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Information on EC 2.1.1.320 - type II protein arginine methyltransferase and Organism(s) Homo sapiens

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EC Tree
IUBMB Comments
The enzyme catalyses the methylation of one of the terminal guanidino nitrogen atoms in arginine residues within proteins, forming monomethylarginine, followed by the methylation of the second terminal nitrogen atom to form a symmetrical dimethylarginine. The mammalian enzyme is active in both the nucleus and the cytoplasm, and plays a role in the assembly of snRNP core particles by methylating certain small nuclear ribonucleoproteins. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.321, type III protein arginine methyltransferase, and EC 2.1.1.322, type IV protein arginine methyltransferase.
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Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
prmt5, prmt7, protein arginine methyltransferase 5, prmt9, type ii protein arginine methyltransferase, prmt-5, prmt-9, jak-binding protein 1, janus kinase-binding protein 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Jak-binding protein 1
-
Janus kinase-binding protein 1
-
-
PRMT5
PRMT9
protein arginine methyltransferase 5
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming)
The enzyme catalyses the methylation of one of the terminal guanidino nitrogen atoms in arginine residues within proteins, forming monomethylarginine, followed by the methylation of the second terminal nitrogen atom to form a symmetrical dimethylarginine. The mammalian enzyme is active in both the nucleus and the cytoplasm, and plays a role in the assembly of snRNP core particles by methylating certain small nuclear ribonucleoproteins. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.321, type III protein arginine methyltransferase, and EC 2.1.1.322, type IV protein arginine methyltransferase.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + [D2 dopamine receptor]-L-arginine
2 S-adenosyl-L-homocysteine + [D2 dopamine receptor]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
recombinant fragment of the third intracellular loop of D2, corresponding to amino acid residues 211 to 241 fused to glutathione S-transferase. Residues Arg217 and Arg219 are key methylation sites within this region
-
-
?
2 S-adenosyl-L-methionine + [DOP-3 receptor]-L-arginine
2 S-adenosyl-L-homocysteine + [DOP-3 receptor]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
recombinant fragment of the third intracellular loop of Caenorhabditis elegans DOP-3, amino acid residues 202 to 232 fused to GST. Residues Arg208 and Arg210 are key methylation sites within this region
-
-
?
2 S-adenosyl-L-methionine + [golgin GM130]-L-arginine
2 S-adenosyl-L-homocysteine + [golgin GM130]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
overall reaction
-
?
2 S-adenosyl-L-methionine + [histone H3R2]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H3R2]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [histone H3R8]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H3R8]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [histone H3]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H3]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
isoform PRMT5 bound to nuclear protein COPR5 methylates histone histone H3 at residue R8. Methylation of histone H4 is preferred over histone H3
-
?
2 S-adenosyl-L-methionine + [histone H4 peptide]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H4 peptide]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
both PRMT5 alone and PRMT5 in complex with MEP50 are able to generate di-methylated H4 peptide product. The PRMT5:MEP50 complex consistently has a higher level of methyltransferase activity compared with PRMT5
-
?
2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [histone H4]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H4]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [KRAB-associated protein 1]-L-arginine
2 S-adenosyl-L-homocysteine + [KRAB-associated protein 1]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [SmD3 protein]-L-arginine
2 S-adenosyl-L-homocysteine + [SmD3 protein]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [splicing factor SF3B2]-L-arginine
2 S-adenosyl-L-homocysteine + [splicing factor SF3B2]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
overall reaction, isoform PRMT9 symmetrically dimethylates arginine residues on splicing factor SF3B2. A peptide containing the methylatable Arg508 of SF3B2 is not recognized by PRMT9 in vitro. Amino acid substitutions of residues surrounding Arg508 have no great effect on PRMT9 recognition of SF3B2, but moving the arginine residue within this sequence abolishes methylation
-
?
