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S-adenosyl-L-methionine + CNBr peptide
?
-
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
S-adenosyl-L-methionine + myoglobin L-lysine
S-adenosyl-L-homocysteine + myoglobin N6-methyl-L-lysine
-
10% activity compared to cytochrome c
-
?
S-adenosyl-L-methionine + [apocytochrome c]-L-lysine
S-adenosyl-L-homocysteine + [apocytochrome c]-N6-methyl-L-lysine
-
-
-
-
r
S-adenosyl-L-methionine + [cytochrome c]-L-lysine
S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
a single lysine residue at position 72 of horse heart cytochrome c is methylated
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
a single lysine residue at position 72 of horse heart cytochrome c is methylated
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
important features in determining methyl-accepting activity: 1. reactive site such as-X-Lys-Lys-Y-, 2. length of polypeptide chain, 3. tertiary structure
a single lysine residue at position 72 of horse heart cytochrome c is methylated, mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
does not randomly methylate cytochrome c, but shows absolute specificity for some amino acid sequences
a single lysine residue at position 72 of horse heart cytochrome c is methylated
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
does not randomly methylate cytochrome c, but shows absolute specificity for some amino acid sequences
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
does not randomly methylate cytochrome c, but shows absolute specificity for some amino acid sequences
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
also CNBr peptides of horse heart cytochrome c can serve as substrates, overview
a single lysine residue at position 72 of horse heart cytochrome c is methylated
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
also CNBr peptides of horse heart cytochrome c can serve as substrates, overview
a single lysine residue at position 72 of horse heart cytochrome c is methylated
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
also CNBr peptides of horse heart cytochrome c can serve as substrates, overview
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
also CNBr peptides of horse heart cytochrome c can serve as substrates, overview
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
overview: substrate activity of various cytochromes c
a single lysine residue at position 72 of horse heart cytochrome c is methylated, mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
specific for unmethylated cytochrome c
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
specific for unmethylated cytochrome c
a single lysine residue at position 72 of horse heart cytochrome c is methylated, 9:17:74, mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
recombinant substrate iso-1-apocytochrome c
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
a single lysine residue at position 72 of horse heart cytochrome c is methylated, 9:17:74, mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
trimethylation of recombinant iso-1-cytochrome c of lysine at position 72
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
overview: substrate activity of various cytochromes c
a single lysine residue at position 72 of horse heart cytochrome c is methylated, 9:17:74, mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
in vivo methylation of cytochrome c in yeast occurs probably before cytochrome c is attached to the mitochondria
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
regulation of enzyme and cytochrome c substrate is not in parallel manner
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
lysine-72 of horse cytochrome c is a poor acceptor
uptake of methyl groups occurs only at lysine residue 8 and the terminal proline residue
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
Crithidia cytochrome c-557 is far the best substrate
uptake of methyl groups occurs only at lysine residue 8 and the terminal proline residue
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
avian cytochromes c are much better substrates than those from mammalian sources
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
does not randomly methylate cytochrome c, but shows absolute specificity for some amino acid sequences
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
also CNBr peptides of horse heart cytochrome c can serve as substrates, overview
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
overview: substrate activity of various cytochromes c
-
?
