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Information on EC 2.1.1.45 - thymidylate synthase and Organism(s) Pseudomonas aeruginosa

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.45 thymidylate synthase
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This record set is specific for:
Pseudomonas aeruginosa
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The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms
Synonyms
thymidylate synthase, thymidylate synthetase, human ts, dtmp synthase, thymidylate synthase a, tmp synthetase, y110a7a.4, 5,10-methylenetetrahydrofolate:dump c-methyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dTMP synthase
-
-
-
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methylenetetrahydrofolate:dUMP C-methyltransferase
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-
-
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thymidylate synthetase
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-
-
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TMP synthetase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dehalogenation
-
-
-
-
methylene group transfer
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-
-
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reductive methylation
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-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9031-61-2
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5,10-methylenetetrahydrofolate + dUMP
dihydrofolate + dTMP
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
N5,N10-methylenetetrahydrofolate
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-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,1-bis-(4-hydroxyphenyl)-1H-naphtho[1,2-c]furan-3-one
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-
3,3-bis-(3-chloro-4-hydroxyphenyl)-1H,3H-[1,8-c,d]pyran-1-one
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-
benzyloxycarbonylamino-N,O-didansyl-L-tyrosine
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-
N,O-didansyl-L-tyrosine
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-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A444M3P1_PSEAI
264
0
29989
TrEMBL
-
A0A8G3ZMR9_PSEAI
264
0
30045
TrEMBL
-
A0A8G4L2D1_PSEAI
264
1
30036
TrEMBL
-
A0A8G2QX89_PSEAI
264
1
30031
TrEMBL
-
A0A2R3IZ33_PSEAI
264
1
30100
TrEMBL
-
A0A8G2VM79_PSEAI
264
1
30028
TrEMBL
-
A0A8G1VFI5_PSEAI
264
0
30040
TrEMBL
-
A0A8G5QB87_PSEAI
264
0
30016
TrEMBL
-
A0A069Q9W1_PSEAI
264
0
30016
TrEMBL
-
A0A8G3CVI7_PSEAI
264
1
30059
TrEMBL
-
A0A8F9P4X5_PSEAI
264
1
30029
TrEMBL
-
A0A8G4A4Y8_PSEAI
264
0
29998
TrEMBL
-
A0A3S0J4Z3_PSEAI
264
1
30070
TrEMBL
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ferrari, S.; Losasso, V.; Costi, M.
Sequence-based identification of specific drug target regions in the thymidylate synthase enzyme family
ChemMedChem
3
392-401
2008
Acinetobacter baumannii, Aeromonas hydrophila, Bordetella bronchiseptica, Ascaris suum, Aspergillus clavatus, Aspergillus fischeri, Aspergillus fumigatus, Aspergillus nidulans, Bacillus amyloliquefaciens, Bacillus anthracis, Bacillus cereus, Bacillus licheniformis, Bacillus mycoides, Bacteroides thetaiotaomicron, Bacteroides fragilis, Porphyromonas gingivalis, Bartonella bacilliformis, Bordetella parapertussis, Bordetella pertussis, Brucella abortus, Brucella melitensis, Burkholderia mallei, Burkholderia pseudomallei, Candida albicans, Debaryomyces hansenii, [Candida] glabrata, Chaetomium globosum, Chromobacterium violaceum, Clostridioides difficile, Coccidioides immitis, Comamonas testosteroni, Corynebacterium diphtheriae, Coxiella burnetii, Cryptococcus neoformans, Cryptosporidium parvum, Streptococcus pneumoniae, Enterobacter sp., Enterococcus faecalis, Enterococcus faecium, Salmonella enterica, Francisella tularensis, Fusobacterium nucleatum, [Haemophilus] ducreyi, Haemophilus influenzae, Human alphaherpesvirus 1, Legionella pneumophila, Leishmania amazonensis, Leishmania braziliensis, Leishmania donovani, Leishmania infantum, Leishmania major, Leishmania tropica, Listeria monocytogenes, Staphylococcus aureus, Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium tuberculosis variant bovis, Mycobacterium leprae, Mycoplasma genitalium, Mycoplasma pneumoniae, Neisseria gonorrhoeae, Neisseria meningitidis, Pasteurella multocida, Yersinia pestis, Yersinia pseudotuberculosis, Plasmodium vivax, Pneumocystis carinii, Cutibacterium acnes, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Pseudomonas mendocina, Shewanella putrefaciens, Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Paratyphi A, Salmonella enterica subsp. enterica serovar Typhi, Schistosoma japonicum, Shigella boydii, Shigella dysenteriae, Shigella flexneri, Shigella sonnei, Novosphingobium aromaticivorans, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus saprophyticus, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus mutans, Streptococcus sanguinis, Toxoplasma gondii, Trichinella spiralis, Trypanosoma brucei, Trypanosoma cruzi, Vibrio alginolyticus, Vibrio parahaemolyticus, Yersinia enterocolitica, Plasmodium malariae, Cryptosporidium hominis, Encephalitozoon cuniculi, Vibrio vulnificus, Bartonella henselae, Bartonella quintana, Mycobacterium ulcerans, Burkholderia multivorans, Yersinia bercovieri, Yersinia frederiksenii, Brucella suis, Serratia proteamaculans, Yersinia intermedia, Burkholderia vietnamiensis, Nocardia farcinica, Malacoplasma penetrans, Burkholderia ambifaria, Corynebacterium jeikeium, Yersinia mollaretii, Burkholderia dolosa, Vibrio cholerae serotype O1, Plasmodium falciparum (P13922)
Manually annotated by BRENDA team