2 S-adenosyl-L-methionine + [voltage-gated sodium channel NaV1.5]-L-arginine
2 S-adenosyl-L-homocysteine + [voltage-gated sodium channel NaV1.5]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
S-adenosyl-L-methionine + [GST-fibrillarin]-L-arginine
S-adenosyl-L-homocysteine + [GST-fibrillarin]-Nomega-methyl-L-arginine
show the reaction diagram
substrate is amino terminus of fibrillarin fused to glutathione S-transferase
-
-
?
S-adenosyl-L-methionine + [GST-fibrillarin]-Nomega-methyl-L-arginine
S-adenosyl-L-homocysteine + [GST-fibrillarin]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [GST-GAR]-L-arginine
S-adenosyl-L-homocysteine + [GST-GAR]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + [GST-GAR]-Nomega-methyl-L-arginine
S-adenosyl-L-homocysteine + [GST-GAR]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + [histone H2A]-L-arginine
S-adenosyl-L-homocysteine + [histone H2A]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + [histone H2A]-Nomega-methyl-L-arginine
S-adenosyl-L-homocysteine + [histone H2A]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + [histone]-L-arginine
S-adenosyl-L-homocysteine + [histone]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [histone]-Nomega-methyl-L-arginine
S-adenosyl-L-homocysteine + [histone]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [myelin basic protein]-L-arginine
S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega-methyl-L-arginine
show the reaction diagram
S-adenosyl-L-methionine + [myelin basic protein]-Nomega-methyl-L-arginine
S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + [histone H3R2]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H3R2]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [histone H3R8]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H3R8]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
the enzyme (PRMT5) catalyse the formation of either activating H3R2me2s or repressive H3R8me2s and H4R3me2s marks as a part of epigenetic histone code
-
-
?
2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [KRAB-associated protein 1]-L-arginine
2 S-adenosyl-L-homocysteine + [KRAB-associated protein 1]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
methylation of KRAB-associated protein 1 (KAP1) arginine residues regulates the KAP1-ZNF224 interaction, thus suggesting that this KAP1 post-translational modification can actively contribute to the regulation of ZNF224-mediated repression
-
-
?
2 S-adenosyl-L-methionine + [SmD3 protein]-L-arginine
2 S-adenosyl-L-homocysteine + [SmD3 protein]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
-
-
?
2 S-adenosyl-L-methionine + [voltage-gated sodium channel NaV1.5]-L-arginine
2 S-adenosyl-L-homocysteine + [voltage-gated sodium channel NaV1.5]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
PRMT5, along with PRMT3, binds to and methylate the voltage-gated sodium channel NaV1.5
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,2S,3R,5R)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(E)-2-(quinolin-7-yl)ethenyl]cyclopentane-1,2-diol
-
(1R,2S,3R,5R)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(S)-(3,4-difluorophenyl)(hydroxy)methyl]cyclopentane-1,2-diol
-
(1R,2S,3R,5R)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[[(quinolin-7-yl)oxy]methyl]cyclopentane-1,2-diol
-
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(2-[2-[(cyclopropylmethyl)amino]quinolin-7-yl]ethyl)cyclopentane-1,2-diol
-
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(2,3-dimethylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
-
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(2-aminoquinolin-7-yl)ethyl]cyclopentane-1,2-diol
-
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(3-methylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
-
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(6-chloro-3-methylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
-
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(6-fluoro-3-methylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
-
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(quinolin-7-yl)ethyl]cyclopentane-1,2-diol
-
(1S,2R,3R,5R)-3-[(R)-hydroxy(1,2,3,4-tetrahydroisoquinolin-8-yl)methyl]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
-
(1S,2R,3S,5R)-3-[2-(2-amino-3-bromoquinolin-7-yl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
-
(1S,2R,3S,5R)-3-[2-(6-aminopyridin-3-yl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
-
(1S,2R,3S,5R)-3-[4-(6-aminopyridin-2-yl)butyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
-
(1S,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(4-chloro-3-fluorophenyl)sulfanyl]cyclopentane-1,2-diol
-
