inflammatory Bowel Disease.
Inflammatory Bowel Diseases
The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.
Inflammatory Bowel Diseases
The utility of thiopurine methyltransferase enzyme testing in inflammatory bowel disease.
Inflammatory Bowel Diseases
Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold.
Inflammatory Bowel Diseases
Thiopurine metabolites and the role of thiopurine methyltransferase activity in inflammatory bowel disease.
Inflammatory Bowel Diseases
Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients.
Inflammatory Bowel Diseases
Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease.
Inflammatory Bowel Diseases
Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease.
Inflammatory Bowel Diseases
Thiopurine methyltransferase and thiopurine metabolite testing in patients with inflammatory bowel disease who are taking thiopurine drugs.
Inflammatory Bowel Diseases
Thiopurine methyltransferase enzyme activity determination before treatment of inflammatory bowel disease with azathioprine: effect on cost and adverse events.
Inflammatory Bowel Diseases
Thiopurine methyltransferase gene polymorphisms and activity in Chinese patients with inflammatory bowel disease treated with azathioprine.
Inflammatory Bowel Diseases
Thiopurine methyltransferase gene polymorphisms in Chinese patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
Thiopurine Methyltransferase genetic polymorphisms and activity and metabolic products of azathioprine in patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
Thiopurine methyltransferase genotype and thiopurine S-methyltransferase activity in Greek children with inflammatory bowel disease.
Inflammatory Bowel Diseases
Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment.
Inflammatory Bowel Diseases
Thiopurine S-methyltransferase as a target for drug interactions.
Inflammatory Bowel Diseases
Thiopurine s-methyltransferase gene polymorphisms in a healthy slovak population and pediatric patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
Thiopurine S-methyltransferase genetic polymorphisms in adult patients with inflammatory bowel diseases in the Latvian population.
Inflammatory Bowel Diseases
Thiopurine S-methyltransferase genotype and the use of thiopurines in paediatric inflammatory bowel disease Greek patients.
Inflammatory Bowel Diseases
Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease.
Inflammatory Bowel Diseases
Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response.
Inflammatory Bowel Diseases
Timing of Myelosuppression During Thiopurine Therapy for Inflammatory Bowel Disease: Implications for Monitoring Recommendations.
Inflammatory Bowel Diseases
Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases.
Inflammatory Bowel Diseases
Whole-Blood Thiopurine S-Methyltransferase Genotype and Phenotype Concordance in Iranian Kurdish Ulcerative Colitis (UC) Patients.
Inflammatory Bowel Diseases
[Erythrocyte activity of thiopurine methyltransferase and treatment with thiopurines in inflammatory bowel disease]
Inflammatory Bowel Diseases
[Frequency of serious adverse events of thiopurine treatment in normal thiopurine S-methyltransferase genotype children with inflammatory bowel disease].
Inflammatory Bowel Diseases
[Monitoring of thiopurine methyltransferase and thiopurine metabolites to optimize azathioprine therapy in inflammatory bowel disease]
Inflammatory Bowel Diseases
[Not Available].
Inflammatory Bowel Diseases
[Pharmacogenomics in gastroenterologic diseases].
Inflammatory Bowel Diseases
[Significance of thiopurine s-methyltransferase gene test in a clinical case].
Inflammatory Bowel Diseases
[Therapeutic drug monitoring of 6-thioguanine nucleotides in inflammatory bowel disease: interest and limits].
Inflammatory Bowel Diseases
[Thiopurine methyltransferase activity and myelosuppression in inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine]
Inflammatory Bowel Diseases
[Thiopurine methyltransferase activity in inflammatory bowel disease. A study on 7046 Spanish patients]
Leukemia
A case of recurrent pancytopenia in a patient with acute promyelocytic leukemia on maintenance chemotherapy and concomitant methyltetrahydrofolate reductase and thiopurine S-methyltransferase mutation?-?review of literature.
Leukemia
A Simple Method for TPMT and ITPA Genotyping Using Multiplex HRMA for Patients Treated with Thiopurine Drugs.
Leukemia
Comparison of three methods for measuring thiopurine methyltransferase activity in red blood cells and human leukemia cells.
Leukemia
Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate.
Leukemia
Differential role of thiopurine methyltransferase in the cytotoxic effects of 6-mercaptopurine and 6-thioguanine on human leukemia cells.
Leukemia
Four human thiopurine s-methyltransferase alleles severely affect protein structure and dynamics.
Leukemia
Frequency of thiopurine S-methyltransferase gene variations in Turkish children with acute leukemia.
Leukemia
Frequency of thiopurine S-methyltransferase genetic variation in Thai children with acute leukemia.
Leukemia
Genotyping of thiopurine methyltransferase in patients with acute leukemia using LightCycler PCR.
Leukemia
Genotyping of thiopurine methyltransferase using pyrosequencing.
Leukemia
High-resolution melting analysis of the TPMT gene: a study in the Polish population.
Leukemia
Myelotoxicity after high-dose methotrexate in childhood acute leukemia is influenced by 6-mercaptopurine dosing but not by intermediate thiopurine methyltransferase activity.
Leukemia
Systematic review of thiopurine methyltransferase genotype and enzymatic testing strategies.
Leukemia
The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukemia.
Leukemia
Thiopurine methyltransferase activity in children with acute myeloid leukemia.
Leukemia
Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations.
Leukemia
Thiopurine S-Methyltransferase and Methylenetetrahydrofolate Reductase Polymorphisms in Leukemia.
Leukemia
Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods.
Leukemia
Thiopurine S-methytransferase Gene Polymorphism in Rheumatoid Arthritis.
Leukemia
[Relationship between single nucleotide polymorphisms in thiopurine methyltransferase gene and tolerance to thiopurines in acute leukemia]
Leukemia
[Studies on the mutation and polymorphism of the TPMT gene in Chinese children with acute leukemia]
Leukemia, Myeloid, Acute
Acute lymphoblastic leukemia.
Leukemia, Myeloid, Acute
Azathioprine-associated acute myeloid leukemia in a patient with Crohn's disease and thiopurine S-methyltransferase deficiency.
Leukemia, Myeloid, Acute
The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukemia.
Leukemia, Myeloid, Acute
Thiopurine methyltransferase activity in children with acute myeloid leukemia.
Leukemia, Myeloid, Acute
Treatment-related Myelodysplastic Syndrome in a Child With Acute Myeloid Leukemia and TPMT Heterozygosity.
Leukemia, Promyelocytic, Acute
A case of recurrent pancytopenia in a patient with acute promyelocytic leukemia on maintenance chemotherapy and concomitant methyltetrahydrofolate reductase and thiopurine S-methyltransferase mutation?-?review of literature.