S-adenosyl-L-methionine + [cytochrome c]-L-lysine
S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine
-
-
-
-
r
S-adenosyl-L-methionine + [cytochrome c]-L-lysine
S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine
-
-
-
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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CTM1_ASHGO
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
478
0
53392
Swiss-Prot
other Location (Reliability: 2)
CTM1_CANGA
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
551
0
63533
Swiss-Prot
other Location (Reliability: 2)
CTM1_KLULA
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
503
0
58504
Swiss-Prot
other Location (Reliability: 1)
CTM1_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
585
0
68284
Swiss-Prot
other Location (Reliability: 4)
C8Z9Q2_YEAS8
Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)
585
0
68256
TrEMBL
other Location (Reliability: 4)
G2WFI3_YEASK
Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557)
585
0
68210
TrEMBL
other Location (Reliability: 4)
A6ZT17_YEAS7
Saccharomyces cerevisiae (strain YJM789)
585
0
68256
TrEMBL
other Location (Reliability: 4)
K0KFB3_WICCF
Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL Y-1031 F-60-10)
638
0
74280
TrEMBL
other Location (Reliability: 1)
N1P9F1_YEASC
Saccharomyces cerevisiae (strain CEN.PK113-7D)
585
0
68284
TrEMBL
other Location (Reliability: 4)
A0A8B8USQ9_SACPA
606
0
70907
TrEMBL
Mitochondrion (Reliability: 4)
A0A8H4BZM2_YEASX
585
0
68284
TrEMBL
other Location (Reliability: 4)
C7GLZ5_YEAS2
Saccharomyces cerevisiae (strain JAY291)
585
0
68256
TrEMBL
other Location (Reliability: 4)
A0A0L8VPB9_9SACH
585
0
68256
TrEMBL
other Location (Reliability: 4)
B5VK44_YEAS6
Saccharomyces cerevisiae (strain AWRI1631)
585
0
68314
TrEMBL
other Location (Reliability: 4)
H0GHF6_SACCK
Saccharomyces cerevisiae x Saccharomyces kudriavzevii (strain VIN7)
584
0
67983
TrEMBL
other Location (Reliability: 4)
A0A0W0DMF6_CANGB
551
0
63533
TrEMBL
other Location (Reliability: 2)
R9XFC4_ASHAC
481
0
54138
TrEMBL
other Location (Reliability: 4)
A0A6C1DSU9_SACPS
585
0
68216
TrEMBL
other Location (Reliability: 4)
B3LSM4_YEAS1
Saccharomyces cerevisiae (strain RM11-1a)
585
0
68256
TrEMBL
other Location (Reliability: 4)
A0A5P2UCF9_KLULC
501
0
58363
TrEMBL
other Location (Reliability: 2)
B9WN35_CANDC
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)
685
0
79461
TrEMBL
other Location (Reliability: 2)
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Valentine, J.; Pettigrew, G.W.
A cytochrome c methyltransferase from Crithidia oncopelti
Biochem. J.
201
329-338
1982
Strigomonas oncopelti
brenda
Nochumson, S.; Durban, E.; Kim, S.; Paik, W.K.
Cytochrome c-specific protein methylase III from Neurospora crassa
Biochem. J.
165
11-18
1977
Neurospora crassa
brenda
Durban, E.; Nochumson, S.; Kim, S.; Ki Paik, W.
Cytochrome c-specific protein-lysine methyltransferase from Neurospora crassa. Purification, characterization, and substrate requirements
J. Biol. Chem.
253
1427-1435
1978
Neurospora crassa
brenda
Park, K.S.; Frost, B.; Tuck, M.; Ho, L.L.; Kim, S.; Paik, W.K.
Enzymatic methylation of in vitro synthesized apocytochrome c enhances its transport into mitochondria
J. Biol. Chem.
262
14702-14708
1987
Saccharomyces cerevisiae
brenda
Polevoda, B.; Martzen, M.R.; Das, B.; Phizicky, E.M.; Sherman, F.
Cytochrome c methyltransferase, Ctm1p, of yeast
J. Biol. Chem.
275
20508-20513
2000
Saccharomyces cerevisiae
brenda
Durban, E.; Kim, S.; Jun, G.J.; Paik, W.K.
Cytochrome c-specific protein-lysine methyltransferase from Neurospora crassa: kinetic mechanism
Korean J. Biochem.
15
19-24
1983
Neurospora crassa
-
brenda
Paik, W.K.; DiMaria, P.
Enzymatic methylation and demethylation of protein-bound lysine residues
Methods Enzymol.
106
274-287
1984
Neurospora crassa
brenda
DiMaria, P.; Kim, S.; Paik, W.K.
Cytochrome c specific methylase from wheat germ
Biochemistry
21
1036-1044
1982
Triticum aestivum
brenda
DiMaria, P.; Polastro, E.; DeLange, R.J.; Kim, S.; Paik, W.K.
Studies on cytochrome c methylation in yeast
J. Biol. Chem.
254
4645-4652
1979
Saccharomyces cerevisiae
brenda