(1S,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(quinolin-7-yl)methoxy]cyclopentane-1,2-diol
-
(1S,2S,3R,5S)-3-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(1,2,3,4-tetrahydroisoquinolin-8-yl)oxy]cyclopentane-1,2-diol
-
(1S,2S,3R,5S)-3-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[[6-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]cyclopentane-1,2-diol
-
(1S,2S,3S,5R)-3-[(5-fluoro-6-methoxy-1,2,3,4-tetrahydroisoquinolin-8-yl)oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
-
(1S,2S,3S,5R)-3-[(6-bromo-1,2,3,4-tetrahydroisoquinolin-8-yl)oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
-
(1S,2S,3S,5R)-3-[[6-(difluoromethoxy)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
-
(1S,2S,3S,5R)-3-[[6-(difluoromethyl)-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
-
(1S,2S,3S,5R)-3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
-
(1S,2S,3S,5R)-3-[[6-(difluoromethyl)-5-fluoro-4-methyl-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
-
(2R,3S,4R,5R)-2-[(S)-hydroxy(1,2,3,4-tetrahydroisoquinolin-8-yl)methyl]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)oxolane-3,4-diol
-
(4Z)-7-[(5R)-5-amino-5-(4-chlorophenyl)-5-deoxy-beta-D-ribofuranosyl]-4-hydrazinylidene-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine
-
(5R)-5'-C-(3,4-difluorophenyl)adenosine
-
1-(6-bromo-9-ethyl-9H-carbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine
-
1-[(5R)-5-C-(4-chlorophenyl)-beta-D-ribofuranosyl]-3-ethynyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
-
2-([[2-(benzyloxy)-1,4-dihydronaphthalen-1-yl]methyl]amino)-1-phenylethan-1-ol
-
3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(3-fluorophenyl)propanamide
-
3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-[3-(trifluoromethoxy)phenyl]propanamide
-
3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-[4-(trifluoromethyl)pyrimidin-2-yl]propanamide
-
7-[(5R)-5-amino-5-deoxy-5-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-4-methyl-7H-pyrrolo[2,3-d]pyrimidine
-
7-[(5R)-5-C-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-4-methyl-7H-pyrrolo[2,3-d]pyrimidine
-
7-[(5R)-5-C-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-amine
-
7-[(5R)-5-C-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
-
7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
-
7-[(5R)-5-C-(4-chlorophenyl)-beta-D-ribofuranosyl]-5-ethynyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
-
7-[(5R)-5-C-(4-chlorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
-
7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
-
7-[5-O-(quinolin-7-yl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
-
8-[[(1S,2S,3S,4R)-2,3-dihydroxy-4-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentyl]oxy]-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile
-
dehydrosinefungin
-
GSK3326595
substrate competitive inhibitor, clinic trials for multiple cancer types
methyl 2-[2-(3,4-dihydroisoquinolin-2(1H)-yl)acetamido]benzoate
-
methyl 2-[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetamido]benzoate
-
methyl 2-[3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamido]benzoate
-
methyl 2-[4-(3,4-dihydroisoquinolin-2(1H)-yl)butanamido]benzoate
-
N'-[3-(3,4-dihydroisoquinolin-2(1H)-yl)propanoyl]benzohydrazide
-
N-(2-cyanophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
-
N-(3-acetylphenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
-
N-(3-bromo-2-cyanophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
-
N-(3-bromophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
-
N-(3-chlorophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
-
N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide
i.e. EPZ015666
N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-[(oxetan-3-yl)amino]pyrimidine-4-carboxamide
-
S-adenosyl-L-homocysteine
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
PRMT7
PRMT7-mediated monomethylation of histone H4 Arg17 regulates PRMT5 activity at Arg3 in the same protein. Monomethylation at Arg-17 in histone H4 raises the general activity of PRMT5 with this substrate, but also ameliorates the low activity of PRMT5 at low substrate concentrations
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000022 - 0.001
S-adenosyl-L-methionine
0.0042 - 0.0102
[histone H4 peptide]-L-arginine
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000079
(1R,2S,3R,5R)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(E)-2-(quinolin-7-yl)ethenyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000002
(1R,2S,3R,5R)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(S)-(3,4-difluorophenyl)(hydroxy)methyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000026
(1R,2S,3R,5R)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[[(quinolin-7-yl)oxy]methyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.00000079