Leukopenia
An intronic FTO variant rs16952570 confers protection against thiopurine-induced myelotoxicities in multiethnic Asian IBD patients.
Leukopenia
Azathioprine and diffuse alveolar haemorrhage: the pharmacogenetics of thiopurine methyltransferase.
Leukopenia
Clinical pharmacology of inflammatory bowel disease therapies.
Leukopenia
Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis.
Leukopenia
Combining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice.
Leukopenia
Complete remission of refractory pemphigus vulgaris in a Chinese patient with mutated NUDT15 by combination of minimal doses of azathioprine and prednisone.
Leukopenia
Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease.
Leukopenia
Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease.
Leukopenia
Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease: A Retrospective Cohort Study.
Leukopenia
Influences of XDH genotype by gene-gene interactions with SUCLA2 for thiopurine-induced leukopenia in Korean patients with Crohn's disease.
Leukopenia
Initiating Azathioprine for Crohn's Disease.
Leukopenia
Leukopenia due to Parvovirus B19 in a Crohn's Disease Patient Using Azathioprine.
Leukopenia
NUDT15 gene variants and thiopurine-induced leukopenia in patients with inflammatory bowel disease.
Leukopenia
NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis.
Leukopenia
NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease.
Leukopenia
NUDT15 R139C Variants Increase the Risk of Azathioprine-Induced Leukopenia in Chinese Autoimmune Patients.
Leukopenia
State-of-the-art: immunosuppression and biologic therapy.
Leukopenia
The Pharmacogenetics of Immune-Modulating Therapy.
Leukopenia
The utility of thiopurine methyltransferase enzyme testing in inflammatory bowel disease.
Leukopenia
Thiopurine S-methyltranferase testing in idiopathic pulmonary fibrosis: a pharmacogenetic cost-effectiveness analysis.
Leukopenia
TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India.
Leukopenia
Update on thiopurine pharmacogenetics in inflammatory bowel disease.
Leukopenia
Use of Thiopurines in Inflammatory Bowel Disease: A Consensus Statement by the Korean Association for the Study of Intestinal Diseases (KASID).
Leukopenia
[Homozygote deficiency of thiopurine methyltransferase. A contraindication to the use of azathioprine in kidney transplantation]
Liver Diseases
Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.
Liver Diseases
Thiopurine S-methyltransferase gene polymorphism in Japanese patients with autoimmune liver diseases.
Lupus Erythematosus, Systemic
Aplastic anemia secondary to azathioprine in systemic lupus erythematosus: report of a case with normal thiopurine S-methyltransferase enzyme activity and review of the literature.
Lupus Erythematosus, Systemic
Association of thiopurine methyltransferase status with azathioprine side effects in Chinese patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
High frequency of mutant thiopurine S-methyltransferase genotypes in Mexican patients with systemic lupus erythematosus and rheumatoid arthritis.
Lupus Erythematosus, Systemic
Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine.
Lupus Erythematosus, Systemic
Plasma thiopurine S-methyltransferase levels and azathioprine-related adverse events in patients with Behçet's disease.
Lupus Erythematosus, Systemic
Thiopurine methyltransferase genotype and phenotype status in Japanese patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Thiopurine S-methyltransferase polymorphisms and the relationship between the mutant alleles and the adverse effects in systemic lupus erythematosus patients taking azathioprine.
Lymphoma, Non-Hodgkin
DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma.
Multiple Sclerosis
Azathioprine myelosuppression in multiple sclerosis: characterizing thiopurine methyltransferase polymorphisms.
Multiple Sclerosis
Thiopurine methyltransferase activity in a Spanish population sample: decrease of enzymatic activity in multiple sclerosis patients.
Myasthenia Gravis
A New Thiopurine S-Methyltransferase Haplotype Associated With Intolerance to Azathioprine.
Myasthenia Gravis
A new thiopurine s-methyltransferase haplotype associated with intolerance to azathioprine.
Myelodysplastic Syndromes
Treatment-related Myelodysplastic Syndrome in a Child With Acute Myeloid Leukemia and TPMT Heterozygosity.
Neoplasm, Residual
Thiopurine methyltransferase and treatment outcome in the UK acute lymphoblastic leukaemia trial ALL2003.
Neoplasms
A drug-repositioning screen for primary pancreatic ductal adenocarcinoma cells identifies 6-thioguanine as an effective therapeutic agent for TPMT-low cancer cells.
Neoplasms
Genetic polymorphisms influencing therapy and susceptibility to rejection in organ allograft recipients.
Neoplasms
Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned.
Neoplasms
In Vitro Protein Stability of Two Naturally Occurring Thiopurine S-Methyltransferase Variants: Biophysical Characterization of TPMT*6 and TPMT*8.
Neoplasms
Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes.
Neoplasms
Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia.
Neoplasms
Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: Influence on cure rates and risk of second cancer.
Neoplasms
Testing for thiopurine methyltransferase status for safe and effective thiopurine administration: a systematic review of clinical guidance documents.
Neoplasms
The role of inherited TPMT and COMT genetic variation in cisplatin-induced ototoxicity in children with cancer.
Neoplasms
The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.
Neoplasms
Thiopurine methyltransferase activity in a French population: h.p.l.c. assay conditions and effects of drugs and inhibitors.
Neoplasms
Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols.
Neoplasms
Toward individualized treatment: prediction of anticancer drug disposition and toxicity with pharmacogenetics.
Neoplasms
[Cancer chemotherapy and drug metabolism enzyme]
Neoplasms, Second Primary
Children with low-risk acute lymphoblastic leukemia are at highest risk of second cancers.
Neuromyelitis Optica
Association between TPMT*3C and decreased thiopurine S-methyltransferase activity in patients with neuromyelitis optica spectrum disorders in China.
Neuromyelitis Optica
WITHDRAWN: Association between TPMT*3C and decreased thiopurine S-methyltransferase activity in patients with neuromyelitis optica spectrum disorders in China.
Neutropenia
Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease.
Neutropenia
Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.
Neutropenia
Relevance of thiopurine methyltransferase activity in inflammatory bowel disease patients maintained on low-dose azathioprine.
Neutropenia
[Homozygote deficiency of thiopurine methyltransferase. A contraindication to the use of azathioprine in kidney transplantation]
Osteoporosis
Treatment of autoimmune blistering diseases.
Ototoxicity
Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts.
Ototoxicity
Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines.
Ototoxicity
TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity.
Pancreatitis
TPMT and HLA-DQA1-HLA-DRB genetic profiling to guide the use of azathioprine in the treatment of interstitial lung disease: First experience.
Pancytopenia
A case of recurrent pancytopenia in a patient with acute promyelocytic leukemia on maintenance chemotherapy and concomitant methyltetrahydrofolate reductase and thiopurine S-methyltransferase mutation?-?review of literature.
