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The expected taxonomic range for this enzyme is: Hordeum vulgare
Synonyms
DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid), methyltransferase, tyramine N-, S-adenosyl-methionine:tyramine N-methyltransferase, tyramine methylpherase,
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DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)
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methyltransferase, tyramine N-
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S-adenosyl-methionine:tyramine N-methyltransferase
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tyramine methylpherase
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S-adenosyl-L-methionine + tyramine = S-adenosyl-L-homocysteine + N-methyltyramine
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S-adenosyl-L-methionine:tyramine N-methyltransferase
Has some activity on phenylethylamine analogues.
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4-chlorophenethylamine + S-adenosyl-L-methionine
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29% of activity with tyramine
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beta-phenethanolamine + S-adenosyl-L-methionine
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23% of activity with tyramine
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S-adenosyl-L-methionine + alpha-methyltyramine
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i.e. paredrine, 53% of activity with tyramine
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S-adenosyl-L-methionine + tyramine
N-methyltyramine + S-adenosyl-L-homocysteine
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conversion rate is higher with (-)-L-diastereoisomer of methionine
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additional information
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involved in hordenine biosynthesis
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additional information
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involved in hordenine biosynthesis
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additional information
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no cofactor requirement
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p-chloromercuribenzoate
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strong
additional information
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EDTA is not inhibitory
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0.03
S-adenosyl-L-methionine
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L. var. Betzes, barley
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brenda
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of seedling
brenda
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heat-labile: 70% loss of activity after 10 min
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sulfhydryl compound necessary for stabilization
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441284
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-18°C, addition of sucrose to a final concentration of 0.2 M, several weeks
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4°C, pH 7.0 and 5 mM 2-mercaptoethanol, several days
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Mann, J.D.; Mudd, S.H.
Alkaloids and plant metabolism
J. Biol. Chem.
238
381-385
1963
Hordeum vulgare
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brenda
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2.1.1.27 tyramine N-methyltransferase
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