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(2-[2-[(cyclopropylmethyl)amino]quinolin-7-yl]ethyl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000002
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(2,3-dimethylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.00000025
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(2-aminoquinolin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000008
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(3-methylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000016
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(6-chloro-3-methylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.00000032
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(6-fluoro-3-methylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000063
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(quinolin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000002
(1S,2R,3R,5R)-3-[(R)-hydroxy(1,2,3,4-tetrahydroisoquinolin-8-yl)methyl]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.00000013
(1S,2R,3S,5R)-3-[2-(2-amino-3-bromoquinolin-7-yl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000000501
(1S,2R,3S,5R)-3-[2-(6-aminopyridin-3-yl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000004
(1S,2R,3S,5R)-3-[4-(6-aminopyridin-2-yl)butyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000026
(1S,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(4-chloro-3-fluorophenyl)sulfanyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000126
(1S,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(quinolin-7-yl)methoxy]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3R,5S)-3-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(1,2,3,4-tetrahydroisoquinolin-8-yl)oxy]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000002
(1S,2S,3R,5S)-3-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[[6-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[(5-fluoro-6-methoxy-1,2,3,4-tetrahydroisoquinolin-8-yl)oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[(6-bromo-1,2,3,4-tetrahydroisoquinolin-8-yl)oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[[6-(difluoromethoxy)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[[6-(difluoromethyl)-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[[6-(difluoromethyl)-5-fluoro-4-methyl-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(2R,3S,4R,5R)-2-[(S)-hydroxy(1,2,3,4-tetrahydroisoquinolin-8-yl)methyl]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)oxolane-3,4-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000006
(4Z)-7-[(5R)-5-amino-5-(4-chlorophenyl)-5-deoxy-beta-D-ribofuranosyl]-4-hydrazinylidene-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
pH and temperature not specified in the publication
0.000003
(5R)-5'-C-(3,4-difluorophenyl)adenosine
Homo sapiens
pH and temperature not specified in the publication
0.000517
1-(6-bromo-9-ethyl-9H-carbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine
Homo sapiens
pH and temperature not specified in the publication
0.000116
1-[(5R)-5-C-(4-chlorophenyl)-beta-D-ribofuranosyl]-3-ethynyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.0028
2-([[2-(benzyloxy)-1,4-dihydronaphthalen-1-yl]methyl]amino)-1-phenylethan-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.04587
3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(3-fluorophenyl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.06295
3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-[3-(trifluoromethoxy)phenyl]propanamide
Homo sapiens
pH and temperature not specified in the publication
0.06987
3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-[4-(trifluoromethyl)pyrimidin-2-yl]propanamide
Homo sapiens
pH and temperature not specified in the publication
0.000009
7-[(5R)-5-amino-5-deoxy-5-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-4-methyl-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
pH and temperature not specified in the publication
0.000003
7-[(5R)-5-C-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-4-methyl-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
pH and temperature not specified in the publication
0.000002
7-[(5R)-5-C-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.000001
7-[(5R)-5-C-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.00000002
7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.000017
7-[(5R)-5-C-(4-chlorophenyl)-beta-D-ribofuranosyl]-5-ethynyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.0000043
7-[(5R)-5-C-(4-chlorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.0000095 - 0.000026
7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