Pancytopenia
Autoimmune hepatitis with sclerosing cholangitis in a patient with thiopurine methyltransferase deficiency: case presentation.
Pancytopenia
Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism.
Pancytopenia
Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase.
Pancytopenia
Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis.
Pancytopenia
Paradoxical elevated thiopurine S-methyltransferase activity after pancytopenia during azathioprine therapy: potential influence of red blood cell age.
Pancytopenia
Severe 6-thioguanine-induced marrow aplasia in a child with acute lymphoblastic leukemia and inherited thiopurine methyltransferase deficiency.
Pancytopenia
Severe pancytopenia and aspergillosis caused by thioguanine in a thiopurine S-methyltransferase deficient patient: a case report.
Pancytopenia
Severe pancytopenia from thiopurine methyltransferase deficiency: a preventable complication of 6-mercaptopurine therapy in children with Crohn disease.
Pemphigus
Complete remission of refractory pemphigus vulgaris in a Chinese patient with mutated NUDT15 by combination of minimal doses of azathioprine and prednisone.
Pemphigus
Role of thiopurine methyltransferase activity in the safety and efficacy of azathioprine in the treatment of pemphigus vulgaris.
Pemphigus
Thiopurine S-methyltransferase and Pemphigus Vulgaris: A Phenotype-Genotype Study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A cost effectiveness analysis of thiopurine methyltransferase testing for guiding 6-mercaptopurine dosing in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A personalized approach to cancer treatment: how biomarkers can help.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Allelic variants of the thiopurine methyltransferase (TPMT) gene in the Colombian population.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Analysis of Thiopurine S-Methyltransferase Deficient Alleles in Acute Lymphoblastic Leukemia Patients in Mexican Patients.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Analysis of thiopurine S-methyltransferase polymorphism in the population of Serbia and Montenegro and mercaptopurine therapy tolerance in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Clinical implication of thiopurine methyltransferase polymorphism in children with acute lymphoblastic leukemia: A preliminary Egyptian study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Comparative pharmacogenetic analysis of risk polymorphisms in Caucasian and Vietnamese children with acute lymphoblastic leukemia: prediction of therapeutic outcome?
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Comprehensive screening of the thiopurine methyltransferase polymorphisms by denaturing high-performance liquid chromatography.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cost-effectiveness of pharmacogenomics in clinical practice: a case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Frequency of thiopurine S-methyltransferase mutant alleles in indigenous and admixed Guatemalan patients with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic Polymorphism of Thiopurine S-methyltransferase in Children with Acute Lymphoblastic Leukemia in Jordan
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic Polymorphisms of Drug-Metabolizing Enzymes Involved in 6-Mercaptopurine-Induced Myelosuppression in Thai Pediatric Acute Lymphoblastic Leukemia Patients.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Impact of age, gender and haplotypes of thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genes on 6-mercaptopurine toxicity in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Influence of age, sex, and haplotypes of thiopurine methyltransferase (TPMT) gene on 6- mercaptopurine toxicity in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pharmacogenetic studies in children with acute lymphoblastic leukemia in Argentina.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pharmacogenomics and ALL treatment: How to optimize therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Risk factors for symptomatic osteonecrosis in childhood ALL: A retrospective study of a Slovenian pediatric ALL population between 1970 and 2004.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Role of TPMT and ITPA variants in mercaptopurine disposition.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Severe 6-thioguanine-induced marrow aplasia in a child with acute lymphoblastic leukemia and inherited thiopurine methyltransferase deficiency.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Structural Characteristics Determine the Cause of the Low Enzyme Activity of Two Thiopurine S-Methyltransferase Allelic Variants: A Biophysical Characterization of TPMT*2 and TPMT*5.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The Relationship of Genetics, Nursing Practice, and Informatics Tools in 6-Mercaptopurine Dosing in Pediatric Oncology [Formula: see text].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The Role of TPMT, ITPA, and NUDT15 Variants during Mercaptopurine Treatment of Swedish Pediatric Patients with Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine methyl transferase: activity and genotyping in patients with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine methyltransferase activity in children with acute myeloid leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine methyltransferase genotype and childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine methyltransferase genotyping in Palestinian childhood acute lymphoblastic leukemia patients.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine methyltransferase in acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine methyltransferase polymorphisms and mercaptopurine tolerance in Turkish children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine methyltransferase polymorphisms in a multiracial asian population and children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine methyltransferase polymorphisms in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine methyltransferase: a review and a clinical pilot study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine S-methyltransferase (TPMT) gene polymorphism in Brazilian children with acute lymphoblastic leukemia: association with clinical and laboratory data.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine S-methyltransferase (TPMT) polymorphisms in children with acute lymphoblastic leukemia, and the need for reduction or cessation of 6-mercaptopurine doses during maintenance therapy: The Polish multicenter analysis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine S-methyltransferase gene polymorphism and 6-mercaptopurine dose intensity in Indian children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine S-methyltransferase pharmacogenetics in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine S-methyltransferase phenotype-genotype correlation in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Understanding thiopurine methyltransferase polymorphisms for the targeted treatment of hematologic malignancies.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Utilization of Thiopurine Metabolites and Allopurinol in Pediatric Acute Lymphoblastic Leukemia: Consideration for an Algorithmic Approach.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Correlations between 6-mercaptopurine treatment-related adverse reactions in children with acute lymphoblastic leukemia and polymorphisms of thiopurine methyltransferase gene].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Significance of thiopurine s-methyltransferase gene test in a clinical case].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[The effect of the adverse events with thiopurine S-methyltransferase gene mutation on outcome of childhood acute lymphoblastic leukemia].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Thiopurine S-Methyltransferase Gene Sequence Analysis of ALL Children Severely Intolerant to 6-Mercaptopurine].
Protein Deficiency
Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C.
Rheumatic Diseases
Characterisation of novel defective thiopurine S-methyltransferase allelic variants.
Rheumatic Diseases
The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.
Rheumatic Diseases
[Association between metabolic enzyme genotype of azathioprine and drug tolerance in patients with rheumatic diseases]
Scleroderma, Systemic
Thiopurine methyltransferase activity in the erythrocytes of adults and children: and HPLC-linked assay.
Spondylarthritis
Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis.