0.0000158
7-[5-O-(quinolin-7-yl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.000001
8-[[(1S,2S,3S,4R)-2,3-dihydroxy-4-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentyl]oxy]-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile
Homo sapiens
pH and temperature not specified in the publication
0.000035
dehydrosinefungin
Homo sapiens
pH and temperature not specified in the publication
0.06
methyl 2-[2-(3,4-dihydroisoquinolin-2(1H)-yl)acetamido]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.00033
methyl 2-[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetamido]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.03162
methyl 2-[3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamido]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.08789
methyl 2-[4-(3,4-dihydroisoquinolin-2(1H)-yl)butanamido]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.07254
N'-[3-(3,4-dihydroisoquinolin-2(1H)-yl)propanoyl]benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.02555
N-(2-cyanophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.05195
N-(3-acetylphenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.00271
N-(3-bromo-2-cyanophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.01812
N-(3-bromophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.04213
N-(3-chlorophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.000047
N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide
Homo sapiens
pH and temperature not specified in the publication
0.000022
N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-[(oxetan-3-yl)amino]pyrimidine-4-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.00056
S-adenosyl-L-homocysteine
Homo sapiens
pH and temperature not specified in the publication
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
lung carcinoma
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
coexpression of candidate tumor suppressor gene RASSF1A and PRMT5 leads to a redistribution of PRMT5 from the cytosol to stabilized microtubules
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug target
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NDUF7_HUMAN
441
0
49238
Swiss-Prot
Mitochondrion (Reliability: 3)
ANM9_HUMAN
845
0
94501
Swiss-Prot
Mitochondrion (Reliability: 3)
ANM5_HUMAN
637
0
72684
Swiss-Prot
other Location (Reliability: 4)
B4DFS5_HUMAN
214
0
23700
TrEMBL
Mitochondrion (Reliability: 3)
B4DXV9_HUMAN
414
0
46106
TrEMBL
Mitochondrion (Reliability: 4)
B4DQY3_HUMAN
370
0
41119
TrEMBL
Mitochondrion (Reliability: 3)
H7C3N5_HUMAN
88
0
9801
TrEMBL
other Location (Reliability: 2)
C9JEL7_HUMAN
111
0
12420
TrEMBL
other Location (Reliability: 3)
C9J236_HUMAN
230
0
25414
TrEMBL
other Location (Reliability: 3)
B4E0W7_HUMAN
137
0
15221
TrEMBL
Mitochondrion (Reliability: 3)
C9JS27_HUMAN
267
0
29777
TrEMBL
other Location (Reliability: 3)
C9JP36_HUMAN
148
0
16459
TrEMBL
other Location (Reliability: 3)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
158000
sedimentation analysis
240000
sedimentation analysis
68000
sedimentation analysis
72000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
2 * 72000, SDS-PAGE
monomer
1 * 72000, SDS-PAGE
tetramer
4 * 72000, SDS-PAGE
additional information
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of isoform PRMT5 in complex with methylosome protein MEP50, bound to an S-adenosylmethionine analog and a peptide substrate derived from histone H4
in a structural model, the carboxylate group of the position 4 Asp258 points away from the substrate arginine, possibly to coordinate the binding of one or both of the two lysine residues adjacent to the methylated arginine in the FKRKY sequence of substrate SF3B2
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D258G
mutation mimics type I enzymes, complete loss of activity
DELTA365-369
-
deletion of the sequence GAGRG, residues 365-369 in the -adenosyl-L-methionine-binding motif I, leads to dramatic reduction in catalytic activity
G260E
mutation mimics isoform PRMT7, complete loss of activity
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
curcumin downregulates the PRMT5 expression. Curcumin-mediated signalling events are responsible for its anti-oncogene action against PRMT5
PRMT5 expression is down-regulated in senescent and H2O2-treated macrophages rendering ineffectual induction of MHC II transcription by IFN-gamma
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rho, J.; Choi, S.; Seong, Y.R.; Cho, W.K.; Kim, S.H.; Im, D.S.
PRMT5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family
J. Biol. Chem.
276
11393-11401
2001
Homo sapiens (O14744), Homo sapiens
Manually annotated by BRENDA team
Branscombe, T.L.; Frankel, A.; Lee, J.H.; Cook, J.R.; Yang, Z.; Pestka, S.; Clarke, S.
PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins
J. Biol. Chem.
276
32971-32976
2001
Homo sapiens
Manually annotated by BRENDA team
Lacroix, M.; Messaoudi, S.E.; Rodier, G.; Le Cam, A.; Sardet, C.; Fabbrizio, E.
The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5
EMBO Rep.
9
452-458
2008
Homo sapiens (O14744)
Manually annotated by BRENDA team
Sakai, N.; Saito, Y.; Fujiwara, Y.; Shiraki, T.; Imanishi, Y.; Koshimizu, T.A.; Shibata, K.
Identification of protein arginine N-methyltransferase 5 (PRMT5) as a novel interacting protein with the tumor suppressor protein RASSF1A
Biochem. Biophys. Res. Commun.
467
778-784
2015
Homo sapiens (O14744)
Manually annotated by BRENDA team
Sohail, M.; Zhang, M.; Litchfield, D.; Wang, L.; Kung, S.; Xie, J.
Differential expression, distinct localization and opposite effect on Golgi structure and cell differentiation by a novel splice variant of human PRMT5
Biochim. Biophys. Acta
1853
2444-2452
2015
Homo sapiens (O14744), Homo sapiens
Manually annotated by BRENDA team
Zhou, Z.; Sun, X.; Zou, Z.; Sun, L.; Zhang, T.; Guo, S.; Wen, Y.; Liu, L.; Wang, Y.; Qin, J.; Li, L.; Gong, W.; Bao, S.
PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130
Cell Res.
20
1023-1033
2010
Homo sapiens (O14744)
Manually annotated by BRENDA team
Shilo, K.; Wu, X.; Sharma, S.; Welliver, M.; Duan, W.; Villalona-Calero, M.; Fukuoka, J.; Sif, S.; Baiocchi, R.; Hitchcock, C.L.; Zhao, W.; Otterson, G.A.
Cellular localization of protein arginine methyltransferase-5 correlates with grade of lung tumors
Diagn. Pathol.
8
201
2013
Homo sapiens (O14744)
Manually annotated by BRENDA team
Hadjikyriacou, A.; Yang, Y.; Espejo, A.; Bedford, M.T.; Clarke, S.G.
Unique features of human protein arginine methyltransferase 9 (PRMT9) and its substrate RNA splicing Factor SF3B2
J. Biol. Chem.
290
16723-16743
2015
Homo sapiens (Q6P2P2), Homo sapiens
Manually annotated by BRENDA team
Gonsalvez, G.B.; Tian, L.; Ospina, J.K.; Boisvert, F.M.; Lamond, A.I.; Matera, A.G.
Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins
J. Cell Biol.
178
733-740
2007
Homo sapiens (O14744), Homo sapiens
Manually annotated by BRENDA team
Quan, X.; Yue, W.; Luo, Y.; Cao, J.; Wang, H.; Wang, Y.; Lu, Z.
The protein arginine methyltransferase PRMT5 regulates Abeta-induced toxicity in human cells and Caenorhabditis elegans models of Alzheimers disease
J. Neurochem.
134
969-977
2015
Homo sapiens (O14744), Homo sapiens, Caenorhabditis elegans (P46580), Caenorhabditis elegans
Manually annotated by BRENDA team
Gu, Z.; Li, Y.; Lee, P.; Liu, T.; Wan, C.; Wang, Z.
Protein arginine methyltransferase 5 functions in opposite ways in the cytoplasm and nucleus of prostate cancer cells
PLoS ONE
7
e44033
2012
Homo sapiens (O14744)
Manually annotated by BRENDA team
Antonysamy, S.; Bonday, Z.; Campbell, R.M.; Doyle, B.; Druzina, Z.; Gheyi, T.; Han, B.; Jungheim, L.N.; Qian, Y.; Rauch, C.; Russell, M.; Sauder, J.M.; Wasserman, S.R.; Weichert, K.; Willard, F.S.; Zhang, A.; Emtage, S.