Systemic Vasculitis
Plasma thiopurine S-methyltransferase levels and azathioprine-related adverse events in patients with Behçet's disease.
thiopurine s-methyltransferase deficiency
Acute lymphoblastic leukemia.
thiopurine s-methyltransferase deficiency
Allelic variants of the thiopurine S-methyltransferase deficiency in patients with ulcerative colitis and in healthy controls.
thiopurine s-methyltransferase deficiency
Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia.
thiopurine s-methyltransferase deficiency
Arrayed primer extension: a robust and reliable genotyping platform for the diagnosis of single gene disorders: beta-thalassemia and thiopurine methyltransferase deficiency.
thiopurine s-methyltransferase deficiency
Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study.
thiopurine s-methyltransferase deficiency
Autoimmune hepatitis with sclerosing cholangitis in a patient with thiopurine methyltransferase deficiency: case presentation.
thiopurine s-methyltransferase deficiency
Autoimmune liver disease.
thiopurine s-methyltransferase deficiency
Azathioprine and diffuse alveolar haemorrhage: the pharmacogenetics of thiopurine methyltransferase.
thiopurine s-methyltransferase deficiency
Azathioprine myelosuppression in multiple sclerosis: characterizing thiopurine methyltransferase polymorphisms.
thiopurine s-methyltransferase deficiency
Azathioprine pharmacogenetics: the relationship between 6-thioguanine nucleotides and thiopurine methyltransferase in patients after heart and kidney transplantation.
thiopurine s-methyltransferase deficiency
Azathioprine-associated acute myeloid leukemia in a patient with Crohn's disease and thiopurine S-methyltransferase deficiency.
thiopurine s-methyltransferase deficiency
Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.
thiopurine s-methyltransferase deficiency
Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia.
thiopurine s-methyltransferase deficiency
Early Assessment of Thiopurine Metabolites Identifies Patients at Risk of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease.
thiopurine s-methyltransferase deficiency
Increasing relevance of pharmacogenetics of drug metabolism in clinical practice.
thiopurine s-methyltransferase deficiency
Molecular diagnosis of thiopurine S-methyltransferase deficiency.
thiopurine s-methyltransferase deficiency
Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance.
thiopurine s-methyltransferase deficiency
Pharmacokinetics, dose adjustments, and 6-mercaptopurine/methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency.
thiopurine s-methyltransferase deficiency
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine.
thiopurine s-methyltransferase deficiency
Severe 6-thioguanine-induced marrow aplasia in a child with acute lymphoblastic leukemia and inherited thiopurine methyltransferase deficiency.
thiopurine s-methyltransferase deficiency
Severe pancytopenia from thiopurine methyltransferase deficiency: a preventable complication of 6-mercaptopurine therapy in children with Crohn disease.
thiopurine s-methyltransferase deficiency
Thiopurine methyltransferase deficiency and azathioprine intolerance in autoimmune hepatitis.
thiopurine s-methyltransferase deficiency
Thiopurine methyltransferase deficiency in childhood lymphoblastic leukaemia: 6-mercaptopurine dosage strategies.
thiopurine s-methyltransferase deficiency
Thiopurine S-methyltransferase activity in a Chinese population.
thiopurine s-methyltransferase deficiency
Thiopurine S-methyltransferase deficiency associated with a novel mutation.
thiopurine s-methyltransferase deficiency
Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.
thiopurine s-methyltransferase deficiency
Transporter-mediated protection against thiopurine-induced hematopoietic toxicity.
thiopurine s-methyltransferase deficiency
Update on thiopurine pharmacogenetics in inflammatory bowel disease.
thiopurine s-methyltransferase deficiency
[Homozygote deficiency of thiopurine methyltransferase. A contraindication to the use of azathioprine in kidney transplantation]
Thrombocytopenia
Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.
Uremia
Human thiopurine S-methyltransferase activity in uremia and after renal transplantation.
Vasculitis
Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study.
Whooping Cough
A tellurite-resistance genetic determinant from phytopathogenic pseudomonads encodes a thiopurine methyltransferase: evidence of a widely-conserved family of methyltransferases.
xanthine oxidase deficiency
[Hematotoxicity caused by azathioprine genetically determined and aggravated by xanthine oxidase deficiency in a patient following renal transplantation]
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Woodson, L.C.; Weinshilboum, R.M.
Human kidney thiopurine methyltransferase. Purification and biochemical properties
Biochem. Pharmacol.
32
819-826
1983
Homo sapiens
brenda
Ames, M.M.; Selassie, C.D.; Woodson, L.C.; Van Loon, J.A.; Hansch, C.; Weinshilboum, R.M.
Thiopurine methyltransferase: structure-activity relationships for benzoic acid inhibitors and thiophenol substrates
J. Med. Chem.
29
354-358
1986
Homo sapiens
brenda
Van Loon, J.A.; Weinshilboum, R.M.
Thiopurine methyltransferase isozymes in human renal tissue
Drug Metab. Dispos.
18
632-638
1990
Homo sapiens, Mus musculus
brenda
Szumlanski, C.L.; Honchel, R.; Scott, M.C.; Weinshilboum, R.M.
Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes
Pharmacogenetics
2
148-159
1992
Homo sapiens, Mus musculus
brenda
Deininger, M.; Szumlanski, C.L.; Otterness, D.M.; Van Loon, J.; Ferber, W.; Weinshilboum, R.M.
Purine substrates for human thiopurine methyltransferase
Biochem. Pharmacol.
48
2135-2138
1994
Homo sapiens
brenda
Krynetski, E.Y.; Krynetskaia, N.F.; Yanishevski, Y.; Evans, W.E.
Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase
Mol. Pharmacol.
47
1141-1147
1995
Homo sapiens
brenda
Krynetski, E.Y.; Schuetz, J.D.; Galpin, A.J.; Pui, C.H.; Relling, M.V.; Evans, W.E.
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase
Proc. Natl. Acad. Sci. USA
92
949-953
1995
Homo sapiens
brenda
Lysaa, R.A.; Giverhaug, T.; Wold, H.L.; Aarbakke, J.
Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide
Eur. J. Clin. Pharmacol.
49
393-396
1996
Homo sapiens
brenda
Stupans, I.; Kirlich, A.; McKinnon, R.A.
Human thiopurine methyltransferase: no evidence of activation by its substrates
Life Sci.
62
343-350
1997
Homo sapiens
brenda
Fessing, M.Y.; Belkov, V.M.; Krynetski, E.Y.; Evans, W.E.
Molecular cloning and functional characterization of the cDNA encoding the murine thiopurine S-methyltransferase (TPMT)
FEBS Lett.
424
143-145
1998
Homo sapiens, Mus musculus (O55060), Mus musculus
brenda
Kroeplin, T.; Iven, H.
Methylation of 6-mercaptopurine and 6-thioguanine by thiopurine S-methyltransferase. A comparison of activity in red blood cell samples of 199 blood donors
Eur. J. Clin. Pharmacol.
56
343-345
2000
Homo sapiens
brenda
Dervieux, T.; Blanco, J.G.; Krynetski, E.Y.; Vanin, E.F.; Roussel, M.F.; Relling, M.V.
Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells
Cancer Res.
61
5810-5816
2001
Homo sapiens, Mus musculus
brenda
Weinshilboum, R.
Thiopurine pharmacogenetics: Clinical and molecular studies of thiopurine methyltransferase
Drug Metab. Dispos.
29
601-605
2001
Homo sapiens
brenda
Keizer-Garritsen, J.J.; Brouwer, C.; Lambooy, L.H.; Ter Riet, P.; Bokkerink, J.P.; Trijbels, F.J.; De Abreu, R.A.
Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children
Ann. Clin. Biochem.
40
86-93
2003
Homo sapiens
brenda
Hamdan-Khalil, R.; Allorge, D.; Lo-Guidice, J.M.; Cauffiez, C.; Chevalier, D.; Spire, C.; Houdret, N.; Libersa, C.; Lhermitte, M.; Colombel, J.F.; Gala, J.L.; Broly, F.
In vitro characterization of four novel non-functional variants of the thiopurine S-methyltransferase
Biochem. Biophys. Res. Commun.
309
1005-1010
2003
Homo sapiens
brenda
Hamdan-Khalil, R.; Gala, J.L.; Allorge, D.; Lo-Guidice, J.M.; Horsmans, Y.; Houdret, N.; Broly, F.
Identification and functional analysis of two rare allelic variants of the thiopurine S-methyltransferase gene, TPMT*16 and TPMT*19
Biochem. Pharmacol.
69
525-529
2005
Homo sapiens (P51580), Homo sapiens
brenda
Brouwer, C.; de Abreu, R.A.; Keizer-Garritsen, J.J.; Lambooy, L.H.; Ament, K.; ter Riet, P.G.; van Wering, E.R.; Trijbels, F.J.; Veerman, A.J.; Hoogerbrugge, P.M.; Bokkerink, J.P.
Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects
Eur. J. Cancer
41
613-623
2005
Homo sapiens
brenda
Xin, H.W.; Fischer, C.; Schwab, M.; Klotz, U.
Thiopurine S-methyltransferase as a target for drug interactions
Eur. J. Clin. Pharmacol.
61
395-398
2005
Homo sapiens
brenda
Ford, L.T.; Berg, J.D.
Determination of thiopurine S-methyltransferase activity in erythrocytes using 6-thioguanine as substrate and a non-extraction liquid chromatographic technique
J. Chromatogr. B
798
111-115
2003
Homo sapiens
brenda
Winter, J.W.; Gaffney, D.; Shapiro, D.; Spooner, R.J.; Marinaki, A.M.; Sanderson, J.D.; Mills, P.R.
Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease
Aliment. Pharmacol. Ther.
25
1069-1077
2007
Homo sapiens
brenda
Winter, J.W.; Marinaki, A.M.; Sanderson, J.D.; Mills, P.R.
TPMT genotype and the response to azathioprine in inflammatory bowel disease: authors reply to comments
Aliment. Pharmacol. Ther.
26
1084-1085
2007
Homo sapiens
brenda
Palmieri, O.; Latiano, A.; Bossa, F.; Vecchi, M.; DInca, R.; Guagnozzi, D.; Tonelli, F.; Cucchiara, S.; Valvano, M.R.; Latiano, T.; Andriulli, A.; Annese, V.
Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines toxicity and efficacy
Aliment. Pharmacol. Ther.
26
737-745
2007
Homo sapiens
brenda
Roblin, X.; Biroulet, L.P.; Phelip, J.M.; Nancey, S.; Flourie, B.
A 6-Thioguanine Nucleotide Threshold Level of 400 pmol/8 x 10(8) Erythrocytes Predicts Azathioprine Refractoriness in Patients With Inflammatory Bowel Disease and Normal TPMT Activity
Am. J. Gastroenterol.
102
1-8
2007
Homo sapiens
brenda
Tumer, T.B.; Ulusoy, G.; Adali, O.; Sahin, G.; Gozdasoglu, S.; Arinc, E.
The low frequency of defective TPMT alleles in Turkish population: a study on pediatric patients with acute lymphoblastic leukemia
Am. J. Hematol.
82
906-910
2007
Homo sapiens
brenda
Yenson, P.R.; Forrest, D.; Schmiegelow, K.; Dalal, B.I.
Azathioprine-associated acute myeloid leukemia in a patient with Crohns disease and thiopurine S-methyltransferase deficiency
Am. J. Hematol.
83
80-83
2008
Homo sapiens
brenda
Litos, I.K.; Emmanouilidou, E.; Glynou, K.M.; Laios, E.; Ioannou, P.C.; Christopoulos, T.K.; Kampa, M.; Castanas, E.; Gravanis, A.
Rapid genotyping of CYP2D6, CYP2C19 and TPMT polymorphisms by primer extension reaction in a dipstick format
Anal. Bioanal. Chem.
389
1849-1857
2007
Homo sapiens (P51580)
brenda
Firooz, A.; Ghandi, N.; Hallaji, Z.; Chams-Davatchi, C.; Valikhani, M.; Karbakhsh Davari, M.
Role of thiopurine methyltransferase activity in the safety and efficacy of azathioprine in the treatment of pemphigus vulgaris
Arch. Dermatol.
144
1143-1147
2008
Homo sapiens
brenda
Hogarth, L.A.; Redfern, C.P.; Teodoridis, J.M.; Hall, A.G.; Anderson, H.; Case, M.C.; Coulthard, S.A.
The effect of thiopurine drugs on DNA methylation in relation to TPMT expression
Biochem. Pharmacol.
76
1024-1035
2008
Homo sapiens
brenda
Garat, A.; Cauffiez, C.; Renault, N.; Lo-Guidice, J.M.; Allorge, D.; Chevalier, D.; Houdret, N.; Chavatte, P.; Loriot, M.A.; Gala, J.L.; Broly, F.
Characterisation of novel defective thiopurine S-methyltransferase allelic variants
Biochem. Pharmacol.
76
404-415
2008
Homo sapiens (P51580), Homo sapiens
brenda
Peng, Y.; Feng, Q.; Wilk, D.; Adjei, A.A.; Salavaggione, O.E.; Weinshilboum, R.M.; Yee, V.C.
Structural basis of substrate recognition in thiopurine s-methyltransferase
Biochemistry
47
6216-6225
2008
Mus musculus (O55060), Mus musculus, Homo sapiens (P51580), Homo sapiens
brenda
Haglund, S.; Taipalensuu, J.; Peterson, C.; Almer, S.
IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations
Br. J. Clin. Pharmacol.
65
69-77
2008
Homo sapiens
brenda
Tamm, R.; Oselin, K.; Kallassalu, K.; Magi, R.; Anier, K.; Remm, M.; Metspalu, A.
Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population
Clin. Chem. Lab. Med.
46
974-979
2008
Homo sapiens
brenda
Zhang, L.; Song, D.; Zhang, W.; Zhao, J.; Jia, L.; Xing, D.
Efficient screening method of the thiopurine methyltransferase polymorphisms for patients considering taking thiopurine drugs in a Chinese Han population in Henan Province (central China)
Clin. Chim. Acta
376
45-51
2007
Homo sapiens
brenda
Lee, S.S.; Kim, W.Y.; Jang, Y.J.; Shin, J.G.
Duplex pyrosequencing of the TPMT3C and TPMT6 alleles in Korean and Vietnamese populations
Clin. Chim. Acta
398
82-85
2008
Homo sapiens
brenda
Gardiner, S.J.; Gearry, R.B.; Begg, E.J.; Zhang, M.; Barclay, M.L.
Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold
Clin. Gastroenterol. Hepatol.
6; 654-60
quiz 604
2008
Homo sapiens
brenda
Jones, T.S.; Yang, W.; Evans, W.E.; Relling, M.V.
Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphism
Clin. Pharmacol. Ther.
81
729-734
2007
Homo sapiens
brenda
Gisbert, J.P.; Gomollon, F.; Cara, C.; Luna, M.; Gonzalez-Lama, Y.; Pajares, J.M.; Mate, J.; Guijarro, L.G.
Thiopurine methyltransferase activity in Spain: a study of 14,545 patients
Dig. Dis. Sci.
52
1262-1269
2007
Homo sapiens
brenda
Kwan, L.Y.; Devlin, S.M.; Mirocha, J.M.; Papadakis, K.A.
Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease
Dig. Liver Dis.
40
425-432
2008
Homo sapiens
brenda
Oselin, K.; Anier, K.
Inhibition of human thiopurine S-methyltransferase by various nonsteroidal anti-inflammatory drugs in vitro: a mechanism for possible drug interactions
Drug Metab. Dispos.
35
1452-1454
2007
Homo sapiens
brenda
Oliveira, E.; Quental, S.; Alves, S.; Amorim, A.; Prata, M.J.
Do the distribution patterns of polymorphisms at the thiopurine S-methyltransferase locus in sub-Saharan populations need revision? Hints from Cabinda and Mozambique
Eur. J. Clin. Pharmacol.
63
703-706
2007
Homo sapiens
brenda
Kham, S.K.; Soh, C.K.; Liu, T.C.; Chan, Y.H.; Ariffin, H.; Tan, P.L.; Yeoh, A.E.
Thiopurine S-methyltransferase activity in three major Asian populations: a population-based study in Singapore
Eur. J. Clin. Pharmacol.
64
373-379
2008
Homo sapiens
brenda
Bezier, M.; Reguiai, Z.; Vitry, F.; Broly, F.; Bernard, P.
Thiopurine S-methyltransferase genotypic analysis in autoimmune bullous diseases
Eur. J. Dermatol.
18
512-517
2008
Homo sapiens
brenda
Perri, D.; Cole, D.E.; Friedman, O.; Piliotis, E.; Mintz, S.; Adhikari, N.K.
Azathioprine and diffuse alveolar haemorrhage: the pharmacogenetics of thiopurine methyltransferase
Eur. Respir. J.
30
1014-1017
2007
Homo sapiens
brenda
Richard, V.S.; Al-Ismail, D.; Salamat, A.
Should we test TPMT enzyme levels before starting azathioprine?
Hematology
12
359-360
2007
Homo sapiens
brenda
Compagni, A.; Bartoli, S.; Buehrlen, B.; Fattore, G.; Ibarreta, D.; de Mesa, E.G.
Avoiding adverse drug reactions by pharmacogenetic testing: a systematic review of the economic evidence in the case of TPMT and AZA-induced side effects
Int. J. Technol. Assess. Health Care
24
294-302
2008
Homo sapiens
brenda
Fargher, E.A.; Tricker, K.; Newman, W.; Elliott, R.; Roberts, S.A.; Shaffer, J.L.; Bruce, I.; Payne, K.
Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription
J. Clin. Pharm. Ther.
32
187-195
2007
Homo sapiens
brenda
Fakhoury, M.; Andreu-Gallien, J.; Mahr, A.; Medard, Y.; Azougagh, S.; Vilmer, E.; Jacqz-Aigrain, E.
Should TPMT genotype and activity be used to monitor 6-mercaptopurine treatment in children with acute lymphoblastic leukaemia?
J. Clin. Pharm. Ther.
32
633-639
2007
Homo sapiens
brenda
Hoover, S.; Striker, R.
Thiopurines inhibit bovine viral diarrhea virus production in a thiopurine methyltransferase-dependent manner
J. Gen. Virol.
89
1000-1009
2008
Bos taurus, Homo sapiens
brenda
Rutherford, K.; Daggett, V.
Four human thiopurine s-methyltransferase alleles severely affect protein structure and dynamics
J. Mol. Biol.
379
803-814
2008
Homo sapiens
brenda
Chowdhury, J.; Kagiala, G.V.; Pushpakom, S.; Lauzon, J.; Makin, A.; Atrazhev, A.; Stickel, A.; Newman, W.G.; Backhouse, C.J.; Pilarski, L.M.
Microfluidic platform for single nucleotide polymorphism genotyping of the thiopurine S-methyltransferase gene to evaluate risk for adverse drug events
J. Mol. Diagn.
9
521-529
2007
Homo sapiens
brenda
Tamori, A.; Shinzaki, M.; Kosaka, S.; Hayashi, T.; Iwai, S.; Enomoto, M.; Habu, D.; Sakaguchi, H.; Kawada, N.; Hino, M.; Shiomi, S.; Nishiguchi, S.
Thiopurine S-methyltransferase gene polymorphism in Japanese patients with autoimmune liver diseases
Liver Int.
27
95-100
2007
Homo sapiens
brenda
Taja-Chayeb, L.; Vidal-Millan, S.; Gutierrez, O.; Ostrosky-Wegman, P.; Duenas-Gonzalez, A.; Candelaria, M.
Thiopurine S-methyltransferase gene (TMPT) polymorphisms in a Mexican population of healthy individuals and leukemic patients
Med. Oncol.
25
56-62
2008
Homo sapiens
brenda
Slanar, O.; Bortlik, M.; Buzkova, H.; Donoval, R.; Pechandova, K.; Sebesta, I.; Lukas, M.; Perlik, F.
Polymorphisms of the TPMT gene in the Czech healthy population and patients with inflammatory bowel disease
Nucleosides Nucleotides Nucleic Acids
27
835-838
2008
Homo sapiens
brenda
Lindqvist, M.; Skoglund, K.; Karlgren, A.; Soederkvist, P.; Peterson, C.; Kidhall, I.; Almer, S.
Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23
Pharmacogenet. Genomics
17
891-895
2007
Homo sapiens
brenda
Roberts, R.L.; Gearry, R.B.; Bland, M.V.; Sies, C.W.; George, P.M.; Burt, M.; Marinaki, A.M.; Arenas, M.; Barclay, M.L.; Kennedy, M.A.
Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity
Pharmacogenet. Genomics
18
434-438
2008
Homo sapiens
brenda
Ujiie, S.; Sasaki, T.; Mizugaki, M.; Ishikawa, M.; Hiratsuka, M.
Functional characterization of 23 allelic variants of thiopurine S-methyltransferase gene (TPMT*2 - *24)
Pharmacogenet. Genomics
18
887-893
2008
Homo sapiens
brenda
Cooper, S.C.; Ford, L.T.; Berg, J.D.; Lewis, M.J.
Ethnic variation of thiopurine S-methyltransferase activity: a large, prospective population study
Pharmacogenomics
9
303-309
2008
Homo sapiens
brenda
Chrzanowska, M.; Kurzawski, M.; Dro?dzik, M.; Mazik, M.; Oko, A.; Czekalski, S.
Thiopurine S-methyltransferase phenotype-genotype correlation in hemodialyzed patients
Pharmacol. Rep.
58
973-978
2006
Homo sapiens
brenda
Dilger, K.; Schaeffeler, E.; Lukas, M.; Strauch, U.; Herfarth, H.; Mueller, R.; Schwab, M.
Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohns disease during 1 year of treatment with azathioprine or mesalazine
Ther. Drug Monit.
29
1-5
2007
Homo sapiens
brenda
de Boer, N.K.; van Bodegraven, A.A.; de Graaf, P.; van der Hulst, R.W.; Zoetekouw, L.; van Kuilenburg, A.B.
Paradoxical elevated thiopurine S-methyltransferase activity after pancytopenia during azathioprine therapy: potential influence of red blood cell age
Ther. Drug Monit.
30
390-393
2008
Homo sapiens
brenda
Alvarez Beltran, M.; Infante Pina, D.; Tormo Carnice, R.; Segarra Canton, O.; Redecillas Ferreiro, S.
Optimising azathioprine treatment: determination of thiopurine methyltransferase activity and thiopurine metabolites
An. Pediatr. (Barc. )
70
126-131
2009
Homo sapiens
brenda
el-Azhary, R.A.; Farmer, S.A.; Drage, L.A.; Rogers, R.S.; McEvoy, M.T.; Davis, M.D.; Bridges, A.G.; Gibson, L.E.
Thioguanine nucleotides and thiopurine methyltransferase in immunobullous diseases: optimal levels as adjunctive tools for azathioprine monitoring
Arch. Dermatol.
145
644-652
2009
Homo sapiens
brenda
Milek, M.; Karas Kuzelicki, N.; Smid, A.; Mlinaric-Rascan, I.
S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts
Biochem. Pharmacol.
77
1845-1853
2009
Homo sapiens
brenda
Feng, Q.; Vannaprasaht, S.; Peng, Y.; Angsuthum, S.; Avihingsanon, Y.; Yee, V.C.; Tassaneeyakul, W.; Weinshilboum, R.M.
Thiopurine S-methyltransferase pharmacogenetics: Functional characterization of a novel rapidly degraded variant allozyme
Biochem. Pharmacol.
79
1053-1061
2009
Homo sapiens (P51580), Homo sapiens
brenda
Kham, S.K.; Soh, C.K.; Aw, D.C.; Yeoh, A.E.
TPMT*26 (208F-->L), a novel mutation detected in a Chinese
Br. J. Clin. Pharmacol.
68
120-123
2009
Homo sapiens
brenda
Tsui, N.
Multiple thiopurine S-methyltransferase variation detection: A step toward personalized medicine
Clin. Chem.
54
1598-1599
2008
Homo sapiens
brenda
Schaeffeler, E.; Zanger, U.M.; Eichelbaum, M.; Asante-Poku, S.; Shin, J.G.; Schwab, M.
Highly multiplexed genotyping of thiopurine S-methyltransferase variants using MALD-TOF mass spectrometry: reliable genotyping in different ethnic groups
Clin. Chem.
54
1637-1647
2008
Homo sapiens
brenda
Vestergaard, T.; Bygum, A.
An audit of thiopurine methyltransferase genotyping and phenotyping before intended azathioprine treatment for dermatological conditions
Clin. Exp. Dermatol.
35
140-144
2010
Homo sapiens
brenda
Gisbert, J.
Role of monitoring thiopurine methyltransferase (TPMT) activity in the individualized therapy with azathioprine or 6-mercaptopurine
Curr. Pharmacogenomics Person. Med.
6
33-44
2008
Homo sapiens
-
brenda
Egle, R.; Milek, M.; Mlinaric-Rascan, I.; Fahr, A.; Kristl, J.
A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types
Eur. J. Pharm. Biopharm.
69
23-30
2008
Homo sapiens
brenda
Stocco, G.; Crews, K.R.; Evans, W.E.
Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status
Expert. Opin. Drug Saf.
9
23-37
2010
Homo sapiens
brenda
Cheon, J.H.; Kim, J.H.; Kim, B.Y.; Kim, S.W.; Hong, S.Y.; Eun, C.S.; Hong, S.S.; Byeon, J.S.; Kim, T.I.; Han, D.S.; Yang, S.K.; Lee, K.R.; Kim, W.H.
Allele frequency of thiopurine methyltransferase and inosine triphosphate pyrophosphatase gene polymorphisms in Korean patients with inflammatory bowel diseases
Hepatogastroenterology
56
421-423
2009
Homo sapiens
brenda
Tomkova, J.; Friedecky, D.; Polynkova, A.; Adam, T.
Capillary electrophoresis determination of thiopurine methyl transferase activity in erythrocytes
J. Chromatogr. B
877
1943-1945
2009
Homo sapiens
brenda
Gonzalez-Del Angel, A.; Bermadez-Lapez, C.; Alcantara-Ortigoza, M.; Vela-Amieva, M.; Castillo-Cruz, R.; Martinez, V.; Torres-Espadola, L.
Thiopurine S-methyltransferase (TPMT) genetic polymorphisms in Mexican newborns
J. Clin. Pharm. Ther.
34
703-708
2009
Homo sapiens
brenda
Hindorf, U.; Jahed, K.; Bergquist, A.; Verbaan, H.; Prytz, H.; Wallerstedt, S.; Werner, M.; Olsson, R.; Bjoernsson, E.; Peterson, C.; Almer, S.H.