Crystal structure of the human PRMT5:MEP50 complex
Proc. Natl. Acad. Sci. USA
109
17960-17965
2012
Homo sapiens (O14744), Homo sapiens
Manually annotated by BRENDA team
Likhite, N.; Jackson, C.A.; Liang, M.S.; Krzyzanowski, M.C.; Lei, P.; Wood, J.F.; Birkaya, B.; Michaels, K.L.; Andreadis, S.T.; Clark, S.D.; Yu, M.C.; Ferkey, D.M.
The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling
Sci. Signal.
8
ra115
2015
Homo sapiens (O14744), Homo sapiens, Caenorhabditis elegans (P46580), Caenorhabditis elegans
Manually annotated by BRENDA team
Fan, Z.; Kong, X.; Xia, J.; Wu, X.; Li, H.; Xu, H.; Fang, M.; Xu, Y.
The arginine methyltransferase PRMT5 regulates CIITA-dependent MHC II transcription
Biochim. Biophys. Acta
1859
687-696
2016
Homo sapiens (O14744), Mus musculus (Q8CIG8)
Manually annotated by BRENDA team
di Caprio, R.; Ciano, M.; Montano, G.; Costanzo, P.; Cesaro, E.
KAP1 is a novel substrate for the arginine methyltransferase PRMT5
Biology
4
41-49
2015
Homo sapiens (O14744)
Manually annotated by BRENDA team
Zhu, K.; Song, J.L.; Tao, H.R.; Cheng, Z.Q.; Jiang, C.S.; Zhang, H.
Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors
Bioorg. Med. Chem. Lett.
28
3693-3699
2018
Homo sapiens (O14744), Homo sapiens
Manually annotated by BRENDA team
Lin, H.; Luengo, J.I.
Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors
Bioorg. Med. Chem. Lett.
29
1264-1269
2019
Homo sapiens (O14744)
Manually annotated by BRENDA team
Sheng, X.; Wang, Z.
Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation
BMC Cancer
16
567
2016
Homo sapiens (O14744)
Manually annotated by BRENDA team
Stopa, N.; Krebs, J.E.; Shechter, D.
The PRMT5 arginine methyltransferase many roles in development, cancer and beyond
Cell. Mol. Life Sci.
72
2041-2059
2015
Homo sapiens (O14744), Homo sapiens, Caenorhabditis elegans (P46580), Caenorhabditis elegans, Xenopus laevis (Q6NUA1)
Manually annotated by BRENDA team
Chung, J.; Karkhanis, V.; Baiocchi, R.A.; Sif, S.
Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/?-catenin and AKT/GSK3? proliferative signaling
J. Biol. Chem.
294
7692-7710
2019
Homo sapiens (O14744), Mus musculus (Q8CIG8), Mus musculus
Manually annotated by BRENDA team
Li, M.; An, W.; Xu, L.; Lin, Y.; Su, L.; Liu, X.
The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells
J. Exp. Clin. Cancer Res.
38
64
2019
Homo sapiens (O14744), Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Hu, W.; Yuan, Y.
Protein arginine methyltransferase 5 (PRMT5) as an anticancer target and its inhibitor discovery
J. Med. Chem.
61
9429-9441
2018
Homo sapiens (O14744)
Manually annotated by BRENDA team
Chatterjee, B.; Ghosh, K.; Suresh, L.; Kanade, S.
Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells
Mol. Cell. Biochem.
455
73-90
2019
Homo sapiens (O14744), Homo sapiens
Manually annotated by BRENDA team
Jain, K.; Jin, C.; Clarke, S.
Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases
Proc. Natl. Acad. Sci. USA
114
10101-10106
2017
Homo sapiens (O14744)
Manually annotated by BRENDA team
Favia, A.; Salvatori, L.; Nanni, S.; Iwamoto-Stohl, L.; Valente, S.; Mai, A.; Scagnoli, F.; Fontanella, R.; Totta, P.; Nasi, S.; Illi, B.
The protein arginine methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells
Sci. Rep.
9
15925
2019
Homo sapiens (O14744)
Manually annotated by BRENDA team