Characterisation and utility of thiopurine methyltransferase and thiopurine metabolite measurements in autoimmune hepatitis
J. Hepatol.
52
106-111
2010
Homo sapiens
brenda
Schmiegelow, K.; Forestier, E.; Kristinsson, J.; Soederhaell, S.; Vettenranta, K.; Weinshilboum, R.; Wesenberg, F.; Wesenberg, F.
Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
Leukemia
23
557-564
2009
Homo sapiens
brenda
Sheffield, L.J.; Irving, P.; Gupta, A.; Byron, K.; Macrae, F.A.; Phillimore, H.; Dronavalli, M.; Rose, R.; George, P.; Walmsley, T.; Dixon, B.; Poole, S.; Dooley, M.; Sparrow, M.
Thiopurine methyltransferase and thiopurine metabolite testing in patients with inflammatory bowel disease who are taking thiopurine drugs
Pharmacogenomics
10
1091-1099
2009
Homo sapiens
brenda
Karas-Kuzelicki, N.; Mlinaric-Rascan, I.
Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond
Pharmacogenomics
10
1309-1322
2009
Homo sapiens
brenda
Serpe, L.; Calvo, P.L.; Muntoni, E.; DAntico, S.; Giaccone, M.; Avagnina, A.; Baldi, M.; Barbera, C.; Curti, F.; Pera, A.; Eandi, M.; Zara, G.P.; Canaparo, R.
Thiopurine S-methyltransferase pharmacogenetics in a large-scale healthy Italian-Caucasian population: differences in enzyme activity
Pharmacogenomics
10
1753-1765
2009
Homo sapiens
brenda
Silva, M.R.; de Oliveira, B.M.; Viana, M.B.; Murao, M.; Romanha, A.J.
Thiopurine S-methyltransferase (TPMT) gene polymorphism in Brazilian children with acute lymphoblastic leukemia: association with clinical and laboratory data
Ther. Drug Monit.
30
700-704
2008
Homo sapiens
brenda
Milek, M.; Smid, A.; Tamm, R.; Kuzelicki, N.K.; Metspalu, A.; Mlinaric-Rascan, I.
Post-translational stabilization of thiopurine S-methyltransferase by S-adenosyl-L-methionine reveals regulation of TPMT*1 and *3C allozymes
Biochem. Pharmacol.
83
969-976
2012
Homo sapiens
brenda
Wennerstrand, P.; Dametto, P.; Hennig, J.; Klingstedt, T.; Skoglund, K.; Lindqvist Appell, M.; Martensson, L.G.
Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5
Biochemistry
51
5912-5920
2012
Homo sapiens
brenda
Pavlovic, S.; Zukic, B.
Individualized therapy: Role of thiopurine S-methyltransferase protein and genetic variants
J. Med. Biochem.
29
150-155
2010
Homo sapiens
-
brenda
Hosni-Ahmed, A.; Barnes, J.D.; Wan, J.; Jones, T.S.
Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure
PLoS ONE
6
e29163
2011
Homo sapiens, Mus musculus
brenda
Kasirer, Y.; Mevorach, R.; Renbaum, P.; Algur, N.; Soiferman, D.; Beeri, R.; Rachman, Y.; Segel, R.; Turner, D.
Thiopurine S-methyltransferase (TPMT) activity is better determined by biochemical assay versus genotyping in the Jewish population
Digest. Dis. Sci.
59
1207-1212
2014
Homo sapiens (P51580)
brenda
Wennerstrand, P.; Martensson, L.G.; Soederhaell, S.; Zimdahl, A.; Appell, M.L.
Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia
Eur. J. Clin. Pharmacol.
69
1641-1649
2013
Homo sapiens (P51580), Homo sapiens
brenda
Roberts, R.L.; Wallace, M.C.; Drake, J.M.; Stamp, L.K.
Identification of a novel thiopurine S-methyltransferase allele (TPMT 37)
Pharmacogenet. Genomics
24
320-323
2014
Homo sapiens (P51580)
brenda
Wennerstrand, P.; Blissing, A.; Martensson, L.G.
In vitro protein stability of two naturally occurring thiopurine S-methyltransferase variants biophysical characterization of TPMT*6 and TPMT*8
ACS Omega
2
4991-4999
2017
Homo sapiens (P51580)
brenda
Citterio-Quentin, A.; El Mahmoudi, A.; Perret, T.; Conway, A.; Ryan, A.; Beringer, A.; Lachaux, A.; Boulieu, R.
Red Blood cell IMPDH activity in adults and children with or without azathioprine Relationship between thiopurine metabolites, ITPA and TPMT activities
Basic Clin. Pharmacol. Toxicol.
124
600-606
2019
Homo sapiens
brenda
Mei, S.; Li, X.; Gong, X.; Zhang, X.; Li, X.; Yang, L.; Zhu, L.; Zhou, H.; Liu, Y.; Zhou, A.; Zhang, X.; Zhao, Z.
Comparison of 6-mercaptopurine with 6-thioguanine for the analysis of thiopurine S-methyltransferase activity in human erythrocyte by LC-MS/MS
Biomed. Chromatogr.
31
e3959
2017
Homo sapiens
brenda
Ma, J.; Sies, C.W.; Pike, L.S.
Analytical and clinical validation of an LC-MS/MS method to measure thiopurine S-methyltransferase activity by quantifying d3-6-MMP
Clin. Biochem.
54
100-105
2018
Homo sapiens
brenda
Rieger, H.; Schmidt, P.; Schaeffeler, E.; Abe, M.; Schiffhauer, M.; Schwab, M.; von Ahsen, N.; Zurek, G.; Kirchherr, H.; Shipkova, M.; Wieland, E.
Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate
Clin. Chem. Lab. Med.
56
803-809
2018
Homo sapiens
brenda
Pashazadeh, P.; Marjani, A.; Asadi, J.; Khoshnia, M.
Thiopurine methyltransferase genetic polymorphisms and activity and metabolic products of azathioprine in patients with inflammatory bowel disease
Endocr. Metab. Immune Disord. Drug Targets
19
541-547
2019
Homo sapiens
brenda
Illamola, S.M.; Echaabi, A.K.; Mazeron, C.; Deshayes, S.; Loriot, M.A.; Pallet, N.
Development and validation of a UPLC-UV method for the quantification of thiopurine methyltransferase enzyme activity in human erythrocytes
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
1113
91-97
2019
Homo sapiens
brenda
Pecher, D.; Dokupilova, S.; Zelinkova, Z.; Peppelenbosch, M.; Mikusova, V.; Mikus, P.
Determination of thiopurine S-methyltransferase activity by hydrophilic interaction liquid chromatography hyphenated with mass spectrometry
J. Pharm. Biomed. Anal.
142
244-251
2017
Homo sapiens
brenda